EP1904827A2 - Biosensorstruktur aus photonischem kristall und herstellungsverfahren - Google Patents

Biosensorstruktur aus photonischem kristall und herstellungsverfahren

Info

Publication number: EP1904827A2
Authority: EP; European Patent Office
Prior art keywords: sensor; refractive index; porous; nanoporous; specific binding
Prior art date: 2005-07-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP06785860A

Other languages

English (en)

French (fr)

Inventor

Brian T. Cunningham

Ian Block

Leo Li-Ying Chan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Illinois at Urbana Champaign

University of Illinois System

Original Assignee

University of Illinois at Urbana Champaign

University of Illinois System

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-08

Filing date

2006-06-29

Publication date

2008-04-02

2005-07-08 Priority claimed from US11/177,707 external-priority patent/US7521769B2/en

2005-07-08 Priority claimed from US11/177,708 external-priority patent/US7479404B2/en

2006-06-29 Application filed by University of Illinois at Urbana Champaign, University of Illinois System filed Critical University of Illinois at Urbana Champaign

2008-04-02 Publication of EP1904827A2 publication Critical patent/EP1904827A2/de

Status Withdrawn legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims abstract description 62
238000004519 manufacturing process Methods 0.000 title claims abstract description 17
239000004038 photonic crystal Substances 0.000 title description 28
238000000151 deposition Methods 0.000 claims abstract description 12
238000000059 patterning Methods 0.000 claims abstract description 4
239000000126 substance Substances 0.000 claims description 67
230000009870 specific binding Effects 0.000 claims description 57
229920000642 polymer Polymers 0.000 claims description 43
239000003989 dielectric material Substances 0.000 claims description 33
239000000758 substrate Substances 0.000 claims description 32
239000011521 glass Substances 0.000 claims description 24
239000007783 nanoporous material Substances 0.000 claims description 22
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 20
239000007788 liquid Substances 0.000 claims description 17
239000004033 plastic Substances 0.000 claims description 12
229920003023 plastic Polymers 0.000 claims description 12
-1 poly(arylene ether Chemical compound 0.000 claims description 12
229920001971 elastomer Polymers 0.000 claims description 10
239000004593 Epoxy Substances 0.000 claims description 9
230000003100 immobilizing effect Effects 0.000 claims description 9
229920003209 poly(hydridosilsesquioxane) Polymers 0.000 claims description 9
229910052581 Si3N4 Inorganic materials 0.000 claims description 6
239000005083 Zinc sulfide Substances 0.000 claims description 6
239000004964 aerogel Substances 0.000 claims description 6
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
BPUBBGLMJRNUCC-UHFFFAOYSA-N oxygen(2-);tantalum(5+) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ta+5].[Ta+5] BPUBBGLMJRNUCC-UHFFFAOYSA-N 0.000 claims description 6
HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 claims description 6
PBCFLUZVCVVTBY-UHFFFAOYSA-N tantalum pentoxide Inorganic materials O=[Ta](=O)O[Ta](=O)=O PBCFLUZVCVVTBY-UHFFFAOYSA-N 0.000 claims description 6
XOLBLPGZBRYERU-UHFFFAOYSA-N tin dioxide Chemical compound O=[Sn]=O XOLBLPGZBRYERU-UHFFFAOYSA-N 0.000 claims description 6
229910001887 tin oxide Inorganic materials 0.000 claims description 6
239000004408 titanium dioxide Substances 0.000 claims description 6
229910052984 zinc sulfide Inorganic materials 0.000 claims description 6
DRDVZXDWVBGGMH-UHFFFAOYSA-N zinc;sulfide Chemical compound [S-2].[Zn+2] DRDVZXDWVBGGMH-UHFFFAOYSA-N 0.000 claims description 6
239000000806 elastomer Substances 0.000 claims description 5
229910002028 silica xerogel Inorganic materials 0.000 claims description 4
239000000463 material Substances 0.000 abstract description 36
230000027455 binding Effects 0.000 description 43
239000010410 layer Substances 0.000 description 40
230000035945 sensitivity Effects 0.000 description 34
239000010408 film Substances 0.000 description 33
239000005373 porous glass Substances 0.000 description 30
238000012360 testing method Methods 0.000 description 29
