EP1616155A2 - Dispositif de securite destine a l'utilisation en laboratoire, notamment a des systemes de chromatographie en phase liquide - Google Patents

Dispositif de securite destine a l'utilisation en laboratoire, notamment a des systemes de chromatographie en phase liquide

Info

Publication number
EP1616155A2
EP1616155A2 EP04722518A EP04722518A EP1616155A2 EP 1616155 A2 EP1616155 A2 EP 1616155A2 EP 04722518 A EP04722518 A EP 04722518A EP 04722518 A EP04722518 A EP 04722518A EP 1616155 A2 EP1616155 A2 EP 1616155A2
Authority
EP
European Patent Office
Prior art keywords
liquid
measuring arrangement
safety device
level measuring
monitoring device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04722518A
Other languages
German (de)
English (en)
Inventor
Thomas Maetzke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1616155A2 publication Critical patent/EP1616155A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
    • G01F23/22—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water
    • G01F23/28—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring the variations of parameters of electromagnetic or acoustic waves applied directly to the liquid or fluent solid material
    • G01F23/296—Acoustic waves
    • G01F23/2966—Acoustic waves making use of acoustical resonance or standing waves
    • G01F23/2967—Acoustic waves making use of acoustical resonance or standing waves for discrete levels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
    • G01M3/00—Investigating fluid-tightness of structures
    • G01M3/02—Investigating fluid-tightness of structures by using fluid or vacuum
    • G01M3/26—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors
    • G01M3/32—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for containers, e.g. radiators
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D9/00—Level control, e.g. controlling quantity of material stored in vessel
    • G05D9/12—Level control, e.g. controlling quantity of material stored in vessel characterised by the use of electric means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/02—Laboratory benches or tables; Fittings therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8804—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 automated systems

