EP2242741A1 - 4-phényl-3,5-dicyanopyridines substituées par un groupe cycloalkoxy, et leur utilisation - Google Patents

4-phényl-3,5-dicyanopyridines substituées par un groupe cycloalkoxy, et leur utilisation

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Publication number
EP2242741A1
EP2242741A1 EP09711052A EP09711052A EP2242741A1 EP 2242741 A1 EP2242741 A1 EP 2242741A1 EP 09711052 A EP09711052 A EP 09711052A EP 09711052 A EP09711052 A EP 09711052A EP 2242741 A1 EP2242741 A1 EP 2242741A1
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Prior art keywords
formula
compound
alkyl
mmol
hydrogen
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EP09711052A
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German (de)
English (en)
Inventor
Walter Hübsch
Peter Nell
Frank SÜSSMEIER
Alexandros Vakalopoulos
Daniel Meibom
Barbara ALBRECHT-KÜPPER
Katja Zimmermann
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Bayer Pharma AG
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Bayer Schering Pharma AG
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Publication of EP2242741A1 publication Critical patent/EP2242741A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Definitions

  • the present application relates to novel, cycloalkoxy-substituted 4-phenyl-3,5-dicyanopyridine derivatives, processes for their preparation, their use for the treatment and / or prevention of diseases and their use for the preparation of medicaments for the treatment and / or prevention of Diseases, preferably for the treatment and / or prevention of cardiovascular and metabolic diseases.
  • Adenosine a purine nucleoside
  • Adenosine is present in all cells and is released from a variety of physiological and pathophysiological stimuli.
  • Adenosine is produced intracellularly by the degradation of adenosine 5'-monophosphate (AMP) and S-adenosyl homocysteine as an intermediate, but can be released from the cell and then functions as a hormone-like substance or neurotransmitter through binding to specific receptors.
  • AMP adenosine 5'-monophosphate
  • S-adenosyl homocysteine as an intermediate, but can be released from the cell and then functions as a hormone-like substance or neurotransmitter through binding to specific receptors.
  • adenosine Under normoxic conditions, the concentration of free adenosine in the extracellular space is very low. However, the extracellular concentration of adenosine in the affected organs increases dramatically under both ischemic and hypoxic conditions. For example, it is known that adenosine inhibits platelet aggregation and increases blood flow to the coronary arteries. It also affects blood pressure, heart rate, neurotransmitter release and lymphocyte differentiation. In adipocytes, adenosine is able to inhibit lipolysis and thus reduce the concentration of free fatty acids and triglycerides in the blood.
  • adenosine aim to increase the supply of oxygen in the affected organs or to reduce the metabolism of these organs in order to achieve an adaptation of the organ metabolism to the organ perfusion under ischemic or hypoxic conditions.
  • adenosine receptor-selective ligands are substances which bind selectively to one or more subtypes of the adenosine receptors and either mimic the action of adenosine (adenosine agonists) or block its action (adenosine antagonists).
  • adenosine receptors are mediated intracellularly by the messenger cAMP.
  • an activation of the membrane-bound adenylate cyclase leads to an increase in the intracellular cAMP, while the binding of adenosine to the Al or A3 receptors causes a decrease in the intracellular cAMP content via adenylate cyclase inhibition.
  • adenosine receptors In the cardiovascular system, the main effects of the activation of adenosine receptors are: bradycardia, negative inotropy and protection of the heart from ischemia (preconditioning) via Al receptors, dilation of the vessels via A2a and A2b receptors as well as inhibition of fibroblasts and smooth muscle cell proliferation via A2b receptors.
  • AI receptors by specific Al agonists leads to a frequency-dependent lowering of the heart rate in humans, without having any influence on the blood pressure.
  • Selective al agonists could thus be suitable, inter alia, for the treatment of angina pectoris and atrial fibrillation.
  • A2b receptors by adenosine or specific A2b agonists leads to a blood pressure reduction via the dilation of vessels. Lowering blood pressure is accompanied by a reflex increase in heart rate. Heart rate increase can be reduced by the activation of AI receptors by specific Al agonists.
  • the aforementioned receptor selectivity can be determined by the action of the substances on cell lines which, after stable transfection with the corresponding cDNA, express the respective receptor subtypes [see the document ME Olah, H. Ren, J. Ostrowski, K. A. Jacobson, GL Stiles, "Cloning, expression, and characterization of the unique bovine al adenosine receptor.” Studies on the ligand binding site by site-directed mutagenesis, J. Biol. Chem. 267 (1992), pages 10764-10770 the disclosure of which is hereby incorporated by reference in its entirety].
  • Adenosine receptor-specific ligands known from the literature are predominantly derivatives based on natural adenosine [S. -A. Poulsen and R.J. Quinn, "Adenosine Receptors: New Opportunities for Future Drugs", Bioorganic and Medicinal Chemistry 6 (1998), pages 619-641].
  • Adenosine ligands of this type of structure generally have the disadvantage that they do not really act receptor specific, are less effective than the natural adenosine or after oral administration are only very weakly effective. Therefore, they are mainly used only for experimental purposes.
  • WO 02/070484, WO 02/070485 and WO 02/079195 are variously substituted 2-thio or 2-oxy-3,5-dicyano-4-phenyl-6-aminopyridine as adenosine receptor ligands disclosed for the treatment of diseases.
  • WO 01/62233 discloses various pyridine and pyrimidine derivatives and their use as adenosine receptor modulators.
  • Substituted 3,5-dicyanopyridines as calcium-dependent potassium channel openers for the treatment of urological diseases are claimed in EP 1 302 463-A1.
  • the use of 2-amino-4-aryl-5-cyanopyridines as androgen receptor modulators is described in US 2005/0182105-A1.
  • WO 98/06697 Compounds having a 4-phenoxypiperidine partial structure disclosed as muscarinic antagonists for the treatment of cognitive disorders.
  • the object of the present invention was to provide novel compounds which act as selective agonists of the adenosine A1 and / or A2b receptor as such for the treatment and / or prevention, in particular of cardiovascular diseases such as hypertension, angina pectoris, myocardial infarction, heart failure and atrial fibrillation, Metabolic syndrome, diabetes and dyslipidaemias and organ protection in transplants and surgical procedures are suitable and also have an improved profile of properties over the known from the prior art compounds.
  • cardiovascular diseases such as hypertension, angina pectoris, myocardial infarction, heart failure and atrial fibrillation, Metabolic syndrome, diabetes and dyslipidaemias and organ protection in transplants and surgical procedures are suitable and also have an improved profile of properties over the known from the prior art compounds.
