EP1937224A2 - Produits pour le soin de la peau - Google Patents
Produits pour le soin de la peauInfo
- Publication number
- EP1937224A2 EP1937224A2 EP06777902A EP06777902A EP1937224A2 EP 1937224 A2 EP1937224 A2 EP 1937224A2 EP 06777902 A EP06777902 A EP 06777902A EP 06777902 A EP06777902 A EP 06777902A EP 1937224 A2 EP1937224 A2 EP 1937224A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- formulation according
- weight
- emulsion
- urea
- hyaluronic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims abstract description 189
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 133
- 239000000839 emulsion Substances 0.000 claims abstract description 84
- 239000004202 carbamide Substances 0.000 claims abstract description 77
- 238000009472 formulation Methods 0.000 claims abstract description 74
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 64
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 63
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 63
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 46
- 239000003380 propellant Substances 0.000 claims abstract description 20
- 235000021588 free fatty acids Nutrition 0.000 claims abstract description 19
- 239000002884 skin cream Substances 0.000 claims abstract description 14
- 239000006260 foam Substances 0.000 claims description 53
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 52
- 150000001720 carbohydrates Chemical class 0.000 claims description 44
- 235000014633 carbohydrates Nutrition 0.000 claims description 44
- 239000000126 substance Substances 0.000 claims description 29
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 22
- 239000000194 fatty acid Substances 0.000 claims description 22
- 229930195729 fatty acid Natural products 0.000 claims description 22
- 150000004665 fatty acids Chemical class 0.000 claims description 20
- 239000004480 active ingredient Substances 0.000 claims description 19
- 208000017520 skin disease Diseases 0.000 claims description 15
- 239000007864 aqueous solution Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- -1 cetyl sarcosinate Chemical compound 0.000 claims description 10
- 239000004909 Moisturizer Substances 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 239000007957 coemulsifier Substances 0.000 claims description 9
- 235000008524 evening primrose extract Nutrition 0.000 claims description 9
- 239000010475 evening primrose oil Substances 0.000 claims description 9
- 229940089020 evening primrose oil Drugs 0.000 claims description 9
- 230000001333 moisturizer Effects 0.000 claims description 9
- 206010013786 Dry skin Diseases 0.000 claims description 8
- 235000021355 Stearic acid Nutrition 0.000 claims description 8
- 230000037336 dry skin Effects 0.000 claims description 8
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 8
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 8
- 239000008117 stearic acid Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 150000002632 lipids Chemical class 0.000 claims description 7
- 208000008960 Diabetic foot Diseases 0.000 claims description 6
- 229910019142 PO4 Inorganic materials 0.000 claims description 6
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 6
- 230000000887 hydrating effect Effects 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000002674 ointment Substances 0.000 claims description 6
- 239000010452 phosphate Substances 0.000 claims description 6
- 208000011580 syndromic disease Diseases 0.000 claims description 6
- 230000003020 moisturizing effect Effects 0.000 claims description 5
- 239000012188 paraffin wax Substances 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims description 5
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 claims description 4
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 4
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 4
- 206010012442 Dermatitis contact Diseases 0.000 claims description 4
- 201000004681 Psoriasis Diseases 0.000 claims description 4
- 208000002029 allergic contact dermatitis Diseases 0.000 claims description 4
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 4
- 201000008937 atopic dermatitis Diseases 0.000 claims description 4
- 239000004359 castor oil Substances 0.000 claims description 4
- 235000019438 castor oil Nutrition 0.000 claims description 4
- 230000001684 chronic effect Effects 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 4
- 150000002191 fatty alcohols Chemical class 0.000 claims description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 4
- 208000001875 irritant dermatitis Diseases 0.000 claims description 4
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 4
- 235000019489 Almond oil Nutrition 0.000 claims description 3
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 3
- 235000021314 Palmitic acid Nutrition 0.000 claims description 3
- 239000008168 almond oil Substances 0.000 claims description 3
- 125000000129 anionic group Chemical group 0.000 claims description 3
- 239000000470 constituent Substances 0.000 claims description 3
- 229940008099 dimethicone Drugs 0.000 claims description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims description 3
- 239000011782 vitamin Substances 0.000 claims description 3
- 235000013343 vitamin Nutrition 0.000 claims description 3
- 229940088594 vitamin Drugs 0.000 claims description 3
- 229930003231 vitamin Natural products 0.000 claims description 3
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 claims description 2
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 claims description 2
- SZQACQUAVJHTKK-UHFFFAOYSA-N 2-hydroxyacetic acid;octadecanoic acid Chemical compound OCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O SZQACQUAVJHTKK-UHFFFAOYSA-N 0.000 claims description 2
