EP1765992A4 - Polypeptides galnact2 tronques et acides nucleiques - Google Patents

Polypeptides galnact2 tronques et acides nucleiques

Info

Publication number
EP1765992A4
EP1765992A4 EP05758682A EP05758682A EP1765992A4 EP 1765992 A4 EP1765992 A4 EP 1765992A4 EP 05758682 A EP05758682 A EP 05758682A EP 05758682 A EP05758682 A EP 05758682A EP 1765992 A4 EP1765992 A4 EP 1765992A4
Authority
EP
European Patent Office
Prior art keywords
galnact2
trunc
polypeptides
nucleic acids
nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05758682A
Other languages
German (de)
English (en)
Other versions
EP1765992A2 (fr
Inventor
Karl F Johnson
Xi Chen
Susann Taudte
Sami Saribas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Neose Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neose Technologies Inc filed Critical Neose Technologies Inc
Publication of EP1765992A2 publication Critical patent/EP1765992A2/fr
Publication of EP1765992A4 publication Critical patent/EP1765992A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP05758682A 2004-06-03 2005-06-03 Polypeptides galnact2 tronques et acides nucleiques Withdrawn EP1765992A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57653004P 2004-06-03 2004-06-03
US59858404P 2004-08-03 2004-08-03
PCT/US2005/019442 WO2005121331A2 (fr) 2004-06-03 2005-06-03 Polypeptides galnact2 tronques et acides nucleiques

Publications (2)

Publication Number Publication Date
EP1765992A2 EP1765992A2 (fr) 2007-03-28
EP1765992A4 true EP1765992A4 (fr) 2009-01-07

Family

ID=35945309

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05758682A Withdrawn EP1765992A4 (fr) 2004-06-03 2005-06-03 Polypeptides galnact2 tronques et acides nucleiques

Country Status (3)

Country Link
EP (1) EP1765992A4 (fr)
JP (1) JP2008512085A (fr)
WO (1) WO2005121331A2 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696163B2 (en) 2001-10-10 2010-04-13 Novo Nordisk A/S Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
AU2004221824B2 (en) 2003-03-14 2009-08-27 Ratiopharm Gmbh Branched water-soluble polymers and their conjugates
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
SG155777A1 (en) 2003-04-09 2009-10-29 Neose Technologies Inc Glycopegylation methods and proteins/peptides produced by the methods
JP2007523630A (ja) 2003-05-09 2007-08-23 ネオス テクノロジーズ インコーポレイテッド ヒト成長ホルモングリコシル化突然変異体の組成と調合法
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
ES2560657T3 (es) 2004-01-08 2016-02-22 Ratiopharm Gmbh Glicosilación con unión en O de péptidos G-CSF
WO2006010143A2 (fr) 2004-07-13 2006-01-26 Neose Technologies, Inc. Remodelage de peg ramifie et glycosylation de peptide-1 semblable a glucagon [glp-1]
EP1799249A2 (fr) 2004-09-10 2007-06-27 Neose Technologies, Inc. Interferon alpha glycopegyle
PL2586456T3 (pl) 2004-10-29 2016-07-29 Ratiopharm Gmbh Remodeling i glikopegilacja czynnika wzrostu fibroblastów (FGF)
US9029331B2 (en) 2005-01-10 2015-05-12 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
EP1871795A4 (fr) 2005-04-08 2010-03-31 Biogenerix Ag Compositions et méthodes utilisées pour la préparation de mutants par glycosylation de l'hormone de croissance humaine résistant à la protéase
EP1891231A4 (fr) 2005-05-25 2011-06-22 Novo Nordisk As Facteur ix glycopegyle
WO2006127910A2 (fr) 2005-05-25 2006-11-30 Neose Technologies, Inc. Formulations d'erythropoietine glycopegylees
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (fr) 2005-11-03 2007-05-18 Neose Technologies, Inc. Purification de sucre de nucleotide en utilisant des membranes
US20080248959A1 (en) 2006-07-21 2008-10-09 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
JP2010505874A (ja) 2006-10-03 2010-02-25 ノヴォ ノルディスク アー／エス ポリペプチドコンジュゲートの精製方法
BRPI0809670A8 (pt) 2007-04-03 2018-12-18 Biogenerix Ag métodos para aumentar a produção de célula tronco, para aumentar o número de granulócitos em um indivíduo, para prevenir, tratar e aliviar a mielossupressão que resulta de uma terapia contra o câncer, para tratar uma condição em um indivíduo, para tratar neutropenia e trombocitopenia em um mamífero, para expandir células tronco hematopoiéticas em cultura, para aumentar a hematopoiese em um indivíduo, para aumentar o número de célulars progenitoras hematopoiéticas em um indivíduo, e para fornecer enxerto estável da medula óssea, e, forma de dosagem oral.
WO2008143944A2 (fr) * 2007-05-14 2008-11-27 Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Procédés de glycosylation et bioconjugaison
MX2009013259A (es) 2007-06-12 2010-01-25 Novo Nordisk As Proceso mejorado para la produccion de azucares de nucleotidos.
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
JP5358840B2 (ja) * 2007-11-24 2013-12-04 独立行政法人産業技術総合研究所 Ｇｆｐ（緑色蛍光蛋白質）の機能賦活・回復方法
ES2476690T3 (es) 2008-02-27 2014-07-15 Novo Nordisk A/S Moléculas conjugadas del Factor VIII
CN103163300B (zh) * 2013-03-01 2015-02-11 苏州大学 人n-乙酰氨基半乳糖转移酶2双抗体夹心elisa试剂盒
CN110636859B (zh) * 2017-05-19 2024-05-03 科学与工业研究委员会 用于产生重折叠的重组人源化兰尼单抗的方法
CN114058602B (zh) * 2020-07-30 2023-08-22 中国中医科学院中药研究所 新疆紫草咖啡酸及迷迭香酸糖基转移酶及编码基因与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7892730B2 (en) * 2000-12-22 2011-02-22 Sagres Discovery, Inc. Compositions and methods for cancer
US6786755B2 (en) * 2002-03-27 2004-09-07 Molex Incorporated Differential signal connector assembly with improved retention capabilities
EP1558728B1 (fr) * 2002-11-08 2007-06-27 Glycozym ApS Methodes servant a identifier des agents modulant les fonctions de galnac-transferases de polypeptides, compositions pharmaceutiques contenant ces agents et utilisation de ces agents pour preparer des medicaments

