EP2012773A4 - Médicaments et utilisations - Google Patents

Médicaments et utilisations

Info

Publication number
EP2012773A4
EP2012773A4 EP07863339A EP07863339A EP2012773A4 EP 2012773 A4 EP2012773 A4 EP 2012773A4 EP 07863339 A EP07863339 A EP 07863339A EP 07863339 A EP07863339 A EP 07863339A EP 2012773 A4 EP2012773 A4 EP 2012773A4
Authority
EP
European Patent Office
Prior art keywords
medicines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP07863339A
Other languages
German (de)
English (en)
Other versions
EP2012773B1 (fr
EP2012773A2 (fr
Inventor
James M Frincke
Christopher L Reading
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harbor Biosciences Inc
Original Assignee
Hollis Eden Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hollis Eden Pharmaceuticals Inc filed Critical Hollis Eden Pharmaceuticals Inc
Priority to PL12167186T priority Critical patent/PL2486924T3/pl
Priority to DK12167186.1T priority patent/DK2486924T3/en
Priority to EP12167186.1A priority patent/EP2486924B1/fr
Priority to PL07863339T priority patent/PL2012773T3/pl
Publication of EP2012773A2 publication Critical patent/EP2012773A2/fr
Publication of EP2012773A4 publication Critical patent/EP2012773A4/fr
Application granted granted Critical
Publication of EP2012773B1 publication Critical patent/EP2012773B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP07863339A 2006-04-22 2007-04-23 Médicaments et utilisations Active EP2012773B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PL12167186T PL2486924T3 (pl) 2006-04-22 2007-04-23 Leki i zastosowania
DK12167186.1T DK2486924T3 (en) 2006-04-22 2007-04-23 Medicines and uses
EP12167186.1A EP2486924B1 (fr) 2006-04-22 2007-04-23 Médicaments et utilisations
PL07863339T PL2012773T3 (pl) 2006-04-22 2007-04-23 Leki i zastosowania

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US79379206P 2006-04-22 2006-04-22
US84311206P 2006-09-08 2006-09-08
US82556906P 2006-09-13 2006-09-13
US82556406P 2006-09-13 2006-09-13
US82984806P 2006-10-17 2006-10-17
US86639506P 2006-11-17 2006-11-17
US86670006P 2006-11-21 2006-11-21
US86804206P 2006-11-30 2006-11-30
US88500307P 2007-01-15 2007-01-15
US88805807P 2007-02-02 2007-02-02
PCT/US2007/067235 WO2008039566A2 (fr) 2006-04-22 2007-04-23 Médicaments et utilisations

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP12167186.1A Division EP2486924B1 (fr) 2006-04-22 2007-04-23 Médicaments et utilisations
EP12167186.1 Division-Into 2012-05-08

Publications (3)

Publication Number Publication Date
EP2012773A2 EP2012773A2 (fr) 2009-01-14
EP2012773A4 true EP2012773A4 (fr) 2010-01-13
EP2012773B1 EP2012773B1 (fr) 2012-06-20

Family

ID=39230844

Family Applications (2)

Application Number Title Priority Date Filing Date
EP12167186.1A Active EP2486924B1 (fr) 2006-04-22 2007-04-23 Médicaments et utilisations
EP07863339A Active EP2012773B1 (fr) 2006-04-22 2007-04-23 Médicaments et utilisations

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP12167186.1A Active EP2486924B1 (fr) 2006-04-22 2007-04-23 Médicaments et utilisations

Country Status (13)

