EP1831670A4 - Nanoelektronische vorrichtungen zur dna-detektion und erkennung von polynucleotidsequenzen - Google Patents

Nanoelektronische vorrichtungen zur dna-detektion und erkennung von polynucleotidsequenzen

Info

Publication number
EP1831670A4
EP1831670A4 EP05855662A EP05855662A EP1831670A4 EP 1831670 A4 EP1831670 A4 EP 1831670A4 EP 05855662 A EP05855662 A EP 05855662A EP 05855662 A EP05855662 A EP 05855662A EP 1831670 A4 EP1831670 A4 EP 1831670A4
Authority
EP
European Patent Office
Prior art keywords
electrodes
dna sequence
recognition
target dna
polynucleotide sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05855662A
Other languages
English (en)
French (fr)
Other versions
EP1831670A2 (de
Inventor
Jean-Christophe P Gabriel
Shripal Gandhi
George Gruner
Charles Steven Joiner Jr
Ron Sosnowski
Alexander Star
Eugene Tu
Christian Valcke
Joseph Niemann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanomix Inc
Original Assignee
Nanomix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/212,026 external-priority patent/US20070178477A1/en
Priority claimed from US11/274,747 external-priority patent/US20070208243A1/en
Application filed by Nanomix Inc filed Critical Nanomix Inc
Publication of EP1831670A2 publication Critical patent/EP1831670A2/de
Publication of EP1831670A4 publication Critical patent/EP1831670A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438Electrodes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403Cells and electrode assemblies
    • G01N27/414Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403Cells and electrode assemblies
    • G01N27/414Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Nanotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Zoology (AREA)
  • Electrochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
EP05855662A 2004-12-28 2005-12-23 Nanoelektronische vorrichtungen zur dna-detektion und erkennung von polynucleotidsequenzen Withdrawn EP1831670A4 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US63995404P 2004-12-28 2004-12-28
US65727505P 2005-02-28 2005-02-28
US66887905P 2005-04-05 2005-04-05
US11/212,026 US20070178477A1 (en) 2002-01-16 2005-08-24 Nanotube sensor devices for DNA detection
US73090505P 2005-10-27 2005-10-27
US11/274,747 US20070208243A1 (en) 2002-01-16 2005-11-15 Nanoelectronic glucose sensors
US73869405P 2005-11-21 2005-11-21
US74883405P 2005-12-09 2005-12-09
PCT/US2005/047143 WO2006071895A2 (en) 2004-12-28 2005-12-23 Nanoelectronic devices for dna detection, and recognition of polynucleotide sequences

Publications (2)

Publication Number Publication Date
EP1831670A2 EP1831670A2 (de) 2007-09-12
EP1831670A4 true EP1831670A4 (de) 2010-09-15

Family

ID=36615493

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05855662A Withdrawn EP1831670A4 (de) 2004-12-28 2005-12-23 Nanoelektronische vorrichtungen zur dna-detektion und erkennung von polynucleotidsequenzen

Country Status (3)

