EP1605923A2 - Dispersion mssn et procede de production de ladite dispersion - Google Patents

Dispersion mssn et procede de production de ladite dispersion

Info

Publication number
EP1605923A2
EP1605923A2 EP04712492A EP04712492A EP1605923A2 EP 1605923 A2 EP1605923 A2 EP 1605923A2 EP 04712492 A EP04712492 A EP 04712492A EP 04712492 A EP04712492 A EP 04712492A EP 1605923 A2 EP1605923 A2 EP 1605923A2
Authority
EP
European Patent Office
Prior art keywords
phase
nanoparticles
dispersion
active substance
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04712492A
Other languages
German (de)
English (en)
Inventor
Gerd Dahms
Holger Seidel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kemira Oyj
Original Assignee
IFAC GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IFAC GmbH and Co KG filed Critical IFAC GmbH and Co KG
Publication of EP1605923A2 publication Critical patent/EP1605923A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Definitions

  • EP-B 0 605 497 describes drug carriers made of solid lipid particles (solid lipid nanospheres (SLN)).
  • the production is carried out by high pressure homogenization or high pressure dispersion at pressures from 500 to 1550 bar.
  • a gap homogenizer or a high-speed homogenizer, for example, are used as the high-pressure linearizer.
  • Predispersion is usually carried out using a rotor-stator disperser.
  • the MSSN can be loaded with a wide variety of active ingredients, as explained in more detail below.
  • the maximum achievable degree of loading depends, among other things. from the melting point of the loading substance (active substance). If the active substance has a high solubility in the active substance carrier, high degrees of loading can be achieved.
  • organic dyes are used as active substances or instead of active substances.
  • the invention also relates to a method for producing a multiple dispersion by mixing a dispersion which has been prepared as described above with a further polyol or oil phase.
  • the invention also relates to a correspondingly produced multiple dispersion. Multiple emulsions are described, for example, in DE-A-43 41 113.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nanoparticules solides à membrane structurée qui possèdent un diamètre moyen des particules de l'ordre de 10 à 10 000 nm, qui sont solides à 25 °C et qui possèdent une combinaison de particules destinées à porter des principes actifs et d'émulsifiants de manière à former des membranes présentes dans la totalité des nanoparticules, si bien que des émulsifiants se trouvent dans l'intérieur et à la surface desdites nanoparticules. La présente invention concerne également un procédé de production d'une dispersion aqueuse de substance destinée à porter des principes actifs renfermant des particules solides destinées à porter des principes actifs, à base de cire, de polymères ou de lipides, ayant un diamètre moyen de l'ordre de 10 à 10 000 nm, qui contiennent au moins un principe actif pharmaceutique, cosmétique et / ou alimentaire. Ledit procédé consiste (a) à mélanger le principe actif avec la substance destinée à porter les principes actifs, à base de cire, de polymères ou de lipides, et avec au moins un émulsifiant qui conduit à l'étape (b) à la formation d'une phase mélangée lyotrope de cristaux liquides, à une température située au-dessus du point de fusion ou de ramollissement de la substance destinée à porter les principes actifs, pour obtenir une phase B, (b) à mélanger mécaniquement la phase B avec une phase aqueuse A qui peut contenir un émulsifiant, à une température située au-dessus du point de fusion ou de ramollissement de la substance destinée à porter les principes actifs, le rapport pondéral de la phase A à la phase B étant de 1/5 à 5/1, sans homogénéisation à haute pression, pour obtenir une phase mélangée lyotrope de cristaux liquides et (c) à diluer la phase mélangée avec une phase aqueuse qui peut contenir un émulsifiant, à une température de la phase aqueuse située au-dessous du point de fusion ou de ramollissement de la substance destinée à porter les principes actifs, avec agitation et sans homogénéisation à haute pression, pour obtenir une concentration finale souhaitée de la dispersion.
EP04712492A 2003-03-21 2004-02-19 Dispersion mssn et procede de production de ladite dispersion Withdrawn EP1605923A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10312763A DE10312763A1 (de) 2003-03-21 2003-03-21 Verfahren zur Herstellung einer SLN-Dispersion
DE10312763 2003-03-21
PCT/EP2004/001589 WO2004082666A2 (fr) 2003-03-21 2004-02-19 Dispersion mssn et procede de production de ladite dispersion

Publications (1)

Publication Number Publication Date
EP1605923A2 true EP1605923A2 (fr) 2005-12-21

Family

ID=32921086

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04712492A Withdrawn EP1605923A2 (fr) 2003-03-21 2004-02-19 Dispersion mssn et procede de production de ladite dispersion

Country Status (8)

Country Link
US (1) US20060257334A1 (fr)
EP (1) EP1605923A2 (fr)
JP (1) JP2006520750A (fr)
KR (1) KR20050114255A (fr)
AU (1) AU2004222631B2 (fr)
CA (1) CA2519697C (fr)
DE (1) DE10312763A1 (fr)
WO (1) WO2004082666A2 (fr)

