EP2037809A2 - Biocontenants auto-assemblés, à micro-motifs et protégés des fréquences radio (rf) et leurs utilisations pour une distribution à distance de composés chimiques contrôlée spatialement - Google Patents

Biocontenants auto-assemblés, à micro-motifs et protégés des fréquences radio (rf) et leurs utilisations pour une distribution à distance de composés chimiques contrôlée spatialement

Info

Publication number
EP2037809A2
EP2037809A2 EP07870998A EP07870998A EP2037809A2 EP 2037809 A2 EP2037809 A2 EP 2037809A2 EP 07870998 A EP07870998 A EP 07870998A EP 07870998 A EP07870998 A EP 07870998A EP 2037809 A2 EP2037809 A2 EP 2037809A2
Authority
EP
European Patent Office
Prior art keywords
particle
faces
dimensional
containers
pores
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07870998A
Other languages
German (de)
English (en)
Other versions
EP2037809A4 (fr
Inventor
David H. Gracias
Timothy Gar-Ming Leong
Hongke Ye
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/491,829 external-priority patent/US8236259B2/en
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of EP2037809A2 publication Critical patent/EP2037809A2/fr
Publication of EP2037809A4 publication Critical patent/EP2037809A4/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Medicinal compositions released by microdevices, e.g. microelectromechanical systems [MEMS], microdevices comprising chips or microdevices on silicon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Definitions

  • FIG. 1 Side view of adjacent faces at the onset of reflow of the folding hinge.
  • D-F Finite element snapshots showing (D) underfolded, (E) right- angle folded, and (F) overfolded faces.
  • G-I Optical microscope images of experimentally fabricated 200 ⁇ m cubes exhibiting the underfolded, right-angle folded, and overfolded faces. Note: Fig IB-F are not drawn to scale in order to illustrate important dimensions.
  • radio frequency refers to a frequency or interval of frequencies within the electromagnetic spectrum used for communications, usually defined as spanning from about 3 kHz to about 300 GHz, which corresponds to wavelengths of about 100 km to about 1 mm respectively.
  • treat or “treating” includes abrogating, substantially inhibiting, slowing or reversing the progression of a condition, substantially ameliorating clinical or symptoms of a condition, and substantially preventing the appearance of clinical or symptoms of a condition.
  • the therapeutic or beneficial effect can be curing, minimizing, preventing or ameliorating a disease or disorder, or may have any other therapeutic or pharmaceutical beneficial effect.
  • disease or “disorder,” as used herein, refers to an impairment of health or a condition of abnormal functioning.
  • the linear dimension of the container was orders of magnitude smaller than the wavelength of the oscillating magnetic field at 500 MHz, which is the highest operating frequency in our magnetic resonance (MR) scanners. Hence, the size of the perforations on the faces of the container had no detrimental effect on the shielding characteristics of the container.
  • the thickness of the faces of the container was designed to be larger than the conductor skin depth at the frequency of the radiation.
  • skin depth refers to a measure of the average depth of penetration of an electromagnetic field into a material. It is defined as the depth at which the primary electromagnetic (EM) field is attenuated by/decreases to (1/e) of the field at the surface, or to approximately 37 % of its value at the surface of the shield (A.
  • the beads were held together by weak van der Waals forces (meaning the weak intermolecular forces that arise from the transient polarization of a given molecule into a dipole) (Fig. 3B); the glass beads could be released by agitation of the container.
  • Fig. 4 shows MR images of a 900 ⁇ m diameter capillary containing a Cu (Fig. 4A) and a Ni (Fig. 4B) container embedded in agarose gel. A characteristic signature was observed for both the Cu and the Ni containers-there is a pronounced darkness in the region of each container.
  • the process used to fabricate the boxes consists of microfabrication and surface tension driven self-assembly [K.F. Harsh, V.M. Bright, & Y.C. Lee, Sens. Actuators A, vol. 77, 237-244, 1999; E.E. Hui, R. T. Howe, & M. S. Rodgers, in IEEE 13th Int. Con/, on Microelectromechanical Sys., 2002, pp. 602-607; R.R.A. Syms, E.M. Yeatman, V.M. Bright, & G.M. Whitesides, J. Microelectromechanical Sys., vol. 12, pp.
  • boxes could function as encapsulation devices, they were loaded with a variety of medically relevant constituents including gels, beads, liquids, and cells (Fig. 8).
  • Fig. 8 For easy visualization, boxes with all open faces were used. However, in real applications, boxes with only one open face for loading, with the other faces closed or porous, would be used.
  • Fig. 16 Shown in Fig. 16 (B-F) are illustrations of the finite element simulation for the folding process.
  • the folding hinge solder is in the form of a T- shaped right prism. On reflow, the solder liquefies and forms a rounded contour (Fig. 16C). Due to the high interfacial tension of the liquid solder ( ⁇ 481 mJ/m ) [White, D. W. G. Metall Trans. 1971, 2, 3067-3070], mere is a strong driving force to minimize the exposed interfacial area between the molten solder and the surrounding fluidic liquid. This driving force causes the solder to ball up which results in the rotation of adjacent faces. The fold angle is primarily controlled by the solder volume.
  • the microwell was fabricated by molding PDMS against an SU-8 photoresist master.
  • the diffusion and reaction medium was water.
  • Phenolphthalein-KOH Reaction (Fig. 24 d-f):
  • the indicator mixture for the phenolphthalein-KOH reaction was prepared by adding 0.25 mL of phenolphthalein solution to an aqueous polymeric solution composed of 1.0 g of Pluronic F68 dissolved in 10 mL water.
  • the alkaline mixture was prepared by adding 0.5 mL of 4M KOH(aq) [Sigma- Aldrich, www.sigma-aldrich.com] to an aqueous polymeric solution composed of 1.0 g Pluronic F68 and 10 mL water.
  • Two containers were loaded with the phenolphthalein solution and one with the KOH solution.
  • the three containers were then placed into a PDMS microwell, with water as the diffusion and reaction medium.
  • the reactions were also imaged using a stereozoom binocular microscope.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne une particule à échelle nanométrique ou micrométrique pour l'encapsulation et la distribution de matériaux ou substances, y compris mais non inclusivement: des cellules, des médicaments, des tissus, des gels et des polymères contenus dans la particule, suivies de la libération des substances thérapeutiques in situ. L'invention concerne également des procédés de préparation de la particule par repliement d'un précurseur 2D dans la particule 3D, et l'utilisation de la particule pour des applications in vivo ou in vitro. La particule peut avoir n'importe quelle forme polyédrique et ses surfaces peuvent ne présenter aucune perforation ou présenter des perforations à échelle nanométrique ou micrométrique. La particule est revêtue d'une couche biocompatible métallique, par exemple l'or, ou un polymère, par exemple, le parylène, et les surfaces et charnières de la particule sont constituées d'une quelconque combinaison de métaux ou de polymères.
EP07870998A 2006-06-23 2007-06-25 Biocontenants auto-assemblés, à micro-motifs et protégés des fréquences radio (rf) et leurs utilisations pour une distribution à distance de composés chimiques contrôlée spatialement Withdrawn EP2037809A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81606306P 2006-06-23 2006-06-23
US11/491,829 US8236259B2 (en) 2005-07-22 2006-07-24 Self-assembled, micropatterned, and radio frequency (RF) shielded biocontainers
PCT/US2007/072029 WO2008108862A2 (fr) 2006-06-23 2007-06-25 Biocontenants auto-assemblés, à micro-motifs et protégés des fréquences radio (rf) et leurs utilisations pour une distribution à distance de composés chimiques contrôlée spatialement

