EP2021364B8 - Verbesserte antimikrobielle peptide - Google Patents

Verbesserte antimikrobielle peptide Download PDF

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Publication number
EP2021364B8
EP2021364B8 EP07748141.4A EP07748141A EP2021364B8 EP 2021364 B8 EP2021364 B8 EP 2021364B8 EP 07748141 A EP07748141 A EP 07748141A EP 2021364 B8 EP2021364 B8 EP 2021364B8
Authority
EP
European Patent Office
Prior art keywords
antimicrobial peptides
improved antimicrobial
improved
peptides
antimicrobial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP07748141.4A
Other languages
English (en)
French (fr)
Other versions
EP2021364A4 (de
EP2021364B1 (de
EP2021364A1 (de
Inventor
Artur Schmidtchen
Martin Malmsten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pergamum AB
Original Assignee
Pergamum AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pergamum AB filed Critical Pergamum AB
Publication of EP2021364A1 publication Critical patent/EP2021364A1/de
Publication of EP2021364A4 publication Critical patent/EP2021364A4/de
Application granted granted Critical
Publication of EP2021364B1 publication Critical patent/EP2021364B1/de
Publication of EP2021364B8 publication Critical patent/EP2021364B8/de
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP07748141.4A 2006-05-16 2007-05-15 Verbesserte antimikrobielle peptide Not-in-force EP2021364B8 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80064406P 2006-05-16 2006-05-16
SE0601088 2006-05-16
PCT/SE2007/000477 WO2007133153A1 (en) 2006-05-16 2007-05-15 Improved antimicrobial peptides

Publications (4)

Publication Number Publication Date
EP2021364A1 EP2021364A1 (de) 2009-02-11
EP2021364A4 EP2021364A4 (de) 2009-11-25
EP2021364B1 EP2021364B1 (de) 2014-04-09
EP2021364B8 true EP2021364B8 (de) 2014-05-21

Family

ID=38694156

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07748141.4A Not-in-force EP2021364B8 (de) 2006-05-16 2007-05-15 Verbesserte antimikrobielle peptide

Country Status (8)

Country Link
US (1) US8227406B2 (de)
EP (1) EP2021364B8 (de)
JP (1) JP5330230B2 (de)
KR (1) KR101487719B1 (de)
AU (1) AU2007250558B2 (de)
CA (1) CA2651990C (de)
MX (1) MX2008014415A (de)
WO (1) WO2007133153A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002328203C1 (en) 2001-08-24 2009-01-08 Migenix Inc. Antimicrobial and anti-inflammatory peptides
CA2691645A1 (en) * 2007-06-25 2008-12-31 Lipopeptide Ab New medical products
CZ301822B6 (cs) * 2008-03-04 2010-06-30 Ústav organické chemie a biochemie Akademie ved Ceské republiky, v.v.i. Peptid, zpusob jeho prípravy a jeho použití
EP2265631B1 (de) * 2008-03-04 2012-04-25 Ustav Organicke Chemie a Biochemie Akademie Ved Ceske Republiky, V.V.I. Neue antimikrobielle peptide und ihre anwendung
CZ301774B6 (cs) * 2008-06-10 2010-06-16 Ústav organické chemie a biochemie, Akademie ved CR v. v. i. Syntetické peptidy a jejich použití
GB0821721D0 (en) * 2008-11-27 2008-12-31 Hansa Medical Ab Antimicrobial therapy
JP2011178674A (ja) * 2010-02-26 2011-09-15 Tokai Univ 抗菌剤
WO2011113604A1 (en) * 2010-03-17 2011-09-22 Universität Regensburg Peptides or antibodies which bind to melanoma inhibitory activity (mia) protein
WO2012033450A1 (en) * 2010-09-07 2012-03-15 Dermagen Ab Novel antimicrobial peptides
US9187541B2 (en) 2011-04-27 2015-11-17 The Regents Of The University Of California Anti-microbial peptides and methods of use thereof
US9987316B2 (en) * 2012-09-14 2018-06-05 Case Western Reserve University Probiotic controlling fungi and uses thereof
HK1220903A1 (zh) 2013-03-29 2017-05-19 Merrimack Pharmaceuticals, Inc. 软骨结合型融合蛋白
KR101599587B1 (ko) * 2013-10-11 2016-03-14 건국대학교 산학협력단 다제내성균에 대한 항균, 항진균, 항염증 활성을 보이는 프로태티아마이신 항생펩타이드 유도체 및 그 용도
US20190204312A1 (en) * 2016-09-16 2019-07-04 Technische Universität München Magnetic particle-binding peptides
CN110279844A (zh) * 2019-01-31 2019-09-27 浙江星杭泰乐生物医药有限公司 人工合成抗菌肽在制备抑菌消炎祛痘化妆品或外用药物制剂中的应用及抑菌消炎祛痘组合物
WO2021042039A1 (en) * 2019-08-29 2021-03-04 Ajk Pharmaceutical Llc Synthetic antimicrobial peptides
AU2024224596A1 (en) * 2023-02-21 2025-08-07 Amferia Ab Endotoxin neutralising agent