Definitions

  • the invention relates to a safety device for laboratory operation, in particular for liquid chromatography systems according to the preamble of claim 1.
  • the invention is particularly suitable, but not exclusively, for use in the field of high-pressure liquid chromatography (HPLC) or in the field of medium-pressure liquid chromatography, where the discharge of volatile, highly flammable and toxic solvents, which occur there in larger flow rates, for example at 100 ml / min be pumped, must be avoided.
  • HPLC high-pressure liquid chromatography
  • medium-pressure liquid chromatography where the discharge of volatile, highly flammable and toxic solvents, which occur there in larger flow rates, for example at 100 ml / min be pumped, must be avoided.
  • a dishwasher is known from EP 0 333 251 A2, which is provided with an overflow pipe for limiting the liquid level in the machine, the overflow pipe being equipped with a siphon-like part.
  • the siphon-like part has an inverted U-shaped curvature in the overflow pipe.
  • a device for displaying the fluctuation in the liquid level of liquids provided in a container comprises a float which can move up or down in a tube.
  • the float is connected to a magnetic body, which can move back and forth in a second tube. With the second hose, magnetic contacts are provided at the desired heights. As soon as the magnetic body comes close to these contacts, an alarm signal is triggered.
  • US 6 276 200 B1 describes a control system for a liquid level in connection with a swimming pool.
  • This system has a sensor which is attached to a holder. The sensor is able To send signals.
  • a feed valve can be activated or deactivated by the signals sent, which feeds replacement water to the swimming pool.
  • a system for controlling a separation unit for the multiphase separation of liquids is known from WO 01/43867 A1.
  • a level of one or more liquids in the separation unit is set in relation to a reference value.
  • the reference value and the liquid level converted into a pressure are led to a pressure-sensitive, mechanical device, the movement of which is transmitted directly to a mechanical control unit. This is coupled to a monitoring device.
  • a disposal system for liquid waste materials at a laboratory work station is known from EP 1 106 254 A2.
  • This disposal system comprises a receptacle which is assigned to the laboratory work station and / or a laboratory work table and has an inlet for the waste materials, a suction connection and a ventilation closure.
  • a mobile collection container is provided for the purpose of better disposal of the waste materials.
  • a fill level monitoring device is assigned to the receptacle, which activates an optical or acoustic signal when the waste materials in the receptacle reach a predetermined fill level.
  • the monitoring device has a sensor which is held on the outside by a holder in a specific position relative to the receptacle and which generates a control signal or triggers the signal when the specific fill level is reached.
  • the sensor can be, for example, an effector or an ultrasonic sensor.
  • a signal generated by another filling level monitoring device can serve to display the filling level and / or for an operational planning that takes into account the time for which the capacity of the liquid container, such as a large container, is still sufficient.
  • the latter monitoring device has a float, the respective height of which is decisive for the respective signal output.
  • one or more sensors can be provided, which physical parameters, for example pressure, temperature or concentration of the Measure waste, in the container and, if necessary, trigger an alarm using an alarm device or generate a signal to switch off an associated pump.
  • a suitable sensor can be connected to the pump via a signal line, so that the delivery is switched off if a condition for the waste material in the collecting container is not fulfilled, for example if the maximum filling level is reached or an undesired chemical reaction takes place.
  • the invention has for its object to provide a safety device of the type mentioned, which is more versatile.
  • a fill level measuring arrangement is preferably provided in the form of a barrel adapter with a siphon, which adapter is screwed onto a liquid container and in which a fill level sensor is inserted.
  • the barrel adapter has two inlets, which lead directly into the liquid container designed as a waste container, and an inlet, which leads into the siphon and is connected to at least one laboratory work surface, so that liquid leaking out on the at least one laboratory work surface can be detected early, ie before the entire liquid container is full, and an alarm signal can be generated.
  • the fill level measuring arrangement designed and arranged according to the invention is thus able, in the sense of a double action, to detect both the liquid level in a liquid container, such as a solvent container, and leaked liquid and, accordingly, also to send or trigger an alarm signal in the latter case.
  • a liquid container such as a solvent container
  • the fill level measuring arrangement according to the invention can thus be used for Detection of a certain liquid level and / or for the detection, for example, of liquid spilled on a laboratory work surface. This can trigger an alarm signal when the liquid container is full or when, for example, a solvent is collected from a laboratory work surface.
  • the fill level measuring arrangement namely preferably the aforementioned barrel adapter
  • the siphon-like interior can therefore be used to hold different liquids, namely the liquid from a liquid container and a leaked liquid.
  • the level limit switch determines whether there is liquid in the interior and can then trigger an alarm signal regardless of where the liquid comes from.
  • the fill level sensor protrudes from above into the siphon of the barrel adapter, which preferably has in a side wall of its interior a through hole connecting the interior of the liquid container with the interior of the siphon of the barrel adapter.
  • the entire level measuring arrangement consisting of barrel adapter with siphon and level limit switch in turn protrudes from above into the liquid container.
  • liquid can then easily enter the interior of the fill level measuring arrangement, namely the siphon, when the liquid in the liquid container has reached a certain fill level.
  • the through hole thus acts like a kind of overflow.
  • the level measuring arrangement namely the barrel adapter
  • the level measuring arrangement has a cup-like element, which preferably has a thread on its upper side with the lower end of a longitudinal bore of the main part of the Level measuring arrangement, namely the barrel adapter, is screwed, wherein said main part preferably has an additional bore opening into this longitudinal bore, through which liquid running out on a laboratory work surface can flow into the interior of the level measuring arrangement.
