EP1714698A3 - Vorrichtung und Verfahren zur Manipulation einer Flüssigkeit - Google Patents

Vorrichtung und Verfahren zur Manipulation einer Flüssigkeit Download PDF

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Publication number
EP1714698A3
EP1714698A3 EP06007697A EP06007697A EP1714698A3 EP 1714698 A3 EP1714698 A3 EP 1714698A3 EP 06007697 A EP06007697 A EP 06007697A EP 06007697 A EP06007697 A EP 06007697A EP 1714698 A3 EP1714698 A3 EP 1714698A3
Authority
EP
European Patent Office
Prior art keywords
channel section
liquid
capillary stop
handling liquids
channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP06007697A
Other languages
English (en)
French (fr)
Other versions
EP1714698A2 (de
EP1714698B1 (de
Inventor
Thomas Willms
Gert Dr. Blankenstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Microparts GmbH
Original Assignee
Boehringer Ingelheim Microparts GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Microparts GmbH filed Critical Boehringer Ingelheim Microparts GmbH
Publication of EP1714698A2 publication Critical patent/EP1714698A2/de
Publication of EP1714698A3 publication Critical patent/EP1714698A3/de
Application granted granted Critical
Publication of EP1714698B1 publication Critical patent/EP1714698B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0424—Dielectrophoretic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/065—Valves, specific forms thereof with moving parts sliding valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

Abstract

Es werden eine Vorrichtung und ein Verfahren zur Manipulation einer Flüssigkeit vorgeschlagen, wobei die Flüssigkeit von einem ersten Kanalabschnitt in einen zweiten Kanalabschnitt strömen kann und mittels eines Kapillarstops vor einem Übertritt vom ersten Kanalabschnitt in den zweiten Kanalabschnitt temporär angehalten wird. Eine zeitlich genaue Steuerung wird auf einfache Weise dadurch ermöglicht, daß die beiden Kanalabschnitte zur Überbrückung oder Aufhebung des Kapillarstops relativ zueinander bewegt, insbesondere in Anlage gebracht werden.
EP06007697A 2005-04-15 2006-04-12 Vorrichtung und Verfahren zur Manipulation einer Flüssigkeit Expired - Lifetime EP1714698B1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005017653A DE102005017653A1 (de) 2005-04-15 2005-04-15 Vorrichtung und Verfahren zur Manipulation einer Flüssigkeit

Publications (3)

Publication Number Publication Date
EP1714698A2 EP1714698A2 (de) 2006-10-25
EP1714698A3 true EP1714698A3 (de) 2008-07-16
EP1714698B1 EP1714698B1 (de) 2012-12-19

Family

ID=36809083

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06007697A Expired - Lifetime EP1714698B1 (de) 2005-04-15 2006-04-12 Vorrichtung und Verfahren zur Manipulation einer Flüssigkeit

Country Status (5)

Country Link
US (1) US7655189B2 (de)
EP (1) EP1714698B1 (de)
JP (1) JP4813954B2 (de)
CN (1) CN1865714B (de)
DE (1) DE102005017653A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
JPWO2008126403A1 (ja) * 2007-04-05 2010-07-22 パナソニック株式会社 試料液分析チップ
MX346456B (es) 2008-02-27 2017-03-21 Boehringer Ingelheim Microparts Gmbh Dispositivo para la separación de plasma.
US20140000223A1 (en) * 2010-11-10 2014-01-02 Boehringer Ingelheim Microparts Gmbh Method for filling a blister packaging with liquid, and blister packaging with a cavity for filling with liquid
US20140227148A1 (en) * 2011-07-05 2014-08-14 Boehringer Ingelheim Microparts Gmbh Microfluidic Structure Having Recesses
US9789485B2 (en) * 2012-09-21 2017-10-17 Massachusetts Institute Of Technology Micro-fluidic device and uses thereof
US11441701B2 (en) 2017-07-14 2022-09-13 Hewlett-Packard Development Company, L.P. Microfluidic valve
CN108831819A (zh) * 2018-04-20 2018-11-16 中国药科大学 一种原态-变性转换离子源的设备及其应用
EP3861356A4 (de) 2018-10-01 2022-07-06 Polyvalor, Limited Partnership System und verfahren zur flüssigkeitsausgabe

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0075605A1 (de) * 1981-09-25 1983-04-06 Winfried Dr. med. Stöcker Vorrichtung für photometrische Analysen
US4902629A (en) * 1987-10-06 1990-02-20 Personal Diagnostics, Inc. Apparatus and processes for facilitating reaction between analyte and test reagent system
EP0590695A2 (de) * 1989-03-23 1994-04-06 Roger Abraham Bunce Transfervorrichtungen für Flüssigkeiten
US5399316A (en) * 1992-03-13 1995-03-21 Olympus Optical Co., Ltd. Reaction vessel for conducting an immunological assay
US5766962A (en) * 1995-12-22 1998-06-16 Universal Healthwatch, Inc. Device for collecting and testing samples
WO2004007078A1 (en) * 2002-07-12 2004-01-22 British Biocell International Limited Lateral flow assay device and method
WO2004050246A1 (en) * 2002-12-05 2004-06-17 International Business Machines Corporation Method and device for flowing a liquid on a surface

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9324310D0 (en) * 1993-11-26 1994-01-12 Univ Birmingham Liquid transfer device
US6822959B2 (en) * 2000-07-31 2004-11-23 Mindspeed Technologies, Inc. Enhancing performance by pre-fetching and caching data directly in a communication processor's register set
US6802342B2 (en) * 2001-04-06 2004-10-12 Fluidigm Corporation Microfabricated fluidic circuit elements and applications
EP1419818B1 (de) 2002-11-14 2013-10-30 Boehringer Ingelheim microParts GmbH Vorrichtung zum schrittweisen Transport von Flüssigkeit unter Ausnutzung von Kapillarkräften
DE10257004A1 (de) * 2002-12-06 2004-06-17 Steag Microparts Gmbh Vorrichtung zur parallelen Dosierung von Flüssigkeiten
DE10302720A1 (de) 2003-01-23 2004-08-05 Steag Microparts Gmbh Mikrofluidischer Schalter zum Anhalten des Flüssigkeitsstroms während eines Zeitintervalls

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0075605A1 (de) * 1981-09-25 1983-04-06 Winfried Dr. med. Stöcker Vorrichtung für photometrische Analysen
US4902629A (en) * 1987-10-06 1990-02-20 Personal Diagnostics, Inc. Apparatus and processes for facilitating reaction between analyte and test reagent system
EP0590695A2 (de) * 1989-03-23 1994-04-06 Roger Abraham Bunce Transfervorrichtungen für Flüssigkeiten
US5399316A (en) * 1992-03-13 1995-03-21 Olympus Optical Co., Ltd. Reaction vessel for conducting an immunological assay
US5766962A (en) * 1995-12-22 1998-06-16 Universal Healthwatch, Inc. Device for collecting and testing samples
WO2004007078A1 (en) * 2002-07-12 2004-01-22 British Biocell International Limited Lateral flow assay device and method
WO2004050246A1 (en) * 2002-12-05 2004-06-17 International Business Machines Corporation Method and device for flowing a liquid on a surface

Also Published As

Publication number Publication date
JP4813954B2 (ja) 2011-11-09
US20060249387A1 (en) 2006-11-09
EP1714698A2 (de) 2006-10-25
EP1714698B1 (de) 2012-12-19
US7655189B2 (en) 2010-02-02
CN1865714B (zh) 2010-12-08
CN1865714A (zh) 2006-11-22
JP2006300944A (ja) 2006-11-02
DE102005017653A1 (de) 2006-10-19

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