EP2033706A2 - Emulgierungsvorrichtung - Google Patents
Emulgierungsvorrichtung Download PDFInfo
- Publication number
- EP2033706A2 EP2033706A2 EP08014632A EP08014632A EP2033706A2 EP 2033706 A2 EP2033706 A2 EP 2033706A2 EP 08014632 A EP08014632 A EP 08014632A EP 08014632 A EP08014632 A EP 08014632A EP 2033706 A2 EP2033706 A2 EP 2033706A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- flow channel
- phase inlet
- continuous phase
- dispersion phase
- mixing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004945 emulsification Methods 0.000 title description 3
- 239000007788 liquid Substances 0.000 claims abstract description 65
- 230000001804 emulsifying effect Effects 0.000 claims abstract description 52
- 239000000839 emulsion Substances 0.000 claims abstract description 52
- 230000000149 penetrating effect Effects 0.000 claims abstract description 5
- 238000010030 laminating Methods 0.000 claims abstract description 4
- 239000006185 dispersion Substances 0.000 claims description 78
- 238000003475 lamination Methods 0.000 claims description 18
- 230000008859 change Effects 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 239000002245 particle Substances 0.000 description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 27
- 238000000034 method Methods 0.000 description 22
- 239000000463 material Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 6
- 238000012545 processing Methods 0.000 description 5
- 238000007789 sealing Methods 0.000 description 4
- 238000010008 shearing Methods 0.000 description 3
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000003754 machining Methods 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000009937 brining Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000009189 diving Effects 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
- B01F25/4335—Mixers with a converging-diverging cross-section
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
- B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
- B01F33/813—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles mixing simultaneously in two or more mixing receptacles
Definitions
- the particle diameter is equal, and also to obtain an emulsion particle having the relatively large particle diameter; however, with this method, a throughput flow of liquid is small, such as, 1 mL/min or more or less, for example, and therefore it is essential to provide the flow channels in parallel, in order to increase the throughput flow thereof.
- Fig. 3 is a perspective view for showing the above, but seeing it from a side of an emulsion deliver portion.
- each flow channel it should not be limited to the configuration shown in the present embodiment, but for example, the cross-section configuration of the continuous phase introductory flow channel 210, the sheath flow channel 212 or the enlarged flow channel 213 may be a rectangular. However, for the purpose of forming a stable sheath flow and obtaining a uniform emulsion particle, it is desirable that the cross-section configuration of the sheath flow channel 212 and the enlarged flow channel 213 are symmetric to the axis of the flow channel.
- the continuous phase inlet flow channels 302 are disposed to be symmetric to the axis of the dispersion phase inlet flow channel 211, i.e., the continuous phase is distributed by the continuous phase dividing flow channel 301, which is formed on the same plane, in the structures thereof.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Colloid Chemistry (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007230922A JP5023902B2 (ja) | 2007-09-06 | 2007-09-06 | 乳化装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP2033706A2 true EP2033706A2 (de) | 2009-03-11 |
| EP2033706A3 EP2033706A3 (de) | 2009-11-11 |
| EP2033706B1 EP2033706B1 (de) | 2012-11-28 |
Family
ID=40121803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP08014632A Ceased EP2033706B1 (de) | 2007-09-06 | 2008-08-18 | Emulgierungsvorrichtung |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2033706B1 (de) |
| JP (1) | JP5023902B2 (de) |