  • the cup-like element also called a siphon, thus collects the leaked liquid, so that the area of application of the level limit switch, which, as mentioned above, is assigned to the interior and thus to the cup-like element, is expanded. This can therefore detect leaking liquid at an early stage.
  • the cup-like element With the help of the screw connection between the cup-like element and the main part of the barrel adapter, the cup-like element can be easily emptied, so that it and thus the entire level measurement arrangement is ready for use again after a short time.
  • the additional bore of the barrel adapter With the help of the additional bore of the barrel adapter, a simple possibility is created to connect the fill level measuring arrangement on the one hand to the location where a liquid can escape, in particular overflow, and on the other hand to direct the liquid escaping there to the interior of the cup-like element, where even small quantities Liquid can be detected.
  • the safety device according to the invention is therefore able to detect even small amounts of liquid and to generate an alarm signal at an early stage.
  • the fill level measuring arrangement is also a barrel adapter.
  • This can be provided with a G2 inch standard thread and thus forms with the level limit switch a universal level measurement arrangement for overfill prevention of liquid containers, for example waste containers, preferably in liquid chromatography.
  • the barrel adapter is preferably made of metal (such as, for example, stainless steel or aluminum) or of an inert plastic and screwed onto the liquid container, in particular a waste container for liquid substances.
  • the safety device according to the invention can thus be connected to numerous liquid containers and can therefore be used within wide limits. It can be reused as often as you like.
  • the fill level measuring arrangement is connected to a monitoring device which preferably has a plurality of safety circuits and is designed in the form of a so-called liquid control interface, LCI, and which preferably communicates with analysis or control software, for example chromatography software.
  • the monitoring device forms the central power supply unit for an analysis system, for example a preparative HPLC system, and switches it off, preferably with a time delay, in the presence of an alarm signal from one of the safety circuits.
  • the area of application of the safety device according to the invention is also significantly expanded by the monitoring device. Ultimately, several safety circuits can be monitored.
  • Communication preferably in the form of a relay signal from the monitoring device with the analysis or control software, makes it possible to complete a process that is still being processed. Such a process takes about 15 minutes in a chromatography process, for example.
  • the software is therefore able to initiate the end of the process properly.
  • an orderly shutdown can take place by first ending the process and then turning off the power supply.
  • the monitoring device can also be designed in such a way that the power supply is switched off after a time delay of approximately 20 minutes, so that the system, even if the software is not working properly, is switched off automatically after the latter time.
  • an additional timer function can be switched on manually on the monitoring device, which requests a signal in the form of a pulse from the analysis or control software at regular intervals. If this impulse does not arrive regularly or does not occur, the monitoring device can switch off the system, for example, within 4 minutes.
  • liquid-promoting components such as pumps
  • the central power supply unit can be supplied with electrical energy via the central power supply unit. This ensures that the liquid-conveying components are switched off, for example, when the level measuring arrangement detects leaked liquid.
  • the monitoring device can be designed such that the liquid-conveying components are switched off immediately when liquid leaks are detected. If the level measurement arrangement detects that the liquid container is full, a time-delayed shutdown can also be used, as mentioned before, in such a way that an ongoing process can still be completed.
  • the monitoring device is designed such that the maximum and / or the minimum liquid level in a liquid container, for example a storage liquid container, can be detected. It is also possible to connect the monitoring device not only to waste containers, but also to storage containers for liquid substances. In the latter case, an alarm signal is triggered at a minimal liquid level, which also enables the shutdown process to be started again. At the same time, a signal can also be output to the software in this case, which allows a running process to be ended.
  • the monitoring device can also be designed such that a plurality of connections are provided for storage containers. As a result, the area of application of the safety device according to the invention is further enlarged.
  • the monitoring device can thus be able to monitor the liquid level of a waste container, leaked solvent, the liquid level of several storage containers and the system state of the control software, trigger an alarm signal and switch off the power supply with a time delay as soon as one of the safety circuits indicates an alarm state.
  • Monitoring the system status of the control software can include the question of whether the chromatography data system still has control over the HPLC system, in particular over the pumps of the system.
  • the safety device according to the invention can thus also operate fully automatically and, for example, enable work to be carried out overnight. Even if the software is not working correctly, the monitoring device can initiate the shutdown of the entire system.
  • the monitoring device advantageously has further measuring sensors and preferably a timer relay, which generates a signal in the event of an alarm after a preset time delay and thus opens a power current relay, which thus interrupts the power supply at a network output in the form of an output socket.
  • a second timer relay which can preferably be switched on or off, can be provided, which requests a signal in the form of a pulse, for example from a control software, at presettable time intervals and, if the pulse signal is absent, generates a signal itself and thereby opens a power current relay, which thus opens the Interrupts power supply at a network outlet in the form of preferably an outlet box.
  • Figure 1 is a schematic side view of a safety device for laboratory use.
  • FIG. 2 shows a schematic, perspective view of a fill-level measuring arrangement of the safety device