- 244000060011 Cocos nucifera Species 0.000 claims description 2
- 235000013162 Cocos nucifera Nutrition 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 2
- 239000004166 Lanolin Substances 0.000 claims description 2
- 235000019483 Peanut oil Nutrition 0.000 claims description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 2
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 2
- 239000012874 anionic emulsifier Substances 0.000 claims description 2
- 239000008163 avocado oil Substances 0.000 claims description 2
- 235000021302 avocado oil Nutrition 0.000 claims description 2
- 229940074979 cetyl palmitate Drugs 0.000 claims description 2
- 239000002285 corn oil Substances 0.000 claims description 2
- 235000005687 corn oil Nutrition 0.000 claims description 2
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 claims description 2
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 claims description 2
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 claims description 2
- 229940075495 isopropyl palmitate Drugs 0.000 claims description 2
- 229940119170 jojoba wax Drugs 0.000 claims description 2
- 229960003511 macrogol Drugs 0.000 claims description 2
- 229940057917 medium chain triglycerides Drugs 0.000 claims description 2
- 229940105132 myristate Drugs 0.000 claims description 2
- 239000012875 nonionic emulsifier Substances 0.000 claims description 2
- UALFRDIHRIKNPC-UHFFFAOYSA-N octadecaneperoxoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCCCC(=O)OO UALFRDIHRIKNPC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004006 olive oil Substances 0.000 claims description 2
- 235000008390 olive oil Nutrition 0.000 claims description 2
- 239000000312 peanut oil Substances 0.000 claims description 2
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 2
- 229940071089 sarcosinate Drugs 0.000 claims description 2
- 239000008159 sesame oil Substances 0.000 claims description 2
- 235000011803 sesame oil Nutrition 0.000 claims description 2
- 229940057910 shea butter Drugs 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 239000003549 soybean oil Substances 0.000 claims description 2
- 235000012424 soybean oil Nutrition 0.000 claims description 2
- 239000010497 wheat germ oil Substances 0.000 claims description 2
- 239000003871 white petrolatum Substances 0.000 claims description 2
- PWQNOLAKMCLNJI-KTKRTIGZSA-N 2-[2-[2-[(z)-octadec-9-enoxy]ethoxy]ethoxy]ethyl dihydrogen phosphate Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCOCCOCCOP(O)(O)=O PWQNOLAKMCLNJI-KTKRTIGZSA-N 0.000 claims 1
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims 1
- 235000021360 Myristic acid Nutrition 0.000 claims 1
- 239000008240 homogeneous mixture Substances 0.000 claims 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 claims 1
- 229940093440 oleth-3-phosphate Drugs 0.000 claims 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 claims 1
- 235000019271 petrolatum Nutrition 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 235000003441 saturated fatty acids Nutrition 0.000 claims 1
- 150000004671 saturated fatty acids Chemical class 0.000 claims 1
- 239000006071 cream Substances 0.000 abstract description 26
- 238000005187 foaming Methods 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 76
- 239000012071 phase Substances 0.000 description 30
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 15
- 239000007789 gas Substances 0.000 description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 8
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 7
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- 244000234609 Portulaca oleracea Species 0.000 description 5
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- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 4
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- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
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- 230000000087 stabilizing effect Effects 0.000 description 4
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 3
- 241000233788 Arecaceae Species 0.000 description 3
- 239000000443 aerosol Substances 0.000 description 3
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 description 3
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000019197 fats Nutrition 0.000 description 3
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 description 3
- DCEUMOZSMAUPSP-UHFFFAOYSA-N 3,7-dimethyloct-6-enyl 3-methylbut-2-enoate Chemical compound CC(C)=CCCC(C)CCOC(=O)C=C(C)C DCEUMOZSMAUPSP-UHFFFAOYSA-N 0.000 description 2
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- TXNJAVCZNMSELK-UHFFFAOYSA-N CCCCCCCCCCCCOC(=O)CNC Chemical compound CCCCCCCCCCCCOC(=O)CNC TXNJAVCZNMSELK-UHFFFAOYSA-N 0.000 description 2
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 2
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- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
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- 238000006317 isomerization reaction Methods 0.000 description 1
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- 239000006210 lotion Substances 0.000 description 1
- 235000004213 low-fat Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
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- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
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- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
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- 239000008385 outer phase Substances 0.000 description 1
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- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
Definitions
- the invention relates to skin care products, in particular for the treatment and care of dry skin conditions and chronic dermatoses.
