EP1978987A4 - Verfahren und zusammensetzungen in zusammenhang mit der verbesserung von eigenschaften pharmakologischer wirkstoffe für das nervensystem - Google Patents

Verfahren und zusammensetzungen in zusammenhang mit der verbesserung von eigenschaften pharmakologischer wirkstoffe für das nervensystem

Info

Publication number
EP1978987A4
EP1978987A4 EP07717960A EP07717960A EP1978987A4 EP 1978987 A4 EP1978987 A4 EP 1978987A4 EP 07717960 A EP07717960 A EP 07717960A EP 07717960 A EP07717960 A EP 07717960A EP 1978987 A4 EP1978987 A4 EP 1978987A4
Authority
EP
European Patent Office
Prior art keywords
nervous system
pharmacological activities
compositions related
improving properties
improving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP07717960A
Other languages
English (en)
French (fr)
Other versions
EP1978987A2 (de
EP1978987B1 (de
Inventor
Grzegorz Bulaj
Steve H White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation Inc
Original Assignee
University of Utah Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah Research Foundation Inc filed Critical University of Utah Research Foundation Inc
Priority to EP12153130.5A priority Critical patent/EP2545933A3/de
Priority to EP14200660.0A priority patent/EP2913056A1/de
Publication of EP1978987A2 publication Critical patent/EP1978987A2/de
Publication of EP1978987A4 publication Critical patent/EP1978987A4/de
Application granted granted Critical
Publication of EP1978987B1 publication Critical patent/EP1978987B1/de
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP07717960.4A 2006-01-05 2007-01-05 Verfahren und zusammensetzungen in zusammenhang mit der verbesserung von eigenschaften pharmakologischer wirkstoffe für das nervensystem Not-in-force EP1978987B1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP12153130.5A EP2545933A3 (de) 2006-01-05 2007-01-05 Verfahren und Zusammensetzungen in Zusammenhang mit der Verbesserung von Eigenschaften pharmakologischer Wirkstoffe für das Nervensystem
EP14200660.0A EP2913056A1 (de) 2006-01-05 2007-01-05 Verfahren und Zusammensetzungen in Zusammenhang mit der Verbesserung von Eigenschaften pharmakologischer Wirkstoffe für das Nervensystem

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75704706P 2006-01-05 2006-01-05
US84402406P 2006-09-11 2006-09-11
PCT/US2007/000261 WO2007081792A2 (en) 2006-01-05 2007-01-05 Methods and compositions related to improving properties of pharmacological agents targeting nervous system

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP14200660.0A Division EP2913056A1 (de) 2006-01-05 2007-01-05 Verfahren und Zusammensetzungen in Zusammenhang mit der Verbesserung von Eigenschaften pharmakologischer Wirkstoffe für das Nervensystem
EP12153130.5A Division-Into EP2545933A3 (de) 2006-01-05 2007-01-05 Verfahren und Zusammensetzungen in Zusammenhang mit der Verbesserung von Eigenschaften pharmakologischer Wirkstoffe für das Nervensystem

Publications (3)

Publication Number Publication Date
EP1978987A2 EP1978987A2 (de) 2008-10-15
EP1978987A4 true EP1978987A4 (de) 2009-09-30
EP1978987B1 EP1978987B1 (de) 2014-12-31

Family

ID=38256917

Family Applications (3)

Application Number Title Priority Date Filing Date
EP12153130.5A Withdrawn EP2545933A3 (de) 2006-01-05 2007-01-05 Verfahren und Zusammensetzungen in Zusammenhang mit der Verbesserung von Eigenschaften pharmakologischer Wirkstoffe für das Nervensystem
EP07717960.4A Not-in-force EP1978987B1 (de) 2006-01-05 2007-01-05 Verfahren und zusammensetzungen in zusammenhang mit der verbesserung von eigenschaften pharmakologischer wirkstoffe für das nervensystem
EP14200660.0A Withdrawn EP2913056A1 (de) 2006-01-05 2007-01-05 Verfahren und Zusammensetzungen in Zusammenhang mit der Verbesserung von Eigenschaften pharmakologischer Wirkstoffe für das Nervensystem

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP12153130.5A Withdrawn EP2545933A3 (de) 2006-01-05 2007-01-05 Verfahren und Zusammensetzungen in Zusammenhang mit der Verbesserung von Eigenschaften pharmakologischer Wirkstoffe für das Nervensystem

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP14200660.0A Withdrawn EP2913056A1 (de) 2006-01-05 2007-01-05 Verfahren und Zusammensetzungen in Zusammenhang mit der Verbesserung von Eigenschaften pharmakologischer Wirkstoffe für das Nervensystem

