EP2027251A4 - Thermisches wechselbeanspruchungssystem - Google Patents
Thermisches wechselbeanspruchungssystemInfo
- Publication number
- EP2027251A4 EP2027251A4 EP07783905A EP07783905A EP2027251A4 EP 2027251 A4 EP2027251 A4 EP 2027251A4 EP 07783905 A EP07783905 A EP 07783905A EP 07783905 A EP07783905 A EP 07783905A EP 2027251 A4 EP2027251 A4 EP 2027251A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- thermal cycling
- cycling system
- thermal
- cycling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Rigid containers without fluid transport within
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/168—Specific optical properties, e.g. reflective coatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1838—Means for temperature control using fluid heat transfer medium
- B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/02—Water baths; Sand baths; Air baths
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
- B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12178744.4A EP2535427A3 (de) | 2006-05-17 | 2007-05-17 | Thermisches Wechselbeanspruchungssystem |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80117806P | 2006-05-17 | 2006-05-17 | |
| US83249206P | 2006-07-21 | 2006-07-21 | |
| US87317206P | 2006-12-06 | 2006-12-06 | |
| US87308406P | 2006-12-06 | 2006-12-06 | |
| PCT/US2007/069197 WO2008070198A2 (en) | 2006-05-17 | 2007-05-17 | Thermal cycling system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP2027251A2 EP2027251A2 (de) | 2009-02-25 |
| EP2027251A4 true EP2027251A4 (de) | 2010-05-05 |
Family
ID=39492885
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP07783905A Ceased EP2027251A4 (de) | 2006-05-17 | 2007-05-17 | Thermisches wechselbeanspruchungssystem |
| EP12178744.4A Withdrawn EP2535427A3 (de) | 2006-05-17 | 2007-05-17 | Thermisches Wechselbeanspruchungssystem |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP12178744.4A Withdrawn EP2535427A3 (de) | 2006-05-17 | 2007-05-17 | Thermisches Wechselbeanspruchungssystem |
Country Status (3)
| Country | Link |
|---|---|
| EP (2) | EP2027251A4 (de) |
| JP (1) | JP2009537152A (de) |
| WO (1) | WO2008070198A2 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010030647A1 (en) * | 2008-09-09 | 2010-03-18 | Douglas Machine Inc. | Apparatus and methods for performing real time pcr in array tape |
| WO2010088514A1 (en) | 2009-01-30 | 2010-08-05 | Micronics, Inc. | Portable high gain fluorescence detection system |
| US8900854B2 (en) * | 2009-03-31 | 2014-12-02 | Kanagawa Academy Of Science And Technology | Liquid reflux high-speed gene amplification device |
| CN202830041U (zh) * | 2009-04-03 | 2013-03-27 | Illumina公司 | 用于加热生物样本的设备 |
| GB2511693A (en) * | 2009-08-08 | 2014-09-10 | Bibby Scient Ltd | An apparatus for treating a test sample |
| GB2512764B (en) * | 2009-08-08 | 2014-12-24 | Bibby Scient Ltd | An apparatus for treating a test sample |
| JPWO2011021640A1 (ja) * | 2009-08-20 | 2013-01-24 | タカラバイオ株式会社 | 温度サイクル装置 |
| CN201837588U (zh) | 2009-09-09 | 2011-05-18 | 海利克斯公司 | 用于多个反应的光学系统 |
| JP5343801B2 (ja) * | 2009-09-30 | 2013-11-13 | 凸版印刷株式会社 | 遺伝子処理装置用伝熱装置及び遺伝子処理装置 |
| ES2363697B1 (es) | 2009-10-26 | 2012-04-20 | Ingenia Biosystems, S.L. | Aparato para el bloqueo de los ácidos nucleicos mediante fotoactivación de agentes intercalantes. |
| CN104611222B (zh) * | 2010-01-12 | 2017-05-24 | 阿赫姆生物系统公司 | 三阶段热对流装置及其用途 |
