EP1831236A4 - Methode servant a preparer 2'-deoxy-2',2'-difluorocytidine - Google Patents

Methode servant a preparer 2'-deoxy-2',2'-difluorocytidine

Info

Publication number: EP1831236A4
Authority: EP; European Patent Office
Prior art keywords: formula; difluorocytidine; deoxy; preparing; nucleoside
Prior art date: 2004-12-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP05823850.2A

Other languages

German (de)

English (en)

Other versions

EP1831236A1 (fr

Inventor

Jaeheon Lee

Gha Seung Park

Moonsub Lee

Hyo-Jeong Bang

Jae Chul Lee

Cheol Kyong Kim

Chang-Ju Choi

Han Kyong Kim

Hoe Chul Lee

Young-Kil Chang

Gwan Sun Lee

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hanmi Science Co Ltd

Original Assignee

Hanmi Science Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-30

Filing date

2005-12-29

Publication date

2013-11-20

2005-06-23 Priority claimed from PCT/KR2005/001954 external-priority patent/WO2006070985A1/fr

2005-12-29 Application filed by Hanmi Science Co Ltd filed Critical Hanmi Science Co Ltd

2007-09-12 Publication of EP1831236A1 publication Critical patent/EP1831236A1/fr

2013-11-20 Publication of EP1831236A4 publication Critical patent/EP1831236A4/fr

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)

EP05823850.2A 2004-12-30 2005-12-29 Methode servant a preparer 2'-deoxy-2',2'-difluorocytidine Withdrawn EP1831236A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
KR20040116316		2004-12-30
PCT/KR2005/001954 WO2006070985A1 (fr)	2004-12-30	2005-06-23	Méthode de synthèse de la 2’-désoxy-2’,2’-difluorocytidine
PCT/KR2005/004633 WO2006071090A1 (fr)	2004-12-30	2005-12-29	Methode servant a preparer 2'-deoxy-2',2'-difluorocytidine

Publications (2)

Publication Number	Publication Date
EP1831236A1 EP1831236A1 (fr)	2007-09-12
EP1831236A4 true EP1831236A4 (fr)	2013-11-20

Family

ID=36615168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP05823850.2A Withdrawn EP1831236A4 (fr)	2004-12-30	2005-12-29	Methode servant a preparer 2'-deoxy-2',2'-difluorocytidine

Country Status (6)

Country	Link
EP (1)	EP1831236A4 (fr)
CN (1)	CN101010329B (fr)
AU (1)	AU2005320374B2 (fr)
BR (1)	BRPI0514718A (fr)
NO (1)	NO20070865L (fr)
WO (1)	WO2006071090A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE602005019626D1 (de) *	2005-03-04	2010-04-08	Fresenius Kabi Oncology Ltd	Zwischenprodukt und verfahren zur herstellung von an beta-anomeren angereicherten 2'-desoxy,2',2'-difluor-d-ribufuranosylnukleosiden
CN100475832C (zh)	2007-05-31	2009-04-08	南京卡文迪许生物工程技术有限公司	一种新颖的高立体选择性合成吉西他滨工艺及中间体
CN101381387B (zh) *	2007-09-06	2011-08-31	上海希迪制药有限公司	制备2'-脱氧-2',2'-二氟-β-胞苷盐酸盐的方法
KR20100102107A (ko) *	2007-11-06	2010-09-20	파마이센시아 코퍼레이션	β-뉴클레오시드의 새로운 합성 방법
NZ590058A (en) *	2008-06-12	2012-08-31	Scinopharm Taiwan Ltd	Crystalline polymorphs of gemcitabine base
WO2010029574A2 (fr) *	2008-08-18	2010-03-18	Vishwanath Kannan	Procédé amélioré de préparation de gemcitabine et de ses intermédiaires au moyen de nouveaux groupes de protection et de résines échangeuses d'ions
CN102617484B (zh) *	2011-06-30	2014-05-14	江苏豪森药业股份有限公司	盐酸吉西他滨制备过程中胞嘧啶的回收处理方法
CN102617483B (zh) *	2011-06-30	2013-04-24	江苏豪森药业股份有限公司	盐酸吉西他滨制备过程中胞嘧啶的回收处理方法
CN102432654A (zh) *	2011-09-26	2012-05-02	宋云龙	吉西他滨酰胺衍生物及其制备方法和用途
CN103224541B (zh) *	2013-04-27	2015-07-01	江苏豪森药业股份有限公司	吉西他滨α-异构体转化回收工艺
CN106317147B (zh) *	2015-07-06	2018-11-27	扬州硒瑞恩生物医药科技有限公司	核苷类化合物及其制备方法
CN109305992A (zh) *	2017-07-28	2019-02-05	江苏先声药业有限公司	一种阿扎胞苷的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1442420A (zh) *	2003-04-08	2003-09-17	深圳市汉德森技术有限公司	以1，6－脱水－β－D－葡萄糖为原料制备2'－脱氧－2'，2'－二氟－β－核胞苷或其药用盐的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5223608A (en) *	1987-08-28	1993-06-29	Eli Lilly And Company	Process for and intermediates of 2',2'-difluoronucleosides
US5606048A (en) *	1992-06-22	1997-02-25	Eli Lilly And Company	Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5371210A (en) *	1992-06-22	1994-12-06	Eli Lilly And Company	Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
BR9302431A (pt) *	1992-06-22	1994-01-11	Lilly Co Eli	Processo de glicosilacao de anion estereosseletivo
US5401861A (en) *	1992-06-22	1995-03-28	Eli Lilly And Company	Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