  • Fig. 4 is a schematic circuit diagram of a monitoring device of the safety device.
  • FIG. 1 shows a side view of a safety device 1 for laboratory operation, in particular for liquid chromatography systems.
  • 1 is located on a laboratory trolley 2, which has a first, upper laboratory work surface 3, an underlying, second, lower laboratory work surface 4 and a deep sub-floor 5. The latter is arranged below the upper edges of wheels 6 of the laboratory trolley 2.
  • the safety device 1 has a fill level measuring arrangement 7, which is connected to a liquid container 8 and generates an alarm signal when a specific liquid level in the liquid container 8 is detected.
  • the fill level measuring arrangement 7 is also connected to at least one of the laboratory work surfaces 3, 4 and is designed in such a way that the alarm signal is also generated when it detects leaked liquid on the at least one laboratory work surface 3, 4.
  • the fill level measuring arrangement 7 is connected via drain lines 9 to a drain 10 provided in the laboratory work surface or surfaces.
  • the fill level measuring arrangement 7 is connected to both laboratory work surfaces 3, 4 via the drain lines 9 mentioned. Both drain lines 9 open into a common line 11, which is inclined towards the liquid container 8, so that there is a gradient from the drain lines 9 to the container.
  • the liquid container 8 can, for example, be a waste container 12 for liquid products, in particular for solvents.
  • the fill level measuring arrangement 7, namely a barrel adapter 24 of the same, has an inner space 13. Liquid flows into this inner space 13 from a certain fill level in the liquid container 8 through a through hole 18 described in more detail below. Furthermore, on the at least one laboratory work surface 3, 4, liquid flowing out flows into this interior space through an additional bore 23 described below, as will be explained in more detail below.
  • the interior 13 is a sensor in the form of a level switch 14, preferably a so-called Vibration switch, assigned, the vibration forks 15 protrude into the interior.
  • the fill level measuring arrangement 7 projects with the fill level limit switch into the liquid container 8 from above.
  • the fill level measuring arrangement 7, namely a barrel adapter 24, has in a side wall 16 of its interior 13 a through hole 18 connecting the interior 17 of the liquid container 8 with the interior 13 of the barrel adapter 24.
  • the through hole 18 is arranged in the side wall 16 above the lower end of the vibrating forks 15.
  • the barrel adapter 24 of the fill level measuring arrangement 7 has a cup-like element 19 which has the interior 13 and is screwed to the main part 21 of the barrel adapter 24 via its upper side 20.
  • This screw connection can take place between the upper side 20 of the cup-like element 19 and the lower end of a longitudinal bore 22 of the main part 21.
  • the outer diameter of the upper side 20 of the cup-like element 19 corresponds approximately to the inner diameter of the longitudinal bore 22.
  • liquid which arises during the chromatography process can also be conducted directly into the liquid container, for example a waste barrel.
  • the main part 21 of the barrel adapter 24 has an additional bore 23 opening into the longitudinal bore 22, through which liquid running out on one of the laboratory work surfaces 3, 4 can flow into the interior 13 of the barrel adapter 24.
  • the additional bore 23 is L-shaped and only that in FIG. 3 Dotted line 11 or generally connected to the respective work surface 3, 4 via a drain line 9.
  • the fill level measuring arrangement 7 has the so-called barrel adapter 24 and the fill level limit switch 14.
  • the barrel adapter 24 is provided and designed below a flange 25.
  • the barrel adapter 24 preferably has a G2 inch standard thread 27 in its upper region 26, which can be screwed into a corresponding counter thread of the liquid container 8 (not shown).
  • the thread 27 is omitted in FIG. 3. It is clear that the barrel adapter can also carry other thread types.
  • the level limit switch 14 extends on the one hand within the longitudinal bore 22 through the main part 2 1 d of the barrel adapter 24, with the vibration forks 15, which are located at the lower end of the level limit switch 14, in protrude the interior of the cavity formed as a siphon; on the other hand, the housing of the level limit switch also extends partially above the flange 25.
  • the level limit switch 14 is preferably detachably connected to the main part 21.
  • two further bores 28 are provided in the main part 21 of the barrel adapter 24. These bores provide direct access to the interior 17 of the liquid container 8.
  • the further bores 28 thus constitute a so-called direct inlet.
  • the connections can be made via stainless steel angle pipes with a hose olive, onto which drain hoses are placed.
  • An angle tube 29 is only shown in dash-dotted lines in FIG. 3 and is usually pushed into the bore 28 as far as it will go.
  • the angle tubes 29 can have different lengths, so that they cannot be confused with one another.
  • Another of the direct inlets 28 can serve, for example, as an inlet for steel capillaries (not shown) of an HPLC system.
  • the Additional bore 23 connects to the cup-like element 19, called a siphon. Liquid that reaches the liquid container 8, for example the waste container 12, via this inlet is thus guided via the siphon-like element 19.
  • the fill level measuring arrangement 7 is preferably provided with a plurality of safety circuits
  • Monitoring device 31 also called liquid control interface or LCI for short, connected via a signal cable 32 (see FIGS. 1, 4).
  • the monitoring device contains several electrical switching elements, which are explained in more detail below.
  • the monitoring device 31 has a power relay 40, preferably a semiconductor relay, as the central power supply unit.
  • the power relay 40 is connected between the mains input 42 and the mains output 43, hereinafter also referred to as an outlet socket.
  • the signal is led via the signal cable 32 to the monitoring device 31 and converted into a relay signal by a transmitter 33.
  • This relay signal is then passed to a timer relay 39.
  • the signal is forwarded to the control software by means of a signal transmission 35, for example in a personal computer 34, also called a PC.
  • the signal is passed to the power relay 40, which thus interrupts the power supply at the mains outlet 43 in the form of the outlet box.
  • further measuring sensors 41 in the form of level meters can be connected to the monitoring device 31, the connections of which within the monitoring device 31 are linked together in a parallel circuit.
  • this generates a signal via a relay 44, which is sent to the timer relay 39.
  • the latter conducts the delayed switch-off of the power relay 40 in.
