EP2010126A2 - Produit de blanchiment dentaire - Google Patents

Produit de blanchiment dentaire

Info

Publication number
EP2010126A2
EP2010126A2 EP07724239A EP07724239A EP2010126A2 EP 2010126 A2 EP2010126 A2 EP 2010126A2 EP 07724239 A EP07724239 A EP 07724239A EP 07724239 A EP07724239 A EP 07724239A EP 2010126 A2 EP2010126 A2 EP 2010126A2
Authority
EP
European Patent Office
Prior art keywords
bleaching agent
agent according
tooth
tooth bleaching
apatite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07724239A
Other languages
German (de)
English (en)
Inventor
Jürgen Engelbrecht
K. J. Görlich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
S&C Polymer Silicon und Composite Spezialitaeten GmbH
Original Assignee
S&C Polymer Silicon und Composite Spezialitaeten GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S&C Polymer Silicon und Composite Spezialitaeten GmbH filed Critical S&C Polymer Silicon und Composite Spezialitaeten GmbH
Publication of EP2010126A2 publication Critical patent/EP2010126A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
    • A61K6/65—Dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/838—Phosphorus compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/65—Characterized by the composition of the particulate/core
    • A61K2800/651—The particulate/core comprising inorganic material

Definitions

  • the dental bleaching agent of the present invention includes apatite, more preferably in nano-sized particle sizes, also more preferably as fluoroapatite Remineralization of the tooth surface act.
  • the discoloration of teeth may be due to the natural aging process, the use of certain foods and tobacco, diseases, injuries, medicines and innate and environmental conditions. Since white or light teeth are generally more aesthetic than dark or discolored teeth, there has always been much interest in the development of teeth whitening materials and methods.
  • Some dentifrices such as toothpastes, gels and powders contain active oxygen or hydrogen peroxide-releasing bleaching materials.
  • Such bleaches contain peroxides, percarbonates and perborates of alkali and Alkaline earth metals or complex compounds containing hydrogen peroxide.
  • percarbamide also called urea peroxohydrate or urea - hydrogen peroxide.
  • Percarbamide has been used in dentistry for decades as an oral antiseptic. Urea itself is described in the literature as a keratinizing agent for the gums. Tooth whitening was an observed side effect with extended contact times.
  • Other bleaching agents such as. As peroxyacetic acid and sodium perborate, are also well known in the medical, dental and cosmetic field.
  • bleaching gels The bleaching gels on the market, known worldwide as “bleaching gels", are divided into three categories (Reality Report VoI .14 / 2000), namely "Power Bleaching”, “Assisted Bleaching” and “Home Bleaching". To save time and money, "dental bleaching" in the dental office is the preferred method for bleaching discolored teeth.
  • Sodium monofluorophosphate, sodium fluoride and zinc fluoride, antimicrobial agents such as chlorhexidine, tetracycline, cetylpyridinium chloride, benzalkonium chloride, cetylpyridinium bromide, methyl benzoate and propyl benzoate.
  • Discus Dental offers bleach with additions of amorphous calcium triphosphate. Their advantage lies in the addition which is in principle suitable for remineralization during the bleaching process. In slightly acidic conditions, where o.g. Bleaches are generally more stable, but these are not stable. They also contain no fluoride.
  • a remineralizing dental adhesive film which consists of a carrier material adhering to the tooth and active ingredients incorporated therein.
  • the active substances consist of hydroxyapatite, fluorapatite, calcium fluoride and di-tri- or tetracalcium phosphate.
  • An important object of the present invention was to provide a new and improved single or multi-component whitening bleach for teeth desensitizing, fluoride-releasing and remineralizing properties.
  • a dental bleaching agent which comprises an apatite of the general composition
  • M is a cation other than Ca 2+
  • B is an anion other than PO 4 3 "
  • the apatite is characterized by more than 50% by weight.
  • the apatite particles have a particle size in the range of ⁇ 500 nm, more preferably in the range of ⁇ 200 nm, and most preferably in the range of ⁇ 100 nm.
  • the tooth whitening agent of this invention contains at least one orally compatible bleaching agent.
  • Various bleaching agents and / or bleaching mixtures can be used for the preparation of the tooth whitening agent, such as hydrogen peroxide, percarbamide, sodium perborate, potassium peroxomonosulfate, potassium chlorate, potassium percarbonate, Sodium percarbonate, calcium peroxide, magnesium peroxide, perphosphates, persilicates, benzoyl peroxide, glycerol peroxide, calcium hydrogencarbonate peroxide and