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
SE459005B (sv) 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar
US5912230A (en) 1991-11-01 1999-06-15 Periodontix, Inc. Anti-fungal and anti-bacterial histatin-based peptides
US5593866A (en) 1992-08-21 1997-01-14 The University Of British Columbia Cationic peptides and method for production
US5733872A (en) 1993-03-12 1998-03-31 Xoma Corporation Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
WO1995013085A1 (en) 1993-11-08 1995-05-18 Demeter Biotechnologies Ltd. Methylated lysine-rich lytic peptides and method of making same by reductive alkylation
JP3459314B2 (ja) 1994-08-31 2003-10-20 社団法人農林水産技術情報協会 新規ペプチド、抗菌剤、新規ペプチド遺伝子、新規な組み換え体ｄｎａ及び新規ペプチドの製造法
GB9504761D0 (en) * 1995-03-09 1995-04-26 Unilever Plc Amphiphilic peptide and analogs thereof
US5834430A (en) 1995-05-31 1998-11-10 Biosynth S.R.L. Potentiation of antibiotics
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
US6503881B2 (en) 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
DE69903732T2 (de) * 1998-07-02 2003-07-03 Stichting Skeletal Tissue Engineering Group Amsterdam, Amsterdam Knochenzement mit antimikrobiellen peptiden
JP2004508801A (ja) 1999-10-29 2004-03-25 カイロン　ソチエタ　ア　レスポンサビリタ　リミタータ ナイセリア抗原性ペプチド
US20030083244A1 (en) 2000-04-26 2003-05-01 Vernet Corine A.M. Novel proteins and nucleic acids encoding same
AU2002328203C1 (en) * 2001-08-24 2009-01-08 Migenix Inc. Antimicrobial and anti-inflammatory peptides
DE10160170A1 (de) * 2001-12-07 2003-07-17 Ipf Pharmaceuticals Gmbh Neue antimikrobielle Bolisinpeptide
EP1581556A2 (de) 2002-08-15 2005-10-05 Leukotech A/S Bakterizide, antiapoptotischen, pro-entzuendlicher und entzündungshemmende peptide von heparin-binding protein (hbp) oder menschlichen elastase von neutrophilen
JP4154218B2 (ja) * 2002-11-27 2008-09-24 寛紀 高麗 新規抗菌性ポリペプチドとその利用
AU2003287824A1 (en) 2002-12-26 2004-07-22 Affinium Pharmaceuticals, Inc. Novel essential bacterial polypeptides
SE0301431D0 (sv) * 2003-05-19 2003-05-19 Dermagen Novel antimicrobial peptides
US20080175856A1 (en) 2003-05-30 2008-07-24 Intercell Ag Enterococcus Antigens
US7547173B2 (en) 2003-06-30 2009-06-16 Kyong-Ja Jung Method and apparatus for storing and transferring containers
US7504381B2 (en) 2004-09-27 2009-03-17 Technion Research & Development Foundation Ltd. Antimicrobial agents
CA2629751A1 (en) 2004-11-12 2006-05-18 The University Of British Columbia Antimicrobial peptides
SE0402807D0 (sv) * 2004-11-17 2004-11-17 Dermagen Ab Novel antimicrobial peptides

Also Published As

Publication number Publication date
US8227406B2 (en) 2012-07-24
EP2021364A4 (de) 2009-11-25
US20100159006A1 (en) 2010-06-24
AU2007250558A1 (en) 2007-11-22
EP2021364B1 (de) 2014-04-09
WO2007133153A8 (en) 2009-07-23
KR20090027213A (ko) 2009-03-16
CA2651990C (en) 2014-12-23
MX2008014415A (es) 2009-01-29
CA2651990A1 (en) 2007-11-22
AU2007250558B2 (en) 2012-10-25
EP2021364A1 (de) 2009-02-11
WO2007133153A1 (en) 2007-11-22
KR101487719B1 (ko) 2015-01-29
JP2009537515A (ja) 2009-10-29
JP5330230B2 (ja) 2013-10-30
HK1131789A1 (en) 2010-02-05

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