EP1877424A4 - Inhibitoren von proteinkinasen und anwendungen davon - Google Patents

Inhibitoren von proteinkinasen und anwendungen davon

Info

Publication number
EP1877424A4
EP1877424A4 EP06721775A EP06721775A EP1877424A4 EP 1877424 A4 EP1877424 A4 EP 1877424A4 EP 06721775 A EP06721775 A EP 06721775A EP 06721775 A EP06721775 A EP 06721775A EP 1877424 A4 EP1877424 A4 EP 1877424A4
Authority
EP
European Patent Office
Prior art keywords
inhibitors
protein kinases
kinases
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06721775A
Other languages
English (en)
French (fr)
Other versions
EP1877424A1 (de
Inventor
Raphael Terreux
Jenny Phipps
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmagap Inc
Original Assignee
Pharmagap Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmagap Inc filed Critical Pharmagap Inc
Publication of EP1877424A1 publication Critical patent/EP1877424A1/de
Publication of EP1877424A4 publication Critical patent/EP1877424A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP06721775A 2005-04-11 2006-04-11 Inhibitoren von proteinkinasen und anwendungen davon Withdrawn EP1877424A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66989805P 2005-04-11 2005-04-11
PCT/CA2006/000521 WO2006108270A1 (en) 2005-04-11 2006-04-11 Inhibitors of protein kinases and uses thereof

Publications (2)

Publication Number Publication Date
EP1877424A1 EP1877424A1 (de) 2008-01-16
EP1877424A4 true EP1877424A4 (de) 2010-09-29

Family

ID=37086561

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06721775A Withdrawn EP1877424A4 (de) 2005-04-11 2006-04-11 Inhibitoren von proteinkinasen und anwendungen davon

Country Status (3)

Country Link
US (2) US8158586B2 (de)
EP (1) EP1877424A4 (de)
WO (1) WO2006108270A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148924A1 (en) * 2002-07-09 2003-08-07 Tamar Tennenbaum Methods and pharmaceutical compositions of healing wounds
DK1651161T3 (da) 2003-08-07 2012-01-30 Healor Ltd Farmaceutiske præparater og fremgangsmåder til at fremme sårheling
US20060163290A1 (en) * 2005-01-27 2006-07-27 Vincent Ehret Volumetric displacement dispenser
WO2006108270A1 (en) * 2005-04-11 2006-10-19 Pharmagap Inc. Inhibitors of protein kinases and uses thereof
US20110039770A1 (en) * 2005-08-05 2011-02-17 Pharmagap Inc. Inhibitors of protein kinase c isoforms and uses thereof
EP2452686A3 (de) * 2005-08-29 2012-09-05 HealOr Ltd. Verfahren und Zusammensetzungen zur Vorbeugung und Behandlung von diabetischer und alternder Haut
CN101835486B (zh) * 2007-07-30 2012-12-12 希尔洛有限公司 用于治疗创伤的药物组合物以及相关方法
CN102325789A (zh) * 2009-02-24 2012-01-18 希尔洛有限公司 用于治疗痤疮和其它病症的内脂素治疗药物
KR20120082906A (ko) 2009-09-30 2012-07-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 자가포식현상-향상 유전자 생성물의 조절을 통한 자가포식현상의 조절 방법
EP2523677A2 (de) 2010-01-11 2012-11-21 Healor Ltd. Verfahren zur behandlung von entzündungskrankheiten und -erkrankungen
WO2025211983A1 (ru) * 2024-04-05 2025-10-09 Общество с ограниченной ответственностью "Альбоген" Пептиды с противоопухолевой активностью

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EP0666270A2 (de) * 1994-02-08 1995-08-09 Bristol-Myers Squibb Company Peptid-Inhibitoren von p33cdk2 und p34cdc2 Zellzyklus regulierenden Kinasen und humanem Papillomavirus E7 Onkoprotein
US20020031820A1 (en) * 2000-03-21 2002-03-14 Cole Philip A. Bisbubstrate inhibitors of kinases

