EP1919897A4 - Procede de preparation d'esomeprazole et de ses sels - Google Patents

Procede de preparation d'esomeprazole et de ses sels

Info

Publication number: EP1919897A4
Authority: EP; European Patent Office
Prior art keywords: salts; preparing esomeprazole; esomeprazole; preparing
Prior art date: 2005-07-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP06757770A

Other languages

German (de)

English (en)

Other versions

EP1919897B1 (fr

EP1919897A1 (fr

Inventor

Tae Hee Sinnamusil Ha

Won Jeong Kim

Hee Sook Oh

Chang Hee Park

Jae Chul Gyeongwonyeonlip Lee

Han Kyong Kim

Kwee-Hyun Suh

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hanmi Science Co Ltd

Original Assignee

Hanmi Pharmaceutical Co Ltd

Hanmi Pharmaceutical Industries Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-28

Filing date

2006-07-11

Publication date

2009-12-09

2006-07-11 Application filed by Hanmi Pharmaceutical Co Ltd, Hanmi Pharmaceutical Industries Co Ltd filed Critical Hanmi Pharmaceutical Co Ltd

2008-05-14 Publication of EP1919897A1 publication Critical patent/EP1919897A1/fr

2009-12-09 Publication of EP1919897A4 publication Critical patent/EP1919897A4/fr

2014-07-02 Application granted granted Critical

2014-07-02 Publication of EP1919897B1 publication Critical patent/EP1919897B1/fr

2026-07-11 Anticipated expiration legal-status Critical

Status Not-in-force legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP06757770.0A 2005-07-28 2006-07-11 Procede de preparation d'esomeprazole et de ses sels Not-in-force EP1919897B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR1020050068761A KR100641534B1 (ko)	2005-07-28	2005-07-28	에스오메프라졸 및 그의 염의 제조방법
PCT/KR2006/002719 WO2007013743A1 (fr)	2005-07-28	2006-07-11	Procede de preparation d'esomeprazole et de ses sels

Publications (3)

Publication Number	Publication Date
EP1919897A1 EP1919897A1 (fr)	2008-05-14
EP1919897A4 true EP1919897A4 (fr)	2009-12-09
EP1919897B1 EP1919897B1 (fr)	2014-07-02

Family

ID=37621395

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP06757770.0A Not-in-force EP1919897B1 (fr)	2005-07-28	2006-07-11	Procede de preparation d'esomeprazole et de ses sels

Country Status (14)

