EP1833739A2 - Dispositif de distribution de composants multiples, pour substances liquides et pulverulentes - Google Patents

Dispositif de distribution de composants multiples, pour substances liquides et pulverulentes

Info

Publication number
EP1833739A2
EP1833739A2 EP05815906A EP05815906A EP1833739A2 EP 1833739 A2 EP1833739 A2 EP 1833739A2 EP 05815906 A EP05815906 A EP 05815906A EP 05815906 A EP05815906 A EP 05815906A EP 1833739 A2 EP1833739 A2 EP 1833739A2
Authority
EP
European Patent Office
Prior art keywords
chambers
discharge device
blister
discharge
pad
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05815906A
Other languages
German (de)
English (en)
Inventor
Wilhelm A. Keller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medmix Systems AG
Original Assignee
Medmix Systems AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medmix Systems AG filed Critical Medmix Systems AG
Publication of EP1833739A2 publication Critical patent/EP1833739A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C5/00—Filling or capping teeth
    • A61C5/60—Devices specially adapted for pressing or mixing capping or filling materials, e.g. amalgam presses
    • A61C5/62—Applicators, e.g. syringes or guns
    • A61C5/64—Applicators, e.g. syringes or guns for multi-component compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/00503—Details of the outlet element
    • B05C17/00516—Shape or geometry of the outlet orifice or the outlet element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/00583—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes the container for the material to be dispensed being deformable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/771—Containers or packages with special means for dispensing contents for dispensing fluent contents by means of a flexible bag or a deformable membrane or diaphragm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2024—Separating means having peelable seals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/00553—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with means allowing the stock of material to consist of at least two different components