  • Hydrogen peroxide, percarbamide, sodium perborate and potassium peroxomonosulfate are preferred. Hydrogen peroxide, percarbamide, sodium perborate and / or potassium peroxomonosulfate and / or mixtures thereof are present in the total dental bleaching agent, preferably in an amount of 5-70% by weight, preferably in an amount of 5-55% by weight.
  • the content of the bleaching agent in the whole dental bleaching agent may be 5-75% by weight, preferably 5-60% by weight, more preferably 10-30% by weight, still more preferably 15-25% by weight.
  • the tooth whitening agent of this invention may contain one or more activator components.
  • the activator component may be a gel, e.g., an alkaline gel. It preferably contains one or more alkali and / or alkaline earth metal salts. As activators or
  • decomposition catalysts for salts or complexes from the group of copper, manganese and / or iron, very particularly preferably organometallic complexes or salts, for example acetylacetonates, gluconates, lactates, fumarates, naphthenic acid salts, metallocenes, oxalates, citrates, sulfates, oxides, Acetates and / or mixtures thereof. They show violent to mild reactions in the decomposition of peroxides according to their chemical character.
  • the Activator component may additionally contain another peroxide.
  • the content of the activator component in the whole dental bleaching agent may be 0.1-30% by weight, preferably 0.2-20% by weight, more preferably 0.5-10% by weight.
  • the bleach and / or the optional activator component may contain gelling agents or thickeners.
  • gelling agents or thickeners examples are cellulose polymers, polycarboxylic acids, fumed silica, poly (meth) acrylic acids, polysaccharides, polyvinyl butyrals, alginates, coumarone resins, shellac, xanthan, tragacanth, guar, carrageenan, alginic acids, etc., and / or mixtures thereof. They may be present together in an amount of 0.01-20% by weight, preferably in an amount of 0.05-15% by weight.
  • Water or water in combination with other bases is often used as a base material for the production of stable dental bleaching agents.
  • bases include or consist of polyols such as polyethylene glycol, sorbitol, polypropylene glycol, propylene glycol, glycerol, ethanol, acetone, ethers, acetic acid esters, xylitol and others and / or mixtures of the foregoing.
  • Polyols such as glycerol and / or propylene glycol and / or demineralized water are preferred in this invention. They are present either alone or as mixtures and are present in an amount of 0.1-98 weight percent, and preferably in an amount of 0.5-95 weight percent based on the total tooth whitening agent.
  • B. stabilizers such as alkali metal polyphosphates, Alkali metal pyrophosphates, ethylenediaminetetraacetic acid and its salts, tartaric acid and its salts, citric acid and its salts, gluconic acid and its salts, triethanolamine, stannous nitrate, adipic acid, tin phosphate, succinic acid, etc., such as pH change components such as alkali and alkaline earth metal salts such as vitamins as anti-inflammatory agents as well as flavorings such as peppermint, vanillin, etc., colorants for coloring and as indicators, preservatives, fluoride derivatives, wetting agents, etc. They may be present either alone or in mixtures in the bleaches of this invention.
  • the bleaching agents may also be activated by exposure to heat (mouth temperature, hot light, laser, or possibly other sources) in addition to or instead of one or more activators, optionally supported by additions of energy-absorbing substances, e.g. Carotenoids, coronene, bixin, perylene, flavins etc.
  • heat mouth temperature, hot light, laser, or possibly other sources
  • energy-absorbing substances e.g. Carotenoids, coronene, bixin, perylene, flavins etc.
  • apatites provide an important basis for the incorporation of calcium into hard tooth substances (e.g., enamel, dentin, bone) and that they play an important role in healthy teeth, when combined with other phosphate and non-phosphate minerals.
  • hard tooth substances e.g., enamel, dentin, bone
  • the best known representative of this class of substances is the hydroxyapatite with stoichiometric formula Cai 0 (PO 4 ) 6 (OH) 2 or Ca 5 (PO 4 ) 3 0H.
  • Cai 0 (PO 4 ) 6 (OH) 2 or Ca 5 (PO 4 ) 3 0H In its synthetic and biocompatible appearance, it is used in many applications in dentistry, orthopedics and maxillofacial surgery, never occurring in its pure form in biological tissues. This is a consequence of the possible isomorphic exchange of the Ca 2+ , PO 4 3 " and OH " ions, respectively.
  • the Ca 2+ -IOn can be produced by a number of (mostly divalent) cations.
  • the phosphate anion can be replaced by carbonate, hydrogen phosphate, pyrophosphate, sulfate, aluminate and silicate anions; on the other hand, the hydroxide ion can be replaced by halide, carbonate and oxide ions.