  • a signal is forwarded to the control software in the PC 34 by means of a signal transmission 45.
  • the monitoring device 31 has an additional monitoring function in the form of a second timer relay 38 that can be switched on and off manually on the operator panel of the device via a switch 37.
  • This must receive an external signal, such as an impulse, for example, from the control software of a liquid chromatography system via a pulse transmission 36 e at presettable time intervals. Otherwise, it sends a signal to the power relay 40, which then interrupts the power supply at the network outlet 43, for example the aforementioned outlet, without delay.
  • the relays 33, 38, 39 and 44 and the sensor 41 are shown schematically as closing relays. It is clear that the circuit diagram with the same elements can also be constructed with opening relays. Furthermore, the entirety of the switching elements shown schematically in Fig. 4 as a processor, i.e. be formed as an integrated circuit.
  • the monitoring device 31 preferably communicates with analysis and / or control software, for example chromatography software, and at the same time forms the central power supply unit for an analysis system, such as a preparative HPLC system.
  • the monitoring device 31 switches off the analysis system in the presence of an alarm signal from one of the security circuits, as mentioned above, preferably with a time delay.
  • the monitoring device 31 primarily liquid-conveying components (not shown), preferably pumps, can be supplied with electrical energy, so that they can be safely switched off when an alarm signal is present.
  • the monitoring device 31 is designed such that the maximum and / or the minimum liquid level can also be detected in a liquid container 8, for example in a storage liquid container. In this respect, the monitoring device can be connected both to the liquid container 8 designed as waste container 12 and to further liquid containers (not shown) which are designed as liquid storage containers.
  • the monitoring device 31 is thus designed as an intelligent solvent monitoring system with a plurality of safety circuits, which operate independently of the chromatography data system.
  • the monitoring device can communicate with a chromatography software by means of relay signals, so that this in turn can be triggered early for the corresponding actions.
  • the monitoring device preferably forms the central power supply unit for the system, for example a preparative H PLC system.
  • the solvent supply components, namely the pumps, are primarily supplied with electrical energy via the power supply unit.
  • the monitoring device is able to interrupt the entire power supply of the system in the event of an alarm in order to prevent any uncontrolled solvent leakage, due to a full liquid container, in particular a waste container, or for example due to a liquid escaping on a laboratory work surface or, for example, due to a software crash during an unsupervised operation, such as overnight.
  • the monitoring device can monitor four system states during operation, for example. As previously indicated, this can be the fill level of a waste container; on the other hand, leaking solvent can be detected early on a laboratory work surface, and the fill level of, for example, up to four storage liquid containers can be monitored; In addition, the system status of the control software can be monitored so that it can be checked whether the chromatography data system still has control over the HPLC system, ie primarily over the pumps. As soon as the fill level sensor of the fill level measuring arrangement on the waste container responds, a remaining volume usually remains free, so that a time-delayed shutdown, which allows the execution of a currently running laboratory process, such as a chromatography process, is initiated. At the same time, a signal in the form of a relay contact can be sent as input to the control software, which can end the ongoing process but can no longer process further samples. After the time delay has expired, the power supply is then cut off in any case.
  • a sufficient liquid level in storage liquid containers can be monitored, for example, with so-called empty level probes. If the storage container is empty, the monitoring device can transmit a signal as input to the control software so that it can complete the ongoing process, but cannot process another sample. The empty level probes can already respond if there is still a small reserve stock in the storage container. In another case, the monitoring device can transmit a signal, as mentioned above, and then additionally bring about the time-delayed shutdown of the entire system. In addition, the monitoring device can serve to receive a signal from the control software in short time intervals, such as every 4 minutes, and otherwise to switch off the power supply immediately. This procedure can be useful for preparative HPLC systems that should work unattended for long periods. This function ensures that the chromatography data system actually still has control over the system in operation.
  • the fill level measuring arrangement 7 is screwed with its barrel adapter 24 onto the liquid container 8, for example the waste container 12, with its external thread 27. Then the lines 9 and / or 11 or the angle tubes 29 and further lines are introduced. Finally, the fill level limit switch 14 is inserted into the inner bore 22 of the main part 21 to such an extent that the vibrating forks 15 are located below the through bore 18. Furthermore, the fill level limit switch 14 is connected to the monitoring device 31 by means of the signal line 32.
  • an alarm signal is always triggered when there is liquid in the interior, regardless of whether this liquid passes through the through-hole 1 8 from the interior space 1 7 of the liquid container 8 into the interior 13 of the element 19 or via the additional bore 23 has entered the interior 13 of the element 19.
  • the fill level limit switch 14 is preferably a single part and can be lifted as a whole from the main part 2 1 and the cup-like element 19 become.
  • the barrel adapter 24 is preferably made of metal (such as stainless steel or aluminum) or an inert plastic.
  • the through hole 18 serves not only for the entry of liquid from the interior 17 of the liquid container 8 into the interior 13 of the level measuring arrangement 7, but also for the exit of solvent, which reaches the interior 13 of the level measuring arrangement 7 via the additional hole 23.
  • the level switch 14 and the lines including the angle tubes are first lifted out of the barrel adapter and removed. Then the barrel adapter is unscrewed from the liquid container and lifted out. Finally, the cup-like element 19 is detached from the main part 21 of the fill level measuring arrangement 7, preferably unscrewed.