Definitions

  • Multi-component discharge device for liquid and powdery substances
  • the present invention relates to a multi-component discharge device for liquid and powdery substances according to the preamble of claim 1.
  • Such discharge devices are based on the blister system and are described for example in EP-B-1 108 656.
  • a further discharge device for the single discharge of the components is described in WO98 / 01360.
  • Fig. 1 shows a perspective view of a first
  • FIG. 1A shows an embodiment of FIG. 1, FIG.
  • FIGS. 2 to 4 schematically show the process of discharging the substances
  • FIG. 6A shows a detail enlargement of FIG. 6,
  • Fig. 7 shows a variant with an integrated mixer, " ⁇
  • FIG. 7A shows a detail enlargement of FIG. 7, 8-10 show a perspective view of another embodiment in section and in the closed position
  • FIG. 16 shows a further variant of the blister part with a tablet container in a section according to line XVI-XVI in FIG. 17, FIG.
  • FIG. 17 shows the discharge device of FIG. 16 from above
  • Figure 18 shows a further shaping of the blister pad and the discharge parts
  • Figure 19 shows a perspective view of an embodiment with expandable chambers.
  • a first embodiment of a discharge device 1 which has a film part, hereinafter called Blisterteil 2, with four chambers 3, 4 and 5, 6, which is arranged on a Blisterunterlage 7 such that through channels 8 and 9 interconnected chambers 3, 4 and 5, 6 with seams 8S and 9S are vershrloss ⁇ en ⁇ .
  • Di ⁇ ⁇ ed 'em' ⁇ ustragende chambers 3 and 5 nearer each have a channel 10 and 11 with Auslassnahtstelle 1os IIS and which open into a static mixer 12th
  • the channels between the chambers or the outlet can also be closed by sealing or by another method, or the two layers - blister part and blister base - be connected to each other.
  • suture or closure sites are such that they are resilient in pressure application to the chambers such that the contents of one chamber can be transferred to the other chamber.
  • detachable welding or splices in the channels The following is an example of all sorts of seams in channels that release under pressure to give a passage.
  • Embodiment two discharge parts 13 and 14 which may be formed as the blister pack also as a molded part and which are connected via joints 15, and 16 with the blister pad, and first discharge 13.
  • the exree questioning part " T3 " has a " Ve ' rri ' egelungsknöpf 17 which fits into a corresponding opening 18 in the blister part 2 and blister pad 7. iD ⁇
  • the folding of the discharge parts and their depression can be done either by hand or via a dispensing device, which is designed to receive the discharge and fold the discharge and depress. But it is also possible to use a dispenser that acts directly and sequentially on the chambers.
  • Fig. IA an embodiment of the chambers 20, 21 and 22, 23 is shown, in which these chambers taper towards the outlet end in order to allow the most uniform and complete discharge.
  • Fig. 5 is shown by way of example, that the chambers may have different dimensions, the chambers 24 and 25 of blister 28 are smaller than the zereimeteir ge-vorher obtainedd- and " 'also' smaller” than "" d ⁇ e ⁇ "ä ⁇ deren” ⁇ Chambers 26 and 27 and also may have another shape.
  • the remaining parts of this discharge device are the same as shown in FIG. 1.
  • a discharge device 29 is provided with a leveling device 30, as described, for example, in WO2004 / 100854 of the same Applicant.
  • Fig. 6 and in the detail enlargement 6A only a few essential elements of the device are described, wherein the remaining parts may be as previously described. It is the blister part 31 with the chambers 32 and 33, the channels 34 and 35 with the seams 34S and 35S, the blister pad 7 and the two
  • the blister pad includes an outlet portion 43 having the outlets 43A and 43B. Between the blister channels 34 and 35 and the outlets 43A and 43B are each a throttle or drop images in the form of a narrow transition channel 35 D. This makes it possible to form individual drops. This is necessary in the case of too high a pressure to prevent spewing of the low-viscosity components.
  • Fig. 6A can be seen the level-compensating device 30 with the two balancing chambers 36 and 37 and the filter 38 and the input part 3OE, as described in the aforementioned WO application by the same applicant.
  • Compensating device makes it possible to ensure that existing air can escape and any level differences are compensated before a mixer is put on. It is first discharged until ⁇ ent "both" Compon ⁇ : ⁇ s' ⁇ ⁇ irr the "off" greichsKammerh “siclrEbaf" are ⁇ can, after which the level-compensating device removed and mounted a mixer.
  • the use of such a level-compensating device requires the use of a separate mixer, as shown enlarged in Fig. 7A, wherein the mixer 39 has a locking member 40 with paragraph 41, one or more five catch 42 of the Auslasteil 43 of
  • the outlet part likewise has the transition duct 35D, which opens into the outlet 43A or 43B.
  • the mixer inlet part and the outlet part of the discharge device can also be designed such that the mixer can be detachably mounted.
  • the blister pad 45 of the device 44 of FIGS. 7 and 7A has, for each outlet channel 10 and 11 or 35, a hydrophobic filter 46 incorporated in an opening 20.
  • the hydrophobic filter allows the air contained in the system to escape prior to discharge, with the components flowing around the filter as if in a bypass after the channel junctions have been released again.
  • the device 47 contains a blister pad 48, the four filling passages
  • FIGS. 11 to 13 show a small section of the possible great variety of variations.
  • the discharge device 53 has two adjacent chambers 55 and 56, which require only one discharge part 54 in order to discharge the material from the two chambers 55 and 56.
  • the chambers are arranged in two rows, one row having two or three adjacent chambers, and two rows being arranged one behind the other with respect to the outlet, resulting in two or three columns. It is obvious that both the number of chambers in a row and the number of chambers in a column can vary, i. can be more than three, or two. For each row a discharge part is necessary, which is connected via a joint with another discharge part or with the blister pad.
  • two lock buttons are indicated 17 and 17A, in which openings 18 and 18A are pluggable.
  • FIG. 14 starting from FIG. 1, it is shown that the mixer 60, or its housing, can be formed integrally with the blister pad 61 of the device 62.
  • the remaining elements may be as shown in FIG. 1, 13 or as any of the other figures.
  • FIG. 19 Another increase in volume is shown in Figure 19, in which the blister 70 of the discharge apparatus 69 with respect to the rear outlet chambers 72 and 74 and two front chambers 71 and 73 of --Blis1rerte ⁇ l ⁇ 70 ⁇ au ⁇ fwelst ' "who" äüf "" B ⁇ iste ' ru ⁇ TerTage ' T are attached.
  • the front chambers 71 and 73 have annular zones 75, 76, respectively, the inside of which is weaker with the blister pad as in the case of the seams sealed, welded or glued, so that the inside of the zones dissolves when transferring the contents of the rear chambers in the front chambers and allows an increase in volume of the front chambers.
  • the width of the annular zone depends on the desired volume increase.
  • FIGS. 16 and 17 A further variant of the blister part 82 is shown in FIGS. 16 and 17, wherein a container 78 is arranged in a front chamber or in the front chamber (m) 80, in which a tablet 79, for example in the form of a lyophilisate, can be introduced dissolves in the fluid coming from the posterior chamber.
  • the container in the chamber may be shaped to receive the tablet, but not so closed as to prevent the inflowing liquid from reaching the tablet.
  • the edge of the Bezzatnis can also be connected to the blister pad to close the container.
  • the edge of the container must be connected to the base in such a way that, like the sealed channels 83, it separates between the chambers 84 and between the chambers 80 and the outlet upon penetration of the liquid and releases the tablet.
  • a discharge device with chambers whose volume increases upon entry of liquid and / or at least one " ⁇ crizegrrertes' TäbTe 't' tenbehall ⁇ nrs", "is also advantageous without the corresponding mixer.
  • recesses 63 and 64 are attached as finger pads to the fingers to the optimal Positions to position.
  • the devices described are particularly advantageous for single-dose medical applications, but may be used in, for example, dental technology or industry where only small amounts of, for example, adhesive are used. This is especially true for systems whose components are not long-term stable and need to be premixed or dissolved just before use, before they can be mixed and discharged. All applications have in common that no plug is required, even if a mixer is used.