  • hydroxyapatite is the one most used for the production of materials for orthodontics or for biometric applications.
  • Particularly suitable exchange cations are: Na + , K + , Mg 2+ , Ca 2+ , Sr 2+ , Ba 2+ , Y 2+ , Ti 2+ , Zr 2+ , Mn 2+ , Fe 2+ , Pd 2+ , Cu 2+ , Ag + , Zn 2+ , Sn 2+ , Re 2+ , Re 3+ , Al 3+ In 3+ and / or Y 3+ .
  • calcium can be replaced by strontium up to about 30% without altering the crystal structure.
  • strontium up to about 30% without altering the crystal structure.
  • the presence of this element in apatites, which are used in the dental field, is of importance against the background of a possible caries-inhibiting effect as well as a decreased dentin sensitivity. Furthermore, the solubility is lowered. Furthermore, it has been found within the scope of the invention that when certain cations are incorporated into apatites, an antimicrobial effect can be achieved. Particularly useful in this context is the incorporation of Cu 2+ , Ag 2+ , Zn 2+ , and / or Sn 2+ .
  • Anions can also act as exchange ions.
  • CO 3 2 " , HPO 4 2" , HCO 3 " and P 2 O 7 4" are to be mentioned as B anion, the y value is usually 0-2.
  • the hydroxide ions are replaced by fluoride or chloride ions.
  • the fluorapatite is characterized by an increase in crystal dimensions and a decrease in the parameters of the unit cell. Furthermore, its solubility is lower and its thermal stability greater, which is why it is used in the treatment of bone diseases or dental caries.
  • the cell parameter a of the unit cell is increased or the cell parameter c is reduced in the case of chlorapatite.
  • the different crystal lattice is a consequence of the different ionic radii of the fluoride or chloride.
  • Fluorapatite is particularly interesting. Because of its lower solubility in the weakly acidic region, fluoridation of the tooth surfaces, ie, conversion of hydroxyapatite into fluoroapatite on the surface of the tooth, can lead to less acid attackable teeth, thus becoming more caries resistant. The presence of fluoroapatite on the tooth surface provides the opportunity for ion exchange between the hydroxylapatite of the tooth surface and the fluoroapatite during the bleaching time. The tooth surface is thus cleaned oxidatively and at the same time made more acid-resistant.
  • the bleaching agent for use in a dental bleaching agent usually has a slightly acidic pH to ensure the stability of the bleaching agent such as a peroxide, the enamel is easily etched during bleaching.
  • the simultaneous presence of the apatite surprisingly leads directly, ie in situ, during bleaching to a repair of the attacked enamel. Since the specific surface of nano-particles is particularly large, the remineralizing effect of nano-apatites can be orders of magnitude stronger.
  • the nano-apatites preferably consisting of nanoparticles or comprising these can be prepared by the methods customarily used for the production of nanocrystalline materials, eg.
  • atomic-based methods chemical or physical vapor deposition "vapor deposition", condensation in the gas phase, reactions from aerosols or
  • conventional methods mechanical abrasion, crystallization from the amorphous phase, phase separation.
  • the precipitation method is a conventional method of producing very fine powder or colloidal suspensions which are successful in the synthesis of clusters used in the nano area, z. B. in the SoI gel technique.
  • Nanocrystalline materials are generally man-made materials characterized by continuous phases or by granular structures and usually less than 200 nm in length. Depending on the number of dimensions in which these materials have a nanostructure, a distinction is made between (i) zero-dimensional (atomic clusters, eg dispersed in a matrix of non-nanocrystalline material, filaments, tubules), (ii) one-dimensional (monomolecular layers nanodimensioned only in terms of layer thickness), (iii) two-dimensional (granular superpositions, "granular superpositions", ultra fine layers) and (iv) three-dimensional (in all three dimensions nanoscale structures) materials (RW Siegel, in Materials Science and Technology, Vol. 15: Processing of Metals and Alloys, RW Chan, 583 (1991)).
  • zero-dimensional atomic clusters, eg dispersed in a matrix of non-nanocrystalline material, filaments, tubules
  • one-dimensional monomolecular layers nanodimensioned only in terms of layer thickness
  • the specific properties of the nanocrystalline materials result from three fundamental features, namely (i) the atomic size range of ⁇ 200 nm, (ii) the high proportion of atoms involved in the interfaces, and (iii) the interactions between the individual subregions.
  • nanoapatites particularly suitable for bleaching additive addition of the invention: the interactions of crystalline nanoapatite in a bleach formulation with its biological environment can be far more intense than with conventional apatite.
