EP2197590B1 - Dispositif permettant de conserver séparément une substance, de préférence un médicament ou un principe actif pharmaceutique, et un liquide, et de mélanger ceux-ci avant leur administration - Google Patents

Dispositif permettant de conserver séparément une substance, de préférence un médicament ou un principe actif pharmaceutique, et un liquide, et de mélanger ceux-ci avant leur administration Download PDF

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Publication number
EP2197590B1
EP2197590B1 EP08801309A EP08801309A EP2197590B1 EP 2197590 B1 EP2197590 B1 EP 2197590B1 EP 08801309 A EP08801309 A EP 08801309A EP 08801309 A EP08801309 A EP 08801309A EP 2197590 B1 EP2197590 B1 EP 2197590B1
Authority
EP
European Patent Office
Prior art keywords
container
substance
pump
liquid
wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP08801309A
Other languages
German (de)
English (en)
Other versions
EP2197590A1 (fr
Inventor
Stephan Kneer
Roland Kneer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gaplast GmbH
Original Assignee
Gaplast GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gaplast GmbH filed Critical Gaplast GmbH
Publication of EP2197590A1 publication Critical patent/EP2197590A1/fr
Application granted granted Critical
Publication of EP2197590B1 publication Critical patent/EP2197590B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005Components or details
    • B05B11/0078Arrangements for separately storing several components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042Components or details
    • B05B11/1043Sealing or attachment arrangements between pump and container
    • B05B11/1046Sealing or attachment arrangements between pump and container the pump chamber being arranged substantially coaxially to the neck of the container
    • B05B11/1047Sealing or attachment arrangements between pump and container the pump chamber being arranged substantially coaxially to the neck of the container the pump being preassembled as an independent unit before being mounted on the container
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B15/00Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
    • B05B15/30Dip tubes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005Components or details
    • B05B11/0027Means for neutralising the actuation of the sprayer ; Means for preventing access to the sprayer actuation means