| CN (1) | CN101380553A (de) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8252239B2 (en) | 2009-05-22 | 2012-08-28 | Hitachi, Ltd. | Liquid-liquid extraction system |
| EP3520766A4 (de) * | 2016-09-30 | 2020-10-28 | Amorepacific Corporation | Vorrichtung zur herstellung einer kosmetischen zusammensetzung mit sofort emulgiertem emulsionsmaterial auf der basis eines mikrofluidischen kanals |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009090160A (ja) * | 2007-10-03 | 2009-04-30 | Fujifilm Corp | 乳化物または分散物の製造方法、並びにこれを含む食品、皮膚外用剤及び医薬品 |
| JP5081845B2 (ja) | 2009-02-10 | 2012-11-28 | 株式会社日立製作所 | 粒子製造装置 |
| KR101043895B1 (ko) | 2011-02-18 | 2011-06-22 | 최인수 | 고압력 호모게나이저용 분사 모듈 |
| EP3703662A4 (de) * | 2017-11-03 | 2021-12-22 | Mark A. Gray | Herstellung und dosierung von quanten |
| KR102023745B1 (ko) * | 2017-12-06 | 2019-09-20 | (주)아모레퍼시픽 | 순간 유화 화장품 제조 장치 |
| KR102016312B1 (ko) * | 2017-12-06 | 2019-08-30 | (주)아모레퍼시픽 | 피부 코팅 막 화장품 제조 장치 |
| KR102812194B1 (ko) * | 2024-05-08 | 2025-05-22 | 장승규 | 노즐조립체 및 이를 포함하는 노즐유닛과 초고압 균질기 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1142431A (ja) | 1997-07-25 | 1999-02-16 | Jiinasu:Kk | 微粒化方法および装置 |
| JP2004081924A (ja) | 2002-08-23 | 2004-03-18 | Yamatake Corp | マイクロ乳化器および乳化方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1142429A (ja) * | 1997-07-25 | 1999-02-16 | Jiinasu:Kk | 微粒化方法および装置 |
| JPH1142428A (ja) * | 1997-07-25 | 1999-02-16 | Jiinasu:Kk | 微粒化方法 |
| HU224664B1 (hu) * | 1997-09-25 | 2005-12-28 | Ge Bayer Silicones Gmbh & Co.Kg, | Berendezés és eljárás szilikonemulziók előállítására |
| JP3860186B2 (ja) * | 2001-02-23 | 2006-12-20 | 独立行政法人科学技術振興機構 | エマルションの製造装置 |
| JP2006507921A (ja) * | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体分散のための方法および装置 |
| AU2004229440B2 (en) * | 2003-04-10 | 2010-08-12 | President And Fellows Of Harvard College | Formation and control of fluidic species |
| DE10318061A1 (de) * | 2003-04-17 | 2004-10-28 | Behr Gmbh & Co. Kg | Mischvorrichtung |
| JP4042683B2 (ja) * | 2003-11-17 | 2008-02-06 | 東ソー株式会社 | 微小流路構造体及びこれを用いた微小粒子製造方法 |
| EP1757357B1 (de) * | 2004-03-23 | 2013-04-24 | Japan Science and Technology Agency | Verfahren und vorrichtung zur herstellung von mikrotröpfchen |
| JP4339163B2 (ja) * | 2004-03-31 | 2009-10-07 | 宇部興産株式会社 | マイクロデバイスおよび流体の合流方法 |
| JP5148811B2 (ja) * | 2004-06-29 | 2013-02-20 | 新日鉄住金化学株式会社 | ビスフェノール類の製造方法 |
| US20090034362A1 (en) * | 2005-09-29 | 2009-02-05 | Fujifilm Corporation | Microdevice and method for joining fluids |
-
2007
- 2007-09-06 JP JP2007230922A patent/JP5023902B2/ja not_active Expired - Fee Related
-
2008
- 2008-08-13 CN CNA2008102106433A patent/CN101380553A/zh active Pending
- 2008-08-18 EP EP08014632A patent/EP2033706B1/de not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1142431A (ja) | 1997-07-25 | 1999-02-16 | Jiinasu:Kk | 微粒化方法および装置 |
| JP2004081924A (ja) | 2002-08-23 | 2004-03-18 | Yamatake Corp | マイクロ乳化器および乳化方法 |
Non-Patent Citations (2)
| Title |
|---|
| J. MICROMECH. MICROENG., vol. 16, 2006, pages 23362344 |
| NAGASAWA, H.; AOKI, N.; MAE, K.: "Design of a new micromixer for instant mixing based on the collision of micro segments", CHEMICAL ENGINEERING AND TECHNOLOGY, vol. 28, 1 January 2005 (2005-01-01), pages 324 - 331 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8252239B2 (en) | 2009-05-22 | 2012-08-28 | Hitachi, Ltd. | Liquid-liquid extraction system |
| EP3520766A4 (de) * | 2016-09-30 | 2020-10-28 | Amorepacific Corporation | Vorrichtung zur herstellung einer kosmetischen zusammensetzung mit sofort emulgiertem emulsionsmaterial auf der basis eines mikrofluidischen kanals |
| US11534778B2 (en) | 2016-09-30 | 2022-12-27 | Amorepacific Corporation | Device for preparing cosmetic composition containing emulsion material instantly emulsified based on microfluidic channel |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2033706A3 (de) | 2009-11-11 |
| JP5023902B2 (ja) | 2012-09-12 |
| EP2033706B1 (de) | 2012-11-28 |
| CN101380553A (zh) | 2009-03-11 |
| JP2009061382A (ja) | 2009-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2033706A2 (de) | Emulgierungsvorrichtung | |
| JP4798174B2 (ja) | 乳化装置 | |
| JP4339163B2 (ja) | マイクロデバイスおよび流体の合流方法 | |
| EP1473077B1 (de) | Vorrichtung zur Mischung von Fluiden | |
