EP1848410A4 - Compositions d'administration particulaires, polymeriques, et leurs methodes d'utilisation - Google Patents

Compositions d'administration particulaires, polymeriques, et leurs methodes d'utilisation

Info

Publication number
EP1848410A4
EP1848410A4 EP06734169A EP06734169A EP1848410A4 EP 1848410 A4 EP1848410 A4 EP 1848410A4 EP 06734169 A EP06734169 A EP 06734169A EP 06734169 A EP06734169 A EP 06734169A EP 1848410 A4 EP1848410 A4 EP 1848410A4
Authority
EP
European Patent Office
Prior art keywords
methods
administration compositions
particulate polymeric
polymeric administration
particulate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06734169A
Other languages
German (de)
English (en)
Other versions
EP1848410A1 (fr
Inventor
William G Turnell
Hong Li
Zaza D Gomurashvili
Jonathan Macferran Hughes
Jie Da
Huashi Zhang
Ramaz Katsarava
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medivas LLC
Original Assignee
Medivas LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivas LLC filed Critical Medivas LLC
Publication of EP1848410A1 publication Critical patent/EP1848410A1/fr
Publication of EP1848410A4 publication Critical patent/EP1848410A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593Polyesters, e.g. PLGA or polylactide-co-glycolide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595Polyamides, e.g. nylon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153Polyesters, e.g. poly(lactide-co-glycolide)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • C08L77/12Polyester-amides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP06734169A 2005-02-17 2006-01-31 Compositions d'administration particulaires, polymeriques, et leurs methodes d'utilisation Withdrawn EP1848410A4 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US65471505P 2005-02-17 2005-02-17
US68467005P 2005-05-25 2005-05-25
US68757005P 2005-06-03 2005-06-03
US71995005P 2005-09-22 2005-09-22
US73740105P 2005-11-14 2005-11-14
US75917906P 2006-01-13 2006-01-13
PCT/US2006/003575 WO2006088647A1 (fr) 2005-02-17 2006-01-31 Compositions d'administration particulaires, polymeriques, et leurs methodes d'utilisation

Publications (2)

Publication Number Publication Date
EP1848410A1 EP1848410A1 (fr) 2007-10-31
EP1848410A4 true EP1848410A4 (fr) 2011-11-09

Family

ID=36916776

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06734169A Withdrawn EP1848410A4 (fr) 2005-02-17 2006-01-31 Compositions d'administration particulaires, polymeriques, et leurs methodes d'utilisation

Country Status (6)