Definitions

  • the invention relates to an apparatus for separately storing a substance such as a pharmaceutical agent and a liquid, and mixing them before dispensing, with a first container containing the liquid, a second container containing the substance having a bottom to be opened so that the Substance can enter the liquid, and with a device which is advanceable to exert a force on the bottom of the second container, so that it is opened, further comprising a tubular insert which is inserted into a neck of the first container, wherein the front part of a pump device slidably engages in the tubular insert and forms the force-applying device.
  • a substance such as a pharmaceutical agent and a liquid
  • the substance may be any substance in solid or liquid form which is initially intended to be kept separate from the liquid in the first container and mixed with this liquid before use.
  • the substance may be, for example, freeze-dried lactic acid bacteria, which is mixed with a suitable suspension liquid for probiotic applications before use.
  • the second container containing the substance is constituted by a tubular insert inserted in the neck of the first container having a bottle shape.
  • a predetermined breaking groove is formed, so that the soil can be broken or unfolded by the action of force, so that the substance falls into the liquid of the first container.
  • the opening of the floor is accomplished by the front part of an airless pump, which is slidably disposed in the insert. When the airless pump is advanced in the longitudinal direction of the first container, ie pushed into the container, it breaks open the bottom of the insert.
  • US 6,230,884 B1 discloses a container cap having a blister pack which is opened by depressing a neck portion of the cap, a pen-like lug pushing a tablet out of the blister pack which falls into the liquid in a bottle. This ambient air can enter the bottle unhindered.
  • the US 4,770,323 addresses the problem of providing a sterile package for a fluid which is hermetically sealed by a rupturable sealing membrane until it is first dispensed, allowing unobstructed dispensing of the container contents over a long period of time after rupture of the sealing membrane.
  • a tubular perforating member is pushed through the sealing membrane and engages a riser in the container, the riser being connected to a dispensing channel extending through the cap of the package. Even with this packaging, air may enter the package after the sealing membrane breaks open.
  • WO 01/30668 A discloses a dispenser according to the preamble of claim 1.
  • the dispenser includes on the housing part to which the front part of the pump is fixed, a spaced from the peripheral wall of the pump sealing lip which slidably rests against the inner wall of the container, in which engages the pump part , The task of the sealing lip is to prevent the escape of liquid from the container.
  • the housing member which defines an annular air space above the container, is engaged on its cylindrical outer wall either with annular projections in spaced apart annular grooves in the outer side of the neck of the outer container or is in a threaded engagement therewith.
  • the present invention has for its object to provide a device in which the above-mentioned malfunctions when pumping the liquid are largely avoided.
  • the invention provides that the front part of the pump device is held by a pump housing part, which limits an air space in the retracted initial position of the pump above the tubular insert, and in that in a wall, preferably the peripheral wall of the pump housing part, at least one through the wall Is formed opening through which the air escapes from the decreasing air space to the outside during the advancement of the airless pump, without this air enters the first container.
  • the front part of the pump device is sealed at its outer periphery by at least one annular seal against the tubular insert.
  • the peripheral wall of the tubular insert has at least one opening passing through the wall, preferably one or more elongated slots, preferably extending from the free end of the tubular insert to about half its height. Through these openings or slots enters the Liquid in the insert and thus in the intake of the pump, wherein at the same time in the interior of the tubular insert located air can escape through these slots.
  • the second container is formed by a blister pack which is attached to the tubular insert.
  • the substance is sealed in a housing which has a preferably flat bottom and a substantially cup-shaped or bubble-shaped upper chamber wall. To release the substance of the flat bottom or the flat rear wall is broken, wherein the chamber wall is preferably everted through the bottom.
  • the bottom wall consists of an aluminum foil or a multilayer foil containing aluminum, and this may also apply to the chamber wall.
  • an aluminum-containing multilayer film PE-AL-PVC is mentioned without the invention being limited thereto.
  • the chamber wall can be made of LDPE (possibly with an aluminum layer).
  • This blister pack is conveniently attached to the tubular insert, which may protrude into the first container.
  • the attachment can be done in any suitable manner, for example, by the fact that, for example, 3 to 4 mm wide edge of the blister pack is attached by ultrasonic welding to the lower edge of the insert element, wherein instead of a fastening by hot stamping is possible.
  • Other ways of attaching the blister pack are these for example, with an overcap to clamp firmly or to snag with the insert element.
  • the attachment can be done in any suitable way.
  • the front part of the pump means preferably the suction part of an airless pump, is slidably disposed and constitutes the force applying means with which the bottom of the blister pack can be broken.
  • the front part of the pump device is advanced so that the bottom of the blister pack opens inevitably.
  • the curved chamber wall of the blister pack can be everted through the broken bottom without being injured or broken up.
  • the blister pack further closes the lower opening of the tubular insert.
  • a cutting device is attached, which may be formed for example by a sharp-edged metal ring.
  • the curved chamber wall of the blister pack is broken or cut.
  • the tubular insert forms the second container, as in the DE 197 42 559 C2 the case is.
  • the bottom of the second container containing the substance when the bottom of the second container containing the substance is opened by advancing the suction end of the airless pump in the tubular insert, it is prevented that air is pressed into the interior of the liquid container.
  • This is independent of whether a blister pack is used as a container for the substance or - as in the case of DE 197 42 559 C2 -
  • the tubular insert itself forms the second container and has a réellehyroidden floor.
  • FIG. 1 shows the device comprises a bottom cap 1, above a tearing ring 2 for tamper-evident, which is attached to the lower edge of a housing part 3, and an upper cap 4.
  • the upper cap 4 covers a generally designated 5 airless pump 5 and is in front of them Remove operation.
  • the suction part 9 of the pump 5 is fixed to a pump casing part 11 having a cylindrical peripheral wall 12 abutting the outside of the wall portion 8 of the tubular insert 7 and one at the upper end portion of the pump Suction part 9 adjacent upper wall 12a includes, which define an annular chamber 13 together with the suction part 9 and the top of the tubular insert 7.
  • a pump casing part 11 having a cylindrical peripheral wall 12 abutting the outside of the wall portion 8 of the tubular insert 7 and one at the upper end portion of the pump Suction part 9 adjacent upper wall 12a includes, which define an annular chamber 13 together with the suction part 9 and the top of the tubular insert 7.
  • holes or slots 14 passing through the wall.
  • the insert 7 through the wall penetrating, elongated openings 15, which may extend to the lower edge of the insert 7 or short over it.
  • a blister pack 17 is secured in a suitable manner, for example by the edge of the blister pack 17 is welded to the edge 16 of the insert 7.
  • the blister pack 17 has a flat lower bottom 18 and an arched chamber wall 19 projecting upwardly into the interior of the insert 7.
  • the substance within the blister pack 17 is sealed, and by suitable choice of the material of the walls 18 and 19 vapor diffusion into the interior of the blister pack can be excluded.
  • the tear strip 2 is first removed, whereupon the pump 5 can be moved with its suction part 9 in the direction of the blister pack 17.
  • the housing part 3 whose outer wall is aligned with the outer walls of the lower cap 1 and the upper cap 4 in threaded engagement with an inwardly offset upper wall portion 21 of the lower cap 1.
  • the threaded engagement is in FIG. 3 indicated by the reference numeral 22.
  • the housing part 3 can also be rotated with the help of the upper cap 4, which is deducted from the housing part 3 upwards but rotatably connected to this.
  • container liquid enters the suction region of the pump part 9, from which any air present therein can easily be displaced.
  • FIG. 4 shows that the head end 20 of the suction part 9 of the pump 5 is provided with a cutting ring 24 which has cut the curved chamber wall 19 of the blister pack 17.
  • FIG. 4 shows, moreover, details of the airless pump 5, which are known in the art, so that they will not be described here. These details are out FIG. 4 recognizable.