Country Link
EP (1) EP1831670A4 (de)
JP (1) JP2008525822A (de)
WO (1) WO2006071895A2 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8154093B2 (en) 2002-01-16 2012-04-10 Nanomix, Inc. Nano-electronic sensors for chemical and biological analytes, including capacitance and bio-membrane devices
US7948041B2 (en) 2005-05-19 2011-05-24 Nanomix, Inc. Sensor having a thin-film inhibition layer
WO2006024023A2 (en) * 2004-08-24 2006-03-02 Nanomix, Inc. Nanotube sensor devices for dna detection
EP2007379A4 (de) * 2006-04-04 2009-12-09 Nanomix Inc Nanoelektronischer nachweis von biomolekülen mit analytverstärkung und reportern
ES2289948B1 (es) * 2006-07-19 2008-09-16 Starlab Barcelona, S.L. Sensor electrofisiologico.
JP5061342B2 (ja) * 2006-09-11 2012-10-31 国立大学法人大阪大学 カーボンナノチューブ電極及び当該電極を用いたセンサー
JP2010528297A (ja) * 2007-05-23 2010-08-19 アリゾナ ボード オブ リージェンツ フォー アンド オン ビハーフ オブ アリゾナ ステイト ユニバーシティ 統合された電気化学的検出および電気的検出のためのシステムおよび方法
EP2197897A4 (de) * 2007-08-30 2012-08-08 Univ Waterloo Auf aminosäurepaarung basierende selbstzusammenbauende peptide und verfahren
WO2010005080A1 (ja) * 2008-07-10 2010-01-14 株式会社イデアルスター ガスセンサー
AU2009298497B2 (en) 2008-10-02 2013-12-19 12-15 Molecular Diagnostics, Inc. Bionanosensor detection device
GB0822733D0 (en) * 2008-12-12 2009-01-21 Univ Warwick Nanotube electrochemistry
US8993346B2 (en) 2009-08-07 2015-03-31 Nanomix, Inc. Magnetic carbon nanotube based biodetection
JP2011220803A (ja) * 2010-04-08 2011-11-04 Mitsumi Electric Co Ltd 電界効果トランジスタ素子を具備するバイオセンサ
NZ610129A (en) 2010-10-04 2014-08-29 Genapsys Inc Systems and methods for automated reusable parallel biological reactions
US9399217B2 (en) 2010-10-04 2016-07-26 Genapsys, Inc. Chamber free nanoreactor system
US9184099B2 (en) 2010-10-04 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Biosensor devices, systems and methods therefor
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
US8585973B2 (en) 2011-05-27 2013-11-19 The Board Of Trustees Of The Leland Stanford Junior University Nano-sensor array
KR101940833B1 (ko) * 2011-05-27 2019-01-21 제납시스 인크. 유전자 및 생물학적 분석을 위한 시스템 및 방법
CN106591103B (zh) 2011-12-01 2021-06-04 吉纳普赛斯股份有限公司 用于高效电子测序与检测的系统和方法
BR112015008206B1 (pt) 2012-10-16 2020-09-29 Koninklijke Philips N.V. Circuito sensor integrado, aparelho sensor e método de medição de uma substância de interesse a ser analisada em um meio
CN102938397B (zh) * 2012-12-05 2015-09-09 苏州纳格光电科技有限公司 电子器件及其制备方法
EP2971141B1 (de) 2013-03-15 2018-11-28 Genapsys, Inc. Systeme für biologische analysen
WO2014191892A1 (en) * 2013-05-29 2014-12-04 Csir A field effect transistor and a gas detector including a plurality of field effect transistors
WO2015089238A1 (en) 2013-12-11 2015-06-18 Genapsys, Inc. Systems and methods for biological analysis and computation
EP3375892B1 (de) 2013-12-12 2020-07-01 Altratech Limited Kapazitiver sensor
EP3556864B1 (de) 2014-04-18 2020-12-09 Genapsys, Inc. Verfahren und systeme zur nukleinsäureamplifikation
US20180133679A1 (en) * 2015-04-15 2018-05-17 Alastair J. Malcolm Methods of manufacturing semiconductor arrays
WO2017033922A1 (ja) * 2015-08-24 2017-03-02 国立大学法人 東京大学 電界効果トランジスタを用いた目的物質の検出方法
CA3050062A1 (en) * 2016-01-14 2017-07-20 Roswell Biotechnologies, Inc. Molecular sensors and related methods
US10544456B2 (en) 2016-07-20 2020-01-28 Genapsys, Inc. Systems and methods for nucleic acid sequencing
CN111108216B (zh) 2017-09-20 2024-02-23 阿尔查技术有限公司 诊断装置和系统
CA3076378A1 (en) 2017-09-21 2019-03-28 Genapsys, Inc. Systems and methods for nucleic acid sequencing
US20190219512A1 (en) * 2018-01-12 2019-07-18 Clifford H. Kern, III Device, procedure and system for detecting bacterial pathogens including methicillin-resistant staphylococcus aureus or clostridium difficile
WO2022159553A1 (en) 2021-01-20 2022-07-28 12-15 Molecular Diagnostics, Inc. Self-disinfecting sensor and method of operation
CN113588605B (zh) * 2021-06-18 2024-08-06 山东师范大学 一种检测多种环境雌激素的方法及其应用
WO2022266714A1 (en) 2021-06-23 2022-12-29 Royal Melbourne Institute Of Technology Conductometric sensor for detecting a nucleic acid and a method for the detection thereof
KR20240095169A (ko) * 2021-09-17 2024-06-25 다이아그메트릭스, 인코포레이티드 날숨 응축물 및 범용 바이오센서 검사를 위한 진단 플랫폼
US11845079B2 (en) * 2021-12-08 2023-12-19 International Business Machines Corporation Integrated silicon platform for electronic biosensors
JP7849335B2 (ja) * 2023-07-03 2026-04-21 株式会社東芝 センサシステム及びセンサ素子の評価方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040202603A1 (en) * 1994-12-08 2004-10-14 Hyperion Catalysis International, Inc. Functionalized nanotubes
US7416699B2 (en) * 1998-08-14 2008-08-26 The Board Of Trustees Of The Leland Stanford Junior University Carbon nanotube devices
WO2001044796A1 (en) * 1999-12-15 2001-06-21 Board Of Trustees Of The Leland Stanford Junior University Carbon nanotube devices
ATE408140T1 (de) * 2000-12-11 2008-09-15 Harvard College Vorrichtung enthaltend nanosensoren zur ekennung eines analyten und verfahren zu ihrer herstellung
JP2003322653A (ja) * 2002-05-07 2003-11-14 Toshiba Corp プローブ固定支持体及びプローブ固定担体
JP2006505806A (ja) * 2002-11-08 2006-02-16 ナノミックス・インコーポレーテッド ナノチューブをベースとする生体分子の電子検知
JP2004347532A (ja) * 2003-05-23 2004-12-09 Japan Science & Technology Agency バイオセンサー