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 24
238000002493 microarray Methods 0.000 description 22
230000003287 optical effect Effects 0.000 description 22
239000000523 sample Substances 0.000 description 21
102000004169 proteins and genes Human genes 0.000 description 20
108090000623 proteins and genes Proteins 0.000 description 20
238000001514 detection method Methods 0.000 description 18
230000003993 interaction Effects 0.000 description 17
239000000243 solution Substances 0.000 description 16
239000008367 deionised water Substances 0.000 description 13
230000008569 process Effects 0.000 description 12
239000000872 buffer Substances 0.000 description 11
210000004027 cell Anatomy 0.000 description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 10
230000000694 effects Effects 0.000 description 10
229940027941 immunoglobulin g Drugs 0.000 description 10
239000004205 dimethyl polysiloxane Substances 0.000 description 9
239000002953 phosphate buffered saline Substances 0.000 description 9
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 9
238000004088 simulation Methods 0.000 description 9
108020004707 nucleic acids Proteins 0.000 description 8
102000039446 nucleic acids Human genes 0.000 description 8
150000007523 nucleic acids Chemical class 0.000 description 8
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 7
239000000427 antigen Substances 0.000 description 7
108091007433 antigens Proteins 0.000 description 7
102000036639 antigens Human genes 0.000 description 7
238000010256 biochemical assay Methods 0.000 description 7
238000013461 design Methods 0.000 description 7
239000010703 silicon Substances 0.000 description 7
229910052710 silicon Inorganic materials 0.000 description 7
238000001179 sorption measurement Methods 0.000 description 7
229910001868 water Inorganic materials 0.000 description 7
108020004414 DNA Proteins 0.000 description 6
PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 6
238000006243 chemical reaction Methods 0.000 description 6
230000005672 electromagnetic field Effects 0.000 description 6
239000012634 fragment Substances 0.000 description 6
108090000765 processed proteins & peptides Proteins 0.000 description 6
241000287828 Gallus gallus Species 0.000 description 5
241000282414 Homo sapiens Species 0.000 description 5
238000003556 assay Methods 0.000 description 5
230000008859 change Effects 0.000 description 5
239000012530 fluid Substances 0.000 description 5
230000006870 function Effects 0.000 description 5
125000005647 linker group Chemical group 0.000 description 5
239000000377 silicon dioxide Substances 0.000 description 5
239000010409 thin film Substances 0.000 description 5
238000005406 washing Methods 0.000 description 5
241000894006 Bacteria Species 0.000 description 4
102000053602 DNA Human genes 0.000 description 4
102000004190 Enzymes Human genes 0.000 description 4
108090000790 Enzymes Proteins 0.000 description 4
241001494479 Pecora Species 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
241000700605 Viruses Species 0.000 description 4
239000012620 biological material Substances 0.000 description 4
230000005540 biological transmission Effects 0.000 description 4
238000000576 coating method Methods 0.000 description 4
229910021641 deionized water Inorganic materials 0.000 description 4
238000012482 interaction analysis Methods 0.000 description 4
239000000203 mixture Substances 0.000 description 4
229920001467 poly(styrenesulfonates) Polymers 0.000 description 4
229920000867 polyelectrolyte Polymers 0.000 description 4
229920001184 polypeptide Polymers 0.000 description 4
102000004196 processed proteins & peptides Human genes 0.000 description 4
238000011160 research Methods 0.000 description 4
230000004044 response Effects 0.000 description 4
239000002356 single layer Substances 0.000 description 4
102000017727 Immunoglobulin Variable Region Human genes 0.000 description 3
108010067060 Immunoglobulin Variable Region Proteins 0.000 description 3
230000004913 activation Effects 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
238000013459 approach Methods 0.000 description 3
230000035587 bioadhesion Effects 0.000 description 3
239000012472 biological sample Substances 0.000 description 3