Landscapes

  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Closures For Containers (AREA)
  • Packages (AREA)
  • Package Specialized In Special Use (AREA)

Claims (5)

  1. Dispositif permettant de conserver séparément une substance telle qu'une substance active pharmaceutique et un liquide, et de mélanger ceux-ci avant l'administration, comportant un premier récipient (6) contenant le liquide, un deuxième récipient (17) contenant la substance qui a un fond (18) à ouvrir afin que la substance puisse parvenir dans le liquide et comportant un agencement qui peut s'avancer pour exercer une force sur le fond (18) du deuxième récipient (17) afin que celui-ci s'ouvre, comportant en outre un élément tubulaire (7) qui est inséré dans un col du premier récipient (6), la partie avant (9) d'un dispositif de pompe (5) étant en prise dans l'élément tubulaire (7) et formant l'agencement exerçant une force et la partie avant (9) du dispositif de pompe (5) étant maintenue par une partie de boîtier de la pompe (11) qui délimite un espace d'air (13) dans la position de sortie retirée du dispositif de pompe (5) sur l'élément tubulaire (7),
    caractérisé en ce que
    dans une paroi de la partie de boîtier de la pompe (11), au moins une ouverture (14) traversant la paroi est formée, au travers de laquelle lors de l'avancée du dispositif de pompe (5), de l'air s'échappe hors du premier récipient (6), et en ce que
    se trouve sur le bord supérieur de l'élément (7) un joint annulaire (10) qui ferme de façon étanche à l'air l'espace intermédiaire entre la paroi interne de l'élément (7) et la paroi externe de la partie d'aspiration (9) de la pompe (5).
  2. Dispositif selon la revendication 1
    caractérisé en ce que
    la paroi de pourtour de l'élément tubulaire (7) présente au moins une ouverture, de préférence au moins deux fentes (15).
  3. Dispositif selon la revendication 1
    caractérisé en ce que
    à l'extrémité libre (20) de la partie avant (9) du dispositif de pompe (5) est fixé un dispositif de coupe (24).
  4. Dispositif selon l'une des revendications 1 à 3,
    caractérisé en ce que
    le deuxième récipient est un emballage thermoformé (17) qui est fixé à l'élément tubulaire (7) qui dépasse dans le premier récipient (6).
  5. Dispositif selon la revendication 1 ou 3,
    caractérisé en ce que
    l'élément tubulaire (7) forme le deuxième récipient.
EP08801309A 2007-09-27 2008-09-08 Dispositif permettant de conserver séparément une substance, de préférence un médicament ou un principe actif pharmaceutique, et un liquide, et de mélanger ceux-ci avant leur administration Not-in-force EP2197590B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007046625A DE102007046625B4 (de) 2007-09-27 2007-09-27 Vorrichtung zum getrennten Aufbewahren einer Substanz, vorzugsweise eines medizinischen oder pharmazeutischen Wirkstoffs, und einer Flüssigkeit und zum Mischen derselben vor dem Gebrauch
PCT/DE2008/001505 WO2009039821A1 (fr) 2007-09-27 2008-09-08 Dispositif permettant de conserver séparément une substance, de préférence un médicament ou un principe actif pharmaceutique, et un liquide, et de mélanger ceux-ci avant leur administration