  • the present invention relates to compounds of the formula (I)
  • R 7 is hydrogen, (Ci-C 4) -alkyl, (C r C4) -acyl or (Ci-C 4) alkylsulfonyl,
  • Z stands for O or S
  • R 1 is hydrogen
  • R 2 is hydrogen, hydroxy, amino, mono- (C 1 -C 4 ) -alkylamino or di- (C 1 -C 4 ) -alkylamino
  • R 3 is hydrogen, halogen, cyano, (C r C4) alkyl or (C r C 4) alkoxy,
  • alkyl and alkoxy groups may be substituted up to three times by fluorine,
  • R 4 is a group of the formula -OR 8 or -NR 9 R 10 wherein
  • R 8 is (Ci-Ce) -alkyl which is mono- or disubstituted, identically or differently, by hydroxy, (Q-C 4 ) -alkoxy, carboxyl and / or (C 1 -C 4 ) -alkoxycarbonyl or up to three times by fluorine may be substituted, or (C 4 -Ce) -CyClOaIlCyI means
  • R 9 and R 10 are the same or different and are independently hydrogen or
  • (Ci-C 6) -alkyl which is mono- to trisubstituted by fluorine or or disubstituted by identical or different hydroxyl, (C r C4) alkoxy, amino, mono- (Ci-C 4) alkylamino, di-
  • (C 1 -C 4 ) -alkylamino, carboxyl, (C 1 -C 4 ) -alkoxycarbonyl and / or a 4 to 7-membered heterocycle may be substituted, mean
  • heterocycle contains one or two ring heteroatoms from the series N, O and / or S and in turn one or two times, identically or differently, with (Ci-C 4 ) alkyl, hydroxy, oxo and / or (Ci -C 4 ) -alkoxy may be substituted,
  • R 9 and R 10 together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocycle containing one further ring heteroatom from the series N, O or S and one or two times, same or different , by fluorine, (Ci C 4) alkyl, hydroxy, oxo, (Ci-C 4) -alkoxy, amino, mono- (C r C 4) alkylamino, di- (Ci-C 4) alkylamino, Azetidino, pyrrolidino, piperidino and / or morpholino may be substituted,
  • R 5 is hydrogen or (C r C 4 ) alkyl
  • R 6 is (C 1 -C 4 ) -alkyl which may be substituted by hydroxyl, (C 1 -C 4 ) -alkoxy or by up to three times by fluorine
  • L is a bond, NH or O means
  • R 1 ' is phenyl or 5- or 6-membered heteroaryl having up to three ring heteroatoms from the series N, O and / or S, which in each case one to three times, same or different, with a radical selected from the group halogen , nitro, cyano, (C, -C 6) alkyl, trifluoromethyl, hydroxy, (C r C 6) alkoxy, Difluormeth- oxy, trifluoromethoxy, amino, mono- (Ci-C 6) alkylamino, di- ( C 1 -C 6 ) -alkylamino, (C 1 -C 6 ) -alkoxycarbonyl and carboxyl may be substituted,
  • N-oxides, salts, solvates, salts of N-oxides and solvates of N-oxides and salts are examples of N-oxides, salts, solvates, salts of N-oxides and solvates of N-oxides and salts.
  • Compounds according to the invention are the compounds of the formula (I) and their salts, solvates and solvates of the salts comprising the compounds of the formulas below and their salts, solvates and solvates of the salts encompassed by formula (I) and those of the formula (I), hereinafter referred to as exemplary embodiments compounds and their salts, solvates and solvates the salts, as far as the compounds of the formula (I) mentioned below are not already salts, solvates and solvates of the salts.
  • the compounds of the invention may exist in stereoisomeric forms (enantiomers, diastereomers).
  • the invention therefore includes the enantiomers or diastereomers and their respective mixtures. From such mixtures of enantiomers and / or diastereomers, the stereoisomerically uniform components can be isolated in a known manner.
  • the present invention encompasses all tautomeric forms.
  • Suitable salts in the context of the present invention are physiologically acceptable salts of the compounds according to the invention. Also included are salts which are themselves unsuitable for pharmaceutical applications but can be used, for example, for the isolation or purification of the compounds of the invention.
  • Physiologically acceptable salts of the compounds of the invention include acid addition salts of mineral acids, carboxylic acids and sulfonic acids, e.g. Salts of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, methanesulfonic acid, ethanesulfonic acid, toluenesulfonic acid, benzenesulfonic acid, naphthalenedisulfonic acid, acetic acid, trifluoroacetic acid, propionic acid, lactic acid, tartaric acid, malic acid, citric acid, fumaric acid, maleic acid and benzoic acid.
  • salts of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, methanesulfonic acid, ethanesulfonic acid, toluenesulfonic acid, benzenesulfonic acid, naphthalenedisulfonic acid acetic acid, trifluoroacetic acid, propionic acid
  • Physiologically acceptable salts of the compounds according to the invention also include salts of customary bases, such as, by way of example and by way of preference, alkali metal salts (for example sodium and potassium salts), alkaline earth salts (for example calcium and magnesium salts) and ammonium salts derived from ammonia or organic amines having 1 to 16 carbon atoms, such as, by way of example and by way of illustration, ethylamine, diethylamine, triethylamine, ethyldiisopropylamine, monoethanolamine, diethanolamine, triethanolamine, dicyclohexylamine, dimethylaminoethanol, procaine, dibenzylamine, N-methylmorpholine, arginine, lysine, ethylenediamine and N-methylpiperidine.
  • customary bases such as, by way of example and by way of preference, alkali metal salts (for example sodium and potassium salts), alkaline earth salts (for example calcium and magnesium salts
  • Solvates in the context of the invention are those forms of the compounds according to the invention which form a complex in the solid or liquid state by coordination with solvent molecules. Hydrates are a special form of solvates that coordinate with water. As solvates, hydrates are preferred in the context of the present invention.
  • the present invention also includes prodrugs of the compounds of the invention.
  • prodrugs includes compounds which may themselves be biologically active or inactive, but during their residence time in the body are converted to compounds of the invention (for example metabolically or hydrolytically).
  • (Q-Q) -alkyl and (Q-Q) -alkyl in the context of the invention are a straight-chain or branched alkyl radical having 1 to 6 or 1 to 4 carbon atoms.
  • Preferred is a straight-chain or branched alkyl radical having 1 to 4 carbon atoms. Examples which may be mentioned by way of example include: methyl, ethyl, ⁇ -propyl, isopropyl, -B-butyl, is ⁇ -butyl, sec-butyl, terf. Butyl, 1-ethyl-propyl, n-pentyl and / j-hexyl.
  • (C_-Q) -cycloalkyl in the context of the invention is a monocyclic, saturated cycloalkyl group having 4 to 6 ring carbon atoms. Examples which may be mentioned are: cyclobutyl, cyclopentyl and cyclohexyl.
  • (C 1 -Q) -alkoxy and (C 1 -Q) -alkoxy are a straight-chain or branched alkoxy radical having 1 to 6 or 1 to 4 carbon atoms. Preference is given to a straight-chain or branched alkoxy radical having 1 to 4 carbon atoms.
  • (Q-Q) -alkoxycarbonyl and (Q-Q) -alkoxycarbonyl represent a straight-chain or branched alkoxy radical having 1 to 6 or 1 to 4 carbon atoms, which is linked via a carbonyl group. Preference is given to a straight-chain or branched alkoxycarbonyl radical having 1 to 4 carbon atoms in the alkoxy group. Examples which may be mentioned by preference include: methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, w-butoxycarbonyl and tert-butoxycarbonyl.
  • (QQ) -Acyl and (QQ) acyl [(C] -C 6 ) alkanoyl and (C 1 -C 4 ) alkanoyl] in the context of the invention represent a straight-chain or branched alkyl radical having 1 to 6 or 1 to 4 carbon atoms, which carries a double-bonded oxygen atom in the 1-position and is linked via the 1-position.
