EP2069376A4 - Induction de réponses immunes cellulaires au virus de la grippe grâce à des compositions de peptides et d'acides nucléiques - Google Patents

Induction de réponses immunes cellulaires au virus de la grippe grâce à des compositions de peptides et d'acides nucléiques

Info

Publication number
EP2069376A4
EP2069376A4 EP07861332.0A EP07861332A EP2069376A4 EP 2069376 A4 EP2069376 A4 EP 2069376A4 EP 07861332 A EP07861332 A EP 07861332A EP 2069376 A4 EP2069376 A4 EP 2069376A4
Authority
EP
European Patent Office
Prior art keywords
peptide
nucleic acid
influenza virus
immune responses
cellular immune
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07861332.0A
Other languages
German (de)
English (en)
Other versions
EP2069376A2 (fr
Inventor
Jeffery L Alexander
Scott F Southwood
Pamuk A Bisel
Mark J Newman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmexa Inc
Original Assignee
Pharmexa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmexa Inc filed Critical Pharmexa Inc
Publication of EP2069376A2 publication Critical patent/EP2069376A2/fr
Publication of EP2069376A4 publication Critical patent/EP2069376A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A61K2039/645—Dendrimers; Multiple antigen peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
EP07861332.0A 2006-07-21 2007-07-23 Induction de réponses immunes cellulaires au virus de la grippe grâce à des compositions de peptides et d'acides nucléiques Withdrawn EP2069376A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83211206P 2006-07-21 2006-07-21
PCT/US2007/016529 WO2008039267A2 (fr) 2006-07-21 2007-07-23 Induction de réponses immunes cellulaires au virus de la grippe grâce à des compositions de peptides et d'acides nucléiques

Publications (2)

Publication Number Publication Date
EP2069376A2 EP2069376A2 (fr) 2009-06-17
EP2069376A4 true EP2069376A4 (fr) 2013-10-16

Family

ID=39230737

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07861332.0A Withdrawn EP2069376A4 (fr) 2006-07-21 2007-07-23 Induction de réponses immunes cellulaires au virus de la grippe grâce à des compositions de peptides et d'acides nucléiques

Country Status (4)

Country Link
EP (1) EP2069376A4 (fr)
AU (1) AU2007300663A1 (fr)
CA (1) CA2658559A1 (fr)
WO (1) WO2008039267A2 (fr)