239000011248 coating agent Substances 0.000 description 3
230000000295 complement effect Effects 0.000 description 3
238000005286 illumination Methods 0.000 description 3
238000003384 imaging method Methods 0.000 description 3
238000012986 modification Methods 0.000 description 3
230000004048 modification Effects 0.000 description 3
229910052759 nickel Inorganic materials 0.000 description 3
239000002245 particle Substances 0.000 description 3
230000005855 radiation Effects 0.000 description 3
238000005070 sampling Methods 0.000 description 3
238000001228 spectrum Methods 0.000 description 3
101100136092 Drosophila melanogaster peng gene Proteins 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
239000004642 Polyimide Substances 0.000 description 2
108020004682 Single-Stranded DNA Proteins 0.000 description 2
150000001412 amines Chemical class 0.000 description 2
238000004166 bioassay Methods 0.000 description 2
239000007853 buffer solution Substances 0.000 description 2
125000002091 cationic group Chemical group 0.000 description 2
238000000423 cell based assay Methods 0.000 description 2
238000012512 characterization method Methods 0.000 description 2
229910052681 coesite Inorganic materials 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
238000005094 computer simulation Methods 0.000 description 2
229910052906 cristobalite Inorganic materials 0.000 description 2
LIKFHECYJZWXFJ-UHFFFAOYSA-N dimethyldichlorosilane Chemical compound C[Si](C)(Cl)Cl LIKFHECYJZWXFJ-UHFFFAOYSA-N 0.000 description 2
238000009826 distribution Methods 0.000 description 2
238000004049 embossing Methods 0.000 description 2
239000007850 fluorescent dye Substances 0.000 description 2
125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 2
230000014509 gene expression Effects 0.000 description 2
238000013537 high throughput screening Methods 0.000 description 2
238000009396 hybridization Methods 0.000 description 2
230000006872 improvement Effects 0.000 description 2
238000001459 lithography Methods 0.000 description 2
238000004377 microelectronic Methods 0.000 description 2
239000013307 optical fiber Substances 0.000 description 2
238000005457 optimization Methods 0.000 description 2
230000000737 periodic effect Effects 0.000 description 2
229920001721 polyimide Polymers 0.000 description 2
238000001878 scanning electron micrograph Methods 0.000 description 2
238000012216 screening Methods 0.000 description 2
210000002966 serum Anatomy 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
230000003595 spectral effect Effects 0.000 description 2
229910052682 stishovite Inorganic materials 0.000 description 2
229910052905 tridymite Inorganic materials 0.000 description 2
GUHKMHMGKKRFDT-UHFFFAOYSA-N 1785-64-4 Chemical compound C1CC(=C(F)C=2F)C(F)=C(F)C=2CCC2=C(F)C(F)=C1C(F)=C2F GUHKMHMGKKRFDT-UHFFFAOYSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
238000002965 ELISA Methods 0.000 description 1
102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
238000012773 Laboratory assay Methods 0.000 description 1
229920002274 Nalgene Polymers 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
229920002518 Polyallylamine hydrochloride Polymers 0.000 description 1
206010036790 Productive cough Diseases 0.000 description 1
BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
241000295644 Staphylococcaceae Species 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
239000002099 adlayer Substances 0.000 description 1
210000004381 amniotic fluid Anatomy 0.000 description 1
125000000129 anionic group Chemical group 0.000 description 1
238000007507 annealing of glass Methods 0.000 description 1
210000003567 ascitic fluid Anatomy 0.000 description 1
238000002820 assay format Methods 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
238000004113 cell culture Methods 0.000 description 1
239000013592 cell lysate Substances 0.000 description 1
210000001175 cerebrospinal fluid Anatomy 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
230000008878 coupling Effects 0.000 description 1
238000010168 coupling process Methods 0.000 description 1
238000005859 coupling reaction Methods 0.000 description 1
238000013036 cure process Methods 0.000 description 1
210000002726 cyst fluid Anatomy 0.000 description 1