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US4923802A (en) * 1985-06-13 1990-05-08 Immunex Corporation Peptide substrates for the detection, characterization and purification of protein kinase C
US5501959A (en) * 1989-01-17 1996-03-26 Alamar Biosciences Laboratory, Inc. Antibiotic and cytotoxic drug susceptibility assays using resazurin and poising agents
US5204370A (en) * 1990-11-05 1993-04-20 Sphinx Pharmaceuticals Corporation Bis-(hydroxyalkylamino)-anthraquinone inhibitors of protein kinase C
US5141957A (en) * 1990-11-02 1992-08-25 Sphinx Pharmaceuticals Corporation 1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for inhibiting protein kinase c
CA2072889A1 (en) * 1990-11-02 1992-05-03 Jack B. Jiang Bis-(hydroxyalkylamino)-anthraquinone inhibitors of protein kinase c
US5216014A (en) * 1991-09-10 1993-06-01 Sphinx Pharmaceuticals Corporation Furo-coumarinsulfonamides as protein kinase C inhibitors
US5360818A (en) * 1991-09-23 1994-11-01 Sphinx Pharmaceuticals Corporation 1,3-dioxane derivatives having protein kinase C inhibitory activity
US5270310A (en) * 1991-12-13 1993-12-14 Sphinx Pharmaceuticals Corporation N-aminoalkyl amide inhibitors of protein kinase C
JPH06508154A (ja) 1992-04-06 1994-09-14 グラクソ、ソシエダッド、アノニマ ペプチド
US5292737A (en) * 1992-10-23 1994-03-08 Sphinx Pharmaceuticals Corporation N,N'-bis(sulfonamido)-2-amino-4-iminonaphthalen-1-ones and N,N'-bis(amido)-2-amino-4-iminonaphthalen-1-ones
DE4243321A1 (de) * 1992-12-21 1994-06-23 Goedecke Ag Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
US5559209A (en) * 1993-02-18 1996-09-24 The General Hospital Corporation Regulator regions of G proteins
US5624949A (en) 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
PL182124B1 (pl) * 1993-12-07 2001-11-30 Lilly Co Eli Nowe zwiazki oraz srodek farmaceutyczny przeznaczony do leczenia powiklan cukrzycowych lub do leczenia nowotworów PL PL PL PL PL PL PL PL
US5545636A (en) 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
DK0817627T3 (da) * 1993-12-23 2005-06-06 Lilly Co Eli Inhibitorer af proteinkinase C
US5783405A (en) * 1994-02-01 1998-07-21 Terrapin Technologies, Inc. Rapid screening method for effectors of signal transduction
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
US5432198A (en) * 1994-08-18 1995-07-11 Sphinx Pharmaceuticals Corporation Vicinal-substituted carbocyclic compounds as therapeutic agents
US5616577A (en) * 1994-08-25 1997-04-01 Smithkline Beecham Corporation Protein Kinase C inhibitor
DE69532434T2 (de) * 1994-10-27 2004-11-11 Mitsubishi Corp. Gerät für Dateiurheberrechte-Verwaltungssystem
US6518397B1 (en) * 1997-07-24 2003-02-11 Shoukat Dedhar Pharmaceuticals for modulating hormone responsiveness
CA2237221C (en) * 1995-11-20 2003-03-25 Eli Lilly And Company Protein kinase c inhibitor
EP0888458A4 (de) * 1996-02-20 2004-05-06 Sloan Kettering Institutefor C Kombination von pkc-inhibitoren und therapeutischen agenzien zur behandlung von krebs
US5821072A (en) * 1996-02-20 1998-10-13 Sloan-Kettering Institute For Cancer Research Combinations of PKC inhibitors and therapaeutic agents for treating cancers
EA001450B1 (ru) * 1996-05-01 2001-04-23 Эли Лилли Энд Компани Галогензамещенные ингибиторы протеинкиназы с
US6232299B1 (en) * 1996-05-01 2001-05-15 Eli Lilly And Company Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy
JP2001514484A (ja) 1996-08-21 2001-09-11 スージェン・インコーポレーテッド タンパク質チロシンキナーゼの結晶構造
WO1998017299A1 (en) * 1996-10-18 1998-04-30 The Board Of Trustees Of The Leland Stanford Junior University Isozyme-specific activators of protein kinase c, methods and compositions
US5741890A (en) * 1996-12-19 1998-04-21 Oregon Health Sciences University Protein binding fragments of gravin
US6833436B2 (en) * 1997-05-21 2004-12-21 Children's Medical Center Corporation Short peptides which selectively modulate the activity of serine/threonine kinases
