EP1904110A4 - Ciblage de cellules présentant un microarn d'expression modifiée - Google Patents

Ciblage de cellules présentant un microarn d'expression modifiée

Info

Publication number
EP1904110A4
EP1904110A4 EP06741167A EP06741167A EP1904110A4 EP 1904110 A4 EP1904110 A4 EP 1904110A4 EP 06741167 A EP06741167 A EP 06741167A EP 06741167 A EP06741167 A EP 06741167A EP 1904110 A4 EP1904110 A4 EP 1904110A4
Authority
EP
European Patent Office
Prior art keywords
microrna expression
targeting cells
altered microrna
altered
targeting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06741167A
Other languages
German (de)
English (en)
Other versions
EP1904110A1 (fr
Inventor
Michael Zenon Michael
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SOUTHERN ADELAIDE HEALTH SERVICE - FLINDERS MEDICA
Original Assignee
SOUTHERN ADELAIDE HEALTH SERVICE - FLINDERS MEDICAL CENTRE
SOUTHERN ADELAIDE HEALTH SERVI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SOUTHERN ADELAIDE HEALTH SERVICE - FLINDERS MEDICAL CENTRE, SOUTHERN ADELAIDE HEALTH SERVI filed Critical SOUTHERN ADELAIDE HEALTH SERVICE - FLINDERS MEDICAL CENTRE
Priority to EP11161737A priority Critical patent/EP2377559A1/fr
Publication of EP1904110A1 publication Critical patent/EP1904110A1/fr
Publication of EP1904110A4 publication Critical patent/EP1904110A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/10—Vectors comprising a special translation-regulating system regulates levels of translation
    • C12N2840/102—Vectors comprising a special translation-regulating system regulates levels of translation inhibiting translation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP06741167A 2005-06-03 2006-06-02 Ciblage de cellules présentant un microarn d'expression modifiée Withdrawn EP1904110A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP11161737A EP2377559A1 (fr) 2005-06-03 2006-06-02 Ciblage de cellules dotées d'une expression de microARN

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68754705P 2005-06-03 2005-06-03
PCT/AU2006/000750 WO2006128245A1 (fr) 2005-06-03 2006-06-02 Ciblage de cellules presentant un microarn d'expression modifiee

Publications (2)

Publication Number Publication Date
EP1904110A1 EP1904110A1 (fr) 2008-04-02
EP1904110A4 true EP1904110A4 (fr) 2009-02-11

Family

ID=37481150

Family Applications (2)

Application Number Title Priority Date Filing Date
EP06741167A Withdrawn EP1904110A4 (fr) 2005-06-03 2006-06-02 Ciblage de cellules présentant un microarn d'expression modifiée
EP11161737A Withdrawn EP2377559A1 (fr) 2005-06-03 2006-06-02 Ciblage de cellules dotées d'une expression de microARN

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP11161737A Withdrawn EP2377559A1 (fr) 2005-06-03 2006-06-02 Ciblage de cellules dotées d'une expression de microARN

Country Status (5)

Country Link
EP (2) EP1904110A4 (fr)
JP (1) JP2008541737A (fr)
AU (1) AU2006254732A1 (fr)
CA (1) CA2610702A1 (fr)
WO (1) WO2006128245A1 (fr)

Families Citing this family (43)