Country	Link
US (1)	US7888511B2 (fr)
EP (1)	EP1919897B1 (fr)
JP (1)	JP4795435B2 (fr)
KR (1)	KR100641534B1 (fr)
CN (1)	CN101208330B (fr)
AU (1)	AU2006273050B2 (fr)
BR (1)	BRPI0613945A8 (fr)
CA (1)	CA2616119C (fr)
IL (1)	IL188600A (fr)
MX (1)	MX2008000431A (fr)
NZ (1)	NZ566271A (fr)
RU (1)	RU2382777C2 (fr)
WO (1)	WO2007013743A1 (fr)
ZA (1)	ZA200801854B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2259269B1 (es)	2005-03-03	2007-11-01	Esteve Quimica, S.A.	Procedimiento para la preparacion de derivados de 2-(2-piridilmetilsulfinil)-bencimidazol opticamente activos.
WO2007067128A1 (fr) *	2005-12-05	2007-06-14	Astrazeneca Ab	Nouveau procede de fabrication d’esomeprazole sous forme non saline
EP1973896B1 (fr)	2005-12-28	2009-04-15	Union Quimico-Farmaceutica, S.A.	Procede pour la preparation de l'enantiomere (s) d'omeprazole
WO2008004245A1 (fr) *	2006-07-05	2008-01-10	Lupin Limited	Procédé pour la préparation d'énantiomères optiquement purs ou optiquement enrichis de composés sulfoxydes
US8492551B2 (en) *	2007-06-07	2013-07-23	Aurobindo Pharma. Ltd.	Process for preparing an optically active proton pump inhibitor
US7947840B2 (en)	2007-09-25	2011-05-24	Hetero Drugs Limited	Process for preparation of enantiomerically pure esomeprazole
EP2143722A1 (fr) *	2008-07-09	2010-01-13	Lek Pharmaceuticals D.D.	Procédé de préparation de sodium ésoméprazole de haute pureté chimique et nouvelles formes de sodium ésoméprazole
CN101391993B (zh) *	2008-10-28	2012-07-04	安徽美诺华药物化学有限公司	通过与(s)-(-)-1,1'-联萘-2,2'-二酚形成包合配合物制备s-奥美拉唑及其盐的方法
WO2010058409A2 (fr)	2008-11-18	2010-05-27	Hetero Research Foundation	Purification optique d'esoméprazole
EP2376476B1 (fr) *	2008-12-24	2014-06-25	KRKA, tovarna zdravil, d.d., Novo mesto	Procédé de synthèse d'ésoméprazole
WO2010097583A1 (fr)	2009-02-24	2010-09-02	Cipla Limited	Polymorphe de l'ésoméprazole de potassium et sa préparation
WO2010118575A1 (fr) *	2009-04-16	2010-10-21	Chengdu Organic Chemicals Co., Ltd, Chinese Academy Of Science	Résolution d'énantiomères racémiques
WO2010148314A2 (fr) *	2009-06-19	2010-12-23	Dr. Reddy's Laboratories Ltd.	Préparation d'ésoméprazole et de ses sels pharmaceutiquement acceptables
CN101648943B (zh) *	2009-09-11	2013-05-15	南京工业大学	一种分离制备包结拆分后主客体中(s)-奥美拉唑的方法
EP2486032A4 (fr) *	2009-10-09	2013-03-27	Hetero Research Foundation	Résolution optique de 2-(2- pyridinylméthylsulphinyl)-1h-benzimidazoles substitués
US8748619B2 (en)	2009-11-12	2014-06-10	Hetero Research Foundation	Process for the resolution of omeprazole
EP2534144B1 (fr)	2010-02-12	2014-09-03	Esteve Química, S.A.	Procédé de préparation du sel de sodium d' Esoméprazole
CN104887673B (zh) *	2011-06-07	2017-12-29	成都国为生物医药有限公司	一种含埃索美拉唑钠的药物组合物及其制备方法
CN102850323A (zh) *	2011-06-30	2013-01-02	秦引林	一种埃索美拉唑钠的精制方法
CN102321072B (zh) *	2011-08-08	2013-07-03	天津市汉康医药生物技术有限公司	埃索美拉唑钠半水化合物
CN103145694B (zh) *	2011-12-06	2016-01-20	重庆煜澍丰医药有限公司	埃索美拉唑钠盐的晶体r及其制备方法和用途
CN103420979B (zh) *	2012-05-17	2016-04-20	广州莱泰制药有限公司	埃索美拉唑钠的精制方法
EP2980086B1 (fr)	2014-07-29	2016-06-15	F.I.S.- Fabbrica Italiana Sintetici S.p.A.	Procédé efficace pour la préparation d'ésoméprazole (S)-binol complexe
CN104447737A (zh) *	2014-11-05	2015-03-25	沈阳化工大学	一种泰妥拉唑的手性拆分分离方法
CN107698515A (zh) *	2017-09-07	2018-02-16	拉萨泰达医药科技有限公司	一种苯并咪唑类络合物的制备方法
CN110526899A (zh) *	2018-05-24	2019-12-03	刘力	埃索美拉唑锶新化合物及其药物组合物和用途
JP7335002B2 (ja) *	2019-08-29	2023-08-29	学校法人東京理科大学	スルホキシド化合物のエナンチオマー調製方法及びエナンチオマー調製システム

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006094904A1 (fr) *	2005-03-03	2006-09-14	Esteve Química, S. A.	Procede de preparation de derives optiquement actifs de 2-(2-pyridylmethylsulfinyl)-benzimidazole par formation de complexes d'inclusion avec un 1,1'-binaphtalene-2, 2'diol