Publications (2)

Publication Number Publication Date
EP2197590A1 EP2197590A1 (fr) 2010-06-23
EP2197590B1 true EP2197590B1 (fr) 2011-11-02

Family

ID=40344835

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08801309A Not-in-force EP2197590B1 (fr) 2007-09-27 2008-09-08 Dispositif permettant de conserver séparément une substance, de préférence un médicament ou un principe actif pharmaceutique, et un liquide, et de mélanger ceux-ci avant leur administration

Country Status (13)

Country Link
US (1) US8267280B2 (fr)
EP (1) EP2197590B1 (fr)
JP (1) JP5605781B2 (fr)
CN (1) CN101855023B (fr)
AT (1) ATE531460T1 (fr)
AU (1) AU2008302828B2 (fr)
BR (1) BRPI0815960A8 (fr)
CA (1) CA2701051C (fr)
DE (1) DE102007046625B4 (fr)
ES (1) ES2375085T3 (fr)
MX (1) MX338713B (fr)
RU (1) RU2438797C1 (fr)
WO (1) WO2009039821A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010009101A1 (de) 2010-02-24 2011-08-25 GAPLAST GmbH, 82442 Verpackung
DE102010009102B4 (de) 2010-02-24 2014-08-28 Gaplast Gmbh Doppelwandige Quetschflasche mit Ventil im Airless-System
US8141700B2 (en) * 2010-05-28 2012-03-27 Tap the Cap, Inc. Bottle cap for dispersing powdered supplement in situ
KR101192603B1 (ko) * 2010-11-22 2012-10-26 (주)연우 이종 내용물 혼합용기
JP6581506B2 (ja) * 2013-11-29 2019-09-25 株式会社ダイゾー 内容物収容容器、それを用いた内容物収容製品、吐出製品および吐出装置
FR3016617B1 (fr) * 2014-01-17 2016-02-19 Aptar France Sas Reservoir de produit fluide et distributeur integrant un tel reservoir.
EP2957347B1 (fr) * 2014-06-18 2017-02-22 Albea Thomaston Inc. Système permettant de distribuer un mélange d'un premier produit et d'un deuxième produit
KR101619957B1 (ko) * 2015-04-10 2016-05-12 (주)연우 이종 내용물 혼합용기
MA41471A1 (fr) * 2015-04-27 2018-02-28 Microgaia Biotech S L Bouchon mélangeur
FR3042181B1 (fr) * 2015-10-08 2020-02-28 Qualipac Dispositif de conditionnement et distribution par dose d'un produit fluide
CN106829184B (zh) * 2017-01-20 2019-04-02 付佳琦 一种溶质和液体的混合容器及生产方法
FR3089431B1 (fr) * 2018-12-05 2021-01-01 Qualipac Sa Dispositif de conditionnement et distribution par dose d’un produit fluide, incluant un flacon reutilisable
CN210556616U (zh) * 2019-10-11 2020-05-19 浙江越甲药业有限公司 瓶及其瓶盖装置
CN110934794B (zh) * 2019-12-18 2021-07-16 宁夏艾伊生物工程研发有限公司 工业企业专用洗发露
CN113879692B (zh) * 2021-10-16 2024-10-18 上海洁诺德塑胶制品有限公司 一种泵盖及具有该泵盖的容器
CN117284613A (zh) * 2022-06-14 2023-12-26 西尔格定量泵(无锡)有限公司 分配器

