EP1633851A4 - Methods and compositions for amino acid production - Google Patents

Methods and compositions for amino acid production

Info

Publication number
EP1633851A4
EP1633851A4 EP04754180A EP04754180A EP1633851A4 EP 1633851 A4 EP1633851 A4 EP 1633851A4 EP 04754180 A EP04754180 A EP 04754180A EP 04754180 A EP04754180 A EP 04754180A EP 1633851 A4 EP1633851 A4 EP 1633851A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
amino acid
acid production
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04754180A
Other languages
German (de)
French (fr)
Other versions
EP1633851A2 (en
Inventor
Richard B Bailey
Paul Blomquist
Reed Doten
Edward M Driggers
Kevin T Madden
Jessica O'leary
George A O'toole
Joshua Trueheart
Michael J Walbridge
Peter Yorgey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbia Inc
Original Assignee
Microbia Precision Engineering Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbia Precision Engineering Inc filed Critical Microbia Precision Engineering Inc
Publication of EP1633851A2 publication Critical patent/EP1633851A2/en
Publication of EP1633851A4 publication Critical patent/EP1633851A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
EP04754180A 2003-05-30 2004-06-01 Methods and compositions for amino acid production Withdrawn EP1633851A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47500003P 2003-05-30 2003-05-30
US55186004P 2004-03-10 2004-03-10
PCT/US2004/017513 WO2004108894A2 (en) 2003-05-30 2004-06-01 Methods and compositions for amino acid production

Publications (2)

Publication Number Publication Date
EP1633851A2 EP1633851A2 (en) 2006-03-15
EP1633851A4 true EP1633851A4 (en) 2009-04-08

Family

ID=33514039

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04754180A Withdrawn EP1633851A4 (en) 2003-05-30 2004-06-01 Methods and compositions for amino acid production

Country Status (7)

Country Link
EP (1) EP1633851A4 (en)
JP (1) JP2007525951A (en)
KR (1) KR20060018868A (en)
AU (1) AU2004245988A1 (en)
BR (1) BRPI0410861A (en)
CA (1) CA2526365A1 (en)
WO (1) WO2004108894A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2275424C2 (en) 2003-12-05 2006-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Method for preparing l-threonine by using bacterium belonging to genus escherichia
CA2549298C (en) * 2003-12-05 2014-02-25 Ajinomoto Co., Inc. L-threonine producing bacterium belonging to the genus escherichia and method for producing l-threonine
US7723097B2 (en) * 2005-03-11 2010-05-25 Archer-Daniels-Midland Company Escherichia coli strains that over-produce L-threonine and processes for their production
KR20080033413A (en) * 2005-07-18 2008-04-16 바스프 에스이 Use of Dimethyl Disulfide for Methionine Production in Microorganisms
BRPI0614716A2 (en) * 2005-08-05 2011-04-12 Univ Michigan State method for producing a chemical from lane c4 of a. succinogenes
JP2007068437A (en) * 2005-09-05 2007-03-22 Chisso Corp Mutant aspartokinase and methods of use
PL1969130T3 (en) * 2006-01-04 2014-08-29 Evonik Degussa Gmbh Process for the preparation of methionine and its precursors homoserine or succinylhomoserine employing a microorganism
EP3170889A1 (en) * 2006-09-15 2017-05-24 CJ Cheiljedang Corporation A corynebacteria having enhanced l-lysine productivity and a method of producing l-lysine using the same
KR20080061801A (en) * 2006-12-28 2008-07-03 씨제이제일제당 (주) Polypeptide to improve L-methionine production capacity, microorganisms overexpressing the polypeptide and L-methionine production method using the microorganism
US20090215133A1 (en) * 2007-02-02 2009-08-27 Evonik Degussa Gmbh Production of l-lysine and l-lysine-containing feed additives
WO2008127240A1 (en) * 2007-04-11 2008-10-23 Cargill, Incorporated Compositions and methods of producing methionine
US8283152B2 (en) * 2009-08-28 2012-10-09 Cj Cheiljedang Corporation Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism
KR101250651B1 (en) * 2010-12-21 2013-04-03 씨제이제일제당 (주) New O-acetylhomoserine sulfhydrylase or mutants, and L-methionine conversion method uging the enzyme
MY173933A (en) * 2010-12-21 2020-02-27 Cj Cheiljedang Corp Modified polypeptide having homoserine acetyltransferase activity and microorganism expressing the same
KR101485222B1 (en) * 2012-10-05 2015-01-22 상지대학교산학협력단 Corynebacterium sp. microorganism having enhanced L-threonine productivity by regulation of dapA activity and a method of producing L-threonine using the same
KR101947959B1 (en) 2018-05-28 2019-02-13 씨제이제일제당 (주) A modified homoserine dehydrogenase and a method for producing homoserine or L- amino acid derived from homoserine using the same
KR101996769B1 (en) 2018-12-21 2019-10-01 씨제이제일제당 (주) A homoserine dehydrogenase variant and a method for producing homoserine or L-amino acid derived from homoserine using the same
JP7293406B2 (en) * 2019-06-14 2023-06-19 シージェイ チェルジェダン コーポレイション Composition for prevention, treatment or improvement of gastrointestinal disease containing Corynebacterium strain and its culture
KR102472559B1 (en) * 2019-06-28 2022-12-01 씨제이제일제당 주식회사 A method of producing sulfur-containing amino acids and derivatives thereof
KR102617168B1 (en) * 2020-12-09 2023-12-21 씨제이제일제당 (주) Shewanella oneidensis-Drived Protein Expressing Microorganism and Method of L-Amino Acid Production Using the Same
CN120476201A (en) 2022-10-20 2025-08-12 赛斯生物私营有限责任公司 Genetically modified host cells producing L-serine
CN120005781A (en) 2023-11-14 2025-05-16 赛斯生物私人有限公司 Expression of biomolecules with improved promoters and TIRs