  • (C 2 -C 4 -alkylamino is an amino group having a straight-chain or branched acyl substituent which has 1 to 6 carbon atoms and is bonded via the carbonyl group to the nitrogen atom , Propionylamino, / j-butyrylamino, / so-butyrylamino and pivaloylamino.
  • (C r Cft) alkylsulfonyl and (C j -CaVAlkylsulfonyl are in the context of the invention a straight-chain or branched alkylsulphonyl radical having 1 to 6 or 1 to 4 carbon atoms.
  • a linear or branched alkylsulfonyl group is preferably from 1 to 4 Examples which may be mentioned by preference include: methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl and tert-butylsulfonyl.
  • (C 1 -C 4 -alkylsulfonylamino represents an amino group having a straight-chain or branched alkylsulfonyl substituent which has 1 to 6 carbon atoms and is bonded via the sulfonyl group to the nitrogen atom.
  • Di- (CVCV) -alkylamino and di-CCVCVl-alkylamino are in the context of the invention an amino group having two identical or different straight-chain or branched alkyl substituents, each having 1 to 6 or 1 to 4 carbon atoms. Preference is given to a straight-chain or branched dialkylamino radical having in each case 1 to 4 carbon atoms.
  • N N-dimethylamino, N, N-diethylamino, N-ethyl-N-methylamino, N-methyl-Nn-propylamino, N-isopropyl-N-propylamino, N, N-diisopropylamino, Nn-butyl N-methylamino, N-tert.-butyl-N-methylamino, N-ethyl-Nn-pentylamino and NH-hexyl-N-methylamino.
  • Examples which may be mentioned by preference include: methylaminocarbonyl, ethylaminocarbonyl, 2-propylaminocarbonyl, isopropylaminocarbonyl, n-butylaminocarbonyl, tert-butylaminocarbonyl, N, N-dimethylaminocarbonyl, N, N-diethylaminocarbonyl, N-ethyl-N-methylaminocarbonyl, N-methyl-N - ⁇ i-propylaminocarbonyl, Nn-butyl-N-methylaminocarbonyl and N-tert-butyl-N-methylaminocarbonyl.
  • Mono- or di- ((V -W) -alkylaminosulfonyl are in the context of the invention an amino group which is linked via a sulfonyl group and which has one straight-chain or branched or two identical or different straight-chain or branched alkyl substituents each having 1 Examples which may be mentioned are: methylaminosulfonyl, ethylaminosulfonyl, 2-propylaminosulfonyl, isopropylaminosulfonyl, n-butylaminosulfonyl, tert-butylaminosulfonyl, N, N-dimethylaminosulfonyl, N, N-diethylaminosulfonyl, N-ethyl N-methylaminosulfonyl, N-methyl-N-7-propylaminosulfonyl, N-butyl-N-methylaminosulfonyl and N-tert-buty
  • (Cfi-CHi * ) -Aryl is in the context of the invention for an aromatic carbocycle having 6 or 10 ring carbon atoms.
  • Preferred aryl radicals are phenyl and ⁇ aphthyl.
  • a 4- to 7-membered heterocycle in the context of the invention is a saturated heterocycle having a total of 4 to 7 ring atoms which contains one or two ring heteroatoms from the series ⁇ , O and / or S and via a ring carbon atom or optionally a ring nitrogen atom is linked. Preference is given to a 4- to 6-membered heterocycle having one or two ring heteroatoms from the series ⁇ and / or O.
  • 5- to 10-membered heteroaryl is in the context of the invention for a mono- or optionally bicyclic aromatic heterocycle (heteroaromatic) having a total of 5 to 10 ring atoms, up to three identical or different ring heteroatoms from the series ⁇ , O and / or S and is linked via a ring carbon atom or optionally via a ring nitrogen atom.
  • aromatic heterocycle heteromatic
  • Examples which may be mentioned are: furyl, pyrrolyl, thienyl, pyrazolyl, imidazolyl, thiazolyl, oxazolyl, isoxazolyl, isothiazolyl, triazolyl, oxadiazolyl, thiadiazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxa zolyl, benzothiazolyl, benzotriazolyl, indolyl, indazolyl, quinolinyl, isoquinolinyl, ⁇ aphthyridinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo [3,4-b] pyridinyl.
  • Halogen in the context of the invention includes fluorine, chlorine, bromine and iodine. Preference is given to chlorine or fluorine.
  • An oxo group in the context of the invention is an oxygen atom which is bonded via a double bond to a carbon atom.
  • radicals are substituted in the compounds according to the invention, the radicals can, unless otherwise specified, be monosubstituted or polysubstituted. In the context of the present invention, the meaning is independent of each other for all radicals which occur repeatedly. Substitution with one, two or three identical or different substituents is preferred. Most preferably, the substitution with one or two identical or different substituents.
  • A is CH 2 , CH 2 CH 2 , O or NH
  • Z stands for O or S
  • R 1 is hydrogen
  • R 2 is hydrogen, hydroxy or amino
  • R 3 is hydrogen, fluorine, chlorine, methyl or methoxy
  • R 4 is a group of the formula -NR 9 R 10 wherein
  • R 9 is hydrogen
  • R 10 is hydrogen or (Q-GO-alkyl which is monosubstituted or disubstituted by identical or different hydroxyl, (Ci-C 4) -alkoxy, amino, mono- (C r C 4) -alkylamino and / or di- (C 1 -C 4 ) -alkylamino may be substituted
  • R 9 and R 10 together with the nitrogen atom to which they are attached form a 4- to 6-membered heterocycle containing a further ring heteroatom from the series N or O and one or two times, identically or differently, with (Ci-C 4 ) - Alkyl, hydroxy, (Ci-C 4) -alkoxy, amino, mono- (Ci-C 4) -alkylamino and / or di- (Ci-C 4) alkylamino may be substituted,
  • R 5 is hydrogen or methyl
  • R 6 is phenyl or 5- or 6-membered heteroaryl having up to two ring heteroatoms from the series N, O and / or S, which in each case
  • L is a bond or NH
  • R 11 is phenyl or pyridyl, which may be mono- or disubstituted by identical or different radicals selected from the series comprising fluorine, chlorine, cyano, (C r C4) alkyl, Trifiuormethyl, (C r C4) alkoxy , Trifluoromethoxy, (C r C 4 ) alkoxycarbonyl and carboxyl may be substituted,
  • N-oxides, salts, solvates, salts of N-oxides and solvates of N-oxides and salts are examples of N-oxides, salts, solvates, salts of N-oxides and solvates of N-oxides and salts.
  • A is CH 2 or O
  • R 1 is hydrogen
  • R 2 is hydrogen or hydroxy
  • R 3 is hydrogen or fluorine
  • R 4 is a group of the formula -NR 9 R 10 wherein
  • R 9 is hydrogen
  • R 10 is hydrogen or (C 1 -C 4 ) -alkyl which may be monosubstituted or disubstituted by hydroxy
  • R 9 and R 10 together with the nitrogen atom to which they are attached, form an azetidino, pyrrolidino or piperidino ring, each of which may be substituted with hydroxy,
  • R 5 is hydrogen
  • R 6 is phenyl, pyridyl, oxazolyl or thiazolyl, each of which
  • L is a bond or NH
  • R 11 is phenyl which may be monosubstituted or disubstituted, identical or different, with a radical selected from the group consisting of fluorine, chlorine, methyl, trifluoromethyl, methoxycarbonyl, ethoxycarbonyl and carboxyl,
  • Another object of the present invention is a process for the preparation of compounds of the formula (I) according to the invention, in which R 4 is NH 2 , characterized in that
  • X is a suitable leaving group, preferably halogen, in particular chlorine, bromine or iodine, or mesylate, tosylate or triflate,
  • R 1, R 2, R 3, R 5, R 6 and Z are each as defined above, if appropriate by methods known to those skilled in their enantiomers and / or diastereomers and / or optionally converted with the corresponding (J) solvents and / or (Ji) bases or acids in their solvates, salts and / or solvates of the salts.
