EP2114443A4 - Doppelt spezifische il-1a/il-1b-antikörper - Google Patents

Doppelt spezifische il-1a/il-1b-antikörper

Info

Publication number
EP2114443A4
EP2114443A4 EP07868125A EP07868125A EP2114443A4 EP 2114443 A4 EP2114443 A4 EP 2114443A4 EP 07868125 A EP07868125 A EP 07868125A EP 07868125 A EP07868125 A EP 07868125A EP 2114443 A4 EP2114443 A4 EP 2114443A4
Authority
EP
European Patent Office
Prior art keywords
antibodies
dual
specific
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07868125A
Other languages
English (en)
French (fr)
Other versions
EP2114443A2 (de
Inventor
Chung-Ming Hsieh
Bradford L Mcrae
Yuliya Kutskova
John E Memmott
Michael Roguska
Ian Tomlinson
Mihriban Tuna
Steven Grant
Carrie Enever
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Inc
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of EP2114443A2 publication Critical patent/EP2114443A2/de
Publication of EP2114443A4 publication Critical patent/EP2114443A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP07868125A 2006-12-29 2007-12-28 Doppelt spezifische il-1a/il-1b-antikörper Withdrawn EP2114443A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87816506P 2006-12-29 2006-12-29
PCT/US2007/026482 WO2008082651A2 (en) 2006-12-29 2007-12-28 Dual-specific il-1a/ il-1b antibodies

Publications (2)

Publication Number Publication Date
EP2114443A2 EP2114443A2 (de) 2009-11-11
EP2114443A4 true EP2114443A4 (de) 2011-08-10

Family

ID=39589136

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07868125A Withdrawn EP2114443A4 (de) 2006-12-29 2007-12-28 Doppelt spezifische il-1a/il-1b-antikörper

Country Status (3)

Country Link
US (2) US8324350B2 (de)
EP (1) EP2114443A4 (de)
WO (1) WO2008082651A2 (de)

