EP2054384A4 - Promédicaments hydrosolubles chargés positivement contenant des acides aryl- et hétéroarylpropioniques et dotés d'une très grande vitesse de pénétration cutanée - Google Patents

Promédicaments hydrosolubles chargés positivement contenant des acides aryl- et hétéroarylpropioniques et dotés d'une très grande vitesse de pénétration cutanée

Info

Publication number: EP2054384A4
Authority: EP; European Patent Office
Prior art keywords: positively; high speed; skin penetration; charged water; containing aryl
Prior art date: 2006-08-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP06795662A

Other languages

German (de)

English (en)

Other versions

EP2054384A1 (fr

Inventor

Chongxi Yu

Lina Xu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

YU, CHONGXI

Techfields Biochem Co Ltd

Original Assignee

Techfields Biochem Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-08-15

Filing date

2006-08-15

Publication date

2010-11-03

2006-08-15 Application filed by Techfields Biochem Co Ltd filed Critical Techfields Biochem Co Ltd

2009-05-06 Publication of EP2054384A1 publication Critical patent/EP2054384A1/fr

2010-11-03 Publication of EP2054384A4 publication Critical patent/EP2054384A4/fr

Status Pending legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Immunology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pyrrole Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)

EP06795662A 2006-08-15 2006-08-15 Promédicaments hydrosolubles chargés positivement contenant des acides aryl- et hétéroarylpropioniques et dotés d'une très grande vitesse de pénétration cutanée Pending EP2054384A4 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IB2006/052815 WO2008020270A1 (fr)	2006-08-15	2006-08-15	Promédicaments hydrosolubles chargés positivement contenant des acides aryl- et hétéroarylpropioniques et dotés d'une très grande vitesse de pénétration cutanée

Publications (2)

Publication Number	Publication Date
EP2054384A1 EP2054384A1 (fr)	2009-05-06
EP2054384A4 true EP2054384A4 (fr)	2010-11-03

Family

ID=39081992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP06795662A Pending EP2054384A4 (fr)	2006-08-15	2006-08-15	Promédicaments hydrosolubles chargés positivement contenant des acides aryl- et hétéroarylpropioniques et dotés d'une très grande vitesse de pénétration cutanée

Country Status (6)

Country	Link
EP (1)	EP2054384A4 (fr)
JP (1)	JP5424880B2 (fr)
CN (1)	CN101506161B (fr)
AU (1)	AU2006347391B2 (fr)
CA (1)	CA2660814C (fr)
WO (1)	WO2008020270A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20090221703A1 (en)	2006-07-09	2009-09-03	Chongxi Yu	High penetration composition and uses thereof
US20090238763A1 (en)	2006-07-09	2009-09-24	Chongxi Yu	High penetration compositions and uses thereof
HUE033687T2 (en) *	2006-07-18	2017-12-28	Techfields Biochem Co Ltd	Ibuprofen positively charged water soluble prodrugs with very fast skin penetration rates
CA2665081C (fr)	2006-10-02	2015-12-01	Techfields Biochem Co. Ltd	Promedicaments hydrosolubles de prostaglandines et composes analogues, positivement charges, a taux de penetration cutanee tres eleve
EP2091914A4 (fr)	2006-11-08	2010-12-29	Chongxi Yu	Systèmes de libération transdermique de peptides et composés associés
EP2656879B1 (fr)	2006-12-10	2017-06-28	Chongxi Yu	Systèmes d'administration transdermique d'antibiotiques de beta-lactame
CN107652212B (zh)	2007-01-15	2019-11-15	于崇曦	维生素a酸类和类维生素a酸化合物的前药
WO2008093173A1 (fr)	2007-01-31	2008-08-07	Chongxi Yu	Promédicaments hydrosolubles à charge positive de 1h-imidazo[4, 5-c]quinolin-4-amines et composés associés à taux élevés de pénétration cutanée
JP2010529101A (ja)	2007-06-04	2010-08-26	テックフィールズインコーポレイテッド	非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
CN108191846B (zh)	2008-12-04	2021-08-20	于崇曦	高穿透性组合物及其应用
EP2660247A3 (fr)	2009-05-08	2014-09-03	Chongxi Yu	Compositions de promédicaments à pénétration élevée de peptides et composés associés au peptide
US9969751B2 (en)	2009-06-10	2018-05-15	Techfields Pharma Co., Ltd.	High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
HK1207562A1 (en)	2012-01-18	2016-02-05	苏州泰飞尔医药有限公司	High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions
BR112015022896B1 (pt)	2013-03-15	2022-08-23	Chongxi Yu	Composto de fármacos de alta penetração, composição farmacêutica e seus usos para o tratamento de doenças de parkinson
JP5940036B2 (ja) *	2013-10-08	2016-06-29	テックフィールズバイオケムカンパニーリミテッド	非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ
EA201790806A1 (ru)	2014-11-05	2017-11-30	Флексус Байосайенсиз, Инк.	Иммунорегулирующие средства
US20160168108A1 (en)	2014-12-16	2016-06-16	Adt Pharmaceuticals, Inc.	Method of treating or preventing ras-mediated diseases
US9862698B2 (en)	2014-12-16	2018-01-09	Adt Pharmaceuticals, Inc.	Indenyl compounds, pharmaceutical compositions, and medical uses thereof
JP6290947B2 (ja) *	2016-02-05	2018-03-07	テックフィールズバイオケムカンパニーリミテッド	非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ
US11186596B2 (en)	2018-04-26	2021-11-30	Adt Pharmaceuticals, Llc	Anticancer indenes, indanes, azaindenes, azaindanes, pharmaceutical compositions and uses
KR20220035334A (ko) *	2020-09-09	2022-03-22	난징 헤론 파마슈티컬 사이언스 앤 테크놀로지 컴퍼니 리미티드	아릴프로피온산 유도체, 약학적 조성물 및 이의 제조방법과 응용
CN114957270B (zh) *	2021-02-25	2025-12-05	南京赛弗斯医药科技有限公司	一种s（+）-普拉洛芬衍生物及其制备方法与用途
CN117916219A (zh) *	2021-07-06	2024-04-19	石家庄迪斯凯威医药科技有限公司	一类抗膀胱癌的季胺盐化合物及其应用
WO2023046078A1 (fr) *	2021-09-24	2023-03-30	石家庄迪斯凯威医药科技有限公司	Nouveau dérivé de pranoprofène, composition pharmaceutique et leur utilisation
EP4512797A4 (fr) *	2022-04-19	2025-07-30	Shijiazhuang Discovery Medicine Tech Co Ltd	Dérivé d'acide arylpropionique chiral et composition pharmaceutique à base de celui-ci, et utilisation associée