- the skin care products are useful in dermatoses including atopic dermatitis, allergic contact dermatitis, irritant contact dermatitis, psoriasis, and are particularly useful for treating dry skin and its concomitants such as inflammation, ulcers, etc. that occur in diabetes mellitus, diabetic foot syndrome.
- DFS diabetic foot syndrome
- dermatoses such as atopic dermatitis, allergic contact dermatitis, irritant contact dermatitis, psoriasis and especially dry skin and their Concomitants such as inflammation, ulcers, etc., which occur in diabetes mellitus, the diabetic foot syndrome, as well as for profilaxe suitable.
- the invention relates in one aspect to formulations comprising an aqueous emulsion and propellant gas for a foam skin cream, characterized in that the emulsion comprises urea and hyaluronic acid, at least one free fatty acid and at least two emulsifiers, the hyaluronic acid having a molecular weight of at least 1 x 10 5 As has.
- the invention relates to formulations comprising an aqueous emulsion and propellant gas for a foam skin cream, characterized in that the emulsion comprises urea and a carbohydrate mixture obtained from naturally occurring carbohydrates, at least one free fatty acid and at least two emulsifiers.
- the invention relates to formulations comprising an aqueous emulsion and propellant for a foam skin cream, characterized in that the emulsion comprises at least one free fatty acid and at least two emulsifiers and with the aid of potassium hydroxide to a pH of 5.5 to 8 is set.
- the invention further relates to a day and night skin care kit comprising a day skin care composition and a night skin care composition, wherein the day skin care composition is a foam skin cream comprising at least one free fatty acid and at least two emulsifiers, wherein the night skin care composition comprises an additional active ingredient or a higher% by weight.
- the day skin care composition is a foam skin cream comprising at least one free fatty acid and at least two emulsifiers
- the night skin care composition comprises an additional active ingredient or a higher% by weight.
- Content of active ingredient or an active substance other than the day skin care composition wherein the Active ingredient selected from the group of lipid substances and hydrating substances or mixtures thereof.
- a night skin care composition according to the invention is applied to the skin to be treated.
- the dermatoses are e.g. dry skin conditions, chronic dermatoses, atopic dermatitis, allergic contact dermatitis, irritant contact dermatitis, psoriasis and diabetic foot syndrome.
- Foam creams are aerosols which are formed from an emulsion by means of propellant gas by spraying from a suitable container / dosage form.
- the foam skin cream of the present invention is produced by spraying a formulation containing an aqueous emulsion and propellant gas from a pressurized container.
- propellant all pharmaceutically acceptable propellant gases can be used, which are suitable for the production of cream foams.
- the aqueous emulsion contains all constituents of the formulation except the propellant gas.