Country Link
EP (2) EP2486924B1 (fr)
JP (2) JP5130591B2 (fr)
KR (1) KR20080112413A (fr)
CN (1) CN103211821A (fr)
AU (2) AU2007300404B2 (fr)
CA (1) CA2649940C (fr)
DK (2) DK2012773T3 (fr)
EA (1) EA200802167A1 (fr)
ES (2) ES2389743T3 (fr)
HU (1) HUE042925T2 (fr)
IL (1) IL194751A0 (fr)
PL (2) PL2012773T3 (fr)
WO (1) WO2008039566A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution
US8217025B2 (en) 2006-11-17 2012-07-10 Harbor Therapeutics, Inc. Drug screening and treatment methods
US8354396B2 (en) 2006-11-17 2013-01-15 Harbor Therapeutics, Inc. Drug identification and treatment method
US8486926B2 (en) 2006-11-17 2013-07-16 Harbor Therapeutics, Inc. Steroid tetrol solid state forms
CA2712005C (fr) * 2008-02-05 2014-04-15 Harbor Biosciences, Inc. Formes pharmaceutiques a l'etat solide
CA2728889C (fr) 2008-04-03 2016-06-14 Harbor Biosciences, Inc. Formes a l'etat solide d'un produit pharmaceutique
DK2300489T3 (en) 2008-06-06 2016-02-15 Neurmedix Inc PROCESSES FOR PREPARING 17-alkynyl-7-HYDROXY STEROIDS AND RELATED COMPOUNDS
US20130217749A1 (en) * 2010-06-10 2013-08-22 Yale University Modulation of phosphoenolpyruvate carboxykinase-mitchondrial (pepck-m) expression
AU2011343548A1 (en) * 2010-12-17 2013-05-09 Harbor Biosciences, Inc. Steroid tetrol solid state forms-2
HUE062616T2 (hu) * 2011-09-08 2023-11-28 Sage Therapeutics Inc Neuroaktív szteroidok, készítmények és alkalmazásaik
ITMI20121472A1 (it) * 2012-09-04 2014-03-05 Ind Chimica Srl Processo per la preparazione di 11-metilen-18-metilestr-4-en-3,17-dione, utile come intermedio per la sintesi di molecole ad attivita' farmacologica
KR101687061B1 (ko) * 2014-02-25 2016-12-16 순천향대학교 산학협력단 나이에 따른 당뇨병 진단을 위한 글루코코르티코이드 수용체의 검출제제를 포함하는 타입 2 당뇨 진단 키트
CN105017361A (zh) * 2015-07-16 2015-11-04 湖北竹溪人福药业有限责任公司 一种去氢表雄酮的合成方法
CN109985047B (zh) 2017-12-29 2021-07-27 广州市赛普特医药科技股份有限公司 5α-雄甾-3β,5,6β-三醇在制备治疗出血性脑卒中药物中的应用
CN109369761B (zh) * 2018-12-18 2021-01-01 湖南科瑞生物制药股份有限公司 一种去氢甲基睾丸素的制备方法
CN109369760B (zh) * 2018-12-18 2021-01-01 湖南科瑞生物制药股份有限公司 一种制备去氢甲基睾丸素的方法
CN113318114B (zh) * 2020-02-28 2023-02-17 广州市赛普特医药科技股份有限公司 小分子化合物在治疗肺上皮细胞损伤和/或血管内皮细胞损伤介导的疾病中的用途
CN114195844B (zh) * 2021-12-29 2023-03-17 湖北武当安泰药业有限公司 一种去氢表雄酮的制备方法
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same
WO2025155561A1 (fr) * 2024-01-16 2025-07-24 Biovie Inc. Méthodes de traitement de la covid longue

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010527A1 (fr) * 1993-10-13 1995-04-20 Neurocrine Biosciences, Inc. Composes 3,17-dihydroxy-3,7,16 et/ou 17-methyl-androst-5-ene, leurs derives ainsi que leur utilisation
US20040097475A1 (en) * 2002-11-07 2004-05-20 Wuts Peter Guillaume Marie Processes for preparing C-7 substituted steroids
EP1422234A2 (fr) * 1999-03-23 2004-05-26 Hollis-Eden Pharmaceuticals Inc. Steroides avec activité d'immunomodulation, surtout le hemihydrat du 16.alpha.-bromoepiandrosterone
US20040116359A1 (en) * 1999-03-23 2004-06-17 Ahlem Clarence Nathaniel Pharmaceutical compositions and treatment methods
AU2005211675A1 (en) * 1999-03-23 2005-10-20 Harbor Biosciences, Inc. Immunomodulatory steroids, in particular the hemihydrate of 16.alpha.-bromoepiandrosterone

Family Cites Families (16)