230000003013 cytotoxicity Effects 0.000 description 1
231100000135 cytotoxicity Toxicity 0.000 description 1
230000008021 deposition Effects 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
239000010432 diamond Substances 0.000 description 1
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000007717 exclusion Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
210000003608 fece Anatomy 0.000 description 1
239000000835 fiber Substances 0.000 description 1
238000009501 film coating Methods 0.000 description 1
229940104869 fluorosilicate Drugs 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
238000007654 immersion Methods 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
229910010272 inorganic material Inorganic materials 0.000 description 1
239000011147 inorganic material Substances 0.000 description 1
230000001788 irregular Effects 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
230000001926 lymphatic effect Effects 0.000 description 1
238000004949 mass spectrometry Methods 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000003278 mimic effect Effects 0.000 description 1
230000008450 motivation Effects 0.000 description 1
238000000465 moulding Methods 0.000 description 1
238000001127 nanoimprint lithography Methods 0.000 description 1
239000013642 negative control Substances 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
239000011368 organic material Substances 0.000 description 1
230000035515 penetration Effects 0.000 description 1
238000000206 photolithography Methods 0.000 description 1
210000002381 plasma Anatomy 0.000 description 1
239000002985 plastic film Substances 0.000 description 1
229920006255 plastic film Polymers 0.000 description 1
230000010287 polarization Effects 0.000 description 1
229920000052 poly(p-xylylene) Polymers 0.000 description 1
229920001464 poly(sodium 4-styrenesulfonate) Polymers 0.000 description 1
229920000515 polycarbonate Polymers 0.000 description 1
239000004417 polycarbonate Substances 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
239000005518 polymer electrolyte Substances 0.000 description 1
239000002861 polymer material Substances 0.000 description 1
239000004810 polytetrafluoroethylene Substances 0.000 description 1
229920001343 polytetrafluoroethylene Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
239000013641 positive control Substances 0.000 description 1
238000012545 processing Methods 0.000 description 1
238000000159 protein binding assay Methods 0.000 description 1
230000006916 protein interaction Effects 0.000 description 1
238000003908 quality control method Methods 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
230000010076 replication Effects 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
238000000640 scanning angle reflectometry Methods 0.000 description 1
230000028327 secretion Effects 0.000 description 1
210000000582 semen Anatomy 0.000 description 1
229910000077 silane Inorganic materials 0.000 description 1
150000003384 small molecules Chemical class 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000000935 solvent evaporation Methods 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
210000003802 sputum Anatomy 0.000 description 1
208000024794 sputum Diseases 0.000 description 1
238000004381 surface treatment Methods 0.000 description 1
210000001179 synovial fluid Anatomy 0.000 description 1
230000002123 temporal effect Effects 0.000 description 1
239000012085 test solution Substances 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
238000002834 transmittance Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
- G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y20/00—Nanooptics, e.g. quantum optics or photonic crystals
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/20—Material Coatings
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
- G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
- G02B6/122—Basic optical elements, e.g. light-guiding paths
- G02B6/1225—Basic optical elements, e.g. light-guiding paths comprising photonic band-gap structures or photonic lattices
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7769—Measurement method of reaction-produced change in sensor
- G01N2021/7776—Index