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Electromagnetism (AREA)
  • Thermal Sciences (AREA)
  • Fluid Mechanics (AREA)
  • Engineering & Computer Science (AREA)
  • Automation & Control Theory (AREA)
  • Measurement Of Levels Of Liquids Or Fluent Solid Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

La présente invention concerne un dispositif de sécurité (1) destiné à l'utilisation en laboratoire, notamment à des systèmes de chromatographie en phase liquide. Le dispositif de sécurité présente un système de mesure de niveau de remplissage (7) qui est relié à un réservoir de liquide (8) et produit un signal d'avertissement à la détection d'un niveau de liquide donné dans le réservoir de liquide (8). Selon l'invention, le dispositif de mesure de niveau de remplissage (7) est également relié à au moins un plan de travail de laboratoire (3, 4) et produit aussi un signal d'avertissement lorsqu'il détecte que du liquide s'écoule sur la/les plan(s) de travail de laboratoire (3, 4). De préférence, le dispositif de mesure de niveau de remplissage (7) est relié à un dispositif de surveillance (31) qui sert d'unité d'alimentation électrique et se présente sous la forme d'une interface de régulation de liquide (Liquid Control Interface / LCI), qui comprend plusieurs circuits de sécurité et qui, en cas d'avertissement, déclenche une interruption différée du courant dans l'un des circuits de sécurité.
EP04722518A 2003-04-22 2004-03-23 Dispositif de securite destine a l'utilisation en laboratoire, notamment a des systemes de chromatographie en phase liquide Withdrawn EP1616155A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH00714/03A CH696214A5 (de) 2003-04-22 2003-04-22 Sicherheitseinrichtung für den Laborbetrieb, insbesondere für Flüssigchromatographie-Systeme.
PCT/CH2004/000176 WO2004095017A2 (fr) 2003-04-22 2004-03-23 Dispositif de securite destine a l'utilisation en laboratoire, notamment a des systemes de chromatographie en phase liquide