* Cited by examiner, † Cited by third party
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US6150090A (en) 1986-01-09 2000-11-21 Massachusetts Institute Of Technology Nuclear factors associated with transcriptional regulation
US5071773A (en) 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US4898694A (en) * 1987-11-25 1990-02-06 Schwartz Arthur G 17-Hydroxy-steroids
US6545027B1 (en) 1995-06-07 2003-04-08 Eli Lilly And Company Methods of modulating NF-kB transcription factor
US5989835A (en) 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
US5753266A (en) * 1996-12-03 1998-05-19 Youssefyeh; Parvin Safflower seed powder compositions for the treatment of rheumatoid based arthritic diseases
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
EP1231264A1 (fr) * 1999-08-06 2002-08-14 Glaxo Wellcome, S.A. Nouvelle proteine
US6864355B1 (en) 2000-05-02 2005-03-08 Yale University Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain
AU7736300A (en) * 1999-09-30 2001-04-30 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment of androgen receptor driven conditions
US6593511B1 (en) 2000-05-12 2003-07-15 Bioseek, Inc. Models of chronic and acute inflammatory diseases
JP2004537506A (ja) * 2001-03-01 2004-12-16 ホリス − イーデン ファーマスーティカルズ、 インコーポレイテッド 血液細胞欠乏症を治療するためのある種のステロイドの使用
EP1385872A4 (fr) 2001-05-11 2004-12-15 Res Dev Foundation Inhibiteurs de recepteur activateur de nf-kappa b et utilisations de ces inhibiteurs
CA2461343A1 (fr) * 2001-10-09 2003-04-17 Immunex Corporation Lectines de type c mammiferes
WO2004019953A1 (fr) * 2002-08-28 2004-03-11 Hollis-Eden Pharmaceuticals, Inc. Procedes de traitement therapeutique
US7884196B2 (en) 2004-10-06 2011-02-08 Oliver Lawless Vaccine composition comprising methylated DNA and immunomodulatory motifs

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010527A1 (fr) * 1993-10-13 1995-04-20 Neurocrine Biosciences, Inc. Composes 3,17-dihydroxy-3,7,16 et/ou 17-methyl-androst-5-ene, leurs derives ainsi que leur utilisation
EP1422234A2 (fr) * 1999-03-23 2004-05-26 Hollis-Eden Pharmaceuticals Inc. Steroides avec activité d'immunomodulation, surtout le hemihydrat du 16.alpha.-bromoepiandrosterone
US20040116359A1 (en) * 1999-03-23 2004-06-17 Ahlem Clarence Nathaniel Pharmaceutical compositions and treatment methods
AU2005211675A1 (en) * 1999-03-23 2005-10-20 Harbor Biosciences, Inc. Immunomodulatory steroids, in particular the hemihydrate of 16.alpha.-bromoepiandrosterone
US20040097475A1 (en) * 2002-11-07 2004-05-20 Wuts Peter Guillaume Marie Processes for preparing C-7 substituted steroids

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHINN L J ET AL: "3 16-BETA 17-BETA DI HYDROXY-3-OXANDROST-4-EN-17-ALPHA-YL PROPIONIC-ACID GAMMA LACTONE ITS PREPARATION AND ANTI MINERALO CORTICOID ACTIVITY", JOURNAL OF MEDICINAL CHEMISTRY, vol. 16, no. 7, 1973, pages 839 - 843, XP002557791, ISSN: 0022-2623 *
See also references of WO2008039566A2 *

Also Published As

Publication number Publication date
WO2008039566A2 (fr) 2008-04-03
EP2486924A2 (fr) 2012-08-15
EP2012773B1 (fr) 2012-06-20
JP2012255033A (ja) 2012-12-27
HUE042925T2 (hu) 2019-07-29
EP2486924B1 (fr) 2018-12-26
JP2009534427A (ja) 2009-09-24
CA2649940C (fr) 2012-08-07
AU2007300404A1 (en) 2008-04-03
KR20080112413A (ko) 2008-12-24
DK2486924T3 (en) 2019-03-04
WO2008039566A3 (fr) 2008-11-27
IL194751A0 (en) 2009-08-03
DK2012773T3 (da) 2012-09-24
CA2649940A1 (fr) 2008-04-03
EP2012773A2 (fr) 2009-01-14
PL2486924T3 (pl) 2019-07-31
AU2010201023A1 (en) 2010-04-08
EP2486924A3 (fr) 2013-01-09
EA200802167A1 (ru) 2009-04-28
AU2007300404B2 (en) 2009-12-17
AU2010201023B2 (en) 2012-02-09
CN103211821A (zh) 2013-07-24
PL2012773T3 (pl) 2012-12-31
JP5130591B2 (ja) 2013-01-30
ES2389743T3 (es) 2012-10-31
ES2710288T3 (es) 2019-04-24

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