Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
  • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
  • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
  • A61M15/0033—Details of the piercing or cutting means
  • A61M15/0035—Piercing means
  • A61M15/0036—Piercing means hollow piercing means
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
  • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
  • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
  • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
  • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
  • A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
  • A61M15/0055—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2202/00—Special media to be introduced, removed or treated
  • A61M2202/06—Solids
  • A61M2202/064—Powder

Definitions

• the present invention relates to a fluid dispenser device, and more particularly to a dry powder inhaler.
• Inhalers are well known in the state of the art. There are different kinds.
• a first type of inhaler contains a reservoir receiving a multitude of doses of powder, the inhaler being provided with dosing means allowing each actuation to separate a dose of this powder from the reservoir to bring it into an expulsion conduit to to be distributed to the user.
• Inhalers with individual reservoirs, such as capsules, which are to be loaded into the inhaler just prior to use thereof have also been described in the state of the art.
• the advantage of these devices is that it is not necessary to store all the doses inside the device, so that it can be reduced in size. By cons, the use is more complex, since the user is obliged to load a capsule in the inhaler before each use.
• inhaler Another type of inhaler is to package the doses of powder in pre-dosed individual tanks, then to open one of these tanks each actuation of the inhaler. This implementation ensures a better seal of the powder, since each dose is open at the time of its expulsion.
• various variants have already been proposed, such as an elongated blister strip or blisters arranged on a rotating circular disk. All types of inhalers described above and existing have advantages and disadvantages related to their structure and operation. Thus, with some inhalers, there is the problem of accuracy and reproducibility of the dosage at each actuation.
• the effectiveness of the distribution is also a problem with a number of inhalers.
• One solution to this specific problem has been to synchronize the expulsion of the dose with the inhalation of the patient. Again, this could cause drawbacks, that generally in this type of device, the dose is loaded into an expulsion conduit prior to inhalation, and then the expulsion is synchronized with the inhalation.
• the present invention aims to provide a fluid dispenser device, in particular a dry powder inhaler that does not reproduce the aforementioned drawbacks.
• the present invention aims to provide such an inhaler that is simple and inexpensive to manufacture and assemble, reliable of use, guaranteeing an accuracy of dosing and a reproducibility of the dosage at each actuation, providing an optimal yield as for the effectiveness of the treatment, by allowing to distribute a large part of the dose at the level of the zones to be treated, in particular the lungs, safely and effectively avoiding the risks of overdose, of dimensions as small as possible, while ensuring a seal and absolute integrity of all doses until their expulsion.
• the present invention also aims to provide such an inhaler provided with a blister strip, wherein the storage of the band portion used is optimized, and the risk of blocking the band minimized.
• the present invention therefore relates to a fluid dispenser device comprising a body, an elongate flexible strip supporting a plurality of reservoirs each containing a dose of fluid or powder, reservoir opening means for opening a respective reservoir each actuation, and moving means for moving said flexible band before and / or during and / or after each actuation, to bring a tank full face to said tank opening means, the front end of said flexible band, in the direction of movement thereof, wrapping around a receiving element fixed in rotation relative to said body.
• said receiving element comprises a rod extending parallel to the width of said flexible band.
• said displacement means comprise an indexing wheel cooperating with said flexible band, said indexing wheel being rotated during the actuation of the device for advancing said flexible band.
• said wheel comprises at least one recess adapted to receive a respective reservoir of said flexible band.
• the portion of the flexible strip comprising the empty tanks is wound in a receiving housing having guide walls and said receiving element.
• said receiving housing comprises an outer curved guide wall, in particular a cylindrical one, against which said flexible strip slides.
• said receiving housing comprises an inlet guide wall approximately parallel to said external guide wall to form a guide channel at the entrance of said receiving housing.