Definitions

a grating of a photonic crystal sensor of the invention has a grating period that is small compared to the wavelength of incident light such that no diffractive orders other than the reflected and transmitted zeroth orders are allowed.
a photonic crystal sensor can comprise a grating, which is comprised of or coated with a high dielectric constant dielectric material, sandwiched between a substrate layer and a cover layer that fills the grating grooves. Optionally, a cover layer is not used.
the grating structure selectively couples light at a narrow band of wavelengths. This highly sensitive coupling condition can produce a resonant grating effect on the reflected radiation spectrum, resulting in a narrow band of reflected or transmitted wavelengths. The depth and period of the grating are less than the wavelength of the resonant grating effect.
the reflected or transmitted color of a photonic crystal sensor structure can be modified by the addition of molecules such as specific binding substances or binding partners or both to the upper surface of the cover layer or the grating surface.
the added molecules increase the optical path length of incident radiation through the sensor structure, and thus modify the wavelength at which maximum reflectance or transmittance will occur.
a low-k nanoporous material is an inorganic, porous, oxide-like low dielectric material, wherein the refractive index, n, is about 1.1 to about 2.2, and preferably about 1.1 to about 1.5.
a low-k nanoporous material can be, for example, porous silica xerogels and aerogels (about 1.1- about 2.2); porous HSQ (about 1.7- about 2.2); porous SiLKTM (a B staged polymer) (about 1.5- about 2.0); porous MSQ (about 1.8- about 2.2); porous PAE (about 1.8- about 2.2).
the nanoporous material is NANOGLASS®, which is porous SiO 2 . Porosity is created in the SiO 2 thereby reducing the dielectric constant from about 3.9 to as low as 1.9.
the PDMS replicas are then used to imprint a thin film of uncured NANOGLASS ⁇ (Honeywell Elec. Mat.), a low-index sol-gel glass, spun-on to a glass substrate. Once the low-index dielectric becomes rigid, the flexible PDMS mold is removed and the sol-gel glass is fully cured by further baking.
the sensor structure is completed by evaporating 175nm of TiO 2 onto the patterned surface. A subsequent surface treatment with dimethyldichlorosilane encourages bio-adsorption and promotes sensor stability.
a schematic illustrating the cross-section of the device is shown in Figure 7.
the polymer devices were provided as an array of sensors aligned and attached to bottomless 96-well standard microtiter plates (SRU Biosystems).
the porous glass devices are fabricated on 75mm x 25mm x lmm glass microscope slides.
Adhesive rubber wells (Research International Corp.) are attached to the glass surface to provide liquid containment for 5-6 sensors on each slide.
FIG. 11 gives a spatial profile of PWV shift versus polymer thickness, where each PWV shift was measured in buffer after the wash step.
Each monolayer of polyelectrolyte is approximately 4.4 nm thick and has a refractive index of 1.49. See, e.g., Picart et al., Determination of structural parameters characterizing thin films by optical methods: A comparison between scanning angle reflectometry and optical waveguide lightmode spectroscopy. Journal of Chemical Physics, 2001. 115(2): p. 1086-1094.
the porous glass sensor exhibits an average surface sensitivity ⁇ 1.5x that of the polymer sensor.

Landscapes

Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Physics & Mathematics (AREA)
Wood Science & Technology (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Nanotechnology (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
Sustainable Development (AREA)
Biomedical Technology (AREA)
Analytical Chemistry (AREA)
General Physics & Mathematics (AREA)
General Engineering & Computer Science (AREA)
Optics & Photonics (AREA)
Biotechnology (AREA)
Immunology (AREA)
Biophysics (AREA)
Clinical Laboratory Science (AREA)
Microelectronics & Electronic Packaging (AREA)
Crystallography & Structural Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Plasma & Fusion (AREA)
Pathology (AREA)
Investigating Or Analysing Materials By Optical Means (AREA)
Photometry And Measurement Of Optical Pulse Characteristics (AREA)

EP06785860A 2005-07-08 2006-06-29 Biosensorstruktur aus photonischem kristall und herstellungsverfahren Withdrawn EP1904827A2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US11/177,707 US7521769B2 (en)	2005-07-08	2005-07-08	Photonic crystal biosensor structure and fabrication method
US11/177,708 US7479404B2 (en)	2005-07-08	2005-07-08	Photonic crystal biosensor structure and fabrication method
PCT/US2006/025400 WO2007008440A2 (en)	2005-07-08	2006-06-29	Photonic crystal biosensor fabrication method