| US9132423B2 (en) | 2010-01-29 | 2015-09-15 | Micronics, Inc. | Sample-to-answer microfluidic cartridge |
| JP6117694B2 (ja) * | 2010-04-09 | 2017-04-19 | ライフ テクノロジーズ コーポレーション | 動的制御を用いた熱サイクラ器具に対する熱均一性改良 |
| US9170028B1 (en) | 2010-10-06 | 2015-10-27 | Lawrence Livermore National Security, Llc | Methods and compositions for rapid thermal cycling |
| EP2646542B1 (de) | 2010-12-03 | 2023-10-18 | BioFire Defense, LLC | Thermocycler-vorrichtung |
| JP5687514B2 (ja) * | 2011-02-17 | 2015-03-18 | 株式会社日立ハイテクノロジーズ | 核酸配列解析装置 |
| JP2012187054A (ja) * | 2011-03-11 | 2012-10-04 | Hitachi High-Technologies Corp | 核酸増幅反応装置 |
| EP2697657B8 (de) * | 2011-04-15 | 2017-08-16 | Becton, Dickinson and Company | Mikrofluidischer abtastender echtzeit-thermocycler und verfahren zur optischen detektion mittels synchronisierter thermozyklierung und abtastung |
| JP5663541B2 (ja) * | 2012-09-19 | 2015-02-04 | 株式会社日立ハイテクノロジーズ | 反応容器,並列処理装置、及びシーケンサ |
| US20140112829A1 (en) * | 2012-10-22 | 2014-04-24 | Qiagen Gaithersburg, Inc. | Tube strip handling and heating apparatus |
| WO2014100743A2 (en) | 2012-12-21 | 2014-06-26 | Micronics, Inc. | Low elasticity films for microfluidic use |
| EP2935908B1 (de) | 2012-12-21 | 2019-08-14 | PerkinElmer Health Sciences, Inc. | Fluidkreisläufe und zugehörige herstellungsverfahren |
| EP2935559B1 (de) | 2012-12-21 | 2020-09-16 | PerkinElmer Health Sciences, Inc. | Fluoreszenznachweissystem |
| US10386377B2 (en) | 2013-05-07 | 2019-08-20 | Micronics, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
| EP2994532B1 (de) | 2013-05-07 | 2017-11-15 | Micronics, Inc. | Verfahren zur herstellung von nukleinsäurehaltigen proben mittels tonmineralien und alkalischen lösungen |
| EP2994543B1 (de) | 2013-05-07 | 2018-08-15 | Micronics, Inc. | Vorrichtung zur herstellung und analyse von nukleinsäuren |
| US9352502B2 (en) | 2013-06-25 | 2016-05-31 | Lawrence Livermore National Security, Llc | Porous media heat transfer for injection molding |
| SG11201601275UA (en) | 2013-09-16 | 2016-04-28 | Life Technologies Corp | Apparatuses, systems and methods for providing thermocycler thermal uniformity |
| WO2015126621A1 (en) | 2014-02-18 | 2015-08-27 | Life Technologies Corporation | Apparatuses, systems and methods for providing scalable thermal cyclers and isolating thermoelectric devices |
| US11224873B2 (en) * | 2018-03-15 | 2022-01-18 | Kryptos Biotechnologies, Inc. | Microfluidic system incorporating light absorbing materials |
| CN109030133B (zh) * | 2018-06-14 | 2021-04-30 | 华东交通大学 | 一种t型试样制作试件的方法 |
| US11440015B2 (en) | 2018-08-08 | 2022-09-13 | Lawrence Livermore National Security, Llc | Integrated solid-state rapid thermo-cycling system |
| CN109168298A (zh) * | 2018-10-18 | 2019-01-08 | 中国科学院合肥物质科学研究院 | 一种用于pcr检测仪温控系统的散热装置 |
| EP3876881A4 (de) | 2018-11-09 | 2022-08-03 | Dignitana AB | Kopfhautkühlvorrichtung, -verfahren und -system |
| SG10201908290RA (en) * | 2019-09-09 | 2021-04-29 | Star Array Pte Ltd | Apparatus for polymerase chain reaction of nucleic acid |
| DE102022109312A1 (de) | 2021-05-05 | 2022-11-10 | Frieder Weidhase | Vorrichtung zum beschleunigten, miniaturisierten Kühlen und Heizen in der Medizintechnik |
| CN114854570B (zh) * | 2022-07-05 | 2022-09-02 | 鲲鹏基因(北京)科技有限责任公司 | 温控装置、液冷温控系统及pcr仪 |
| EP4630582A1 (de) * | 2022-12-08 | 2025-10-15 | Becton, Dickinson and Company | Vollautomatische dpcr-systeme und verfahren zur verwendung davon |