• said receiving element is disposed approximately in the center of said receiving housing.
• the front end of said flexible band comprises a loop loosely surrounding said receiving element.
• the front end edge of the flexible band is folded down and fixed to said flexible band to form said loop.
• said flexible band before the first actuation of the device, said flexible band is wound in a storage compartment of the body, said flexible band progressively unwinding each time the device is actuated, and said flexible band, after emptying a respective reservoir at each actuation, progressively wraps in a receiving housing around said fixed receiving member.
• said opening means are controlled by the inhalation of the user.
• said opening means comprise piercing and / or cutting means, such as a needle, adapted to penetrate inside a respective reservoir at each actuation.
• This inhaler comprises a body 10 on which can be slidably mounted one or two cover portions (not shown) adapted to be open to open and load the device.
• the body 10 may be approximately rounded in shape as shown in the figures, but it could have any other suitable shape.
• the body 10 comprises a mouthpiece or inhalation 1 defining a dispensing orifice through which the user will inhale during actuation of the device.
• the covers may open by pivoting about a common axis of rotation, but any other means of opening the device is possible.
• This blister strip 20 is advantageously constituted by a layer or base wall forming the cavities 21 receiving the doses of powder, and a layer or closure wall which sealingly closes each of said blisters 21.
• the blister strip 20 can be wound inside the body 10, preferably in a storage housing 11, and band drive means 40 are provided to progressively unroll this blister strip and bring an individual reservoir or blister respective 21 in a dispensing position with each actuation of the device.
• the band portion 25 comprising the empty tanks is advantageously adapted to wind in another location of said body 10, preferably a receiving housing 15, as will be described in more detail below.
• the inhaler comprises reservoir opening means 30 preferably comprising means for piercing and / or cutting the closure layer of the blisters.
• the tank opening means advantageously comprise a needle 30, preferably fixed relative to the body 10, and against which a respective blister 21 is moved at each actuation. The blister is then pierced by said needle, which penetrates into said blister to expel the powder by means of the inhalation flow of the user.
• Displacement means 40 are also provided in the device, and are adapted to move the blister strip 20 before and / or during and / or after each actuation of the device.
• these displacement means 40 are also adapted to move the reservoir to be emptied 21 against said piercing and / or cutting means 30 during actuation.
• These displacement means 40 may be biased by an elastic element, such as a spring or any other equivalent elastic element, said elastic element being preloadable during opening of the device.
• the displacement means 40 comprise an indexing wheel 40 which receives and guides the blisters. A rotation of this wheel
• a given reservoir 21 is always in position to be opened by the opening means 30.
• means for positioning in rotation of said indexing wheel 40 can be provided to accurately determine its angular position after each rotation.
• These positioning means may, according to an advantageous variant, comprise a projection or finger, one end of which cooperates elastically with notches provided around said wheel 40.
• a complementary wheel could be provided to assist in guiding and / or training of the blister strip 20.
• An actuation cycle of the device may be the following.
• the two lateral parts forming the cover are spaced apart from each other by pivoting on the body to open the device, and thus charge the device.
• the indexing wheel 40 can not move towards the needle 30 because it is retained by appropriate locking means 100.
• these locking means are released, which then causes the displacement of said indexing wheel 40 towards the needle 30, and therefore
• the reservoir 21 moves towards its open position to be opened by the needle 30 which is fixed relative to the body.
• this needle can also be mobile during the opening phase of the reservoir 21.
• the needle could move towards the reservoir 21 while the reservoir 21 moves towards the needle.
• the reservoir 21 and the needle move in the same direction during actuation, the reservoir 21 moving more rapidly in this direction so that it comes into contact with the needle to be opened.
• an inhalation triggering system which advantageously comprises a unit 60 that can be displaced and / or deformable by inhalation, this unit 60 being suitable to release the blocking means 100.
• This unit 60 advantageously comprises a deformable air chamber 61.