| WO2004002627B1 (en) | Method and apparatus for fluid dispersion | |
| CA2236460A1 (en) | Method of producing dispersions and carrying out chemical reactions in the disperse phase | |
| US20140313849A1 (en) | Fluid mixer and fluid mixing method | |
| CN101873890A (zh) | 过程加强的微流体装置 | |
| EP2164617A1 (de) | Erzeugung von monodispersen tropfen | |
| Abate et al. | Air-bubble-triggered drop formation in microfluidics | |
| JP6924556B2 (ja) | マイクロリアクタ、化成品製造システム及びマイクロリアクタの製造方法 | |
| CN117504959B (zh) | 一种基于微管的微液滴产生装置及方法 | |
| JP5146562B2 (ja) | 微小流路構造体及び微小流路構造体による溶媒抽出方法 | |
| EP1930070A1 (de) | Mikrovorrichtung und verfahren zum zusammenführen von fluiden | |
| WO2024223458A2 (en) | Microfluidic mixing | |
| CN112495269A (zh) | 一种生成装置 | |
| JP3149372B2 (ja) | 多点衝突式微粒化装置 | |
| JP4946180B2 (ja) | 乳化装置 | |
| CN214076357U (zh) | 一种生成装置 | |
| WO2008082324A2 (en) | Plate multichannel cavitation reactor | |
| CN117482809A (zh) | 一种基于注射针头的微液滴产生装置及方法 | |
| KR102131252B1 (ko) | 유로 장치 및 액적 형성 방법 | |
| JP2005054023A (ja) | ポリマー粒子の製造方法 | |
| JP4640017B2 (ja) | 乳化装置 | |
| JP2004195338A (ja) | 粒子製造方法及びそのための微小流路構造体 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR |
|
| AX | Request for extension of the european patent |
Extension state: AL BA MK RS |
|
| PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
|
| AK | Designated contracting states |
Kind code of ref document: A3 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR |
|
| AX | Request for extension of the european patent |
Extension state: AL BA MK RS |
|
| 17P | Request for examination filed |
Effective date: 20091125 |
|
| 17Q | First examination report despatched |
Effective date: 20100127 |
|
| AKX | Designation fees paid |
Designated state(s): CH DE LI |
|
| GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
| RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: ENDO, YOSHISHIGE Inventor name: SUZUKI, MIO Inventor name: MIYAMOTO, TETSURO Inventor name: TOGASHI, SHIGENORI |
|
| GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
| GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
| AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): CH DE LI |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 602008020357 Country of ref document: DE Effective date: 20130124 |
|
| PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
| 26N | No opposition filed |
Effective date: 20130829 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R097 Ref document number: 602008020357 Country of ref document: DE Effective date: 20130829 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R082 Ref document number: 602008020357 Country of ref document: DE Representative=s name: BEETZ & PARTNER PATENT- UND RECHTSANWAELTE, DE |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R082 Ref document number: 602008020357 Country of ref document: DE Representative=s name: BEETZ & PARTNER MBB PATENT- UND RECHTSANWAELTE, DE Effective date: 20140218 Ref country code: DE Ref legal event code: R082 Ref document number: 602008020357 Country of ref document: DE Representative=s name: BEETZ & PARTNER MBB, DE Effective date: 20140218 Ref country code: DE Ref legal event code: R082 Ref document number: 602008020357 Country of ref document: DE Representative=s name: BEETZ & PARTNER MBB PATENTANWAELTE, DE Effective date: 20140218 Ref country code: DE Ref legal event code: R082 Ref document number: 602008020357 Country of ref document: DE Representative=s name: BEETZ & PARTNER PATENT- UND RECHTSANWAELTE, DE Effective date: 20140218 Ref country code: DE Ref legal event code: R081 Ref document number: 602008020357 Country of ref document: DE Owner name: HITACHI, LTD., JP Free format text: FORMER OWNER: HITACHI PLANT TECHNOLOGIES, LTD., TOKYO, JP Effective date: 20140218 |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130831 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130831 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20150811 Year of fee payment: 8 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 602008020357 Country of ref document: DE |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20170301 |