  • the particle size of the apatites to be used in the dental material according to the invention is not critical over the ranges indicated. In preferred embodiments, they are characterized in that the particle size of Apatitteilchen to more than 50 wt .-%, optionally more than 60 wt .-% or even more than 70 wt .-% in the range ⁇ 500 nm, more preferably more than 50 wt .-%, optionally to more than 60 wt .-% or even more than 70 wt .-% in the range ⁇ 200 nm, and most preferably to more than 50 wt .-%, optionally to more than 60 wt .-% or even more than 70 wt% in the range ⁇ 100 nm. In a preferred embodiment of the invention, the apatite particles are surface-treated to achieve better dispersivity.
  • the Apatit sleepllstoffe may be surface-treated with esters of phosphoric, phosphonic or carboxylic acids.
  • esters of mono-di- and triphosphonic acids such as e.g. Tris (phosphonomethyl) amine, azacycloheptane-2, 2-diphosphonic acid, hydroxyethane-1, 1-diphosphonic acid.
  • treatments with phosphate salts can be beneficial.
  • Another method is to apply a layer of SiO 2 or ZrO 2 on the nanometer scale and subsequent treatment with a functional silane such as hydroxy, amino, alkylorganosilanes.
  • the apatites are present in the bleaching material in an amount sufficient to allow ion exchange with the biological environment. Preference is given to proportions by weight of from 1 to 20% by weight, more preferably from 2 to 10%, based on the total weight of the bleaching material.
  • the bleaching material may contain additives of optional, but nevertheless very advantageous and no less preferred desensitizing agents, which also have the desensitizing and remineralizing effects in bleaches such as fluorides (sodium monofluorophosphate, sodium fluoride, calcium fluoride, etc.), nitrates (sodium nitrate, potassium nitrate, etc.), strontium compounds (eg, strontium chloride, etc.).
  • fluorides sodium monofluorophosphate, sodium fluoride, calcium fluoride, etc.
  • nitrates sodium nitrate, potassium nitrate, etc.
  • strontium compounds eg, strontium chloride, etc.
  • bioactive or antibiotic substances may be added without any limitation, e.g. Transforming Growth Factor Beta, Cell Attachment Factors, Endothelial Growth Factors, Bone Morphogenetic Proteins, Penicillin, Chlortetracycline Hydrochloride, Chloramphenicol, Oxytetracycline, etc.
  • wetting agents may also be present in the tooth whitening agent according to the invention as further additives. Preference is given here to the use of sodium lauryl sulfate.
  • the bleaching agents according to the invention can be used very well for whitening teeth because of their excellent remineralizing and desensitizing properties.
  • the apatite portion of the tooth bleaching formulation may deliver ions to the tooth to be bleached (including fluoride, phosphate, calcium).
  • the retention of nanocrystals in interstitial clefts of the enamel or dentin can provide a remineralizing effect beyond the bleaching process.
  • the effect envisaged according to the invention namely whitening of the teeth with simultaneous repair of minor lesions by exchange of ions with the tooth substance and, especially when using nano-fluorapatite, the "hardening" of enamel by fluoride exchange is achieved by the tooth bleaching formulations according to the invention.
  • the apatite additive of the invention can be used in typical dental bleaching formulations such as glycerol as a base material, pyrogenic silica as a thickener, percarbamide as a bleaching agent.
  • Nanocrystalline fluoroapatite was crystallized from a ternary microemulsion.
  • an aqueous phase containing CaCl 2 (Merk, Darmstadt, Germany) was emulsified in a mixture of Empilan KB6ZA (ethoxylated lauryl alcohol, Albright's Wilson, Meuse, France) and octane (Sigma-Aldrich, Schnelldorf, Germany) in a fixed ratio of 3: 7 ,
  • the microemulsion was stirred at 30 0 C with 30 (I), 36.36 (II) and 50 (III) wt.% 1.0 mol CaCl 2 vigorously, to obtain a micro emulsion.
  • the SEM-EDX data (Energy Dispersive X-ray spectrometry) of the powder show sufficiently good agreement with calcium fluorapatite, cf. also figures.
  • nanoapatite powder from Example 1 (I) 100 g is slurried in acetone and mixed with 6 g of hydroxyethyl phosphoric ester with constant stirring. After stirring for 2 h, centrifuging off and washing three times with acetone, it was dried.
  • One-component gels The basic material used was glycerol and the thickener fumed silica.
  • the bleaching formulations prepared were used for whitening enamel and dentin.
  • the basic material used was glycerol and the thickener fumed silica.
  • Component II Glycerol 93.00% w / w
  • Component I Glycerol 74.00% w / w
  • Component II Glycerol 93.00% w / w