  • Suitable solvents for the reaction (H) + are all organic solvents which are inert under the reaction conditions. These include ketones such as acetone and methyl ethyl ketone, acyclic and cyclic ethers such as diethyl ether, methyl tert-butyl ether, 1,2-dimethoxyethane, tetrahydrofuran and dioxane, esters such as ethyl acetate or butyl acetate, hydrocarbons such as benzene, toluene, xylene, Hexane and cyclohexane, chlorinated hydrocarbons such as dichloromethane, trichloromethane and chlorobenzene, or other solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), N-methylpyrrolidinone (NMP), acetonitrile or pyridine.
  • ketones such as acetone and methyl ethyl ketone
  • the usual inorganic or organic bases are suitable. These include preferably alkali metal hydroxides such as lithium, sodium or potassium hydroxide, alkali metal carbonates such as lithium, sodium, potassium or cesium carbonate, alkali hydrogen carbonates such as sodium or potassium bicarbonate, alkali metal such as sodium or potassium, sodium or potassium or potassium tert.-butylate, amides such as sodium amide, lithium, sodium or potassium bis (trimethylsilyl) amide or lithium diisopropylamide, organometallic compounds such as butyllithium or phenyllithium, or organic amines such as triethylamine, diisopropylethylamine, pyridine, l, 8-diazabicyclo [5.4.0] undec-7-ene (DBU) or 1,5-diazabicyclo [4.3
  • the base may in this case be used in an amount of 1 to 10 mol, preferably 1 to 5 mol, in particular 1 to 3 mol, based on 1 mol of the compound of the formula (II).
  • the reaction can be carried out at normal, elevated or reduced pressure (for example in the range from 0.5 to 5 bar). Generally, one works at normal pressure.
  • inert solvents for the reaction (IV-A) + (V) are in particular acyclic and cyclic ethers such as diethyl ether, methyl tert-butyl ether, 1, 2-dimethoxyethane, tetrahydrofuran and dioxane, hydrocarbons such as benzene, toluene, xylene, Hexane and cyclohexane, or dipolar solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), N-methylpyrrolidinone ( ⁇ MP) and pyridine. It is also possible to use mixtures of these solvents. Preference is given to using 1,2-dimethoxyethane.
  • acyclic and cyclic ethers such as diethyl ether, methyl tert-butyl ether, 1, 2-dimethoxyethane, tetrahydrofuran and dioxane
  • hydrocarbons such as benzene, to
  • Suitable bases for this reaction are, in particular, alkali metal alkoxides, such as sodium or potassium methoxide, sodium or potassium ethoxide or sodium or potassium tert-butoxide, amides, such as sodium amide, lithium, sodium or potassium bis (trimethylsilyl) amide or Lithium diisopropylamide, or organometallic compounds such as butyllithium or phenyllithium suitable.
  • alkali metal alkoxides such as sodium or potassium methoxide, sodium or potassium ethoxide or sodium or potassium tert-butoxide
  • amides such as sodium amide, lithium, sodium or potassium bis (trimethylsilyl) amide or Lithium diisopropylamide
  • organometallic compounds such as butyllithium or phenyllithium suitable.
  • potassium tert-butoxide is used.
  • the base is in this case generally used in an amount of 1 to 1.25 mol, preferably in equimolar amount, based on 1 mol of the compound of formula (V).
  • the reaction (IV-A) + (V) is generally carried out in a temperature range of -20 0 C to +120 0 C, preferably at +20 0 C to +100 0 C.
  • the reaction may be at atmospheric, elevated or ER- low pressure (eg in the range of 0.5 to 5 bar). Generally, one works at normal pressure.
  • R 4 represents the group -NR 9 R 10 , in which at least one of the two radicals R 9 and R 10 does not denote hydrogen
  • R 9 and R 10 can be prepared starting from the compounds of the formula (IA) be that these first in a suitable solvent with isoamyl nitrite in the presence of copper ( ⁇ ) chloride or with sodium nitrite in the presence of hydrochloric acid in compounds of formula (VI)
  • R 1 , R 2 , R 3 , R 5 , R 6 and Z are each as defined above,
  • R 9A has the abovementioned meaning of R 9 ,
  • R 10A has the abovementioned meaning of R 10 ,
  • At least one of the two radicals R 9 ⁇ and R I0A is not hydrogen
  • R 1 , R 2 , R 3 , R 5 , R 6 , R 9A , R 10A and Z are each as defined above,
  • reaction (I-A) -> (VI) is generally carried out in a molar ratio of 2 to 10 moles of isoamyl nitrite and 2 to 10 moles of copper (II) chloride based on 1 mole of the compound of formula (I-A); Alternatively, the reaction can also be carried out with 2 to 10 molar equivalents of sodium nitrite in hydrochloric acid.
  • Suitable solvents for the isoamyl nitrite / copper (II) chloride variant are all organic solvents which are inert under the reaction conditions. These include acyclic and cyclic ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate or butyl acetate, hydrocarbons such as benzene, toluene, xylene, hexane and cyclohexane, chlorinated hydrocarbons such as dichloromethane, 1, 2-dichloroethane and chlorobenzene, or other solvents such as dimethylformamide, Acetonitrile or pyridine.
  • acyclic and cyclic ethers such as diethyl ether and tetrahydrofuran
  • esters such as ethyl acetate or butyl acetate
  • hydrocarbons such as benzene, toluene, xylene, hex
  • solvents are acetonitrile and dimethylformamide.
  • excess hydrochloric acid is preferably used as the solvent, optionally in combination with one of the abovementioned organic solvents.
  • the reaction is generally carried out in a temperature range from -78 ° C to +150 0 C, preferably in the range from -20 0 C to +100 0 C, especially at +0 0 C to +80 0 C.
  • the reaction can in normal , increased or decreased pressure (eg in the range of 0.5 to 5 bar). Generally, one works at normal pressure.
  • reaction (VT) + (VIT) - »(I-B) is generally carried out in a molar ratio of 1 to 8 moles of the compound of formula (VIT) relative to 1 mole of the compound of formula (VI).
  • Suitable solvents for process step (VI) + (VIT) - »(I-B) are all organic solvents which are inert under the reaction conditions. These include alcohols such as methanol, ethanol, n-propanol, isopropanol, n-butanol and tert-butanol, ketones such as acetone and methyl ethyl ketone, acyclic and cyclic ethers such as diethyl ether, 1, 2-dimethoxyethane, tetrahydrofuran and dioxane, esters such as Ethyl acetate or butyl acetate, hydrocarbons such as benzene, toluene, xylene, hexane and cyclohexane, chlorinated hydrocarbons such as dichloromethane, 1, 2-dichloroethane and chlorobenzene, or other solvents such as dimethylformamide, acetonitrile, pyridine or di
  • the reaction is generally carried out in a temperature range of 0 0 C to +180 0 C, preferably in the range of +20 0 C to +150 0 C, especially at + 2O 0 C to +100 0 C.