Country Link
EP (1) EP1848410A4 (fr)
JP (1) JP2008530206A (fr)
CN (1) CN101115471B (fr)
AU (1) AU2006214655A1 (fr)
CA (1) CA2596011C (fr)
WO (1) WO2006088647A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
CA2623198C (fr) 2005-09-22 2014-08-05 Medivas, Llc Formules de poly(ester amide) et de poly(ester urethane) contenant des diesters de bis-(a-amino)-diol et methodes d'emploi
JP5178520B2 (ja) 2005-09-22 2013-04-10 メディバス エルエルシー 固体ポリマー送達組成物およびその使用法
WO2007112046A2 (fr) * 2006-03-24 2007-10-04 Medivas, Llc Poly(ester amides) biodegradables contenant du dicarboxylate d'alkylene et leurs methodes d'utilisation
US8658210B2 (en) * 2006-04-17 2014-02-25 Advanced Cardiovascular Systems, Inc. Polyesteramide platform for site specific drug delivery
WO2007133616A2 (fr) * 2006-05-09 2007-11-22 Medivas, Llc Polymères hydrosolubles biodégradables
WO2008082721A2 (fr) * 2006-09-05 2008-07-10 Medivas, Llc Compositions liposomales stabilisées par des polymères et leurs méthodes d'utilisation
US20090068743A1 (en) * 2007-08-23 2009-03-12 Medivas, Llc Cationic alpha-amino acid-containing biodegradable polymer gene transfer compositions
EP2282720B1 (fr) * 2008-05-15 2013-09-11 Biocompatibles Uk Ltd. Libération intracellulaire d'anticorps
CA2736393A1 (fr) * 2008-10-15 2010-04-22 Medivas, Llc Polymeres biodegradables a base de proline
ES2992024T3 (es) 2011-06-23 2024-12-05 Dsm Ip Assets Bv Nuevos copolímeros de poliesteramida biodegradables para la administración de fármacos
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
US10434071B2 (en) 2014-12-18 2019-10-08 Dsm Ip Assets, B.V. Drug delivery system for delivery of acid sensitivity drugs
WO2016207725A1 (fr) * 2015-06-23 2016-12-29 Phagelux (Canada), Inc. Composition comprenant des polymères d'acide aminé et un agent bioactif et procédé de préparation associé
CN110023407B (zh) * 2016-09-20 2021-10-29 康奈尔大学 标记的聚(酯酰胺氨基甲酸酯)、由其形成的纳米粒子和其用途
KR20210151822A (ko) * 2019-03-14 2021-12-14 엔진 인코포레이티드 키토산-핵산 나노입자의 가역성 코팅 및 이의 사용 방법
CA3160955A1 (fr) * 2019-11-12 2021-05-20 Dsm Ip Assets B.V. Copolymeres de polyesteramides possedant une temperature de transition vitreuse elevee
CN112321822B (zh) * 2020-12-02 2021-12-10 中山大学 一种具有ros响应性的蛋氨酸-聚酯酰胺高分子聚合物及其应用
CN114920869B (zh) * 2022-05-24 2023-07-14 太原工业学院 两亲性精氨酸嵌段环丙沙星共聚物、纳米颗粒及其制备方法和应用
CN119039583B (zh) * 2024-11-01 2025-03-11 浙江农林大学 一种具有立构复合结晶性能侧链碱基生物可降解聚酯酰胺及其酶促制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449513A (en) * 1992-08-14 1995-09-12 Research Development Corporation Of Japan Physical trapping type polymeric micelle drug preparation
US5861387A (en) * 1991-06-28 1999-01-19 Endorecherche Inc. Controlled release systems and low dose androgens
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US20020015720A1 (en) * 2000-01-11 2002-02-07 Ramaz Katsarava Polymer blends as biodegradable matrices for preparing biocomposites
WO2003062298A1 (fr) * 2002-01-17 2003-07-31 Polyrava Llc Co-poly(ester amide) et co-poly(ester urethane) compositions presentant une biodegradabilite, procedes de production et utilisation associes
WO2004039944A2 (fr) * 2002-05-15 2004-05-13 Rutgers, The State University Polymeres triblocs pour administration de gene ou de medicament a base de nanospheres
EP1945682A2 (fr) * 2005-10-21 2008-07-23 Medivas, LLC Polymeres de poly(ester-uree) et leurs procedes d'utilisation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020164374A1 (en) * 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
BR9813548A (pt) * 1997-12-12 2000-10-10 Samyang Corp Micelas poliméricas misturadas biodegradáveis para distribuição de gene
CN1339964A (zh) * 1999-02-19 2002-03-13 生化研究股份公司 用以生产微胶囊的生物可降解复合材料
ATE313341T1 (de) * 2000-01-11 2006-01-15 Intralytix Inc Polymermischungen als bioabbaubare matrizen zur herstellung von biokompositen
CA2397404C (fr) * 2000-01-14 2008-12-02 Brown University Research Foundation Particules lyophilisees microfines
FR2811227A1 (fr) * 2000-07-07 2002-01-11 Philippe Maincent Vecteurs particulaires destines a ameliorer l'absorption orale de principes actifs
US6503538B1 (en) * 2000-08-30 2003-01-07 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
CN1119172C (zh) * 2000-12-12 2003-08-27 天津大学 脂肪族聚酯表面的壳聚糖/明胶网络修饰方法
US20050152980A1 (en) * 2002-03-13 2005-07-14 Michael Ausborn Pharmeutical microparticles
WO2003092585A2 (fr) * 2002-05-02 2003-11-13 Pr Pharmaceuticals, Inc. Compositions a liberation regulee de metabolites d'estradiol
CN101044638B (zh) * 2004-10-18 2012-05-09 株式会社明电舍 帕尔帖元件或塞贝克元件的结构及其制造方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5861387A (en) * 1991-06-28 1999-01-19 Endorecherche Inc. Controlled release systems and low dose androgens
US5449513A (en) * 1992-08-14 1995-09-12 Research Development Corporation Of Japan Physical trapping type polymeric micelle drug preparation
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US20020015720A1 (en) * 2000-01-11 2002-02-07 Ramaz Katsarava Polymer blends as biodegradable matrices for preparing biocomposites
WO2003062298A1 (fr) * 2002-01-17 2003-07-31 Polyrava Llc Co-poly(ester amide) et co-poly(ester urethane) compositions presentant une biodegradabilite, procedes de production et utilisation associes
WO2004039944A2 (fr) * 2002-05-15 2004-05-13 Rutgers, The State University Polymeres triblocs pour administration de gene ou de medicament a base de nanospheres
EP1945682A2 (fr) * 2005-10-21 2008-07-23 Medivas, LLC Polymeres de poly(ester-uree) et leurs procedes d'utilisation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARABULI N ET AL: "HETEROCHAIN POLYMERS BASED ON NATURAL AMINO ACIDS. SYNTHESIS AND ENZYMATIC HYDROLYSIS OF REGULAR POL(ESTER AMIDE)S BASED ON BIS(L-PHENYLALANINE)ALPHA,OMEGA-ALKYLENE DIESTERS AND ADIPIC ACID", MACROMOLECULAR CHEMISTRY AND PHYSICS, WILEY-VCH VERLAG, WEINHEIM, DE, vol. 195, no. 6, 1 January 1994 (1994-01-01), pages 2279 - 2289, XP002171341, ISSN: 1022-1352, DOI: 10.1002/MACP.1994.021950633 *
See also references of WO2006088647A1 *

Also Published As

Publication number Publication date
CN101115471B (zh) 2011-02-09
CN101115471A (zh) 2008-01-30
CA2596011C (fr) 2013-05-14
EP1848410A1 (fr) 2007-10-31
CA2596011A1 (fr) 2006-08-24
JP2008530206A (ja) 2008-08-07
WO2006088647A1 (fr) 2006-08-24
AU2006214655A1 (en) 2006-08-24

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