EP1993519A4 - Verfahren und zusammensetzungen zum verhindern des missbrauchs von oral verabreichten pharmazeutischen produkten - Google Patents

Verfahren und zusammensetzungen zum verhindern des missbrauchs von oral verabreichten pharmazeutischen produkten

Info

Publication number: EP1993519A4
Authority: EP; European Patent Office
Prior art keywords: compositions; methods; orally administered; pharmaceutical products; administered pharmaceutical
Prior art date: 2006-03-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP07753168A

Other languages

English (en)

French (fr)

Other versions

EP1993519A2 (de

Inventor

James F Emigh

Andrew D Reddick

Ron J Spivey

Ronald L Leech Jr

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Acura Pharmaceuticals Inc

Original Assignee

Acura Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-03-15

Filing date

2007-03-14

Publication date

2011-12-21

2007-03-14 Application filed by Acura Pharmaceuticals Inc filed Critical Acura Pharmaceuticals Inc

2008-11-26 Publication of EP1993519A2 publication Critical patent/EP1993519A2/de

2011-12-21 Publication of EP1993519A4 publication Critical patent/EP1993519A4/de

Status Withdrawn legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Botany (AREA)
Zoology (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP07753168A 2006-03-15 2007-03-14 Verfahren und zusammensetzungen zum verhindern des missbrauchs von oral verabreichten pharmazeutischen produkten Withdrawn EP1993519A4 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US78244806P	2006-03-15	2006-03-15
PCT/US2007/006519 WO2007106550A2 (en)	2006-03-15	2007-03-14	Methods and compositions for deterring abuse of orally administered pharmaceutical products

Publications (2)

Publication Number	Publication Date
EP1993519A2 EP1993519A2 (de)	2008-11-26
EP1993519A4 true EP1993519A4 (de)	2011-12-21

Family

ID=38510088

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP07753168A Withdrawn EP1993519A4 (de)	2006-03-15	2007-03-14	Verfahren und zusammensetzungen zum verhindern des missbrauchs von oral verabreichten pharmazeutischen produkten

Country Status (5)

Country	Link
EP (1)	EP1993519A4 (de)
AU (1)	AU2007225101A1 (de)
CA (1)	CA2647360C (de)
IL (1)	IL193766A0 (de)
WO (1)	WO2007106550A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1429744A1 (de)	2001-09-21	2004-06-23	Egalet A/S	Polymeres freigabungssystem mit morphin
US20040234602A1 (en)	2001-09-21	2004-11-25	Gina Fischer	Polymer release system
WO2004084868A1 (en)	2003-03-26	2004-10-07	Egalet A/S	Morphine controlled release system
EP2155167A2 (de)	2007-06-04	2010-02-24	Egalet A/S	Pharmazeutische zusammensetzungen mit gesteuerter freisetzung für verlängerte wirkung
AU2015200313B2 (en) *	2007-12-17	2016-12-01	Alpharma Pharmaceuticals, Llc	Pharmaceutical composition
US8486448B2 (en)	2007-12-17	2013-07-16	Paladin Labs Inc.	Misuse preventative, controlled release formulation
US20090196890A1 (en) *	2007-12-17	2009-08-06	Alpharma Pharmaceuticals, Llc	Pharmaceutical compositions
ES2509497T3 (es)	2008-12-16	2014-10-17	Paladin Labs Inc.	Formulación de liberación controlada para evitar un uso indebido
NZ594207A (en)	2009-02-06	2013-03-28	Egalet Ltd	Immediate release composition resistant to abuse by intake of alcohol
NZ597283A (en)	2009-06-24	2013-07-26	Egalet Ltd	Controlled release formulations
BR112015000150A2 (pt)	2012-07-06	2017-06-27	Egalet Ltd	composições farmacêuticas dissuasoras de abuso de liberação controlada
CA3042642A1 (en)	2013-08-12	2015-02-19	Pharmaceutical Manufacturing Research Services, Inc.	Extruded immediate release abuse deterrent pill
US10172797B2 (en)	2013-12-17	2019-01-08	Pharmaceutical Manufacturing Research Services, Inc.	Extruded extended release abuse deterrent pill
US9492444B2 (en)	2013-12-17	2016-11-15	Pharmaceutical Manufacturing Research Services, Inc.	Extruded extended release abuse deterrent pill
CA2955229C (en)	2014-07-17	2020-03-10	Pharmaceutical Manufacturing Research Services, Inc.	Immediate release abuse deterrent liquid fill dosage form
US9132096B1 (en)	2014-09-12	2015-09-15	Alkermes Pharma Ireland Limited	Abuse resistant pharmaceutical compositions
AU2015336065A1 (en)	2014-10-20	2017-05-04	Pharmaceutical Manufacturing Research Services, Inc.	Extended release abuse deterrent liquid fill dosage form

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050214223A1 (en) *	2002-10-25	2005-09-29	Gruenenthal Gmbh	Abuse-safeguarded dosage form
WO2006058249A2 (en) *	2004-11-24	2006-06-01	Acura Pharmaceuticals, Inc.	Methods and compositions for deterring abuse of orally administered pharmaceutical products

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7201920B2 (en) *	2003-11-26	2007-04-10	Acura Pharmaceuticals, Inc.	Methods and compositions for deterring abuse of opioid containing dosage forms
US20060110327A1 (en) *	2004-11-24	2006-05-25	Acura Pharmaceuticals, Inc.	Methods and compositions for deterring abuse of orally administered pharmaceutical products