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EP2290076B1 (fr) 2004-05-28 2015-03-25 Asuragen, Inc. Procédés et compositions impliquant du microARN
AU2005333165B2 (en) 2004-11-12 2012-07-19 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
WO2008015662A1 (fr) † 2006-08-04 2008-02-07 Dublin City University Procédé d'obtention de produits biologiques recombinants
AU2007299748A1 (en) * 2006-09-19 2008-03-27 Asuragen, Inc. miR-15, miR-26, miR -31,miR -145, miR-147, miR-188, miR-215, miR-216 miR-331, mmu-miR-292-3p regulated genes and pathways as targets for therapeutic intervention
WO2008036765A2 (fr) * 2006-09-19 2008-03-27 Asuragen, Inc. Micro arn exprimés par différenciation dans les maladies du pancréas, et leur utilisation
JP2010504350A (ja) * 2006-09-19 2010-02-12 アシュラジェン インコーポレイテッド 治療的介入の標的としての、ｍｉＲ−２００によって調節される遺伝子および経路
CA2663812A1 (fr) * 2006-09-19 2008-03-27 Asuragen, Inc. Genes et trajets regules par mir-143 comme cibles d'intervention therapeutique
EP2111408A4 (fr) * 2007-01-17 2010-02-03 Univ Johns Hopkins Compositions et procédés comprenant des microarn pour traiter une néoplasie
EP2136846A4 (fr) 2007-03-26 2011-04-13 Crc For Asthma And Airways Ltd Cibles therapeutique et molecules
CA2683314A1 (fr) * 2007-04-11 2008-10-23 Merck & Co., Inc. Molecules d'acide nucleique isolees correspondant au micro arn 145 (mirna-145) et utilisation de ces dernieres dans le traitement du cancer du colon
US20100204309A1 (en) * 2007-04-19 2010-08-12 Vib Vzw Oligonucleotide compositions for the treatment of alzheimer's disease
KR101706259B1 (ko) 2007-07-31 2017-02-14 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 섬유증을 조절하는 마이크로-ｒｎａ 집단 및 이의 용도
WO2009036332A1 (fr) 2007-09-14 2009-03-19 Asuragen, Inc. Microarn exprimés de manière différentielle dans le cancer du col de l'utérus et leurs utilisations
JP2009100687A (ja) * 2007-10-24 2009-05-14 Chiba Univ ｍｉｃｒｏＲＮＡ発現プロファイリングに基づく膀胱癌の検出方法
EP2280078B1 (fr) * 2008-03-27 2016-05-18 Kuroda, Masahiko Marqueur pour la détermination du cancer du sein, méthode d'essai, et kit d'essai
EP2112235A1 (fr) * 2008-04-24 2009-10-28 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Compositions et procédés pour le profilage de l'expression de microARN du carcinome du nasopharynx
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
US20110098346A1 (en) * 2008-05-19 2011-04-28 Agency For Science, Technology And Research Nucleic acid molecule and method of targeting gene expression to gliomas
TWI414301B (zh) * 2008-12-15 2013-11-11 Univ Nat Taiwan 以微核醣核酸miＲ－１４１為標的治療小核醣核酸病毒感染
AU2010243276B2 (en) 2009-04-30 2016-09-15 Fondazione Telethon Ets Gene vector
WO2010135714A2 (fr) * 2009-05-22 2010-11-25 The Methodist Hospital Research Institute Méthodes de modulation de l'expression des adipocytes utilisant des compositions de micro-arn
EP2341145A1 (fr) * 2009-12-30 2011-07-06 febit holding GmbH Empreinte ARNm dans le diagnostic de maladies
WO2011111715A1 (fr) * 2010-03-09 2011-09-15 協和発酵キリン株式会社 Acide nucléique apte à réguler le cycle cellulaire
EP3210611B1 (fr) 2010-03-12 2019-08-21 The Brigham and Women's Hospital, Inc. Procédés de traitement de troubles inflammatoire vasculaires
EP2594275B1 (fr) * 2010-07-08 2016-05-11 Takeda Pharmaceutical Company Limited Agent de traitement prophylactique ou thérapeutique du diabète
AU2012212105A1 (en) 2011-02-03 2013-09-12 Mirna Therapeutics, Inc. Synthetic mimics of miR-124
WO2013040251A2 (fr) 2011-09-13 2013-03-21 Asurgen, Inc. Méthodes et compositions incluant mir-135b, permettant de faire la distinction entre un cancer du pancréas et une maladie pancréatique bénigne
ITRM20110685A1 (it) 2011-12-23 2013-06-24 Internat Ct For Genetic En Gineering And Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci
HRP20220607T1 (hr) 2012-11-26 2022-06-24 Modernatx, Inc. Terminalno modificirana rna
JP5704575B2 (ja) * 2012-12-28 2015-04-22 国立大学法人 千葉大学 ｍｉｃｒｏＲＮＡ発現プロファイリングに基づく膀胱癌の検出方法
JP5704576B2 (ja) * 2012-12-28 2015-04-22 国立大学法人 千葉大学 ｍｉｃｒｏＲＮＡ発現プロファイリングに基づく膀胱癌の検出方法
JP5812361B2 (ja) * 2013-07-11 2015-11-11 国立研究開発法人医薬基盤・健康・栄養研究所 遺伝子発現制御機構を含む新規Ａｄベクター
CN104120128B (zh) * 2014-07-02 2016-04-20 重庆贝羿生物科技有限公司 一种用于促进vhl基因表达的分离的核苷酸分子和促进剂及其制备
CN104726500B (zh) * 2015-03-12 2017-09-12 中国人民解放军第二军医大学 MicroRNA26b‑3p抑制剂在制备人脐带来源间充质干细胞中的应用
ES2810701T5 (es) 2015-10-05 2024-07-11 Modernatx Inc Procedimientos para la administración terapéutica de medicamentos de ácido ribonucleico mensajero
US11293065B2 (en) 2016-03-14 2022-04-05 Aelan Cell Technologies, Inc. Compositions and methods for the quality control of stem cell preparations
AU2017302589A1 (en) * 2016-07-26 2019-02-28 Senti Biosciences, Inc. Spatiotemporal regulators
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
GB201805287D0 (en) * 2018-03-29 2018-05-16 Univ Edinburgh Haematoietic stem cell treatment
AU2019285298A1 (en) 2018-06-14 2021-01-07 Ovid Therapeutics Inc. Use of MIR-92a or MIR-145 in the treatment of Angelman syndrome
WO2021262919A2 (fr) 2020-06-26 2021-12-30 The Research Foundation For The State University Of New York Microarn modifiés par 5-halogéno-uracile et leur utilisation dans le traitement du cancer
CN112301033B (zh) * 2020-11-24 2021-11-19 南通大学 miR-30a-5p及其在促进神经再生和修复周围神经损伤方面的应用
CN113750111A (zh) * 2021-09-23 2021-12-07 清华大学深圳国际研究生院 一种miRNA-15A用于治疗高表达KIF3B肿瘤中的用途