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9002043D0 (sv)	1990-06-07	1990-06-07	Astra Ab	Improved method for synthesis
SE9301830D0 (sv)	1993-05-28	1993-05-28	Ab Astra	New compounds
SE510650C2 (sv)	1997-05-30	1999-06-14	Astra Ab	Ny förening
CN1087739C (zh) *	1998-12-28	2002-07-17	中国科学院成都有机化学研究所	光学纯的苯并咪唑类抗消化性溃疡药物的包结拆分制备法
DE19951960C2 (de)	1999-10-28	2002-06-27	Gruenenthal Gmbh	Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
EP1515963B1 (fr) *	2002-06-27	2007-02-14	Dr. Reddy's Laboratories Ltd.	Procede de preparation de composes sulfoxyde optiquement purs ou optiquement enrichis, notamment de l'esomeprazole amorphe et ses sels

2005
- 2005-07-28 KR KR1020050068761A patent/KR100641534B1/ko not_active Expired - Lifetime
2006
- 2006-07-11 AU AU2006273050A patent/AU2006273050B2/en not_active Ceased
- 2006-07-11 RU RU2008107599/04A patent/RU2382777C2/ru not_active IP Right Cessation
- 2006-07-11 MX MX2008000431A patent/MX2008000431A/es active IP Right Grant
- 2006-07-11 CN CN2006800231940A patent/CN101208330B/zh not_active Expired - Fee Related
- 2006-07-11 CA CA2616119A patent/CA2616119C/fr not_active Expired - Fee Related
- 2006-07-11 ZA ZA200801854A patent/ZA200801854B/xx unknown
- 2006-07-11 BR BRPI0613945A patent/BRPI0613945A8/pt not_active IP Right Cessation
- 2006-07-11 EP EP06757770.0A patent/EP1919897B1/fr not_active Not-in-force
- 2006-07-11 NZ NZ566271A patent/NZ566271A/en not_active IP Right Cessation
- 2006-07-11 WO PCT/KR2006/002719 patent/WO2007013743A1/fr not_active Ceased
- 2006-07-11 US US11/996,657 patent/US7888511B2/en active Active
- 2006-07-11 JP JP2008523792A patent/JP4795435B2/ja not_active Expired - Fee Related
2008
- 2008-01-06 IL IL188600A patent/IL188600A/en not_active IP Right Cessation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006094904A1 (fr) *	2005-03-03	2006-09-14	Esteve Química, S. A.	Procede de preparation de derives optiquement actifs de 2-(2-pyridylmethylsulfinyl)-benzimidazole par formation de complexes d'inclusion avec un 1,1'-binaphtalene-2, 2'diol

Also Published As

Publication number	Publication date
WO2007013743A1 (fr)	2007-02-01
AU2006273050B2 (en)	2009-08-27
RU2008107599A (ru)	2009-09-10
BRPI0613945A2 (pt)	2011-02-22
CN101208330A (zh)	2008-06-25
JP4795435B2 (ja)	2011-10-19
CA2616119C (fr)	2010-05-18
NZ566271A (en)	2010-01-29
IL188600A0 (en)	2008-04-13
KR100641534B1 (ko)	2006-11-01
CN101208330B (zh)	2010-12-22
MX2008000431A (es)	2008-03-10
CA2616119A1 (fr)	2007-02-01
ZA200801854B (en)	2009-08-26
JP2009502906A (ja)	2009-01-29
EP1919897B1 (fr)	2014-07-02
RU2382777C2 (ru)	2010-02-27
EP1919897A1 (fr)	2008-05-14
US20080194828A1 (en)	2008-08-14
BRPI0613945A8 (pt)	2016-06-07
AU2006273050A1 (en)	2007-02-01
IL188600A (en)	2011-12-29
US7888511B2 (en)	2011-02-15
HK1118553A1 (en)	2009-02-13

Legal Events

Date	Code	Title	Description
2008-04-11	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
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2009-12-09	A4	Supplementary search report drawn up and despatched	Effective date: 20091105
2010-04-07	17Q	First examination report despatched	Effective date: 20100308
2011-01-19	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: HANMI HOLDINGS CO., LTD.
2012-07-25	DAX	Request for extension of the european patent (deleted)
2012-10-17	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: HANMI SCIENCE CO., LTD.
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