Landscapes

  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dentistry (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Geometry (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Surgical Instruments (AREA)
  • Coating Apparatus (AREA)
  • Package Specialized In Special Use (AREA)

Abstract

L'invention concerne un dispositif de distribution de composants multiples, conçu pour des substances liquides et pulvérulentes, comprenant : une partie blister (2) qui comporte au moins deux chambres (3-6) adjacentes fermées au moyen d'une feuille, et ; un support de blister (7) qui comporte au moins une pièce de distribution (13, 14) qui agit sur lesdites chambres. Selon l'invention, des canaux fermés (8, 9 ; 10, 11) ou des canaux comportant des points de soudure (8F, 9F ; 10F, 11F) sont disposés entre des chambres successives et/ou entre les dernières chambres par rapport à la sortie et la sortie, et la partie blister est fixée sur le support de blister, de manière que les points de soudure (8F, 9F ; 10F, 11F) soient déformables et permettent ainsi le passage de matière. Le dispositif de distribution (1) selon l'invention comprend un mélangeur statique (12). L'utilisation de pièces de distribution servant à extraire simultanément le contenu de plusieurs rangées de chambre, et l'intégration d'un mélangeur sont deux mesures qui permettent de créer un dispositif de distribution pouvant distribuer des substances de manière très précise et selon un mélange adéquat, au moyen d'éléments peu onéreux, et ainsi de répondre aux exigences de la médecine.
EP05815906A 2004-12-30 2005-12-20 Dispositif de distribution de composants multiples, pour substances liquides et pulverulentes Withdrawn EP1833739A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH21682004 2004-12-30
PCT/CH2005/000765 WO2006069460A2 (fr) 2004-12-30 2005-12-20 Dispositif de distribution de composants multiples, pour substances liquides et pulverulentes

Publications (1)