  • the reaction may be at atmospheric, increased or decreased pressure (eg in the range of 0.5 to 5 bar). Generally, one works at normal pressure.
  • R 1 , R 2 , R 3 , R 9A and R 10A each have the meanings given above,
  • sodium sulfide is preferably used in an amount of 1 to 10 mol, preferably 1 to 8 mol, more preferably 1 to 5 mol, based on 1 mol of the compound of the formula (IV-A).
  • Suitable solvents for this process step are all organic solvents which are inert under the reaction conditions. These include alcohols such as methanol, ethanol, n-propanol, isopropanol, n-butanol and tert-butanol, ketones such as acetone and methyl ethyl ketone, acyclic and cyclic ethers such as diethyl ether, 1, 2-dimethoxyethane, tetrahydrofuran and dioxane, esters such as ethyl acetate or Butyl acetate, hydrocarbons such as benzene, toluene, xylene, hexane and cyclohexane, chlorinated hydrocarbons such as dichloromethane, 1, 2-dichloroethane and chlorobenzene, or dipolar solvents such as acetonitrile, pyridine, dimethylformamide, dimethyl sulfoxide or N-methylpyrroli
  • the reaction is generally carried out in a temperature range of 0 0 C to +180 0 C, preferably in the range of +20 0 C to +120 0 C, in particular at +40 0 C to +100 0 C.
  • the reaction may be at atmospheric, increased or decreased pressure (eg in the range of 0.5 to 5 bar). Generally, one works at normal pressure.
  • alkali hydroxide excess sodium or potassium hydroxide is preferably used.
  • Alcohols such as methanol, ethanol, n-propanol, isopropanol, n-butanol and tert-butanol and mixtures thereof with water are particularly suitable as solvents.
  • the reaction is generally carried out in a temperature range of +20 0 C to +120 0 C, preferably at +50 0 C to +100 0 C.
  • the compounds of the formula (IV-A) in turn can be prepared starting from compounds of the formula (VI) in analogy to processes described in the literature [cf. e.g. Kambe et al., Synthesis, 531-533 (1981); Elnagdi et al., Z. Natu ⁇ rsch. 47b, 572-578 (1991); Reddy et al., J. Med. Chem. 49, 607-615 (2006); Evdokimov et al., Org. Lett. 8, 899-902 (2006)].
  • Such compounds of the formula (IC) wherein Z is S can also be prepared analogously to the previously described reaction sequences starting from compounds of the formula (VJH) by reaction with malononitrile and a corresponding alkoxide, subsequent N / S transformation and alkylation with a compound of the formula (DI) (see Scheme 7, see, for example, US 2005/0182105-A1):
  • the compounds of the formula (IC) can also be obtained by alkylation of compounds of the formula (X) (see Scheme 8):
  • the compounds of the formula (X), for their part, are obtainable by methods known from the literature from compounds of the formula (VT) or (I-A) [cf. e.g. G. Lavecchia et al., Tetrahedron Lett. 45, 6633-6636 (2004)].
  • the compounds of the formula (VIH) can be prepared analogously to processes described in the literature, for example via (A) the ring opening of epoxides or (B) a phenol ether formation under sunsobu conditions, in each case starting from 4-hydroxybenzaldehydes of the formula (XI) - are presented [see Scheme 9; see. eg R. Seemayer et al., Recl. Trav. Chim. Pays-Bas 110, 171 (1991); SR Adams et al., J. Am. Chem. Soc. JJO, 3212 (1988); S. Matsunaga et al., J. Am. Chem. Soc. 122, 2252 (2000); DL Hughes, Org. Prep. Proceed. Int. 28, 127 (1996)]:
  • the compounds of the formula (IQ) are commercially available, known from the literature or can be prepared by methods known from the literature.
  • amides, thioureas or thiourea derivatives with a 1,3-dihaloacetone-substituted oxazole and thiazole derivatives of the formula (EI-A), (DI-B) or (IH-C) be obtained [see Scheme 11; see. eg I. Simiti et al., Chem. Ber. 95, 2672-2679 (1962); Simiti, E. Chindris, Arch. Pharm. (Weinheim) 304, 425-429 (1971)]:
  • 2,5-Disubstituted oxazole derivatives of the formula (III) can be prepared in analogy to processes known from the literature, for example as described by way of example in the following Reaction Scheme 12:
  • Oxazole derivatives of the formula (II) which are substituted in the 5-position can be obtained, for example, by reduction and subsequent halogenation of corresponding oxazole-4-carboxylic acid esters, which in turn are obtainable by acylation of ⁇ -isocyanatoacetates (see Scheme 13):
  • 2-Aryloxazole derivatives according to formula (IH) are also obtainable via a palladium-catalyzed coupling of arylboronic acids with 2-Iodoxazole-4-carboxylic acid esters, as shown by way of example in Scheme 14:
  • the compounds of the formula (V) are likewise commercially available or known from the literature, or they can be prepared analogously to processes described in the literature, for example similar to the compounds of the formula (HT).
  • Other compounds of the invention may optionally also be prepared by conversions of functional groups of individual radicals and substituents, in particular those listed under R 2 , R 4 , R 6 and R 7 , starting from the compounds of the formula (I) obtained by the above method.
  • transformations are carried out by customary methods known to those skilled in the art and include, for example, reactions such as nucleophilic or electrophilic substitution, oxidation, reduction, hydrogenation, halogenation, alkylation, acylation, sulfonylation, amination, hydroxylation, formation of carboxylic acid amides and esters, ester reaction. Cleavage and etherification.
  • the amino-protecting group used is preferably tert-butoxycarbonyl (Boc), benzyloxycarbonyl (Z) or tolylsulfonyl (tosyl).
  • Boc tert-butoxycarbonyl
  • Z benzyloxycarbonyl
  • tolylsulfonyl tosyl
  • carboxyl groups the corresponding methyl, ethyl or tert-butyl esters are particularly suitable.
  • the protective group used is preferably benzyl or a silyl group, such as trimethylsilyl, tert-butyldimethylsilyl or dimethylphenylsilyl.
  • the compounds of the invention show an unpredictable, valuable pharmacological activity spectrum and are therefore particularly suitable for the prophylaxis and / or treatment of diseases, in particular of cardiovascular diseases.
  • the compounds according to the invention have an improved property profile, such as, in particular, increased solubility in physiological media and / or aqueous-organic solvent systems which are relevant for the formulation.
  • the pharmacological activity of the compounds according to the invention can be explained by their action as potent, selective ligands on adenosine A1 and / or A2b receptors. They act as selective al agonists, as selective A2b agonists or as selective dual Al / A2b agonists.
  • adenosine receptor ligands on adenosine A1 and / or A2b receptors those adenosine receptor ligands are referred to, in which on the one hand a significant effect on Al and / or A2b adenosine receptor subtypes and on the other hand no or a clear weaker effect (factor 10 or higher) on A2a and A3 adenosine receptor subtypes, with respect to the test methods for the selectivity of activity, reference is made to those described in section BI. described tests.
  • the compounds of the invention may function as full or as partial adenosine receptor agonists, depending on their particular structure.