Publications (1)

Publication Number	Publication Date
EP1904827A2 true EP1904827A2 (de)	2008-04-02

Family

ID=37637689

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EP06785860A Withdrawn EP1904827A2 (de)	2005-07-08	2006-06-29	Biosensorstruktur aus photonischem kristall und herstellungsverfahren
EP06851538A Withdrawn EP1920235A2 (de)	2005-07-08	2006-06-29	Bionsensor mit photonischer kristallstruktur und herstellungsverfahren

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
EP06851538A Withdrawn EP1920235A2 (de)	2005-07-08	2006-06-29	Bionsensor mit photonischer kristallstruktur und herstellungsverfahren

Country Status (6)

Country	Link
EP (2)	EP1904827A2 (de)
JP (2)	JP2009510391A (de)
AU (2)	AU2006269532B2 (de)
CA (2)	CA2614556A1 (de)
NZ (2)	NZ565682A (de)
WO (2)	WO2008027025A2 (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US12174512B2 (en)	2018-12-18	2024-12-24	Interdigital Ce Patent Holdings	Device for forming an outgoing electromagnetic wave from an incident electromagnetic wave
US12210155B2 (en)	2018-06-29	2025-01-28	Interdigital Ce Patent Holdings	Optical device comprising a multi-layers waveguides
US12214493B2 (en)	2018-12-18	2025-02-04	Interdigital Ce Patent Holdings, Sas	Optical manipulation apparatus
US12228756B2 (en)	2018-12-21	2025-02-18	Interdigital Ce Patent Holdings, Sas	Optical device