• the inhalation of the user causes the deformation of said deformable air chamber 61, thus making it possible to release said blocking means 100 and therefore to allow the displacement of the indexing wheel 40 and a respective tank 21 to its open position.
• the reservoir 21 is therefore open only at the moment of inhalation, so that it is simultaneously emptied. There is therefore no risk of loss of dose between the opening of the tank and its emptying.
• the inhaler further comprises a dispensing chamber 70 which is intended to receive the dose of powder after the opening of a respective tank 21.
• this dispensing chamber 70 is provided with at least one ball 75 which moves to the drum. inside said room 70 during inhalation, to improve the distribution of the air and powder mixture after opening a reservoir 21, in order to increase the effectiveness of the device.
• the opening means 30, in particular the needle may be formed directly on said distribution chamber 70, for example at the end of a channel 69 leading to said chamber 70.
• the individual reservoirs or blisters 21 are formed on an elongated strip 20, which at the beginning is mainly stored as a coil in a storage housing 11 within the body 10 of the device.
• this wound blister strip 20 is held by internal walls of said storage housing 11 without its rear end 28 (in the direction of movement of the blister strip 20) being fixed relative to said body 10, which allows an easier assembly of this coil of blister strip inside the device.
• the blister strip 20 is moved by the user advantageously by means of the indexing wheel 40 which advantageously has at least one, preferably several recesses 41, whose shape corresponds to that of the blisters.
• this indexing wheel 40 rotates, it drives the blister strip 20.
• the front end 25 of the blister strip is simply pushed by said indexing wheel 40, without any traction. exerts itself on her. This simplifies the device and makes it more reliable and less expensive. No other drive system is needed to move the blister strip
• this used blister strip is automatically wound on itself to form a coil again.
• the front end 25 of this blister strip 20 wraps around a receiving element 50 fixed in rotation relative to the body 10.
• This receiving element 50 may be a rod extending vertically to plan of the single figure, and therefore parallel to the width of the blister strip 20.
• the front end 25 of the strip 20 forms a loop 26 loosely surrounding the receiving member 50. This loop 26 can be made by folding and fixing the front end edge 27 of the strip 20, as visible in the figure.
• the loop 26 can thus rotate freely around the receiving member 50 to accompany the winding of the used band portion. This prevents the front part of the belt from jamming, which could happen due to a bad winding. The fact that the front end 25 is held around the receiving element 50 prevents any risk of bad winding.
• the receiving member 50 is disposed approximately in the center of the receiving housing 15.
• This can comprise guide walls, in particular an outer guide wall 16, curved, for example cylindrical, against which the strip will slide. Blisters 20.
• There may also be an internal guide wall 17 provided at the inlet of the receiving housing 15, and preferably extending approximately parallel to the outer guide wall 16 to form a guide channel 18 for the The guiding walls 16, 17 further promote good winding of the blister strip 20 around the receiving element 50.
• the present invention therefore makes it possible to provide a dry powder inhaler which notably provides the following functions: A plurality of individual doses of powder stored in sealed individual reservoirs, for example 30 or 60 doses stored on a coil-wound web;
• Appropriately shaped drive means engaged with the blisters to effect movement of the blister strip at each actuation, and bring a new reservoir into a position in which it is intended to be opened by the appropriate opening means ;

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• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Pulmonology (AREA)
• Anesthesiology (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• Hematology (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Medical Preparation Storing Or Oral Administration Devices (AREA)
• Loading And Unloading Of Fuel Tanks Or Ships (AREA)

Applications Claiming Priority (2)

Publications (1)

Family

ID=38222049

Family Applications (1)

Country Status (6)

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Family Cites Families (18)

• 2006
  • 2006-12-11 FR FR0655409A patent/FR2909643B1/fr active Active
• 2007
  • 2007-12-10 EP EP07871902A patent/EP2097127A2/de not_active Withdrawn
  • 2007-12-10 JP JP2009540825A patent/JP5108023B2/ja not_active Expired - Fee Related
  • 2007-12-10 CN CN2007800457547A patent/CN101563128B/zh not_active Expired - Fee Related
  • 2007-12-10 US US12/518,410 patent/US20100018527A1/en not_active Abandoned
  • 2007-12-10 WO PCT/FR2007/052470 patent/WO2008078035A2/fr not_active Ceased

Non-Patent Citations (1)

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