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WO2009053535A2 (fr) * 2007-10-26 2009-04-30 Glykos Finland Oy Vaccin peptidique contre le virus de la grippe
PT2170365T (pt) * 2007-06-25 2016-07-12 Autoimmune Tech Llc Composições e métodos inibidores de influenza
EA017887B1 (ru) * 2007-08-02 2013-03-29 Байондвакс Фармасьютикалз Лтд. Полимерные мультиэпитопные вакцины против гриппа
FI20080333A0 (fi) * 2008-05-02 2008-05-02 Glykos Finland Oy Influenssaviruksen nukleiinihappoja ja peptidejä
WO2010058236A1 (fr) * 2008-11-19 2010-05-27 Laboratorio Avi-Mex, S.A. De C.V. Vaccin recombinant à vecteur viral inactivé
US8282938B2 (en) * 2008-11-28 2012-10-09 National Institute Of Infectious Diseases Immunogenic compositions comprising liposomes and an influenza PB2 CTL epitope obtained from the highly pathogenic H5N1 strain
WO2010088393A2 (fr) * 2009-01-28 2010-08-05 Antigen Express, Inc. Peptides hybrides li-key modulant la réponse immunitaire à la grippe
EP2391635B1 (fr) 2009-01-28 2017-04-26 Epimmune Inc. Polypeptides de liaison de pan-dr et leurs utilisations
CN101792745B (zh) * 2009-02-04 2014-09-17 中国科学院生物物理研究所 流感病毒聚合酶亚基pa氨基端多肽的表达纯化及pa氨基端多肽的晶体结构
CN101565455B (zh) * 2009-05-25 2012-03-14 中国科学院微生物研究所 禽流感h5n1病毒的ctl表位多肽及其应用
CA2761733C (fr) * 2009-06-01 2019-01-08 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health Reactifs et procedes de detection de proteines du virus de la grippe
JP5903045B2 (ja) 2009-07-31 2016-04-13 パックスバックス， インコーポレイテッド アデノウイルスに基づくベクター
US9265822B2 (en) * 2009-09-30 2016-02-23 Saint Louis University Peptides for inducing heterosubtypic influenza T cell responses
CN102153621B (zh) * 2010-02-12 2014-07-02 广东省疾病预防控制中心 新型甲型h1n1流感na蛋白b细胞表位及其应用
EP2536747B1 (fr) * 2010-02-19 2017-09-27 Université de Liège Un polynucleotide pour l'utilisation dans les traitements de maldies induites par des virus influenza a virus, codant pour une proteine modifiee, cette proteine modifiee et un animal transgénique exprimant un gène codant pour cette protéine modifiée
WO2011138032A2 (fr) * 2010-05-05 2011-11-10 Artemev, Timur Vaccins antigrippaux universels et leurs procédés de production
NZ607996A (en) 2010-09-22 2014-07-25 Alios Biopharma Inc Substituted nucleotide analogs
WO2012114323A1 (fr) 2011-02-22 2012-08-30 Biondvax Pharmaceuticals Ltd. Polypeptides multimères multi-épitopes utilisés dans des vaccins contre la grippe saisonnière et pandémique
WO2013059403A1 (fr) * 2011-10-19 2013-04-25 Immunotope, Inc. Immunogènes induisant des lymphocytes t cytotoxiques pour prévenir, traiter, et diagnostiquer l'infection par le virus de l'influenza
CA2860234A1 (fr) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Analogues de nucleotide phosphorothioate substitue
WO2013093514A2 (fr) * 2011-12-23 2013-06-27 Retroscreen Virology Ltd Vaccins - peptides
HK1206362A1 (zh) 2012-03-21 2016-01-08 Alios Biopharma, Inc. 硫代氨基磷酸酯核苷酸前藥的固體形式
WO2013142157A1 (fr) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Combinaisons pharmaceutiques comprenant un analogue thionucléotidique
CN109045294A (zh) * 2013-01-10 2018-12-21 思齐乐 流感病毒免疫原性组合物及其应用
CN103333224B (zh) * 2013-05-10 2015-03-25 中国农业科学院哈尔滨兽医研究所 禽流感病毒ns1蛋白b细胞抗原表位多肽及其应用
WO2015186721A1 (fr) * 2014-06-03 2015-12-10 国立研究開発法人農業・食品産業技術総合研究機構 Anticorps ou fragment d'anticorps comprenant une région variable de celui-ci, polypeptide antigénique et utilisations de ceux-ci
KR20190129032A (ko) 2016-12-28 2019-11-19 인벡스, 인크. 인플루엔자 백신
CN106589105B (zh) * 2017-01-23 2020-09-15 中国医科大学 Hla-a2限制性ecm1特异性的ctl表位肽及其应用
US11517617B2 (en) 2017-09-08 2022-12-06 The University Of Melbourne Methods and compositions for preventing influenza infection
CN111315407B (zh) 2018-09-11 2023-05-02 上海市公共卫生临床中心 一种广谱抗流感疫苗免疫原及其应用
US12247053B2 (en) 2018-10-26 2025-03-11 Saint Louis University Peptides for inducing heterosubtypic influenza T cell responses
EP4168429A1 (fr) * 2020-06-19 2023-04-26 Intervet International B.V. Vaccin contre le virus de la grippe porcine comprenant une construction d'acide nucléique comprenant des première, deuxième et troisième séquences d'acide nucléique codant pour des antigènes de neuraminidase distincts du virus
CN115836082A (zh) * 2020-06-19 2023-03-21 英特维特国际股份有限公司 包含编码特定病毒谱系抗原的核酸构建体的甲型猪流感病毒疫苗
US20230270838A1 (en) * 2020-08-02 2023-08-31 Richard Ascione Vaccine compositions for influenza viruses and methods of use
WO2022046895A2 (fr) * 2020-08-25 2022-03-03 Genentech, Inc. Dosages et réactifs pour la caractérisation de liaison peptidique mhci
CN116410271B (zh) * 2023-03-13 2024-07-19 华南农业大学 H5n1亚型aiv mhc b1限制性t细胞表位肽及其应用
CN120004989B (zh) * 2025-01-16 2025-12-05 华南农业大学 H5n1亚型aiv mhc b4限制性t细胞表位肽及其筛选方法和应用

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SIDNEY J ET AL: "SPECIFICITY AND DEGENERACY IN PEPTIDE BINDING TO HLA-B7-LIKE CLASS I MOLECULES", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 157, no. 8, 15 October 1996 (1996-10-15), pages 3480 - 3490, XP002055572, ISSN: 0022-1767 *
THRELKELD S C ET AL: "Degenerate and promiscuous recognition by CTL of peptides presented by the MHC class I A3-like superfamily: implications for vaccine development.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 AUG 1997, vol. 159, no. 4, 15 August 1997 (1997-08-15), pages 1648 - 1657, XP002712184, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
WO2008039267A3 (fr) 2008-12-31
AU2007300663A1 (en) 2008-04-03
EP2069376A2 (fr) 2009-06-17
CA2658559A1 (fr) 2008-04-03
WO2008039267A2 (fr) 2008-04-03

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