EP2016066A4 - Procédé de préparation de duloxétine - Google Patents

Procédé de préparation de duloxétine

Info

Publication number: EP2016066A4
Authority: EP; European Patent Office
Prior art keywords: preparing duloxetine; duloxetine; preparing
Prior art date: 2006-05-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP07762094A

Other languages

German (de)

English (en)

Other versions

EP2016066A2 (fr

Inventor

Srinivasalu Gudipati

Srinivas Katkam

Jaya Prakash Pitta

Prasad Ganji

Nageswara Rao Challa

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Dr Reddys Laboratories Ltd

Dr Reddys Laboratories Inc

Original Assignee

Dr Reddys Laboratories Ltd

Dr Reddys Laboratories Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-05-10

Filing date

2007-05-10

Publication date

2010-11-24

2007-05-10 Application filed by Dr Reddys Laboratories Ltd, Dr Reddys Laboratories Inc filed Critical Dr Reddys Laboratories Ltd

2009-01-21 Publication of EP2016066A2 publication Critical patent/EP2016066A2/fr

2010-11-24 Publication of EP2016066A4 publication Critical patent/EP2016066A4/fr

Status Withdrawn legal-status Critical Current

Links

ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 title 1
229960002866 duloxetine Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

EP07762094A 2006-05-10 2007-05-10 Procédé de préparation de duloxétine Withdrawn EP2016066A4 (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
IN828CH2006		2006-05-10
US80525406P	2006-06-20	2006-06-20
US82063606P	2006-07-28	2006-07-28
PCT/US2007/068667 WO2007134168A2 (fr)	2006-05-10	2007-05-10	Procédé de préparation de duloxétine

Publications (2)

Publication Number	Publication Date
EP2016066A2 EP2016066A2 (fr)	2009-01-21
EP2016066A4 true EP2016066A4 (fr)	2010-11-24

Family

ID=38694701

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP07762094A Withdrawn EP2016066A4 (fr)	2006-05-10	2007-05-10	Procédé de préparation de duloxétine

Country Status (2)

Country	Link
EP (1)	EP2016066A4 (fr)
WO (1)	WO2007134168A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2107057A1 (fr)	2008-04-04	2009-10-07	Ranbaxy Laboratories Limited	Procédé de préparation de duloxetine pur
EP2123626A1 (fr)	2008-05-21	2009-11-25	Laboratorios del Dr. Esteve S.A.	Co-cristaux de duloxétine et générateurs de co-cristaux pour le traitement de la douleur
EP2332930A1 (fr) *	2009-11-23	2011-06-15	Laboratorios Del. Dr. Esteve, S.A.	Sels de duloxétine et AINS pour le traitement de la douleur
WO2011077443A1 (fr) *	2009-12-22	2011-06-30	Biocon Limited	Procédé amélioré pour la préparation de chlorhydrate de duloxétine
CN114778707A (zh) *	2019-05-13	2022-07-22	南京制药厂有限公司	用液相色谱测定度洛西汀中间体酰胺的方法
CN113429380B (zh) *	2021-07-14	2022-07-01	新发药业有限公司	一种度洛西汀的制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005108386A1 (fr) *	2004-05-11	2005-11-17	Cipla Limited	Formes cristallines de base sans duloxetine
WO2006027798A2 (fr) *	2004-08-05	2006-03-16	Sun Pharmaceutical Industries Limited	Procede de preparation d'un compose antidepresseur
WO2006045255A1 (fr) *	2004-10-26	2006-05-04	Zentiva, A.S.	Procede de fabrication de (s)-n-methyl-3-(1-naphtyloxy)-3-(2-thienyl)propylamine hydrochlorure (duloxetine)
WO2006071868A2 (fr) *	2004-12-23	2006-07-06	Teva Pharmaceutical Industries Ltd.	Processus de preparation de sels de duloxetine repondant aux normes pharmaceutiques et d'intermediaires de ceux-ci
WO2007105021A2 (fr) *	2006-03-13	2007-09-20	EGIS GYÓGYSZERGYÁR, Nyilvánosan Müködö Részvénytársaság	Sels de duloxetine
WO2007119116A2 (fr) *	2005-12-12	2007-10-25	Medichem, S.A.	Procede perfectionne de synthese et de preparations de sels de duloxetine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5362886A (en) *	1993-10-12	1994-11-08	Eli Lilly And Company	Asymmetric synthesis
US5910319A (en) *	1997-05-29	1999-06-08	Eli Lilly And Company	Fluoxetine enteric pellets and methods for their preparation and use
DE69905938T2 (de) *	1998-11-13	2003-11-13	Eli Lilly And Co., Indianapolis	Kombination von duloxetin mit nichtsteroid-entzündungshemmern für die behandlung von schmerz

2007
- 2007-05-10 EP EP07762094A patent/EP2016066A4/fr not_active Withdrawn
- 2007-05-10 WO PCT/US2007/068667 patent/WO2007134168A2/fr not_active Ceased

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005108386A1 (fr) *	2004-05-11	2005-11-17	Cipla Limited	Formes cristallines de base sans duloxetine
WO2006027798A2 (fr) *	2004-08-05	2006-03-16	Sun Pharmaceutical Industries Limited	Procede de preparation d'un compose antidepresseur
WO2006045255A1 (fr) *	2004-10-26	2006-05-04	Zentiva, A.S.	Procede de fabrication de (s)-n-methyl-3-(1-naphtyloxy)-3-(2-thienyl)propylamine hydrochlorure (duloxetine)
WO2006071868A2 (fr) *	2004-12-23	2006-07-06	Teva Pharmaceutical Industries Ltd.	Processus de preparation de sels de duloxetine repondant aux normes pharmaceutiques et d'intermediaires de ceux-ci
WO2007119116A2 (fr) *	2005-12-12	2007-10-25	Medichem, S.A.	Procede perfectionne de synthese et de preparations de sels de duloxetine
WO2007105021A2 (fr) *	2006-03-13	2007-09-20	EGIS GYÓGYSZERGYÁR, Nyilvánosan Müködö Részvénytársaság	Sels de duloxetine

Also Published As

Publication number	Publication date
WO2007134168A2 (fr)	2007-11-22
WO2007134168A3 (fr)	2008-01-24
EP2016066A2 (fr)	2009-01-21

Legal Events

Date	Code	Title	Description
2008-12-19	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2009-01-21	17P	Request for examination filed	Effective date: 20081106
2009-01-21	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
2009-01-21	AX	Request for extension of the european patent	Extension state: AL BA HR MK RS
2009-08-19	DAX	Request for extension of the european patent (deleted)
2010-11-24	A4	Supplementary search report drawn up and despatched	Effective date: 20101026
2011-11-25	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2011-12-28	18D	Application deemed to be withdrawn	Effective date: 20110526

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ZA200904567B (en)	2010-09-29	Process for producing 2-isopropenyl-5-methyl-4-hexene-1-yl-3-methyl-2-butenoate
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