- urea causes an increase in the water binding capacity of the horny layer both inter- and intracellularly. Its low molecular weight and the resulting strong osmotic properties as well as its polarity and the resulting hygroscopic properties give the urea its effectiveness. In native form, urea is present as a bipolar molecule, at the positive or negative pole preferably water molecules over
- Hyaluronic acid is a natural, endogenous polymer of carbohydrates and highly hygroscopic. Due to its physicochemical structure, hyaluronic acid forms a network of polysaccharides capable of binding water and improving the elasticity of the epidermis. In particular, the high molecular weight hyaluronic acid is able to form such networks and act through their physical properties within the foam cream of the invention. In particular, it has been found in the context of this invention that the hyaluronic acid has a stabilizing effect on the foam structure and thus provides for the formation of the network structure on the skin and the associated protective function.
- the emulsion also contains unsaturated and / or polyunsaturated fatty acids, such as omega-6 Fatty acids, as known, for example, from evening primrose oil and borage oil. It is possible, for example, to use synthetic omega-6 fatty acids or also those derived from plants.
- the emulsion contains evening primrose oil.
- Suitable further moisurizers are propylene glycol and / or polyhydric alcohols, in particular glycerol. Moisturizers may be added in amounts of 1-10% by weight, preferably 2.5-8.5% by weight. Preferably, glycerol and propylene glycol are added.
- purslane is used in one aspect of the invention.
- Purslane can be used in amounts of from 0.01 to 2% by weight, preferably about 0.1% by weight.
- the formulations according to the invention also have a skin-compatible pH, such as from 7.0 to 8.0, 5.5 to 8 or 6.5 to 7.5.
- a skin-compatible pH such as from 7.0 to 8.0, 5.5 to 8 or 6.5 to 7.5.
- AMP 2-amino-2-methyl-l-propanol
- potassium hydroxide is used as described above.
- a foam skin cream is used, which may for example be one of the formulations described above. Especially the foam formulation offers an increased ease of use and a good protective function, which correspond to the daily application.
- a night skin care composition is also a foam skin cream in question, but also greasy ointments and lotions can be used here.
- the active ingredients contained, such as lipid substances and hydrating substances of the day skin care composition and the night skin care composition are coordinated.
- both skin care compositions may contain the same active ingredient or the same active ingredient combination, wherein the
- the day skin care composition is a formulation containing urea and hyaluronic acid as described above and the night skin care composition is a formulation containing urea, hyaluronic acid and the carbohydrate mixture.
- a formulation which contains 11% urea, 0.2% hyaluronic acid and is adjusted to a pH of about 7 by adding KOH as the base is suitable here for the day cream skin foam.
- a night skin care comprising a formulation containing 11% by weight of urea, 0.2% by weight of hyaluronic acid, and 0.6 and 1.25% by weight of the carbohydrate mixture in the form of pentavidin® and with KOH with a pH of about 7, combined.
- the day skin care is a formulation containing urea, preferably 5 to 17% urea or 5 to 15% urea
- the night skin care is a formulation comprising a carbohydrate mixture and optionally hyaluronic acid as described in this application, contains, or vice versa.
- day cream care is a formulation containing 16.5% urea and 1% evening primrose oil, which may also be adjusted to about pH 7 with KOH. As night skin care becomes the
- an ointment having the exemplary composition shown below is used.
- the day and night skin care kit according to the present invention and as described above comprising a day skin care composition and a night skin care composition is suitable for many applications.
- a day skin care composition for the treatment and care of dry skin conditions and chronic Dermatoses.
- stressed skin areas such as hands and feet of athletes, can be treated and (further) skin damage can be prevented.
- Example 1 The foam creams are produced in a heatable and coolable closed apparatus with a self-discharging homogenizer and a heatable metering funnel.
- Phase I is produced in a heatable metering funnel by melting a mixture containing 2% by weight of glyceryl stearate, 4% by weight.
- Day Care Composition Foam cream formulation with an emulsion containing 16.5% urea and 1% evening primrose oil
- Nourishing composition in the form of an ointment having the following composition:
- IPM Isopropyl myristate
- Prunus dulcis (almond oil) 16,00
- the formulations are stored for two weeks at about 11 ° C or at about 35 ° C and then sprayed on a smooth surface.
- the stability of the sprayed foams is assessed visually and evaluated on the basis of a rating scale of 1-4, where 1 represents the worst stability and 4 the best stability.