US6174993B1 (en) * 1997-05-21 2001-01-16 The Children's Medical Center Corp. Short peptides which selectively modulate the activity of serine/threonine kinases
US6218113B1 (en) * 1998-02-24 2001-04-17 Incyte Genomics, Inc. Human protein kinase C inhibitor
SE9801530D0 (sv) 1998-04-30 1998-04-30 Pharmacia & Upjohn Ab Method for screening
US6376467B1 (en) * 1998-10-09 2002-04-23 The Regents Of The University Of California Use of inhibitors of protein kinase C epsilon to treat pain
WO2001042280A2 (en) 1999-12-09 2001-06-14 Children's Medical Center Corporation Short peptides from the b4 and b5 regions of protein kinases which selectively modulate protein activity
JP2002525382A (ja) 1998-09-25 2002-08-13 ザ チルドレンズ メディカル センター コーポレイション プロテインキナーゼの活性を選択的に調節するショートペプチド
AU3114600A (en) * 1998-12-16 2000-07-03 Vertex Pharmaceuticals Incorporated Crystallized p38 complexes
ATE494388T1 (de) 1999-01-13 2011-01-15 Univ New York State Res Found Neues verfahren zum erschaffen von proteinkinase- inhibitoren
WO2000070030A1 (en) 1999-05-19 2000-11-23 Amgen Inc. Crystal of a lymphocyte kinase-ligand complex and methods of use
WO2001044497A2 (en) 1999-12-02 2001-06-21 University Of Dundee Protein kinase regulation
WO2001042243A2 (en) 1999-12-08 2001-06-14 Advanced Medicine, Inc. Protein kinase inhibitors
US20040014082A1 (en) * 2000-08-11 2004-01-22 Invitrogen Corporation Highly homogeneous molecular markers for electrophoresis
US20020115173A1 (en) * 2000-12-11 2002-08-22 Children's Medical Center Corporation Short peptides from the 'A-region' of protein kinases which selectively modulate protein kinase activity
WO2003004050A1 (en) 2001-07-03 2003-01-16 University Of Virginia Patent Foundation Methylation of histone h4 at arginine 3
JP2005503141A (ja) 2001-07-24 2005-02-03 ノボ　ノルディスク　アクティーゼルスカブ アシル化ポリペプチドを作出するための方法
IL144583A0 (en) 2001-07-26 2002-05-23 Peptor Ltd Chimeric protein kinase inhibitors
JP2005504037A (ja) 2001-07-27 2005-02-10 ユニヴァースティ オブ カンザス メディカル センター Ｉｖ型コラーゲンｎｃ１ドメイン六量体の結晶化構造
WO2003059943A2 (en) 2002-01-18 2003-07-24 Karo Bio Ab Conformation-specific, protein kinase binding peptides and related methods and products
US7393835B2 (en) * 2002-04-22 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Peptide inhibitors of protein kinase C
US7052694B2 (en) * 2002-07-16 2006-05-30 Mayo Foundation For Medical Education And Research Dendritic cell potentiation
WO2004062475A2 (en) 2003-01-10 2004-07-29 Albert Einstein College Of Medicine Of Yeshiva University Fluorescent assays for protein kinases
WO2005097983A2 (en) * 2004-04-07 2005-10-20 Wyeth Structure of protein kinase c theta and related applications
WO2005117932A1 (en) * 2004-06-04 2005-12-15 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Bisubstrate inhibitors of protein tyrosine kinases as therapeutic agents
WO2006108270A1 (en) 2005-04-11 2006-10-19 Pharmagap Inc. Inhibitors of protein kinases and uses thereof
US20110039770A1 (en) * 2005-08-05 2011-02-17 Pharmagap Inc. Inhibitors of protein kinase c isoforms and uses thereof
US20100041597A1 (en) * 2005-08-05 2010-02-18 Jenny Phipps Peptides targeted to protein kinase c isoforms and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0666270A2 (de) * 1994-02-08 1995-08-09 Bristol-Myers Squibb Company Peptid-Inhibitoren von p33cdk2 und p34cdc2 Zellzyklus regulierenden Kinasen und humanem Papillomavirus E7 Onkoprotein
US20020031820A1 (en) * 2000-03-21 2002-03-14 Cole Philip A. Bisbubstrate inhibitors of kinases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2006108270A1 *

Also Published As

Publication number Publication date
US20130102522A1 (en) 2013-04-25
US8158586B2 (en) 2012-04-17
US20090042803A1 (en) 2009-02-12
EP1877424A1 (de) 2008-01-16
WO2006108270A1 (en) 2006-10-19

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Legal Events

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