2007
- 2007-03-14 EP EP07753168A patent/EP1993519A4/de not_active Withdrawn
- 2007-03-14 WO PCT/US2007/006519 patent/WO2007106550A2/en not_active Ceased
- 2007-03-14 CA CA2647360A patent/CA2647360C/en not_active Expired - Fee Related
- 2007-03-14 AU AU2007225101A patent/AU2007225101A1/en not_active Abandoned
2008
- 2008-08-28 IL IL193766A patent/IL193766A0/en unknown

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050214223A1 (en) *	2002-10-25	2005-09-29	Gruenenthal Gmbh	Abuse-safeguarded dosage form
WO2006058249A2 (en) *	2004-11-24	2006-06-01	Acura Pharmaceuticals, Inc.	Methods and compositions for deterring abuse of orally administered pharmaceutical products

Also Published As

Publication number	Publication date
CA2647360A1 (en)	2007-09-20
WO2007106550A2 (en)	2007-09-20
EP1993519A2 (de)	2008-11-26
WO2007106550A3 (en)	2008-06-12
AU2007225101A1 (en)	2007-09-20
IL193766A0 (en)	2011-08-01
CA2647360C (en)	2012-05-15

Legal Events

Date	Code	Title	Description
2008-10-24	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2008-11-26	17P	Request for examination filed	Effective date: 20080916
2008-11-26	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
2008-11-26	AX	Request for extension of the european patent	Extension state: AL BA HR MK RS
2009-04-24	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1121393 Country of ref document: HK
2011-12-21	A4	Supplementary search report drawn up and despatched	Effective date: 20111117
2011-12-21	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 45/06 20060101ALI20111111BHEP Ipc: A61K 9/16 20060101ALI20111111BHEP Ipc: A61K 9/50 20060101ALI20111111BHEP Ipc: A61K 9/20 20060101ALI20111111BHEP Ipc: A61K 31/485 20060101AFI20111111BHEP
2012-08-08	DAX	Request for extension of the european patent (deleted)
2012-11-23	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2012-12-26	18D	Application deemed to be withdrawn	Effective date: 20120619
2015-10-09	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1121393 Country of ref document: HK

Publication	Publication Date	Title
EP1993519A4 (de)	2011-12-21	Verfahren und zusammensetzungen zum verhindern des missbrauchs von oral verabreichten pharmazeutischen produkten
EP1817011A4 (de)	2012-07-11	Verfahren und zusammensetzungen zum verhindern des missbrauchs von oral verabreichten pharmazeutischen produkten
IL193762A (en)	2013-05-30	The effective compounds in inhibiting dgat1-related disorders, their medicinal products and their use in the preparation of drugs
ZA200901110B (en)	2009-12-30	Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage from containing same
IL197275A0 (en)	2009-12-24	Pharmaceutical compositions of clonazepam and methods of use thereof
ZA200900423B (en)	2010-04-28	Methods and medicaments for administration of ibuprofen
IL194546A0 (en)	2009-08-03	Arylaminopyridine derivatives and pharmaceutical compositions containing them
IL193727A0 (en)	2009-05-04	Dosage forms for administering combinations of drugs
ZA200809002B (en)	2009-12-30	Cycloalkylamino acid derivatives and pharmaceutical compositions thereof
IL199853A (en)	2015-02-26	Converged history of 5-Hydroxy-Admentil-2-Reindeer and Pharmaceutical Preparation containing them
PL2046312T3 (pl)	2021-02-08	Produkty farmaceutyczne i nutraceutyki zawierające witaminę K2
ZA200900345B (en)	2010-05-26	Preparation of pharmaceutical formulations
SI2086945T1 (sl)	2016-05-31	Novi postopek za pripravo statinov in njihovih farmacevtsko sprejemljivih soli
AP2008004671A0 (en)	2008-12-31	Cycloalkylamino acid derivatives and pharmaceutical compositions thereof
IL206835A (en)	2017-09-28	Pharmaceutical compositions containing oil and particulates for oral administration of insulin and methods for their preparation
AP2008004447A0 (en)	2008-04-30	Orally absorbed pharmaceutical formulation and method of administration
IL193211A (en)	2013-07-31	Derivatives of Indzol-Troaril and pharmaceutical preparations containing them
HUS2000053I1 (hu)	2020-12-28	Kinolinszármazékok és gyógyászati készítményeik
ZA200902061B (en)	2010-02-24	Packaging system for pharmaceutical compositions and kit for intravenous administration
IL178067A0 (en)	2006-12-31	Pharmaceutical dosage forms and compositions
IL191922A0 (en)	2009-08-03	Pharmaceutical formulations of oxcarbazepine and methods for its preparation
PL2008655T3 (pl)	2013-11-29	Kompozycja farmaceutyczna zawierająca środek przeciwbólowy i witaminy
HK1121393A (en)	2009-04-24	Methods and compositions for deterring abuse of orally administered pharmaceutical products
IL183362A0 (en)	2007-09-20	Method and compositions for deterring abuse of orally administered pharmaceutical products
HK1107782A (en)	2008-04-18	Methods and compositions for deterring abuse of orally administered pharmaceutical products