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1377316A (en) *	1972-06-27	1974-12-11	Syntex Corp	Dialkylaminoalkyl esters of arylaliphatic acids and acid addition salts thereof
US3896145A (en) *	1972-07-24	1975-07-22	Hoffmann La Roche	Carbazoles
GB1573322A (en) *	1975-12-24	1980-08-20	Hisamitsu Pharmaceutical Co	Phenylactic acid ester derivatives
JPS58126846A (ja) *	1982-01-22	1983-07-28	Kaken Pharmaceut Co Ltd	プロピオン酸アミノアルキルエステル誘導体、その製法およびそれを有効成分とする消炎、鎮痛剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1593024A (fr) *	1968-09-18	1970-05-25
ZA738203B (en) *	1972-10-24	1975-05-28	Janssen Pharmaceutica Nv	Aroyl-substituted phenylacetic acid derivatives
IT1090782B (it) *	1977-11-30	1985-06-26	Menarini Sas	2 4 bifenilil 2 dietilamino alchil propionamide suoi sali e procedimenti di fabbricazione relativi
JPS6452742A (en) *	1987-04-27	1989-02-28	Syntex Pharma Int	Omega-quaternary ammonium alkyl ester and thioester of acidic non-steroidal antiinflammatory
IT1317826B1 (it) *	2000-02-11	2003-07-15	Dompe Spa	Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.
ITMI20010395A1 (it) *	2001-02-27	2002-08-27	Dompe Spa	Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate
ITMI20012025A1 (it) *	2001-09-28	2003-03-28	Dompe Spa	Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono

2006
- 2006-08-15 EP EP06795662A patent/EP2054384A4/fr active Pending
- 2006-08-15 CA CA2660814A patent/CA2660814C/fr not_active Expired - Lifetime
- 2006-08-15 WO PCT/IB2006/052815 patent/WO2008020270A1/fr not_active Ceased
- 2006-08-15 CN CN2006800556054A patent/CN101506161B/zh not_active Expired - Fee Related
- 2006-08-15 AU AU2006347391A patent/AU2006347391B2/en not_active Ceased
- 2006-08-15 JP JP2009524242A patent/JP5424880B2/ja not_active Expired - Fee Related

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1377316A (en) *	1972-06-27	1974-12-11	Syntex Corp	Dialkylaminoalkyl esters of arylaliphatic acids and acid addition salts thereof
US3896145A (en) *	1972-07-24	1975-07-22	Hoffmann La Roche	Carbazoles
GB1573322A (en) *	1975-12-24	1980-08-20	Hisamitsu Pharmaceutical Co	Phenylactic acid ester derivatives
JPS58126846A (ja) *	1982-01-22	1983-07-28	Kaken Pharmaceut Co Ltd	プロピオン酸アミノアルキルエステル誘導体、その製法およびそれを有効成分とする消炎、鎮痛剤

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JARKKO RAUTIO ET AL: "Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 11, no. 2, 1 August 2000 (2000-08-01), pages 157 - 163, XP055049945, ISSN: 0928-0987, DOI: 10.1016/S0928-0987(00)00090-7 *
KAGAKU: "JPS58126846A -PROPIONIC ACID AMINOALKYL ESTER DERIVATIVE, ITS PREPARATION AND ANTIPHLOGISTIC AND ANALGESIC AGENT CONTAINING SAID DERIVATIVE AS ACTIVE COMPONENT", 28 July 1983 (1983-07-28), XP055442267, Retrieved from the Internet <URL:file:///C:/Users/MH52034/Desktop/JPS58126846%20translation.pdf> [retrieved on 20180118] *
No further relevant documents disclosed *
See also references of WO2008020270A1 *
SHANBHAG V R: "ESTER AND AMIDE PRODRUGS OF IBUPROFEN AND NAPROXEN: SYNTHESIS, ANTI-INFLAMMATORY ACTIVITY, AND GASTROINTESTINAL TOXICITY", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION, WASHINGTON, US, vol. 81, no. 2, 1 February 1992 (1992-02-01), pages 149 - 154, XP000248778, ISSN: 0022-3549, DOI: 10.1002/JPS.2600810210 *

Also Published As

Publication number	Publication date
CA2660814A1 (fr)	2008-02-21
CN101506161B (zh)	2013-11-13
CA2660814C (fr)	2017-07-18
HK1137425A1 (en)	2010-07-30
AU2006347391A1 (en)	2008-02-21
CN101506161A (zh)	2009-08-12
AU2006347391B2 (en)	2013-03-07
JP5424880B2 (ja)	2014-02-26
EP2054384A1 (fr)	2009-05-06
WO2008020270A1 (fr)	2008-02-21
JP2010500989A (ja)	2010-01-14

Legal Events

Date	Code	Title	Description
2009-04-03	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2009-05-06	17P	Request for examination filed	Effective date: 20090220
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