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Publication number Priority date Publication date Assignee Title
US3080094A (en) * 1958-04-29 1963-03-05 Modern Lab Inc Compartmented pressurized container valve assembly and a cutter therefor
US3172568A (en) * 1959-03-27 1965-03-09 Modern Lab Inc Pressurized dispensing device
US3655096A (en) * 1969-10-22 1972-04-11 Pillsbury Co Container for diluting and dispensing material
FR2593147B1 (fr) * 1986-01-17 1988-03-18 Aerosol Inventions Dev Conditionnement sterile de substances fluides liquides et semi-liquides.
SU1666206A1 (ru) * 1989-06-05 1991-07-30 Научно-производственное объединение "Аэрозоль" Распылитель жидких продуктов
DE4030530A1 (de) * 1990-09-27 1992-04-02 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung fuer medien
IT1259853B (it) * 1992-12-09 1996-03-28 Bernardino Parise Contenitore per sostanze concentrate in polvere o liquide da porre in soluzione entro un involucro al momento dell'uso
DE4441263A1 (de) * 1994-11-19 1996-05-23 Caideil M P Teoranta Tormakead Austragvorrichtung für Medien
US5642838A (en) * 1995-12-28 1997-07-01 Stoody; William Robert Frangible sealing lid for spile access
WO1998040289A1 (fr) * 1997-03-12 1998-09-17 Fredrick Michael Coory Bouchon distributeur dote d'un petit panier amovible contenant un comprime
DE19742559C2 (de) * 1997-09-26 1999-08-05 Gaplast Gmbh Behälter mit Pumpe
US6098795A (en) * 1997-10-14 2000-08-08 Mollstam; Bo Device for adding a component to a package
FR2800360B1 (fr) * 1999-10-29 2002-01-18 Valois Sa Distributeur de melange de produit extemporane
KR200266847Y1 (ko) * 2001-12-05 2002-03-04 (주)연우 디스펜서

Also Published As

Publication number Publication date
CA2701051C (fr) 2016-02-02
JP5605781B2 (ja) 2014-10-15
AU2008302828B2 (en) 2013-03-07
WO2009039821A1 (fr) 2009-04-02
AU2008302828A1 (en) 2009-04-02
CN101855023A (zh) 2010-10-06
CN101855023B (zh) 2013-03-13
EP2197590A1 (fr) 2010-06-23
RU2438797C1 (ru) 2012-01-10
MX2010003344A (es) 2010-05-03
BRPI0815960A2 (pt) 2018-02-14
ATE531460T1 (de) 2011-11-15
US20100219202A1 (en) 2010-09-02
RU2010116416A (ru) 2011-11-10
ES2375085T3 (es) 2012-02-24
US8267280B2 (en) 2012-09-18
DE102007046625B4 (de) 2012-06-06
BRPI0815960A8 (pt) 2018-04-17
DE102007046625A1 (de) 2009-04-09
JP2011501721A (ja) 2011-01-13
CA2701051A1 (fr) 2009-04-02
MX338713B (es) 2016-04-28

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