EP2201130A4 - Empfindliche und schnelle verfahren unter verwendung chimärer rezeptoren zur identifizierung einer autoimmunkrankheit - Google Patents

Empfindliche und schnelle verfahren unter verwendung chimärer rezeptoren zur identifizierung einer autoimmunkrankheit

Info

Publication number
EP2201130A4
EP2201130A4 EP08835584A EP08835584A EP2201130A4 EP 2201130 A4 EP2201130 A4 EP 2201130A4 EP 08835584 A EP08835584 A EP 08835584A EP 08835584 A EP08835584 A EP 08835584A EP 2201130 A4 EP2201130 A4 EP 2201130A4
Authority
EP
European Patent Office
Prior art keywords
sensitive
autoimmune disease
chimeric receptors
rapid methods
identify autoimmune
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08835584A
Other languages
English (en)
French (fr)
Other versions
EP2201130A1 (de
Inventor
James L Brown
Leonard Kohn
David Scholl
Yunsheng Li
Giorgio Napolitano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diagnostic Hybrids Inc
Original Assignee
Diagnostic Hybrids Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/906,189 external-priority patent/US8293879B2/en
Application filed by Diagnostic Hybrids Inc filed Critical Diagnostic Hybrids Inc
Publication of EP2201130A1 publication Critical patent/EP2201130A1/de
Publication of EP2201130A4 publication Critical patent/EP2201130A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/046—Thyroid disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Rehabilitation Therapy (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
EP08835584A 2007-10-01 2008-09-24 Empfindliche und schnelle verfahren unter verwendung chimärer rezeptoren zur identifizierung einer autoimmunkrankheit Withdrawn EP2201130A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/906,189 US8293879B2 (en) 2000-03-30 2007-10-01 Methods of using chimeric receptors to identify autoimmune disease
US20632208A 2008-09-08 2008-09-08
PCT/US2008/011027 WO2009045292A1 (en) 2007-10-01 2008-09-24 Sensitive and rapid methods of using chimeric receptors to identify autoimmune disease

Publications (2)

Publication Number Publication Date
EP2201130A1 EP2201130A1 (de) 2010-06-30
EP2201130A4 true EP2201130A4 (de) 2010-10-06

Family

ID=40526500

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08835584A Withdrawn EP2201130A4 (de) 2007-10-01 2008-09-24 Empfindliche und schnelle verfahren unter verwendung chimärer rezeptoren zur identifizierung einer autoimmunkrankheit

Country Status (7)

Country Link
EP (1) EP2201130A4 (de)
JP (1) JP5474802B2 (de)
KR (1) KR101560849B1 (de)
CN (1) CN101918585A (de)
AU (1) AU2008307735B2 (de)
CA (1) CA2701198C (de)
WO (1) WO2009045292A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011001885A1 (ja) * 2009-06-30 2011-01-06 大塚製薬株式会社 甲状腺刺激ホルモンレセプターに対する抗体のバイオアッセイ法及び測定キットとこれらに用いる新規の遺伝子組み換え細胞
WO2020050208A1 (ja) * 2018-09-05 2020-03-12 ヤマサ醤油株式会社 Ｔｓｈ受容体に対する自己抗体活性の迅速測定方法及びキット
CN119351340B (zh) * 2024-10-31 2025-07-08 中国食品药品检定研究院(国家药品监督管理局医疗器械标准管理中心、中国药品检验总所) 一种测定rhTSH药物生物学活性的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9720693D0 (en) * 1997-09-30 1997-11-26 Univ Wales Medicine Assay
US6323334B1 (en) * 1999-09-24 2001-11-27 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding a 103 gene product and uses therefor
US6852546B1 (en) * 2000-03-30 2005-02-08 Diagnostic Hybrids, Inc. Diagnosis of autoimmune disease
US7998681B2 (en) * 2000-10-06 2011-08-16 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Diagnosis and therapy of antibody-mediated inflammatory auto-immune disorders
US6901485B2 (en) * 2001-06-21 2005-05-31 International Business Machines Corporation Memory directory management in a multi-node computer system

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AL-WADEI H A N ET AL: "PKA-dependent growth stimulation of cells derived from human pulmonary adenocarcinoma and small airway epithelium by dexamethasone.", EUROPEAN JOURNAL OF CANCER (OXFORD, ENGLAND : 1990) NOV 2005 LNKD- PUBMED:16239108, vol. 41, no. 17, November 2005 (2005-11-01), pages 2745 - 2753, XP025298198, ISSN: 0959-8049 *
EVANS C ET AL: "DEVELOPMENT OF A LUMINESCENT BIOASSAY FOR THYROID STIMULATING ANTIBODIES", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, THE ENDOCRINE SOCIETY, US LNKD- DOI:10.1210/JC.84.1.374, vol. 84, no. 1, 1 January 1999 (1999-01-01), pages 374 - 377, XP000943995, ISSN: 0021-972X *
HARAGUCHI KAZUTAKA ET AL: "Functional expression of thyrotropin receptor in differentiated 3T3-L1 cells: A possible model cell line of extrathyroidal expression of thyrotropin receptor", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 223, no. 1, 1996, pages 193 - 198, XP002597291, ISSN: 0006-291X *
See also references of WO2009045292A1 *
WATSON P F ET AL: "A new chemiluminescent assay for the rapid detection of thyroid stimulating antibodies in Graves' disease", CLINICAL ENDOCRINOLOGY, BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, GB LNKD- DOI:10.1046/J.1365-2265.1998.00619.X, vol. 49, 1 November 1998 (1998-11-01), pages 577 - 581, XP002089745, ISSN: 0300-0664 *
YAMASHIRO K ET AL: "MECHANISM OF THE AUGMENTATIVE EFFECT OF HIGH POLYETHYLENE GLYCOL (PEG) CONCENTRATIONS ON THE THYROID STIMULATING ACTIVITY IN TSAB-IGG USING A PORCINE THYROID CELL ASSAY", ENDROCRINE RESEARCH, MARCEL DEKKER, NEW YORK, NY, US, vol. 25, no. 1, 1 January 1999 (1999-01-01), pages 67 - 75, XP009009910, ISSN: 0743-5800 *

Also Published As

Publication number Publication date
CA2701198C (en) 2015-07-21
KR101560849B1 (ko) 2015-11-20
AU2008307735A1 (en) 2009-04-09
CN101918585A (zh) 2010-12-15
AU2008307735B2 (en) 2014-04-24
KR20100101072A (ko) 2010-09-16
WO2009045292A1 (en) 2009-04-09
JP2010539975A (ja) 2010-12-24
JP5474802B2 (ja) 2014-04-16
EP2201130A1 (de) 2010-06-30
CA2701198A1 (en) 2009-04-09

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