EP1877104A4 - Verfahren und vorrichtung zur nierenfunktionsanalyse - Google Patents

Verfahren und vorrichtung zur nierenfunktionsanalyse

Info

Publication number
EP1877104A4
EP1877104A4 EP06750582A EP06750582A EP1877104A4 EP 1877104 A4 EP1877104 A4 EP 1877104A4 EP 06750582 A EP06750582 A EP 06750582A EP 06750582 A EP06750582 A EP 06750582A EP 1877104 A4 EP1877104 A4 EP 1877104A4
Authority
EP
European Patent Office
Prior art keywords
renal functions
analyzing
analyzing renal
functions
renal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP06750582A
Other languages
English (en)
French (fr)
Other versions
EP1877104B1 (de
EP1877104A1 (de
Inventor
Weiming Yu
Bruce A Molitoris
Ruben M Sandoval
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indiana University Research and Technology Corp
Original Assignee
Indiana University Research and Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indiana University Research and Technology Corp filed Critical Indiana University Research and Technology Corp
Publication of EP1877104A1 publication Critical patent/EP1877104A1/de
Publication of EP1877104A4 publication Critical patent/EP1877104A4/de
Application granted granted Critical
Publication of EP1877104B1 publication Critical patent/EP1877104B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
EP06750582A 2005-04-19 2006-04-18 Verfahren zur nierenfunktionsanalyse Expired - Lifetime EP1877104B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67270805P 2005-04-19 2005-04-19
PCT/US2006/014576 WO2006113724A1 (en) 2005-04-19 2006-04-18 Method and apparatus for kidney function analysis

Publications (3)

Publication Number Publication Date
EP1877104A1 EP1877104A1 (de) 2008-01-16
EP1877104A4 true EP1877104A4 (de) 2011-06-29
EP1877104B1 EP1877104B1 (de) 2013-03-13

Family

ID=37115492

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06750582A Expired - Lifetime EP1877104B1 (de) 2005-04-19 2006-04-18 Verfahren zur nierenfunktionsanalyse

Country Status (8)

Country Link
US (4) US8329143B2 (de)
EP (1) EP1877104B1 (de)
JP (1) JP5033789B2 (de)
CN (1) CN101208109A (de)
AU (1) AU2006236407B2 (de)
CA (1) CA2649391C (de)
ES (1) ES2413757T3 (de)
WO (1) WO2006113724A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8329143B2 (en) 2005-04-19 2012-12-11 Indiana University Research And Technology Corporation Method and apparatus for kidney function analysis
JP2011521899A (ja) * 2008-04-18 2011-07-28 ファーマコフォトニクス，インコーポレイティド 腎機能の分析方法及び装置
US8591865B2 (en) 2008-04-18 2013-11-26 Pharmacophotonics, Inc. Renal function analysis method and apparatus
AU2013221451A1 (en) * 2012-02-17 2014-08-21 Pharmacophotonics, Inc. Compositions and methods for monitoring biometric indicators
WO2015059083A1 (en) 2013-10-22 2015-04-30 Ralf Heinrich Improved transcutaneous organ function measurement
CA3051963A1 (en) * 2017-01-30 2018-08-02 Medibeacon Inc. Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections
WO2020148757A1 (en) * 2019-01-14 2020-07-23 Gynisus Ltd. System and method for selecting required parameters for predicting or detecting a medical condition of a patient

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001066152A1 (en) * 2000-03-06 2001-09-13 Mallinckrodt Inc. Simultaneous multimodal measurement of physiological function

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5928625A (en) 1997-03-13 1999-07-27 Mallinckrodt Inc. Method of measuring physiological function
CA2327816A1 (en) * 1998-04-09 1999-10-21 Nycomed Imaging As Use of particulate contrast agents in diagnostic imaging for studying physiological parameters
JP3948736B2 (ja) * 2004-02-27 2007-07-25 旭化成メディカル株式会社 血液透析器
US8329143B2 (en) 2005-04-19 2012-12-11 Indiana University Research And Technology Corporation Method and apparatus for kidney function analysis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001066152A1 (en) * 2000-03-06 2001-09-13 Mallinckrodt Inc. Simultaneous multimodal measurement of physiological function