Publications (2)

Publication Number Publication Date
EP2037809A2 true EP2037809A2 (fr) 2009-03-25
EP2037809A4 EP2037809A4 (fr) 2012-11-21

Family

ID=39738947

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07870998A Withdrawn EP2037809A4 (fr) 2006-06-23 2007-06-25 Biocontenants auto-assemblés, à micro-motifs et protégés des fréquences radio (rf) et leurs utilisations pour une distribution à distance de composés chimiques contrôlée spatialement

Country Status (4)

Country Link
EP (1) EP2037809A4 (fr)
JP (1) JP5451385B2 (fr)
CA (1) CA2656648A1 (fr)
WO (1) WO2008108862A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013013328A (ja) * 2009-10-30 2013-01-24 Univ Of Tokyo 折り畳み可能な構造体を含むデバイス
US9630178B2 (en) * 2010-03-17 2017-04-25 Ut-Battelle, Llc Method for preparing small volume reaction containers
CA2883080A1 (fr) * 2011-08-26 2013-03-07 Vecoy Nanomedicines Ltd. Pieges d'agents pathogenes et de substances
US9058552B2 (en) 2011-10-26 2015-06-16 International Business Machines Corporation RFID tag temperature adaptation
US11331085B2 (en) * 2014-10-16 2022-05-17 The Johns Hopkins University Bioresorbable self-folding tools for surgery, single cell capture and manipulation
WO2018034097A1 (fr) * 2016-08-17 2018-02-22 国立研究開発法人物質・材料研究機構 Procédé d'encapsulation de cellule et cellule encapsulée

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2369392A (en) * 1942-07-21 1945-02-13 Nat Folding Box Co Hinged cover container
GB9203037D0 (en) * 1992-02-11 1992-03-25 Salutar Inc Contrast agents
CA2629685A1 (fr) * 2005-07-22 2007-02-01 Johns Hopkins University Bioconteneurs auto-assembles, microstructures, et blindes en radiofrequence

Also Published As

Publication number Publication date
WO2008108862A2 (fr) 2008-09-12
WO2008108862A3 (fr) 2008-11-06
CA2656648A1 (fr) 2008-09-12
JP5451385B2 (ja) 2014-03-26
EP2037809A4 (fr) 2012-11-21
JP2009541490A (ja) 2009-11-26

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