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BENNETT E P ET AL: "cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 271, no. 29, 19 July 1996 (1996-07-19), pages 17006 - 17012, XP002386961, ISSN: 0021-9258 *
BENNETT ERIC PAUL ET AL: "Cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminlytransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 46, 13 November 1998 (1998-11-13), pages 30472 - 30481, XP002504533, ISSN: 0021-9258 *
BOEGGEMAN E E ET AL: "The N-terminal stem region of bovine and human beta1,4-galactosyltransferase I increases the in vitro folding efficiency of their catalytic domain from inclusion bodies", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA, vol. 30, no. 2, 1 August 2003 (2003-08-01), pages 219 - 229, XP004439531, ISSN: 1046-5928 *
DONADIO S ET AL: "Recognition of cell surface acceptors by two human alpha-2,6-sialyltransferases produced in CHO cells", BIOCHIMIE, MASSON, PARIS, FR, vol. 85, no. 3-4, 1 January 2003 (2003-01-01), pages 311 - 321, XP002397070, ISSN: 0300-9084 *
HOMA F L ET AL: "Isolation and expression of a cDNA clone encoding a bovine UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 268, no. 17, 15 June 1993 (1993-06-15), pages 12609 - 12616, XP002965844, ISSN: 0021-9258 *
KUROSAWA N ET AL: "Molecular cloning and expression of GalNAc alpha2,6-Sialyltransferase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 269, no. 2, 14 January 1994 (1994-01-14), pages 1402 - 1409, XP002486638, ISSN: 0021-9258 *
WANDALL H H ET AL: "Substrate specificities of three members of the human UPD-N-acetyl-alpha-D-galactosamine : Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 272, no. 38, 19 September 1997 (1997-09-19), pages 23503 - 23514, XP002904621, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
JP2008512085A (ja) 2008-04-24
EP1765992A2 (fr) 2007-03-28
WO2005121331A8 (fr) 2006-03-09
WO2005121331A2 (fr) 2005-12-22
WO2005121331A9 (fr) 2006-06-01
WO2005121331A3 (fr) 2007-08-30

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Inventor name: SARIBAS, SAMI

Inventor name: TAUDTE, SUSANN

Inventor name: CHEN, XI

Inventor name: JOHNSON, KARL F.

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 5/10 20060101ALI20071109BHEP

Ipc: C12N 15/00 20060101ALI20071109BHEP

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Owner name: NEOSE TECHNOLOGIES, INC.

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