  • Partial adenosine receptor agonists are defined as receptor ligands that elicit a functional response to adenosine receptors that is lower than full agonists. As a result, partial agonists are less effective in receptor activation than full agonists.
  • the compounds of the formula (I) are suitable alone or in combination with one or more other active ingredients for the prophylaxis and / or treatment of various diseases, for example, in particular hypertension and other diseases of the cardiovascular system (cardiovascular diseases), for cardioprotection after damage to the Heart as well as metabolic diseases.
  • various diseases for example, in particular hypertension and other diseases of the cardiovascular system (cardiovascular diseases), for cardioprotection after damage to the Heart as well as metabolic diseases.
  • peripheral and cardiac vascular diseases peripheral and cardiac vascular diseases, coronary heart disease, coronary restenosis such as restenosis after balloon dilatation of peripheral blood vessels, acute Coronary syndrome, stable and unstable angina pectoris, heart failure, tachycardia, arrhythmias, atrial and ventricular fibrillation and peripheral circulatory disorders.
  • the compounds according to the invention are also particularly suitable for the reduction of the myocardium affected by an infarct and for the prophylaxis of secondary infarcts.
  • the compounds according to the invention are particularly suitable for the prophylaxis and / or treatment of thromboembolic disorders and ischaemias such as myocardial infarction, stroke and transient ischemic attacks as well as for the protection of organs during transplantations and surgical interventions, for example at the heart.
  • Urogenital area such as Irritable bladder, erectile dysfunction and female sexual dysfunction, but also the prophylaxis and / or treatment of inflammatory diseases such. Asthma and inflammatory dermatoses, of neuroinflammatory diseases of the
  • Central nervous system such as conditions after cerebral infarction, Alzheimer's disease, and also of neurodegenerative diseases and pain, cancer and
  • Another indication is, for example, in particular the prophylaxis and / or treatment of respiratory diseases such as asthma, chronic bronchitis, emphysema, bronchiectasis, cystic fibrosis (cystic fibrosis) and pulmonary hypertension.
  • respiratory diseases such as asthma, chronic bronchitis, emphysema, bronchiectasis, cystic fibrosis (cystic fibrosis) and pulmonary hypertension.
  • the compounds according to the invention are also especially suitable for the prophylaxis and / or treatment of metabolic diseases, such as, for example, diabetes, in particular diabetes mellitus, diabetic secondary diseases, such as, for example, diabetes mellitus.
  • metabolic diseases such as, for example, diabetes, in particular diabetes mellitus, diabetic secondary diseases, such as, for example, diabetes mellitus.
  • diabetes mellitus in particular diabetes mellitus
  • diabetic secondary diseases such as, for example, diabetes mellitus.
  • Nephropathy and neuropathy the metabolic syndrome and dyslipidaemias.
  • Another object of the present invention is the use of the erf ⁇ ndungswashen compounds for the treatment and / or prophylaxis of diseases, in particular the aforementioned diseases.
  • Another object of the present invention is the use of the erf ⁇ ndungswashen compounds for the manufacture of a medicament for the treatment and / or prophylaxis of diseases, in particular the aforementioned diseases.
  • Another object of the present invention is a method for the treatment and / or prophylaxis of diseases, in particular the aforementioned diseases, using an effective amount of at least one of the inventive compounds.
  • the compounds of the invention may be used alone or as needed in combination with other agents.
  • Another object of the present invention are pharmaceutical compositions containing at least one of the compounds of the invention and one or more other active ingredients, in particular for the treatment and / or prophylaxis of the aforementioned diseases.
  • Suitable combination active ingredients which may be mentioned are fatty acid-changing active substances, antidiabetics, hypotensives, circulation-promoting and / or antithrombotic agents, antioxidants, chemokine receptor antagonists, p38 kinase inhibitors, NPY agonists, orexin Agonists, anorectics, PAF-AH inhibitors, anti-phlogists (COX inhibitors, LTB 4 receptor antagonists) and analgesics such as aspirin.
  • the present invention relates, in particular, to combinations of at least one of the compounds according to the invention with at least one lipid metabolism-altering active ingredient, an antidiabetic agent, a hypotensive agent and / or an antithrombotic agent.
  • the compounds of the invention may preferably be with one or more
  • Fat metabolism-altering agents by way of example and preferably from the group of HMG-CoA reductase inhibitors, inhibitors of HMG-CoA reductase expression, squalene synthesis inhibitors, ACAT inhibitors, LDL receptor inducers, cholesterol absorption inhibitors, polymeric Bile acid adsorbers, bile acid reabsorption inhibitors, MTP inhibitors, lipase inhibitors, LpL activators, fibrates, niacin, CETP inhibitors, PPAR- ⁇ , PPAR- ⁇ and / or PPAR- ⁇ agonists, RXR modulators, FXR Modulators, LXR
  • Modulators thyroid hormones and / or thyroid mimetics, ATP citrate lyase inhibitors, Lp (a) antagonists, cannabinoid receptor 1 antagonists, leptin receptor agonists, bomberin receptor agonists, histamine receptor agonists and the antioxidants / free radical scavengers;
  • Hypertensive agents by way of example and preferably from the group of calcium antagonists, angiotensin AH antagonists, ACE inhibitors, beta-receptor blockers, alpha-receptor blockers, diuretics, phosphodiesterase inhibitors, sGC stimulators, enhancers of the cGMP levels, aldosterone antagonists, mineralocorticoid receptor antagonists, ECE inhibitors and the vasopeptidase inhibitors, and / or
  • Antithrombotic agents by way of example and preferably from the group of platelet aggregation inhibitors or anticoagulants
  • lipid metabolism-changing active compounds are preferably compounds from the group of HMG-CoA reductase inhibitors, squalene synthesis inhibitors, ACAT inhibitors, cholesterol absorption inhibitors, MTP inhibitors, lipase inhibitors, thyroid hormones and / or thyroid mimetics, niacin receptor Agonists, CETP inhibitors, PPAR- ⁇ agonists, PPAR- ⁇ agonists, PPAR- ⁇ agonists, polymeric bile acid adsorbers, bile acid reabsorption inhibitors, antioxidants / free-radical scavengers, and the cannabinoid receptor 1 antagonists.
  • HMG-CoA reductase inhibitors preferably compounds from the group of HMG-CoA reductase inhibitors, squalene synthesis inhibitors, ACAT inhibitors, cholesterol absorption inhibitors, MTP inhibitors, lipase inhibitors, thyroid hormones and / or thyroid mimetics, niacin receptor Agonists
  • the compounds according to the invention are administered in combination with an HMG-CoA reductase inhibitor from the class of statins, by way of example and preferably lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin, rosuvastatin, cerivastatin or pitavastatin ,
  • an HMG-CoA reductase inhibitor from the class of statins, by way of example and preferably lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin, rosuvastatin, cerivastatin or pitavastatin ,
  • the compounds according to the invention are administered in combination with a squalene synthesis inhibitor, such as by way of example and preferably BMS-188494 or TAK-475.
  • a squalene synthesis inhibitor such as by way of example and preferably BMS-188494 or TAK-475.
  • the compounds according to the invention are administered in combination with an ACAT inhibitor, such as by way of example and preferably avasimibe, melinamide, pactimibe, eflucimibe or SMP-797.