Country Status (9)

Country Link
US (4) US8435940B2 (de)
EP (3) EP2545933A3 (de)
JP (5) JP2009523129A (de)
KR (1) KR20090009189A (de)
CA (1) CA2636469A1 (de)
HK (1) HK1214172A1 (de)
RU (1) RU2008132149A (de)
TW (2) TWI406671B (de)
WO (1) WO2007081792A2 (de)

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US7485706B2 (en) * 2003-07-30 2009-02-03 The Board Of Trustees Of The Leland Stanford Junior University Neurodegenerative protein aggregation inhibition methods and compounds
EP2545933A3 (de) 2006-01-05 2013-04-24 University Of Utah Research Foundation Verfahren und Zusammensetzungen in Zusammenhang mit der Verbesserung von Eigenschaften pharmakologischer Wirkstoffe für das Nervensystem
CN102014959B (zh) * 2008-03-10 2016-01-20 康奈尔大学 血脑屏障通透性的调节
CN102256618A (zh) 2008-10-17 2011-11-23 赛诺菲-安万特德国有限公司 胰岛素和glp-1激动剂的组合
TR201809460T4 (tr) 2009-11-13 2018-07-23 Sanofi Aventis Deutschland Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
NZ599847A (en) 2009-11-13 2013-09-27 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine
WO2012028172A1 (en) 2010-08-30 2012-03-08 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
EP2651429B1 (de) * 2010-12-15 2018-03-28 Neuroadjuvants, Inc. Neuropeptidanaloga, zusammensetzungen daraus und verfahren zur behandlung von schmerzen damit
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
US20140056870A1 (en) * 2012-08-27 2014-02-27 Allergan, Inc. Fusion proteins
CN103175973B (zh) * 2013-02-26 2015-05-13 首都医科大学 甘丙肽在制备女性抑郁症检测工具中的应用
EP3046933B1 (de) 2013-09-18 2019-02-27 BCN Peptides, S.A. Cortistatin analoga zur behandlung von entzündlichen und/oder immunerkrankungen
PE20171622A1 (es) 2014-12-12 2017-11-02 Sanofi Aventis Deutschland Formulacion de relacion fija de insulina glargina/lixisenatida
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
KR101885238B1 (ko) * 2015-11-30 2018-08-06 주식회사 뉴라클사이언스 스펙신 기반 갈라닌 ２형 수용체의 효현제 및 이의 용도
CA3027784A1 (en) * 2016-06-16 2017-12-21 Charite - Universitatsmedizin Berlin Neuropeptide-expressing vectors and methods for the treatment of epilepsy
GB201620611D0 (en) * 2016-12-05 2017-01-18 Univ Of Lancaster Treatment of neurological diseases
US10376555B2 (en) * 2017-04-07 2019-08-13 Hong Kong Baptist University Identification of cyclic peptide agonists of galanin receptor 2 and 3 guided by spexin solution structure
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CN114306870A (zh) * 2020-10-09 2022-04-12 李彤 一种调节脑内甘丙肽水平及神经递质浓度的装置及方法

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Also Published As

Publication number Publication date
US20090281031A1 (en) 2009-11-12
JP2012229241A (ja) 2012-11-22
JP2018027092A (ja) 2018-02-22
EP2545933A2 (de) 2013-01-16
TWI406671B (zh) 2013-09-01
WO2007081792A2 (en) 2007-07-19
EP1978987A2 (de) 2008-10-15
US20130244947A1 (en) 2013-09-19
EP1978987B1 (de) 2014-12-31
JP2016074713A (ja) 2016-05-12
EP2913056A1 (de) 2015-09-02
CA2636469A1 (en) 2007-07-19
JP6251115B2 (ja) 2017-12-20
TW201340978A (zh) 2013-10-16
US8435940B2 (en) 2013-05-07
HK1214172A1 (en) 2016-07-22
TW200806312A (en) 2008-02-01
JP2009523129A (ja) 2009-06-18
JP2014147394A (ja) 2014-08-21
US8933020B2 (en) 2015-01-13
US9586999B2 (en) 2017-03-07
KR20090009189A (ko) 2009-01-22
RU2008132149A (ru) 2010-02-10
WO2007081792A3 (en) 2007-12-06
US20150203554A1 (en) 2015-07-23
US20180340012A1 (en) 2018-11-29
EP2545933A3 (de) 2013-04-24
TWI515007B (zh) 2016-01-01

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