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
DUNN KENNETH W ET AL: "Functional studies of the kidney of living animals using multicolor two-photon microscopy.", AMERICAN JOURNAL OF PHYSIOLOGY. CELL PHYSIOLOGY SEP 2002 LNKD- PUBMED:12176747, vol. 283, no. 3, 15 May 2002 (2002-05-15), pages C905 - C916, XP002535756, ISSN: 0363-6143, DOI: 10.1152/apjcell.00159.2002 *
ERLEY C M ET AL: "Plasma clearance of iodine contrast media as a measure of glomerular filtration rate in critically ill patients.", CRITICAL CARE MEDICINE AUG 2001 LNKD- PUBMED:11505124, vol. 29, no. 8, August 2001 (2001-08-01), pages 1544 - 1550, XP009147834, ISSN: 0090-3493 *
MOLITORIS B A ET AL: "Pharmacophotonics: Utilizing multi-photon microscopy to quantify drug delivery and intracellular trafficking in the kidney", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER BV, AMSTERDAM, NL, vol. 58, no. 7, 15 August 2006 (2006-08-15), pages 809 - 823, XP024892136, ISSN: 0169-409X, [retrieved on 20061031], DOI: 10.1016/J.ADDR.2006.07.017 *
MOLITORIS BRUCE A ET AL: "Intravital multiphoton microscopy of dynamic renal processes.", AMERICAN JOURNAL OF PHYSIOLOGY. RENAL PHYSIOLOGY JUN 2005 LNKD- PUBMED:15883167, vol. 288, no. 6, 15 June 2005 (2005-06-15) - June 2005 (2005-06-01), pages F1084 - F1089, XP002535757, ISSN: 1931-857X *
PETI-PETERDI JÁNOS: "Multiphoton imaging of renal tissues in vitro.", AMERICAN JOURNAL OF PHYSIOLOGY. RENAL PHYSIOLOGY JUN 2005 LNKD- PUBMED:15883166, vol. 288, no. 6, June 2005 (2005-06-01), pages F1079 - F1083, XP002636075, ISSN: 1931-857X *
SANDOVAL RUBEN M ET AL: "Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy.", AMERICAN JOURNAL OF PHYSIOLOGY. CELL PHYSIOLOGY AUG 2004 LNKD- PUBMED:15102609, vol. 287, no. 2, 21 April 2004 (2004-04-21) - August 2004 (2004-08-01), pages C517 - C526, XP002636077, ISSN: 0363-6143, DOI: 10.1152/ajpcell.00006.2004 *
See also references of WO2006113724A1 *
SUTTON TIMOTHY A ET AL: "Minocycline reduces renal microvascular leakage in a rat model of ischemic renal injury.", AMERICAN JOURNAL OF PHYSIOLOGY. RENAL PHYSIOLOGY JAN 2005 LNKD- PUBMED:15353401, vol. 288, no. 1, 7 September 2004 (2004-09-07) - January 2005 (2005-01-01), pages F91 - F97, XP002636078, ISSN: 1931-857X, DOI: 10.1152/ajprenal.00051.2004 *
YU WEIMING ET AL: "Quantitative intravital microscopy using a Generalized Polarity concept for kidney studies.", AMERICAN JOURNAL OF PHYSIOLOGY. CELL PHYSIOLOGY NOV 2005 LNKD- PUBMED:16033906, vol. 289, no. 5, November 2005 (2005-11-01), pages C1197 - C1208, XP002636076, ISSN: 0363-6143 *
YU WEIMING ET AL: "Rapid determination of renal filtration function using an optical ratiometric imaging approach", AMERICAN JOURNAL OF PHYSIOLOGY - RENAL PHYSIOLOGY, vol. 292, no. 6, June 2007 (2007-06-01), pages F1873 - F1880, XP002636079 *

Also Published As

Publication number Publication date
WO2006113724A1 (en) 2006-10-26
US9744249B2 (en) 2017-08-29
CN101208109A (zh) 2008-06-25
ES2413757T3 (es) 2013-07-17
US20160256574A1 (en) 2016-09-08
EP1877104B1 (de) 2013-03-13
US8329143B2 (en) 2012-12-11
CA2649391C (en) 2017-11-28
US20140227189A1 (en) 2014-08-14
AU2006236407A1 (en) 2006-10-26
US8741263B2 (en) 2014-06-03
US20130101518A1 (en) 2013-04-25
AU2006236407B2 (en) 2011-04-28
US9352054B2 (en) 2016-05-31
JP5033789B2 (ja) 2012-09-26
JP2008538316A (ja) 2008-10-23
US20090234205A1 (en) 2009-09-17
CA2649391A1 (en) 2006-10-26
EP1877104A1 (de) 2008-01-16