  • an ACAT inhibitor such as by way of example and preferably avasimibe, melinamide, pactimibe, eflucimibe or SMP-797.
  • the compounds according to the invention are administered in combination with a cholesterol absorption inhibitor such as, for example and preferably, ezetimibe, tiqueside or pamaqueside.
  • a cholesterol absorption inhibitor such as, for example and preferably, ezetimibe, tiqueside or pamaqueside.
  • an MTP inhibitor such as, for example and preferably, implitapide, BMS-201038, R-103757 or JTT-130.
  • the compounds according to the invention are administered in combination with a lipase inhibitor, such as, for example and preferably, orlistat.
  • a lipase inhibitor such as, for example and preferably, orlistat.
  • the compounds according to the invention are administered in combination with a thyroid hormone and / or thyroid mimetic, such as by way of example and preferably D-thyroxine or 3,5,3'-triiodothyronine (T3).
  • a thyroid hormone and / or thyroid mimetic such as by way of example and preferably D-thyroxine or 3,5,3'-triiodothyronine (T3).
  • the compounds according to the invention are administered in combination with an agonist of the niacin receptor, such as by way of example and preferably niacin, Acipimox, Anatin or Radecol.
  • the compounds according to the invention are administered in combination with a CETP inhibitor, such as, by way of example and by way of preference, torcetrapib, JTT-705, BAY 60-5521, BAY 78-7499 or CETP vaccine (Avant).
  • a CETP inhibitor such as, by way of example and by way of preference, torcetrapib, JTT-705, BAY 60-5521, BAY 78-7499 or CETP vaccine (Avant).
  • the compounds according to the invention are administered in combination with a PPAR- ⁇ agonist, by way of example and preferably pioglitazone or rosiglitazone.
  • the compounds according to the invention are administered in combination with a PPAR- ⁇ agonist, such as by way of example and preferably GW-501516 or BAY 68-5042.
  • a PPAR- ⁇ agonist such as by way of example and preferably GW-501516 or BAY 68-5042.
  • the compounds of the invention are administered in combination with a polymeric bile acid adsorbent such as, by way of example and by way of preference, cholestyramine, colestipol, colesolvam, cholesta gel or colestimide.
  • a polymeric bile acid adsorbent such as, by way of example and by way of preference, cholestyramine, colestipol, colesolvam, cholesta gel or colestimide.
  • ASBT roAT
  • the compounds according to the invention are administered in combination with an antioxidant / free-radical scavenger, such as, for example and by way of preference, probucol, AGI-1067, BO-653 or AEOL-10150.
  • an antioxidant / free-radical scavenger such as, for example and by way of preference, probucol, AGI-1067, BO-653 or AEOL-10150.
  • the compounds according to the invention are administered in combination with a cannabinoid receptor 1 antagonist, such as by way of example and preferably rimonabant or SR-147778.
  • Antidiabetic agents are preferably understood as meaning insulin and insulin derivatives as well as orally active hypoglycemic agents.
  • Insulin and insulin derivatives here include both insulins of animal, human or biotechnological origin as well as mixtures thereof.
  • the orally active hypoglycemic agents preferably include sulphonylureas, biguanides, meglitinide derivatives, glucosidase inhibitors and PPAR- ⁇ agonists.
  • the compounds according to the invention are administered in combination with insulin.
  • the compounds according to the invention are administered in combination with a sulphonylurea, such as, by way of example and by way of preference, tolbutamide, glibenclamide, glimepiride, glipizide or gliclazide.
  • a sulphonylurea such as, by way of example and by way of preference, tolbutamide, glibenclamide, glimepiride, glipizide or gliclazide.
  • the compounds according to the invention are administered in combination with a biguanide, by way of example and preferably metformin.
  • the compounds according to the invention are administered in combination with a meglitinide derivative, such as by way of example and preferably repaglinide or nateglinide.
  • a meglitinide derivative such as by way of example and preferably repaglinide or nateglinide.
  • the compounds according to the invention are administered in combination with a glucosidase inhibitor, such as by way of example and preferably migolith or acarbose.
  • the compounds according to the invention are administered in combination with a PPAR- ⁇ agonist, for example from the class of thiazolidinediones, such as, by way of example and by way of preference, pioglitazone or rosiglitazone.
  • a PPAR- ⁇ agonist for example from the class of thiazolidinediones, such as, by way of example and by way of preference, pioglitazone or rosiglitazone.
  • the blood pressure lowering agents are preferably understood as meaning compounds from the group of calcium antagonists, angiotensin AH antagonists, ACE inhibitors, beta-receptor blockers, alpha-receptor blockers and diuretics.
  • the compounds according to the invention are administered in combination with a calcium antagonist, such as, by way of example and by way of preference, nifedipine, amlodipine, verapamil or diltiazem.
  • a calcium antagonist such as, by way of example and by way of preference, nifedipine, amlodipine, verapamil or diltiazem.
  • the compounds according to the invention are administered in combination with an angiotensin Aue antagonist, such as by way of example and preferably losartan, valsartan, candesartan, Embusartan, olmesartan or telmisartan.
  • the compounds according to the invention are administered in combination with an ACE inhibitor, such as by way of example and preferably enalapril, captopril, lisinopril, ramipril, delapril, fosinopril, quinopril, perindopril or trandopril.
  • an ACE inhibitor such as by way of example and preferably enalapril, captopril, lisinopril, ramipril, delapril, fosinopril, quinopril, perindopril or trandopril.
  • the compounds according to the invention are used in combination with a beta-receptor blocker, such as by way of example and preferably propranolol, atenolol, timolol, pindolol, alprenolol, oxprenolol, penbutolol, bupranolol, metipropanol, nadolol, mepindolol, carazalol, Sotalol, metoprolol, betaxolol, celiprolol, bisoprolol, Carteolol, esmolol, labetalol, carvedilol, adaprolol, landiolol, nebivolol, epanolol or bucine dolol administered.
  • a beta-receptor blocker such as by way of example and preferably propranolol, atenolol, timolol
  • the compounds according to the invention are administered in combination with an alpha-receptor-B looper, by way of example and preferably prazosin.
  • the compounds according to the invention are used in combination with a diuretic, such as by way of example and preferably furosemide, bumetanide, torsemide, bendroflumethiazide, chlorothiazide, hydrochlorothiazide, hydroflumethiazide, methyclothiazide, polythiazide, trichloromethiazide, chlorthalidone, indapamide, metolazone, quinethazone, Acetazolamide, dichlorophenamide, methazolamide, glycerol, isosorbide, mannitol, amiloride or triamterene.
  • a diuretic such as by way of example and preferably furosemide, bumetanide, torsemide, bendroflumethiazide, chlorothiazide, hydrochlorothiazide, hydroflumethiazide, methyclothiazide, polythiazide, trichloromethia
  • the compounds according to the invention are administered in combination with antisympathotonics such as reserpine, clonidine or alpha-methyl-dopa, with potassium channel agonists such as minoxidil, diazoxide, dihydralazine or hydralazine, or with nitric oxide-releasing substances such as glyceryl nitrate or nitroprusside sodium.
  • antisympathotonics such as reserpine, clonidine or alpha-methyl-dopa
  • potassium channel agonists such as minoxidil, diazoxide, dihydralazine or hydralazine
  • nitric oxide-releasing substances such as glyceryl nitrate or nitroprusside sodium.