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des compositions d'un produit de blanchiment dentaire et leurs utilisations pour éclaircir des dents. Le produit de blanchiment dentaire selon l'invention contient de l'apatite, idéalement constituée de particules de tailles nanométriques et idéalement sous forme d'apatite fluorée. Ce produit de blanchiment dentaire peut avoir une action désensibilisante et une action positive sur la reminéralisation de la surface dentaire.
EP07724239A 2006-04-13 2007-04-13 Produit de blanchiment dentaire Withdrawn EP2010126A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006017814 2006-04-13
PCT/EP2007/003301 WO2007118689A2 (fr) 2006-04-13 2007-04-13 Produit de blanchiment dentaire

Publications (1)

Publication Number Publication Date
EP2010126A2 true EP2010126A2 (fr) 2009-01-07

Family

ID=38510367

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07724239A Withdrawn EP2010126A2 (fr) 2006-04-13 2007-04-13 Produit de blanchiment dentaire

Country Status (3)

Country Link
US (1) US20090175917A1 (fr)
EP (1) EP2010126A2 (fr)
WO (1) WO2007118689A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009133525A2 (fr) * 2008-04-29 2009-11-05 High Tech Laser Composition pour blanchiment des dents
WO2011050369A1 (fr) * 2009-10-23 2011-04-28 Cao Group, Inc. Compositions de vernis thérapeutique pour la surface des dents
US9642687B2 (en) 2010-06-15 2017-05-09 The Procter & Gamble Company Methods for whitening teeth
US20120244491A1 (en) * 2011-03-22 2012-09-27 Remigio Piergallini Device and method for teeth brightening
GB201202341D0 (en) * 2012-02-10 2012-03-28 Periproducts Ltd Multicomponent oral care compostion
US20150238399A1 (en) * 2012-08-13 2015-08-27 Matthew Scott Spaid Tooth whitening composition
DE102013109758B4 (de) * 2013-09-06 2017-07-13 Ferton Holding S.A. Pulvergemisch, Verwendung des Pulvergemischs, Pulverstrahlgerät und Verfahren zur Remineralisierung von Zähnen
EP2853622B1 (fr) * 2013-09-30 2016-01-13 Universidade de Vigo Procédé d'obtention de nanocristaux de fluorapatite à facettes
US9561162B1 (en) * 2015-08-11 2017-02-07 Okey Okechukwu Combined dental whitening, polishing, and re-mineralizing system
CN109689165B (zh) * 2016-08-11 2022-08-26 高露洁-棕榄公司 针对顽渍的过一硫酸盐牙粉组合物
CN110799248B (zh) 2017-06-19 2023-06-16 高露洁-棕榄公司 口腔护理产品及其美白组合物
US10716741B1 (en) 2018-12-26 2020-07-21 Colgate-Palmolive Company Oral care compositions and methods for the same
US12214063B2 (en) 2021-02-19 2025-02-04 Colgate-Palmolive Company Peroxymonosulfate whitening strips