2005
- 2005-12-29 CN CN200580029086XA patent/CN101010329B/zh not_active Expired - Fee Related
- 2005-12-29 AU AU2005320374A patent/AU2005320374B2/en not_active Ceased
- 2005-12-29 EP EP05823850.2A patent/EP1831236A4/fr not_active Withdrawn
- 2005-12-29 WO PCT/KR2005/004633 patent/WO2006071090A1/fr not_active Ceased
- 2005-12-29 BR BRPI0514718-2A patent/BRPI0514718A/pt not_active IP Right Cessation
2007
- 2007-02-15 NO NO20070865A patent/NO20070865L/no not_active Application Discontinuation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1442420A (zh) *	2003-04-08	2003-09-17	深圳市汉德森技术有限公司	以1，6－脱水－β－D－葡萄糖为原料制备2'－脱氧－2'，2'－二氟－β－核胞苷或其药用盐的方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BARDOS, THOMAS J. ET AL: "Stereoselective synthesis of the anomeric 5-mercapto-2'-deoxyuridines and of some other anomeric 2-deoxy-D-erythropentonucleosides", TETRAHEDRON LETTERS, vol. 16, 1966, pages 1759 - 1764, XP002713325, ISSN: 0040-4039 *
KOTICK, MICHAEL P. ET AL: "Synthesis of 5-s-substituted 2'-deoxyuridines. Study of the factors influencing the stereoselectivity of the silyl modification of the Hilbert-Johnson reaction", JOURNAL OF ORGANIC CHEMISTRY, vol. 34, no. 12, 1969, pages 3806 - 3813, XP002713326, ISSN: 0022-3263 *
See also references of WO2006071090A1 *
VORBRUEGGEN, HELMUT ET AL: "Synthesis of nucleosides", ORGANIC REACTIONS, 2000, (HOBOKEN, NJ, UNITED STATES), XP002713324 *

Also Published As

Publication number	Publication date
WO2006071090A1 (fr)	2006-07-06
AU2005320374A1 (en)	2006-07-06
BRPI0514718A (pt)	2008-07-01
CN101010329A (zh)	2007-08-01
EP1831236A1 (fr)	2007-09-12
NO20070865L (no)	2007-04-24
AU2005320374B2 (en)	2009-01-08
CN101010329B (zh)	2011-06-08

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Legal Events

Date	Code	Title	Description
2007-08-10	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2007-09-12	17P	Request for examination filed	Effective date: 20070302
2007-09-12	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
2008-03-12	RIN1	Information on inventor provided before grant (corrected)	Inventor name: KIM, HAN KYONG Inventor name: CHOI, CHANG-JU Inventor name: CHANG, YOUNG-KIL Inventor name: LEE, HOE CHUL Inventor name: LEE, JAEHEON Inventor name: PARK, GHA SEUNG Inventor name: KIM, CHEOL KYONG Inventor name: LEE, JAE CHUL Inventor name: BANG, HYO-JEONG Inventor name: LEE, MOONSUB Inventor name: LEE, GWAN SUN
2008-04-09	DAX	Request for extension of the european patent (deleted)
2011-01-19	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: HANMI HOLDINGS CO., LTD.
2012-10-17	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: HANMI SCIENCE CO., LTD.
2013-10-30	RIC1	Information provided on ipc code assigned before grant	Ipc: C07H 19/04 20060101AFI20130923BHEP
2013-11-13	RIC1	Information provided on ipc code assigned before grant	Ipc: C07H 19/04 20060101AFI20131009BHEP
2013-11-20	A4	Supplementary search report drawn up and despatched	Effective date: 20131021
2014-12-12	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2015-01-14	18D	Application deemed to be withdrawn	Effective date: 20140520