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WO2005078096A2 (fr) * 2004-02-09 2005-08-25 University Of Massachusetts Oligonucleotides fonctionnels doubles utilises pour reprimer l'expression d'un gene mutant

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EP1713938A2 (fr) * 2004-02-09 2006-10-25 Thomas Jefferson University Diagnostic et traitement de cancers a l'aide de microarn present dans ou au voisinage de caracteristiques chromosomiennes liees aux cancers
WO2005111211A2 (fr) * 2004-05-14 2005-11-24 Rosetta Genomics Ltd. Micro-arn et utilisations de ceux-ci
EP1751311A2 (fr) * 2004-05-26 2007-02-14 Rosetta Genomics ltd Arnmi viraux ou associes aux virus et leur utilisation
HUE027013T2 (en) * 2005-05-27 2016-10-28 Ospedale San Raffaele Srl A gene vector containing MI-RNA

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WO2005078096A2 (fr) * 2004-02-09 2005-08-25 University Of Massachusetts Oligonucleotides fonctionnels doubles utilises pour reprimer l'expression d'un gene mutant

Non-Patent Citations (3)

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Title
JOHN BINO ET AL: "Human MicroRNA targets.", PLOS BIOLOGY NOV 2004, vol. 2, no. 11, November 2004 (2004-11-01), pages e363, XP009109996, ISSN: 1545-7885 *
MANSFIELD JENNIFER H ET AL: "MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression", NATURE GENETICS, NATURE PUBLISHING GROUP, NEW YORK, US, vol. 36, no. 10, 1 October 2004 (2004-10-01), pages 1079 - 1083, XP002394622, ISSN: 1061-4036 *
See also references of WO2006128245A1 *

Also Published As

Publication number Publication date
EP2377559A1 (fr) 2011-10-19
CA2610702A1 (fr) 2006-12-07
AU2006254732A1 (en) 2006-12-07
WO2006128245A1 (fr) 2006-12-07
JP2008541737A (ja) 2008-11-27
EP1904110A1 (fr) 2008-04-02

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