| DE102023131381A1 (de) * | 2023-11-10 | 2025-05-15 | Attomol Gmbh Molekulare Diagnostika | Kompakter Präzisions-ThermoCycler mit Wärmespeicher und Verfahren zur schnellen Temperierung von Proben |
| US12517073B2 (en) * | 2024-01-25 | 2026-01-06 | Futura Medical Developments Limited | Topical composition testing method and apparatus |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0363143A2 (de) * | 1988-10-06 | 1990-04-11 | Coy Corporation | Temperaturregelungsvorrichtung |
| JPH07185363A (ja) * | 1993-12-27 | 1995-07-25 | Shuji Ueda | 加熱冷却器 |
| US20020086417A1 (en) * | 2000-12-29 | 2002-07-04 | Shuqi Chen | Sample processing device and method |
| US20030157721A1 (en) * | 1998-08-13 | 2003-08-21 | Symyx Technologies, Inc. | Parallel reactor with internal sensing and method of using same |
| US20040178357A1 (en) * | 2003-02-28 | 2004-09-16 | Applera Corporation | Excitation and emission filter |
| WO2004105947A2 (en) * | 2003-05-23 | 2004-12-09 | Bio-Rad Laboratories, Inc. | Localized temperature control for spatial arrays of reaction media |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| KR100236506B1 (ko) * | 1990-11-29 | 2000-01-15 | 퍼킨-엘머시터스인스트루먼츠 | 폴리머라제 연쇄 반응 수행 장치 |
| US5440388A (en) | 1993-08-02 | 1995-08-08 | Erickson; Jon W. | Chemical analysis and imaging by discrete fourier transform spectroscopy |
| US5792610A (en) | 1996-05-01 | 1998-08-11 | Biorad Laboratories, Inc. | Method for conducting multiparametric fluorescence in situ hybridization |
| ATE428801T1 (de) * | 1996-06-04 | 2009-05-15 | Univ Utah Res Found | Überwachung der hybridisierung während pcr |
| JPH10117765A (ja) * | 1996-10-18 | 1998-05-12 | Ngk Insulators Ltd | 試料容器及びその製造方法 |
| US6207392B1 (en) | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| AU751280B2 (en) | 1997-12-12 | 2002-08-08 | Applera Corporation | Optical resonance analysis system |
| US6369893B1 (en) | 1998-05-19 | 2002-04-09 | Cepheid | Multi-channel optical detection system |
| GB9810350D0 (en) | 1998-05-14 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
| GB9812768D0 (en) | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
| US6037130A (en) | 1998-07-28 | 2000-03-14 | The Public Health Institute Of The City Of New York, Inc. | Wavelength-shifting probes and primers and their use in assays and kits |
| US6306658B1 (en) * | 1998-08-13 | 2001-10-23 | Symyx Technologies | Parallel reactor with internal sensing |
| JP2000214506A (ja) | 1998-11-03 | 2000-08-04 | Toshiba Research Europe Ltd | 放射光線源及び撮像システム |
| WO2000069561A1 (en) * | 1999-05-14 | 2000-11-23 | Hitachi Chemical Research Center, Inc. | Liquid metal-heating apparatus for biological/chemical sample |
| DE29917313U1 (de) * | 1999-10-01 | 2001-02-15 | MWG-BIOTECH AG, 85560 Ebersberg | Vorrichtung zur Durchführung chemischer oder biologischer Reaktionen |
| US6852986B1 (en) * | 1999-11-12 | 2005-02-08 | E. I. Du Pont De Nemours And Company | Fluorometer with low heat-generating light source |
| US6403037B1 (en) | 2000-02-04 | 2002-06-11 | Cepheid | Reaction vessel and temperature control system |
| US6783934B1 (en) | 2000-05-01 | 2004-08-31 | Cepheid, Inc. | Methods for quantitative analysis of nucleic acid amplification reaction |
| JP2003024063A (ja) * | 2001-07-12 | 2003-01-28 | Toshio Kawai | Dnaの連続増幅方法とその装置 |
| CN1537229A (zh) * | 2001-07-31 | 2004-10-13 | ���ְ�˹��ʽ���� | 基因检查装置和使用该装置检测靶核酸的方法 |
| AU2002336613A1 (en) | 2001-09-18 | 2003-04-01 | U.S. Genomics, Inc. | Differential tagging of polymers for high resolution linear analysis |