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101403742B (zh) *	2008-10-29	2012-05-23	东南大学	利用光电镊对微纳米生物粒子进行介电表征的方法
WO2011044682A1 (en) *	2009-10-16	2011-04-21	Opalux Incorporated	Photonic crystal combinatorial sensor
US8437965B2 (en) *	2010-03-01	2013-05-07	Empire Technology Development Llc	Sensing chemicals in aqueous environments
JP5149321B2 (ja) *	2010-03-24	2013-02-20	株式会社東芝	電磁場シミュレーション方法、電磁場シミュレーション装置、半導体装置の製造方法
JP2012098272A (ja) *	2010-08-23	2012-05-24	Nsk Ltd	標的物質濃度測定装置および標的物質濃度測定方法
EP2500314A1 (de)	2011-03-14	2012-09-19	Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO	Photonischer Kristallsensor
KR102061533B1 (ko) *	2015-03-13	2020-01-02	롬 앤드 하스 일렉트로닉 머트어리얼즈 엘엘씨	나노구조 물질 방법 및 장치
CN105655719B (zh) *	2016-01-07	2017-11-17	内蒙古科技大学	电磁波透射增强装置
WO2017151582A1 (en)	2016-02-29	2017-09-08	The University Of North Carolina At Chapel Hill	Array of micro-elements for high resolution and high content imaging and sorting of cells
WO2018155556A1 (ja) *	2017-02-23	2018-08-30	デンカ株式会社	フォトニック結晶
JP7345782B2 (ja) *	2018-07-31	2023-09-19	積水化学工業株式会社	検査方法、検査用器具及び検査装置
CN120703879A (zh)	2018-10-22	2025-09-26	加州理工学院	基于三维工程材料的彩色多光谱图像传感器
NL2023516B1 (en)	2019-05-28	2020-12-08	Illumina Inc	Manufacturing a flowcell with a planar waveguide
EP4031868A1 (de) *	2019-09-17	2022-07-27	F. Hoffmann-La Roche AG	Biomolekulare detektionsvorrichtung
CN114556166B (zh) *	2019-10-18	2024-05-28	加州理工学院	具有超材料分色的cmos彩色图像传感器
US12320988B2 (en)	2019-10-18	2025-06-03	California Institute Of Technology	Broadband polarization splitting based on volumetric meta-optics
WO2021133109A1 (ko)	2019-12-24	2021-07-01	삼성전자주식회사	센서 디바이스 및 센서 디바이스 제조방법
RU2725011C1 (ru) *	2019-12-24	2020-06-29	Самсунг Электроникс Ко., Лтд.	Сенсорное устройство для распознавания смесей летучих соединений и способ его изготовления
JP7264134B2 (ja) *	2020-08-26	2023-04-25	横河電機株式会社	分光分析装置、光学系、及び方法
US20220252779A1 (en) *	2021-02-08	2022-08-11	Applied Materials, Inc.	Method for amorphous, high-refractive-index encapsulation of nanoparticle imprint films for optical devices
CN113744767A (zh) *	2021-08-31	2021-12-03	广东工业大学	一种利用dvd光盘制备具有光栅结构二氧化钛薄膜的方法及其制成的薄膜和应用
CN116147766A (zh) *	2022-12-27	2023-05-23	北京工业大学	一种覆盖parylene提升传感芯片灵敏度及重复利用的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6270846B1 (en) *	2000-03-02	2001-08-07	Sandia Corporation	Method for making surfactant-templated, high-porosity thin films
US7101660B2 (en) *	2000-10-30	2006-09-05	Sru Biosystems, Inc.	Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7306827B2 (en) *	2000-10-30	2007-12-11	Sru Biosystems, Inc.	Method and machine for replicating holographic gratings on a substrate
US7070987B2 (en) *	2000-10-30	2006-07-04	Sru Biosystems, Inc.	Guided mode resonant filter biosensor using a linear grating surface structure
US7264973B2 (en) *	2000-10-30	2007-09-04	Sru Biosystems, Inc.	Label-free methods for performing assays using a colorimetric resonant optical biosensor
EP1520591B1 (de) *	2002-07-11	2012-06-20	Sumitomo Electric Industries, Ltd.	Poröser halbleiter und zugehöriges herstellungsverfahren
JP4054718B2 (ja) *	2003-05-28	2008-03-05	キヤノン株式会社	センサ装置
JP2005016963A (ja) *	2003-06-23	2005-01-20	Canon Inc	化学センサ、化学センサ装置

2006
- 2006-06-29 EP EP06785860A patent/EP1904827A2/de not_active Withdrawn
- 2006-06-29 EP EP06851538A patent/EP1920235A2/de not_active Withdrawn
- 2006-06-29 NZ NZ565682A patent/NZ565682A/en not_active IP Right Cessation
- 2006-06-29 AU AU2006269532A patent/AU2006269532B2/en not_active Ceased
- 2006-06-29 WO PCT/US2006/025317 patent/WO2008027025A2/en not_active Ceased
- 2006-06-29 AU AU2006344709A patent/AU2006344709B2/en not_active Ceased
- 2006-06-29 JP JP2008520290A patent/JP2009510391A/ja active Pending
- 2006-06-29 CA CA002614556A patent/CA2614556A1/en not_active Abandoned
- 2006-06-29 JP JP2008532214A patent/JP2009520947A/ja active Pending
- 2006-06-29 NZ NZ565681A patent/NZ565681A/en not_active IP Right Cessation
- 2006-06-29 WO PCT/US2006/025400 patent/WO2007008440A2/en not_active Ceased
- 2006-06-29 CA CA002615417A patent/CA2615417A1/en not_active Abandoned