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
JP2008525822A (ja) 2008-07-17
WO2006071895A3 (en) 2007-02-08
WO2006071895A2 (en) 2006-07-06
EP1831670A2 (de) 2007-09-12

Similar Documents

Publication Publication Date Title
EP1831670A4 (de) Nanoelektronische vorrichtungen zur dna-detektion und erkennung von polynucleotidsequenzen
WO2006024023A3 (en) Nanotube sensor devices for dna detection
Barbaro et al. Fully electronic DNA hybridization detection by a standard CMOS biochip
Roy et al. Direct electrical measurements on single-molecule genomic DNA using single-walled carbon nanotubes
Liu et al. Carbon nanomaterials field-effect-transistor-based biosensors
CN103620406B (zh) 适配体包覆的测量电极和参比电极以及用其进行生物标记物检测的方法
Penner Chemical sensing with nanowires
Tran et al. Detection of influenza A virus using carbon nanotubes field effect transistor based DNA sensor
Sakata et al. Potential Response of Genetic Field Effect Transistor to Charged Nanoparticle-DNA Conjugate
US8138496B2 (en) Addressable transistor chip for conducting assays
Rahn et al. Label-free electrochemical methods for disease detection
MX2010004084A (es) Dispositivo para la produccion de capa de nanoparticulas a traves de hilado electrostatico de matrices polimericas y electrodo recolector para este dispositivo.
WO2010059687A3 (en) A semiconductor for measuring biological interactions
FR2875007B1 (fr) Puce biologique comportant un reseau d'electrodes sur un substrat
SG130107A1 (en) Polymer/nanoparticle composites, film and molecular detection device
MX373009B (es) Biosensores salivales y celdas de biocombustible.
WO2007084076A8 (en) Biosensor
EP2148191A4 (de) Impedanzmesser und anwendungen dafür
Mai et al. Highly sensitive DNA sensor based on polypyrrole nanowire
WO2009145836A3 (en) Methods and devices based upon a novel form of nucleic acid duplex on a surface
Di Lauro et al. The substrate is a pH-controlled second gate of electrolyte-gated organic field-effect transistor
Park et al. Mechanism of label-free DNA detection using the floating electrode on pentacene thin film transistor
WO2007040558A3 (en) Method of fabricating nanowires and electrodes having nanogaps
Tapia et al. Binding of polynucleotides to conjugated polyelectrolytes and its applications in sensing
Lazerges et al. Electrochemical DNA-biosensors: Two-electrode setup well adapted for miniaturized devices

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20070619

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: NANOMIX, INC.

A4 Supplementary search report drawn up and despatched

Effective date: 20100818

RIC1 Information provided on ipc code assigned before grant

Ipc: C12M 3/00 20060101ALI20100812BHEP

Ipc: G01N 27/00 20060101ALI20100812BHEP

Ipc: G01N 27/12 20060101ALI20100812BHEP

Ipc: G01N 21/00 20060101AFI20070709BHEP

Ipc: G01N 33/543 20060101ALI20100812BHEP

Ipc: C12Q 1/68 20060101ALI20100812BHEP

Ipc: G01N 33/00 20060101ALI20100812BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20110317