Publication Number Publication Date
EP1833739A2 true EP1833739A2 (fr) 2007-09-19

Family

ID=35811570

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05815906A Withdrawn EP1833739A2 (fr) 2004-12-30 2005-12-20 Dispositif de distribution de composants multiples, pour substances liquides et pulverulentes

Country Status (5)

Country Link
US (1) US20080073372A1 (fr)
EP (1) EP1833739A2 (fr)
JP (1) JP2008526623A (fr)
CN (1) CN101094795A (fr)
WO (1) WO2006069460A2 (fr)

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AU2010286439A1 (en) * 2009-08-30 2012-04-19 Aktivpak, Inc. Dispensing device incorporating frangible section, along with dispensing method
JP2013503019A (ja) * 2009-08-30 2013-01-31 アクティヴパック， インコーポレイテッド 投与装置および製品投与方法
SG184103A1 (en) * 2010-03-19 2012-10-30 Red Flag Diagnostics Gmbh In vitro process for the quick determination of a patient's status relating to infection with mycobacterium tuberculosis
DE102010042740A1 (de) * 2010-10-21 2012-04-26 Ing. Erich Pfeiffer Gmbh Austragvorrichtung für Medien
JP5969497B2 (ja) * 2011-01-17 2016-08-17 アクティヴパック， インコーポレイテッド 無菌カートリッジおよびディスペンサ装置
US11759572B2 (en) 2011-01-17 2023-09-19 Aktivax, Inc. Aseptic cartridge and dispenser arrangement
ES2423909B1 (es) * 2012-03-21 2014-09-29 Genoveva Serra Caselles Depósito desechable con dosificador de producto
US10039884B2 (en) * 2012-06-26 2018-08-07 Becton, Dickinson And Company Clip syringe
US10010685B2 (en) * 2012-06-26 2018-07-03 Becton, Dickinson And Company Single use delivery device having a primer element
JP2014104979A (ja) * 2012-11-22 2014-06-09 Takeuchi Press Ind Co Ltd チューブ容器絞り出し器具
GB2520962A (en) * 2013-12-04 2015-06-10 Team Consulting Ltd A method and apparatus for manufacturing a container of pressurised fluid
JP6691532B2 (ja) * 2015-03-15 2020-04-28 法基 岡部 密封容器
DE102016202529A1 (de) * 2016-02-18 2017-08-24 Henkel Ag & Co. Kgaa Vorrichtung zum Aufbringen von Kleb- und oder Dichtstoff
US10231846B2 (en) 2016-08-19 2019-03-19 Stryker European Holdings I, Llc Bone graft delivery loading assembly
US20190166974A1 (en) * 2017-12-05 2019-06-06 Mark Davidov Disposable Portable Pocket Fluid/Floss Dispenser
US11206910B2 (en) * 2018-08-01 2021-12-28 Mark Davidov Disposable portable pocket fluid/floss dispenser
JP7614103B2 (ja) 2018-10-15 2025-01-15 アプレシア・ファーマスーティカルズ・エルエルシー 包装内に剤形を形成する方法およびシステム
WO2020251431A1 (fr) * 2019-06-11 2020-12-17 Miltech Ab Procédé et appareil de stockage d'échantillons biologiques de fluide dans un emballage
CN114787048A (zh) * 2019-10-07 2022-07-22 桑德斯创新有限公司 容器
WO2022208318A1 (fr) * 2021-03-28 2022-10-06 Koska Family Limited Systèmes et procédés de distribution et de désactivation de soufflage-remplissage-scellage assistés
WO2026043981A1 (fr) * 2024-08-21 2026-02-26 Genzyme Corporation Ensemble de préparation et procédé de préparation d'un médicament liquide

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Also Published As

Publication number Publication date
WO2006069460A3 (fr) 2006-10-12
WO2006069460A2 (fr) 2006-07-06
JP2008526623A (ja) 2008-07-24
US20080073372A1 (en) 2008-03-27
CN101094795A (zh) 2007-12-26

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