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KR100919593B1 (ko) 2000-06-29 2009-09-29 아보트 러보러터리즈 이중 특이성 항체 및 이의 제조 방법 및 이를 포함하는 조성물
US7981420B2 (en) 2000-12-22 2011-07-19 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Therapeutic use of antibodies directed against repulsive guidance molecule (RGM)
CA2617637C (en) 2005-08-02 2017-07-18 Xbiotech Inc. Diagnosis, treatment, and prevention of vascular disorders using il-1.alpha. autoantibodies
EP1928905B1 (de) 2005-09-30 2015-04-15 AbbVie Deutschland GmbH & Co KG Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung
EP2114443A4 (de) 2006-12-29 2011-08-10 Abbott Lab Doppelt spezifische il-1a/il-1b-antikörper
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
EP2116556B1 (de) 2008-05-09 2016-03-23 AbbVie Deutschland GmbH & Co KG Antikörper zu Rezeptor für Endprodukte der fortgeschrittenen Glykierung (RAGE) und Verwendungen davon
EP2285409B1 (de) 2008-05-30 2016-04-20 XBiotech, Inc Il-1-alpha-antikörper
CA2737056C (en) 2008-09-12 2018-10-30 Xbiotech Inc. Targeting pathogenic monocytes
WO2011053707A1 (en) 2009-10-31 2011-05-05 Abbott Laboratories Antibodies to receptor for advanced glycation end products (rage) and uses thereof
MX2012006560A (es) 2009-12-08 2012-10-05 Abbott Gmbh & Co Kg Anticuerpos monoclonales contra la proteina rgm a para utilizarse en el tratamiento de degeneracion de capa de fibra de nervio retinal.
BR112012028557A2 (pt) 2010-05-07 2019-09-24 Xoma Technology Ltd. uso de um anticorpo anti-il-1b ou de fragmentos de ligação do mesmo.
AR081246A1 (es) 2010-05-14 2012-07-18 Abbott Lab Proteinas de union a il-1
AU2016222339B2 (en) * 2010-05-14 2017-11-23 Abbvie Inc. IL-1 binding proteins
EP2582391B1 (de) 2010-06-18 2018-10-03 XBiotech, Inc Arthritis-behandlung
KR101910760B1 (ko) 2010-08-23 2018-10-22 엑스바이오테크, 인크. 종양성 질병들에 대한 치료
MX341578B (es) 2011-02-08 2016-08-25 Abbvie Inc Tratamiento de la osteoartritis y del dolor.
DK2694107T3 (en) * 2011-04-01 2018-12-10 Xbiotech Inc TREATMENT OF DERMATOLOGICAL DISORDERS
US9724409B2 (en) 2011-04-01 2017-08-08 Xbiotech, Inc. Treatment of inflammatory skin disease
CN108404127B (zh) 2011-09-23 2025-12-12 埃克斯生物科技公司 恶病质治疗
WO2013078135A2 (en) * 2011-11-21 2013-05-30 Abbott Laboratories Il-1 binding proteins
EP3369746A1 (de) 2012-01-27 2018-09-05 AbbVie Deutschland GmbH & Co KG Zusammensetzung und verfahren zur diagnose und behandlung von krankheiten im zusammenhang mit neuritenabbau
UY34905A (es) 2012-07-12 2014-01-31 Abbvie Inc Proteínas de unión a il-1
US9545441B2 (en) 2012-09-18 2017-01-17 Xbiotech, Inc. Treatment of diabetes
WO2014106015A2 (en) * 2012-12-28 2014-07-03 Abbvie, Inc. Multivalent binding protein compositions
US11542332B2 (en) 2016-03-26 2023-01-03 Bioatla, Inc. Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
EP3582813A4 (de) 2017-02-16 2020-12-30 XBiotech, Inc Behandlung von hidradenitis suppurativa
AU2018265261B2 (en) * 2017-05-10 2025-05-22 Inovio Pharmaceuticals, Inc. Optimized nucleic acid antibody constructs
CN113557036A (zh) 2019-01-18 2021-10-26 奥泽生物疗法公司 基因编辑以改善关节功能
CA3095679A1 (en) 2020-10-07 2022-04-07 Xbiotech Inc. True human antibody specific for interleuken 1 alpha (il-1a)
CA3095676A1 (en) 2020-10-07 2022-04-07 Xbiotech Inc. True human antibody specific for interleukin 1 alpha (il-1a)
CA3095740A1 (en) 2020-10-07 2022-04-07 Xbiotech Inc. True human antibody specific for interleukin alpha (il-1a)
CA3095675A1 (en) 2020-10-07 2022-04-07 Xbiotech Inc. True human antibody specific for interleukin 1 alpha (il-1a)
CN117957250A (zh) * 2022-12-20 2024-04-30 成都优洛生物科技有限公司 一种靶向IL-1α的抗体或其抗原结合片段及其应用
WO2025099120A1 (en) 2023-11-09 2025-05-15 F. Hoffmann-La Roche Ag Multispecific antibodies with conditional activity

Citations (3)

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WO2001053353A2 (en) * 2000-01-21 2001-07-26 Novartis Ag Recombinant antibodies to human interkleukin-1 beta
WO2002002773A2 (en) * 2000-06-29 2002-01-10 Abbott Laboratories Dual specificity antibodies and methods of making and using
WO2003002609A2 (en) * 2001-06-28 2003-01-09 Domantis Limited Dual-specific ligand and its use

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EP2114443A4 (de) 2006-12-29 2011-08-10 Abbott Lab Doppelt spezifische il-1a/il-1b-antikörper

Patent Citations (3)

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WO2001053353A2 (en) * 2000-01-21 2001-07-26 Novartis Ag Recombinant antibodies to human interkleukin-1 beta
WO2002002773A2 (en) * 2000-06-29 2002-01-10 Abbott Laboratories Dual specificity antibodies and methods of making and using
WO2003002609A2 (en) * 2001-06-28 2003-01-09 Domantis Limited Dual-specific ligand and its use

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FRANCOIS C ET AL: "Consturction of a bispecific antibody reacting with the alpha-and beta-chains ofthe human IL-2 receptor", JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 150, no. 10, 1 January 1993 (1993-01-01), pages 4610 - 4619, XP002974197, ISSN: 0022-1767 *
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Also Published As

Publication number Publication date
WO2008082651A2 (en) 2008-07-10
US20090291081A1 (en) 2009-11-26
WO2008082651A3 (en) 2009-04-09
EP2114443A2 (de) 2009-11-11
US20130171146A1 (en) 2013-07-04
US8324350B2 (en) 2012-12-04

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