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Publication number Priority date Publication date Assignee Title
PL1668105T3 (pl) 2003-09-29 2019-03-29 Deb Ip Limited Kompozycje żelopodobne i pieniące o dużej zawartości alkoholu
US9682043B2 (en) 2003-12-09 2017-06-20 Medcrystalforms, Llc Method of preparation of mixed phase co-crystals with active agents
DE102004062775A1 (de) 2004-12-21 2006-06-29 Stockhausen Gmbh Alkoholischer Pumpschaum
BRPI0608347A2 (pt) 2005-03-07 2009-12-08 Deb Worldwide Healthcare Inc composição alcoólica espumável, concentrado de composição, composição alcoólica desinfetante espumável, métodos para formar, produzir e dispensar uma espuma, dispensador não pressurizado, e, métodos para usar uma composição alcoólica de espuma para desinfecção pessoal e para produzir e aplicar a uma pele de indivìduo uma composição alcoólica de espuma desinfetante de pele
US8580860B2 (en) * 2007-02-23 2013-11-12 Gojo Industries, Inc. Foamable alcoholic composition
DE102007063134A1 (de) * 2007-12-24 2009-06-25 Sasol Germany Gmbh Verfahren zur Herstellung von Öl in Wasser Emulsionen aus selbstemulgierenden Gelkonzentraten
DE102007063133A1 (de) * 2007-12-24 2009-06-25 Sasol Germany Gmbh Verfahren zur Herstellung von Wachs in Wasser Dispersionen aus selbstemulgierenden Gelkonzentraten
EP2123606A1 (fr) * 2008-05-19 2009-11-25 Kemira Pigments Oy Nanoparticules de dioxyde de titane ultrafin et dispersions associées
AR080551A1 (es) * 2009-10-05 2012-04-18 Marrone Bio Innovations Derivados que contienen antraquinona como productos agricolas bioquimicos
US8637569B2 (en) 2009-10-22 2014-01-28 Api Genesis, Llc Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds
WO2011049629A2 (fr) * 2009-10-22 2011-04-28 Api Genesis, Llc Procédés de fabrication et d'utilisation de compositions comprenant des flavonoïdes
WO2011133996A2 (fr) 2010-04-30 2011-11-03 Kemira Oyj Dispersions aqueuses pour l'encollage du papier
US20110275738A1 (en) * 2010-05-05 2011-11-10 Basf Se Process for producing finely divided suspensions by melt emulsification
EP2823811A1 (fr) * 2013-07-09 2015-01-14 OTC GmbH Système de libération active ciblée comprenant des nanoparticules lipidiques solides
CN114026178B (zh) * 2019-08-19 2024-01-30 Jsr株式会社 分散组合物、分散剂、各向异性膜及其制造方法、以及各向异性膜形成装置
CN115955959A (zh) * 2020-02-26 2023-04-11 康普萨姆公司 纳米结构脂质载体递送系统、组合物和方法

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DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
US5188837A (en) * 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
AU658608B2 (en) * 1991-03-25 1995-04-27 Astellas Pharma Europe B.V. Topical preparation containing a suspension of solid lipid particles
FR2681248B1 (fr) * 1991-09-13 1995-04-28 Oreal Composition pour un traitement cosmetique et/ou pharmaceutique de longue duree des couches superieures de l'epiderme par une application topique sur la peau.
DE4131562A1 (de) 1991-09-18 1993-03-25 Medac Klinische Spezialpraep Arzneistofftraeger aus festen lipidteilchen-feste lipidnanosphaeren (sln)
US5885486A (en) * 1993-03-05 1999-03-23 Pharmaciaand Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
CA2091152C (fr) * 1993-03-05 2005-05-03 Kirsten Westesen Particules lipidiques solides, particules d'agents bioactifs, et methode de preparation et d'utilisation
US5747012A (en) * 1993-06-11 1998-05-05 Tioxide Specialties Limited Compositions containing sunscreens
DE4327063A1 (de) * 1993-08-12 1995-02-16 Kirsten Dr Westesen Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften
DE4341113B4 (de) * 1993-12-02 2006-04-13 IFAC Institut für angewandte Colloidtechnologie GmbH & Co. KG Stabile multiple X/O/Y-Emulsion
EP0766992B1 (fr) * 1995-10-06 2003-07-30 ENITECNOLOGIE S.p.a. Catalyseur et procédé d'élimination des oxydes d'azote dans les gaz d'échappement
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JP2002292270A (ja) * 2001-03-30 2002-10-08 Sunstar Inc 多相エマルジョン
JP4182195B2 (ja) * 2001-09-03 2008-11-19 独立行政法人農業・食品産業技術総合研究機構 単分散複合型エマルションの製造装置
EP1628626B2 (fr) * 2003-05-07 2013-12-04 OTC GmbH Compositions permettant une liberation ciblee de parfums et d'aromes

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See references of WO2004082666A2 *

Also Published As

Publication number Publication date
AU2004222631A1 (en) 2004-09-30
DE10312763A1 (de) 2004-09-30
WO2004082666A2 (fr) 2004-09-30
CA2519697A1 (fr) 2004-09-30
AU2004222631B2 (en) 2009-02-26
US20060257334A1 (en) 2006-11-16
JP2006520750A (ja) 2006-09-14
CA2519697C (fr) 2011-01-18
WO2004082666A3 (fr) 2005-05-12
KR20050114255A (ko) 2005-12-05

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