EP1701937A4 - Polymorphes stables de (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide - Google Patents

Polymorphes stables de (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide

Info

Publication number: EP1701937A4
Authority: EP; European Patent Office
Prior art keywords: nitrophenyl; dihydroxy; acrylamide; cyano; diethyl
Prior art date: 2003-12-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

EP03768046A

Other languages

German (de)

English (en)

Other versions

EP1701937A1 (fr

Inventor

Mukarram Siddiqui Moham Jaweed

Rashid Abdul Rehman Khan

Ram Prasad Yadav

Zakir Gafoor Shaikh

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

JAWEED MUKARRAM, SIDDIQUI MOHAMMED

Khan Rashid Abdul Rehman

Shaikh Zakir Gafoor

YAVAD, RAM PRASAD

Wockhardt Ltd

Original Assignee

Wockhardt Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-29

Filing date

2003-12-29

Publication date

2007-05-02

2003-12-29 Application filed by Wockhardt Ltd filed Critical Wockhardt Ltd

2006-09-20 Publication of EP1701937A1 publication Critical patent/EP1701937A1/fr

2007-05-02 Publication of EP1701937A4 publication Critical patent/EP1701937A4/fr

Status Ceased legal-status Critical Current

Links

JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EP03768046A 2003-12-29 2003-12-29 Polymorphes stables de (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide Ceased EP1701937A4 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IB2003/006200 WO2005066117A1 (fr)	2003-12-29	2003-12-29	Polymorphes stables de (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide

Publications (2)

Publication Number	Publication Date
EP1701937A1 EP1701937A1 (fr)	2006-09-20
EP1701937A4 true EP1701937A4 (fr)	2007-05-02

Family

ID=34746624

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP03768046A Ceased EP1701937A4 (fr)	2003-12-29	2003-12-29	Polymorphes stables de (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide

Country Status (5)

Country	Link
EP (1)	EP1701937A4 (fr)
AU (1)	AU2003292465A1 (fr)
BR (1)	BR0318690A (fr)
CA (1)	CA2551791A1 (fr)
WO (1)	WO2005066117A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007054950A1 (fr) *	2005-11-09	2007-05-18	Usv Limited	Procédé pour la préparation de (e)-n,n-diéthyl-2-cyano-3-(3,4-dihydroxy-5-nitrophényl)acrylamide (entacapone) extrêmement pur
CN101460451A (zh) *	2006-01-02	2009-06-17	阿克塔维什集团Ptc公司	A型恩他卡朋的制备方法
KR101382160B1 (ko) *	2006-02-06	2014-04-07	오리온 코포레이션	엔타카폰을 제조하는 방법
GB0610207D0 (en) *	2006-05-23	2006-07-05	Pliva Istrazivanje I Razvoj D	New forms of active pharmaceutical ingredient
WO2008023380A1 (fr) *	2006-08-24	2008-02-28	Srinivasa Reddy Battula	PROCÉDé AMÉLioré ET SIMPLIFIÉ POUR LA PRÉPARATION DU (E) N,N-DIÉTHYL-2-CYANO-3-(3,4-DIHYDROXY-5-NITROPHéNYL)ACRYLAMiDE
ES2306587B1 (es) *	2006-11-15	2009-08-07	Quimica Sintetica, S.A.	Nueva forma cristalina de entacapona y procedimiento para su obtencion.
ES2319024B1 (es)	2007-02-13	2009-12-11	Quimica Sintetica, S.A.	Procedimiento para la obtencion de entacapona sustancialmente libre de isomero z, sus intermedios de sintesis y nueva forma cristalina.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2200109A (en) *	1986-11-28	1988-07-27	Orion Yhtymae Oy	Catechol derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2238047B (en) *	1989-11-03	1993-02-10	Orion Yhtymae Oy	Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation

2003
- 2003-12-29 AU AU2003292465A patent/AU2003292465A1/en not_active Abandoned
- 2003-12-29 CA CA002551791A patent/CA2551791A1/fr not_active Abandoned
- 2003-12-29 EP EP03768046A patent/EP1701937A4/fr not_active Ceased
- 2003-12-29 WO PCT/IB2003/006200 patent/WO2005066117A1/fr not_active Ceased
- 2003-12-29 BR BRPI0318690-3A patent/BR0318690A/pt not_active IP Right Cessation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2200109A (en) *	1986-11-28	1988-07-27	Orion Yhtymae Oy	Catechol derivatives

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CAIRA M R: "CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS", TOPICS IN CURRENT CHEMISTRY, SPRINGER, BERLIN, DE, vol. 198, 1 January 1998 (1998-01-01), pages 163 - 208, XP001156954, ISSN: 0340-1022, ISBN: 978-3-540-36760-4, DOI: 10.1007/3-540-69178-2_5 *
CHRISTIAN NÄTHER: "Grundlagen der Einkristallstrukturanalyse und der Pulverbeugung mit Röntgen-und Neutronenstrahlung", 1 January 2004 (2004-01-01), pages 1 - 58, XP055157521, Retrieved from the Internet <URL:http://www.christian.naether.uni-kiel.de/pdf/Wien_2004_Stunde 1 und 2.pdf> [retrieved on 20141209] *
No further relevant documents disclosed *
See also references of WO2005066117A1 *

Also Published As

Publication number	Publication date
CA2551791A1 (fr)	2005-07-21
EP1701937A1 (fr)	2006-09-20
AU2003292465A1 (en)	2005-08-12
BR0318690A (pt)	2006-12-26
WO2005066117A1 (fr)	2005-07-21

Legal Events

Date	Code	Title	Description
2006-08-18	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2006-09-20	17P	Request for examination filed	Effective date: 20060719
2006-09-20	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
2007-04-04	DAX	Request for extension of the european patent (deleted)
2007-05-02	A4	Supplementary search report drawn up and despatched	Effective date: 20070329
2008-02-27	17Q	First examination report despatched	Effective date: 20080128
2011-11-02	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: WOCKHARDT LIMITED Owner name: JAWEED MUKARRAM, SIDDIQUI MOHAMMED Owner name: KHAN, RASHID ABDUL REHMAN Owner name: YAVAD, RAM PRASAD Owner name: SHAIKH, ZAKIR GAFOOR
2014-12-08	REG	Reference to a national code	Ref country code: DE Ref legal event code: R003
2015-05-01	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED
2015-06-03	18R	Application refused	Effective date: 20141208

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