Similar Documents

Publication Publication Date Title
EP1867997A4 (de) Präparatanalyseverfahren und präparatanalysevorrichtung
EP1756338A4 (de) Elektrospray-/elektrospinnvorrichtung und verfahren
EP1980204A4 (de) Bluttestverfahren und bluttestvorrichtung
EP1809174A4 (de) Herzanalyseverfahren und gerät
EP2052239A4 (de) Steinanalysevorrichtung und -verfahren
EP1633235A4 (de) Verfahren und gerät für die entnahme von körperflüssigkeiten und analyten-nachweis
EP1824390A4 (de) Vorrichtung und verfahren für elastizitätsbildgebung
EP1742716A4 (de) Trocknungsverfahren und -vorrichtung
EP1787149A4 (de) Verfahren und vorrichtung für ein fiberscope
EP1682002A4 (de) Verfahren und gerät für die urodynamische analyse
EP1869555A4 (de) Verfahren und vorrichtung zur leistungsanalyse eines softwareprogramms
EP1880363A4 (de) Verfahren und vorrichtung zur bildsegmentierung
EP1868544A4 (de) Verfahren und gerät zur durchführung einer offenen hoch tibialen keil-osteotomie
EP1804645A4 (de) Verfahren und gerät zur untersuchung auf retinopathie
EP1970704A4 (de) Reagens und verfahren zur aggregationsmessung
EP1662474A4 (de) Vorrichtung und methode zur bildanzeige
EP1707017A4 (de) Verfahren und vorrichtung zur jitter-messung
EP1765152A4 (de) Verfahren und gerät für einen integrierten einwegartikel zur probenerfassung und auswertung
EP1668890A4 (de) Entrauschungsverfahren und -vorrichtung
EP2021693A4 (de) Verbrennungsverfahren und vorrichtung
EP1766574A4 (de) Vorrichtung und verfahren zur bildverarbeitung
EP2202516A4 (de) Reagenzien-kit für probenanalyse und probenanalyseverfaren
EP1958730A4 (de) Bearbeitungsvorrichtung und bearbeitungsverfahren
EP1882374A4 (de) Verfahren und vorrichtung zur bestimmung gekoppelter pfadverluste
EP1698999A4 (de) Vorrichtung und verfahren zum untersuchen eines rfid-labels

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20071112

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20110527

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 602006035055

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: A61K0051000000

Ipc: G01N0033543000

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/543 20060101AFI20120706BHEP

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

Ref country code: AT

Ref legal event code: REF

Ref document number: 601098

Country of ref document: AT

Kind code of ref document: T

Effective date: 20130315

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602006035055

Country of ref document: DE

Effective date: 20130508

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: KELLER AND PARTNER PATENTANWAELTE AG, CH

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2413757

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20130717

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130313

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130613

REG Reference to a national code

Ref country code: NL

Ref legal event code: T3

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 601098

Country of ref document: AT

Kind code of ref document: T

Effective date: 20130313

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130614

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130313

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130313

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130313

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130715

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130313

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130313

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130313

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130713

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130313

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130313

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130313

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130313

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130313

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130313

26N No opposition filed

Effective date: 20131216

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602006035055

Country of ref document: DE

Effective date: 20131216

REG Reference to a national code

Ref country code: CH

Ref legal event code: PCAR

Free format text: NEW ADDRESS: EIGERSTRASSE 2 POSTFACH, 3000 BERN 14 (CH)

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130313

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20060418

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130418

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 11

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20170426

Year of fee payment: 12

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 13

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: NL

Ref legal event code: MM

Effective date: 20180501

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20180430

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180501

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180430

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180430

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180430

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 20220427

Year of fee payment: 17

Ref country code: IT

Payment date: 20220421

Year of fee payment: 17

Ref country code: IE

Payment date: 20220427

Year of fee payment: 17

Ref country code: GB

Payment date: 20220427

Year of fee payment: 17

Ref country code: FR

Payment date: 20220425

Year of fee payment: 17

Ref country code: ES

Payment date: 20220503

Year of fee payment: 17

Ref country code: DE

Payment date: 20220427

Year of fee payment: 17

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 602006035055

Country of ref document: DE

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20230418

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230418

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230419

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230418

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230430

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20231103

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230418

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230418

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230418

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20240528

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230419

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230419