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2007008440A2 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US12210155B2 (en)	2018-06-29	2025-01-28	Interdigital Ce Patent Holdings	Optical device comprising a multi-layers waveguides
US12174512B2 (en)	2018-12-18	2024-12-24	Interdigital Ce Patent Holdings	Device for forming an outgoing electromagnetic wave from an incident electromagnetic wave
US12214493B2 (en)	2018-12-18	2025-02-04	Interdigital Ce Patent Holdings, Sas	Optical manipulation apparatus
US12228756B2 (en)	2018-12-21	2025-02-18	Interdigital Ce Patent Holdings, Sas	Optical device

Also Published As

Publication number	Publication date
JP2009510391A (ja)	2009-03-12
AU2006344709B2 (en)	2012-01-19
CA2614556A1 (en)	2007-01-18
NZ565681A (en)	2009-11-27
AU2006344709A1 (en)	2008-03-06
CA2615417A1 (en)	2007-01-08
AU2006269532B2 (en)	2011-06-30
JP2009520947A (ja)	2009-05-28
WO2007008440A3 (en)	2007-04-05
AU2006269532A1 (en)	2007-01-18
NZ565682A (en)	2009-11-27
WO2008027025A2 (en)	2008-03-06
WO2008027025A3 (en)	2008-05-08
WO2007008440A2 (en)	2007-01-18
EP1920235A2 (de)	2008-05-14

Legal Events

Date	Code	Title	Description
2008-02-29	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2008-04-02	17P	Request for examination filed	Effective date: 20080208
2008-04-02	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
2008-04-09	DAX	Request for extension of the european patent (deleted)
2008-11-28	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1115447 Country of ref document: HK
2010-12-15	17Q	First examination report despatched	Effective date: 20101112
2012-07-25	DAX	Request for extension of the european patent (deleted)
2013-05-17	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2013-06-19	18D	Application deemed to be withdrawn	Effective date: 20130103

Publication	Publication Date	Title
US7479404B2 (en)	2009-01-20	Photonic crystal biosensor structure and fabrication method
US7521769B2 (en)	2009-04-21	Photonic crystal biosensor structure and fabrication method
AU2006269532B2 (en)	2011-06-30	Photonic crystal biosensor fabrication method
Block et al.	2006	Photonic crystal optical biosensor incorporating structured low-index porous dielectric
US7101660B2 (en)	2006-09-05	Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
AU2007273113B2 (en)	2010-11-25	Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface to bulk sensitivity ratio
Estevez et al.	2012	Integrated optical devices for lab‐on‐a‐chip biosensing applications
US7611836B2 (en)	2009-11-03	Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US7615339B2 (en)	2009-11-10	Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
Cunningham et al.	2002	Colorimetric resonant reflection as a direct biochemical assay technique
US7292336B2 (en)	2007-11-06	Method and instrument for detecting biomolecular interactions
JP4851582B2 (ja)	2012-01-11	線形光学表面構造を用いた導波モード共鳴フィルターバイオセンサー
US7534578B1 (en)	2009-05-19	Self-referencing biodetection method and patterned bioassays
US20050227374A1 (en)	2005-10-13	Label-free high-throughput optical technique for detecting biomolecular interactions
US20030113766A1 (en)	2003-06-19	Amine activated colorimetric resonant biosensor
JP2007506107A (ja)	2007-03-15	比色共鳴反射光バイオセンサーを用いる非標識アッセイ実施法
US7429492B2 (en)	2008-09-30	Multiwell plates with integrated biosensors and membranes
WO2004092730A2 (en)	2004-10-28	Method and device for detecting the presence of an analyte
Lu	2009	Label-free biosensor based upon replica-molded vertically emitting distributed feedback laser

EP1904827A2 - Biosensorstruktur aus photonischem kristall und herstellungsverfahren - Google Patents

Info

Links

Classifications

Definitions

Landscapes

Applications Claiming Priority (3)

Publications (1)

Family

ID=37637689

Family Applications (2)

Family Applications After (1)

Country Status (6)

Cited By (4)

Families Citing this family (22)

Family Cites Families (8)

Non-Patent Citations (1)

Cited By (4)

Also Published As

Similar Documents

Legal Events