Publications (1)

Publication Number Publication Date
EP1616155A2 true EP1616155A2 (fr) 2006-01-18

Family

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EP04722518A Withdrawn EP1616155A2 (fr) 2003-04-22 2004-03-23 Dispositif de securite destine a l'utilisation en laboratoire, notamment a des systemes de chromatographie en phase liquide

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US (1) US20060261964A1 (fr)
EP (1) EP1616155A2 (fr)
CH (1) CH696214A5 (fr)
WO (1) WO2004095017A2 (fr)

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US7419598B2 (en) * 2005-03-08 2008-09-02 Teledyne Isco, Inc. Chromatographic solvent monitor
US20140379588A1 (en) 2013-03-15 2014-12-25 Compology, Inc. System and method for waste managment
US20140278630A1 (en) * 2013-03-15 2014-09-18 Compology, Inc. System and method for waste material managment
EP3032229B1 (fr) * 2014-12-09 2020-11-25 VEGA Grieshaber KG Système de mesure de niveau limite
WO2017144083A1 (fr) * 2016-02-23 2017-08-31 Eclolab Usa Inc. Appareil conçu pour fournir un liquide à partir d'un récipient de stockage à un dispositif d'admission de liquide
US10995740B2 (en) * 2016-09-26 2021-05-04 Shimadzu Corporation Switching valve, binary pump, and liquid chromatograph with binary pump
JP6702498B2 (ja) * 2017-02-21 2020-06-03 株式会社島津製作所 液体クロマトグラフ質量分析装置
US12254403B2 (en) 2018-12-12 2025-03-18 Compology Llc Method and system for fill level determination
US10943356B2 (en) 2018-12-12 2021-03-09 Compology, Inc. Method and system for fill level determination
US10798522B1 (en) 2019-04-11 2020-10-06 Compology, Inc. Method and system for container location analysis
US11172325B1 (en) 2019-05-01 2021-11-09 Compology, Inc. Method and system for location measurement analysis

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JP4245779B2 (ja) * 1999-07-12 2009-04-02 株式会社イトーキ 実験台
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Also Published As

Publication number Publication date
WO2004095017A3 (fr) 2005-01-13
WO2004095017A2 (fr) 2004-11-04
CH696214A5 (de) 2007-02-15
WO2004095017B1 (fr) 2005-02-24
US20060261964A1 (en) 2006-11-23

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