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5098303A (en) * 1990-03-22 1992-03-24 Ultradent Products, Inc. Method for bleaching teeth
US5376006A (en) * 1990-03-22 1994-12-27 Ultradent Products, Inc. Dental bleaching compositions and methods for bleaching teeth surfaces
US6036943A (en) * 1990-03-22 2000-03-14 Ultradent Products, Inc. Methods for treating a person's teeth using sticky dental compositions in combination with passive-type dental trays
US5985249A (en) * 1990-03-22 1999-11-16 Ultradent Products, Inc. Sticky dental compositions for adhering a passive-type dental tray over a person's teeth
US5234342A (en) * 1990-03-22 1993-08-10 Ultradent Products, Inc. Sustained release method for treating teeth surfaces
JP3340265B2 (ja) * 1994-11-21 2002-11-05 一枝 山岸 歯の漂白剤
US5858332A (en) * 1997-01-10 1999-01-12 Ultradent Products, Inc. Dental bleaching compositions with high concentrations of hydrogen peroxide
US5785527A (en) * 1997-01-10 1998-07-28 Ultradent Products, Inc. Stable light or heat activated dental bleaching compositions
JP2001233749A (ja) * 2000-02-28 2001-08-28 Kazue Yamagishi 歯牙美白用組成物
ES2320321T3 (es) * 2000-03-17 2009-05-21 LG HOUSEHOLD & HEALTH CARE LTD. Parches para blanquear dientes.
US20050123490A1 (en) * 2003-12-04 2005-06-09 Kazue Yamagishi Composition and method for prevention and treatment of dental caries
DE102004025030A1 (de) * 2004-05-18 2005-12-15 S&C Polymer Silicon- und Composite-Spezialitäten GmbH Nano-Apatit-Füllstoffe enthaltende härtbare Restaurationsmaterialien
US9271902B2 (en) * 2005-02-15 2016-03-01 Martin S. Giniger Whitening system capable of delivering effective whitening action

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2007118689A3 *

Also Published As

Publication number Publication date
WO2007118689A3 (fr) 2008-12-11
WO2007118689A2 (fr) 2007-10-25
US20090175917A1 (en) 2009-07-09

Similar Documents

Publication Publication Date Title
WO2007118689A2 (fr) Produit de blanchiment dentaire
DE3921133C2 (de) Wasserstoffperoxid freisetzende Zahnpasta
DE69830992T2 (de) Desensibilisierende zahnpaste mit beschränkter astringenz
DE69004004T2 (de) Kolloidales Fluorid und orale Zusammensetzung.
DE69522956T2 (de) Orale zusammensetzung enthaltend stabilisierte zinn komponente
DE60109207T2 (de) Orale zusammensetzung
EP1139995B1 (fr) Suspensions de sels de calcium de fine dispersion et peu solubles dans l'eau et leur utilisation dans des produits d'hygiene dentaire
DE3619867A1 (de) Zahnpasta mit hydrogenkarbonat
EP0216189A2 (fr) Composition d'hygiène orale
DE10340542A1 (de) Mund- und Zahnpflegemittel
CN101489925A (zh) 用碳酸根置换的羟磷灰石的生物活性纳米粒子及其制备方法和包含其的组合物
DE102004025030A1 (de) Nano-Apatit-Füllstoffe enthaltende härtbare Restaurationsmaterialien
DE10340543A1 (de) Mund- und Zahnpflegemittel
WO2012119155A1 (fr) Compositions antimicrobiennes pour la fluoruration et la reminéralisation des dents
DE3044448A1 (de) Zahncreme
DE3786920T2 (de) Periodontische zusammensetzung und verfahren.
DE3545985A1 (de) Oral anzuwendendes mittel
EP1572142B1 (fr) Matieres composites constituees de composes de calcium et de polysaccharides contenant de l'acide glucuronique
EP1824445A1 (fr) Agents de blanchiment des dents
DE10064637A1 (de) Nanopartikuläres oberflächenmodifiziertes Titanoxid und seine Verwendung in Zahnpflegemitteln
DE60217857T2 (de) Remineralisierende zahnhygieneprodukte
WO2008031619A1 (fr) Fluorures alcalino-terreux nano-cristallin dans des agents de blanchiment dentaire
DE2522042A1 (de) Zahnpasta
DE102006039632A1 (de) Zusammensetzung enthaltend schwer wasserlösliche Calciumsalze und/oder deren Kompositmaterialien in einer Menge von 1 bis 99 Gew.-%
DE2400721C2 (fr)

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20081113

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK RS

R17D Deferred search report published (corrected)

Effective date: 20081211

RIN1 Information on inventor provided before grant (corrected)

Inventor name: GOERLICH, KARL-JOACHIM

Inventor name: ENGELBRECHT, JUERGEN

17Q First examination report despatched

Effective date: 20091026

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20100306