- Examples 1 (ae) are based on the composition of Example 2 (5.5% urea), Examples 2 (ae) are based on the composition of Example 3 (11% urea) and Examples 3 (ae) on the composition of Example 2 or 3, containing 16.5% urea.
- the base and the amount of hyaluronic acid were changed and the stability after storage was tested.
- the KOH examples are more stable than the AMP or NaOH examples. It can also be seen that the use of hyaluronic acid causes an increase in stability and a further increase in stability is caused by the use of 0.2% by weight instead of 0.1% by weight. The best results are achieved using KOH as the base and 0.2% hyaluronic acid.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention concerne une formulation comprenant une émulsion aqueuse et un gaz propulseur, cette formulation étant destinée à une crème moussante pour la peau. L'invention se caractérise en ce que l'émulsion contient de l'urée et de l'acide hyaluronique, au moins un acide gras libre et au moins deux émulsifiants, l'acide hyaluronique présentant un poids moléculaire d'au moins 1 x 10<SUP>5</SUP> Da.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10004152A EP2238977A3 (fr) | 2005-09-28 | 2006-07-21 | Produits pour le soin de la peau |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72117005P | 2005-09-28 | 2005-09-28 | |
| DE202005015309 | 2005-09-28 | ||
| US78539106P | 2006-03-23 | 2006-03-23 | |
| DE202006004676U DE202006004676U1 (de) | 2005-09-28 | 2006-03-23 | Hautpflegeprodukte |
| PCT/EP2006/064533 WO2007036376A2 (fr) | 2005-09-28 | 2006-07-21 | Produits pour le soin de la peau |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1937224A2 true EP1937224A2 (fr) | 2008-07-02 |
Family
ID=37763493
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP10004152A Withdrawn EP2238977A3 (fr) | 2005-09-28 | 2006-07-21 | Produits pour le soin de la peau |
| EP06777902A Withdrawn EP1937224A2 (fr) | 2005-09-28 | 2006-07-21 | Produits pour le soin de la peau |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP10004152A Withdrawn EP2238977A3 (fr) | 2005-09-28 | 2006-07-21 | Produits pour le soin de la peau |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20080241079A1 (fr) |
| EP (2) | EP2238977A3 (fr) |
| CA (1) | CA2624356A1 (fr) |
| DE (2) | DE202006004676U1 (fr) |
| WO (1) | WO2007036376A2 (fr) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| ES2532906T5 (es) | 2002-10-25 | 2022-03-23 | Foamix Pharmaceuticals Ltd | Espuma cosmética y farmacéutica |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
| US7700076B2 (en) * | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
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2006
- 2006-03-23 DE DE202006004676U patent/DE202006004676U1/de not_active Expired - Lifetime
- 2006-07-21 CA CA002624356A patent/CA2624356A1/fr not_active Abandoned
- 2006-07-21 WO PCT/EP2006/064533 patent/WO2007036376A2/fr not_active Ceased
- 2006-07-21 EP EP10004152A patent/EP2238977A3/fr not_active Withdrawn
- 2006-07-21 EP EP06777902A patent/EP1937224A2/fr not_active Withdrawn
- 2006-07-21 US US12/088,599 patent/US20080241079A1/en not_active Abandoned
- 2006-09-18 DE DE202006014258U patent/DE202006014258U1/de not_active Expired - Lifetime
- 2006-09-27 US US11/535,526 patent/US20070098647A1/en not_active Abandoned
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| Title |
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| "Rohstofflexikon 2005/2006", article "Pentavitin" * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE202006014258U1 (de) | 2006-11-16 |
| EP2238977A3 (fr) | 2010-12-22 |
| DE202006004676U1 (de) | 2007-02-08 |
| US20080241079A1 (en) | 2008-10-02 |
| WO2007036376A2 (fr) | 2007-04-05 |
| WO2007036376A3 (fr) | 2007-09-20 |
| US20070098647A1 (en) | 2007-05-03 |
| EP2238977A2 (fr) | 2010-10-13 |
| CA2624356A1 (fr) | 2007-04-05 |
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