| US6928860B1 (en) * | 2002-02-08 | 2005-08-16 | King Refrigeration, Inc. | Heat-transfer-inhibiting motor and rotor |
| JP2004028775A (ja) * | 2002-06-25 | 2004-01-29 | Olympus Corp | 遺伝子検査装置およびそれを用いた検出方法 |
| US6998598B2 (en) | 2002-08-02 | 2006-02-14 | Sandia National Labroatories | Modular optical detector system |
| US7113624B2 (en) | 2002-10-15 | 2006-09-26 | Palo Alto Research Center Incorporated | Imaging apparatus and method employing a large linear aperture |
| KR100480637B1 (ko) | 2002-11-27 | 2005-03-31 | 삼성전자주식회사 | 고속의 프로그램 가능한 고정 우선 순위 및 라운드 로빈아비터 및 그 버스 제어 방법 |
| US20050136448A1 (en) | 2003-10-02 | 2005-06-23 | Dakota Technologies, Inc. | Apparatus and methods for fluorescent detection of nucleic acids |
| US20060134644A1 (en) | 2003-10-28 | 2006-06-22 | Dakota Technologies, Inc. | Apparatus and methods for detecting target analyte |
| US7122799B2 (en) | 2003-12-18 | 2006-10-17 | Palo Alto Research Center Incorporated | LED or laser enabled real-time PCR system and spectrophotometer |
| US7489401B2 (en) | 2004-03-01 | 2009-02-10 | National Institute Of Advanced Industrial Science And Technology | Device for detecting emission light of micro-object |
-
2007
- 2007-05-17 EP EP07783905A patent/EP2027251A4/de not_active Ceased
- 2007-05-17 WO PCT/US2007/069197 patent/WO2008070198A2/en not_active Ceased
- 2007-05-17 EP EP12178744.4A patent/EP2535427A3/de not_active Withdrawn
- 2007-05-17 JP JP2009511244A patent/JP2009537152A/ja active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0363143A2 (de) * | 1988-10-06 | 1990-04-11 | Coy Corporation | Temperaturregelungsvorrichtung |
| JPH07185363A (ja) * | 1993-12-27 | 1995-07-25 | Shuji Ueda | 加熱冷却器 |
| US20030157721A1 (en) * | 1998-08-13 | 2003-08-21 | Symyx Technologies, Inc. | Parallel reactor with internal sensing and method of using same |
| US20020086417A1 (en) * | 2000-12-29 | 2002-07-04 | Shuqi Chen | Sample processing device and method |
| US20040178357A1 (en) * | 2003-02-28 | 2004-09-16 | Applera Corporation | Excitation and emission filter |
| WO2004105947A2 (en) * | 2003-05-23 | 2004-12-09 | Bio-Rad Laboratories, Inc. | Localized temperature control for spatial arrays of reaction media |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009537152A (ja) | 2009-10-29 |
| EP2027251A2 (de) | 2009-02-25 |
| EP2535427A2 (de) | 2012-12-19 |
| WO2008070198A3 (en) | 2009-04-16 |
| WO2008070198A8 (en) | 2008-12-24 |
| WO2008070198A2 (en) | 2008-06-12 |
| EP2535427A3 (de) | 2013-04-24 |
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Legal Events
| Date | Code | Title | Description |
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| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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| 17P | Request for examination filed |
Effective date: 20081212 |
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| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR |
|
| AX | Request for extension of the european patent |
Extension state: AL BA HR MK RS |
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| R17D | Deferred search report published (corrected) |
Effective date: 20090416 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12Q 1/10 20060101ALI20090430BHEP Ipc: C12Q 1/68 20060101AFI20090430BHEP |
|
| A4 | Supplementary search report drawn up and despatched |
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