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4601983A (en) * 1983-06-15 1986-07-22 Ajinomoto Co., Inc. Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production of L-threonine and L-isoleucine
US5766925A (en) * 1994-03-04 1998-06-16 Ajinomoto Co., Inc. Method of producing L-lysine
WO1999053035A1 (en) * 1998-04-13 1999-10-21 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6451564B1 (en) * 1999-07-02 2002-09-17 Massachusetts Institute Of Technology Methods for producing L-isoleucine
WO2004024933A2 (en) * 2002-08-26 2004-03-25 Basf Aktiengesellschaft Method for zymotic production of fine chemicals (mety) containing sulphur

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4601983A (en) * 1983-06-15 1986-07-22 Ajinomoto Co., Inc. Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production of L-threonine and L-isoleucine
US5766925A (en) * 1994-03-04 1998-06-16 Ajinomoto Co., Inc. Method of producing L-lysine
WO1999053035A1 (en) * 1998-04-13 1999-10-21 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6451564B1 (en) * 1999-07-02 2002-09-17 Massachusetts Institute Of Technology Methods for producing L-isoleucine
WO2004024933A2 (en) * 2002-08-26 2004-03-25 Basf Aktiengesellschaft Method for zymotic production of fine chemicals (mety) containing sulphur

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ARCHER J A C ET AL: "A C-terminal deletion in Corynebacterium glutamicum homoserine dehydrogenase abolishes allosteric inhibition by l-threonine", GENE, ELSEVIER, AMSTERDAM, NL, vol. 107, no. 1, 30 October 1991 (1991-10-30), pages 53 - 59, XP023539886, ISSN: 0378-1119, [retrieved on 19911030] *
FERNÁNDEZ MÓNICA ET AL: "Characterization of the hom-thrC-thrB cluster in aminoethoxyvinylglycine-producing Streptomyces sp. NRRL 5331.", MICROBIOLOGY (READING, ENGLAND) MAY 2002 LNKD- PUBMED:11988515, vol. 148, no. Pt 5, May 2002 (2002-05-01), pages 1413 - 1420, ISSN: 1350-0872 *
SRITHARAN V. ET AL: "METABOLISM OF ASPARTATE IN MYCOBACTERIUM-SMEGMATIS", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 180, no. 3, 1989, pages 587 - 594, ISSN: 0014-2956 *

Also Published As

Publication number Publication date
EP1633851A2 (en) 2006-03-15
CA2526365A1 (en) 2004-12-16
AU2004245988A1 (en) 2004-12-16
WO2004108894A3 (en) 2007-11-22
WO2004108894A2 (en) 2004-12-16
BRPI0410861A (en) 2006-05-23
JP2007525951A (en) 2007-09-13
KR20060018868A (en) 2006-03-02

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Inventor name: YORGEY, PETER

Inventor name: WALBRIDGE, MICHAEL, J.

Inventor name: TRUEHEART, JOSHUA

Inventor name: O'TOOLE, GEORGE, A.

Inventor name: O'LEARY, JESSICA

Inventor name: MADDEN, KEVIN, T.

Inventor name: DRIGGERS, EDWARD, M.

Inventor name: DOTEN, REED

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