  • Antithrombotic agents are preferably understood as meaning compounds from the group of platelet aggregation inhibitors or anticoagulants.
  • the compounds according to the invention are administered in combination with a platelet aggregation inhibitor, such as, by way of example and by way of preference, aspirin, clopidogrel, ticlopidine or dipyridamole.
  • a platelet aggregation inhibitor such as, by way of example and by way of preference, aspirin, clopidogrel, ticlopidine or dipyridamole.
  • the compounds according to the invention are administered in combination with a thrombin inhibitor, such as, by way of example and by way of preference, ximelagatran, melagatran, bivalirudin or Clexane.
  • the compounds according to the invention are administered in combination with a GPUb / IIIa antagonist, such as, by way of example and by way of preference, tirofiban or abciximab.
  • the compounds according to the invention are used in combination with a factor Xa inhibitor, such as by way of example and preferably rivaroxaban (BAY 59-7939), DU-176b, apixaban, otamixaban, fidexaban, razaxaban, fondaparinux, idraparinux, PMD No. 3112, YM-150, KFA-1982, EMD-503982, MCM-17, MLN-1021, DX 9065a, DPC 906, JTV 803, SSR-126512 or SSR-128428.
  • a factor Xa inhibitor such as by way of example and preferably rivaroxaban (BAY 59-7939), DU-176b, apixaban, otamixaban, fidexaban, razaxaban, fondaparinux, idraparinux, PMD No. 3112, YM-150, KFA-1982, EMD-503982, MCM
  • the compounds according to the invention are administered in combination with heparin or a low molecular weight (LMW) heparin derivative.
  • LMW low molecular weight
  • the compounds according to the invention are administered in combination with a vitamin K antagonist, such as by way of example and preferably coumarin.
  • compositions containing at least one compound of the invention usually together with one or more inert, non-toxic, pharmaceutically suitable excipients, and their use for the purposes mentioned above.
  • the compounds according to the invention can act systemically and / or locally.
  • they may be applied in a suitable manner, e.g. oral, parenteral, pulmonary, nasal, sublingual, lingual, buccal, rectal, dermal, transdermal, conjunctivae otic or as an implant or stent.
  • the compounds according to the invention can be administered in suitable administration forms.
  • the compounds of the invention rapidly and / or modified donating application forms containing the compounds of the invention in crystalline and / or amorphized and / or dissolved form, such as tablets (uncoated or coated Tablets, for example with enteric or delayed-release or insoluble coatings that control the release of the compound of the invention), orally disintegrating tablets or films / wafers, films / lyophilisates, capsules (for example, hard or soft gelatin capsules), dragees, granules, pellets, powders, Emulsions, suspensions, aerosols or solutions.
  • tablets uncoated or coated Tablets, for example with enteric or delayed-release or insoluble coatings that control the release of the compound of the invention
  • capsules for example, hard or soft gelatin capsules
  • dragees dragees, granules, pellets, powders, Emulsions, suspensions, aerosols or solutions.
  • Parenteral administration can be accomplished by bypassing a resorption step (e.g., intravenous, intraarterial, intracardiac, intraspinal, or intralumbar) or by resorting to absorption (e.g., intramuscular, subcutaneous, intracutaneous, percutaneous, or intraperitoneal).
  • a resorption step e.g., intravenous, intraarterial, intracardiac, intraspinal, or intralumbar
  • absorption e.g., intramuscular, subcutaneous, intracutaneous, percutaneous, or intraperitoneal.
  • parenteral administration are suitable as application forms u.a. Injection and infusion preparations in the form of solutions, suspensions, emulsions, lyophilisates or sterile powders.
  • Inhalation medicaments including powder inhalers, nebulizers
  • nasal drops solutions or sprays
  • lingual, sublingual or buccal tablets films / wafers or capsules
  • suppositories ear or ophthalmic preparations
  • vaginal capsules aqueous suspensions (lotions, shake mixtures), lipophilic suspensions
  • Ointments creams, transdermal therapeutic systems (eg patches), milk, pastes, foams, powdered powders, implants or stents.
  • the compounds according to the invention can be converted into the stated administration forms. This can be done in a conventional manner by mixing with inert, non-toxic, pharmaceutically suitable excipients.
  • excipients for example microcrystalline cellulose, lactose, mannitol
  • solvents for example liquid polyethylene glycols
  • emulsifiers and dispersants or wetting agents for example sodium dodecyl sulfate, polyoxysorbitanoleate
  • binders for example polyvinylpyrrolidone
  • synthetic and natural polymers for example albumin
  • Stabilizers eg, antioxidants such as ascorbic acid
  • dyes eg, inorganic pigments such as iron oxides
  • flavor and / or odoriferous include, among others.
  • Excipients for example microcrystalline cellulose, lactose, mannitol
  • solvents for example liquid polyethylene glycols
  • emulsifiers and dispersants or wetting agents for example sodium dodecy
  • the dosage is about 0.01 to 100 mg / kg, preferably about 0.01 to 20 mg / kg and most preferably 0.1 to 10 mg / kg of body weight.
  • Device type MS Micromass ZQ
  • Device type HPLC Waters Alliance 2795; Column: Merck Chromolith SpeedROD RP-18e 100 mm x 4.6 mm; Eluent A: water + 500 ⁇ l 50% formic acid / 1, eluent B: acetonitrile + 500 ⁇ l 50% formic acid / 1; Gradient: 0.0 min 10% B -> 7.0 min 95% B ⁇ 9.0 min 95% B; Oven: 35 ° C; Flow: 0.0 min 1.0 ml / min ⁇ 7.0 min 2.0 ml / min ⁇ 9.0 min 2.0 ml / min; UV detection: 210 nm.
  • Device type MS Micromass ZQ
  • Device type HPLC HP 1100 Series
  • UV DAD Column: Phenomenex Gemini 3 ⁇ 30 mm x 3.00 mm
  • Eluent A 1 l of water + 0.5 ml of 50% formic acid
  • eluent B 1 l of acetonitrile + 0.5 ml of 50% formic acid
  • Flow 0.0 min 1 ml / min ⁇ 2.5 min / 3.0 min / 4.5 min 2 ml / min
  • Oven 50 ° C .
  • UV detection 210 nm.
  • Device Type MS Waters ZQ
  • Device type HPLC Waters Alliance 2795
  • Eluent A 1 l of water + 0.5 ml of 50% formic acid
  • eluent B 1 l of acetonitrile + 0.5 ml of 50% formic acid
  • Flow 2 ml / min
  • Oven 40 ° C
  • UV detection 210 nm.
  • Device type MS Micromass ZQ
  • Device type HPLC Waters Alliance 2795; Column: Phenomenex Synergi 2.5 ⁇ MAX-RP 100A Mercury 20mm x 4mm; Eluent A: 1 l of water + 0.5 ml of 50% formic acid, eluent B: 1 l of acetonitrile + 0.5 ml of 50% formic acid; Gradient: 0.0 min 90% A -> 0.1 min 90% A ⁇ 3.0 min 5% A ⁇ 4.0 min 5% A ⁇ 4.01 min 90% A; Flow: 2 ml / min; Oven: 50 ° C .; UV detection: 210 nm.
  • Device type MS Micromass ZQ
  • Device type HPLC HP 1100 Series
  • UV DAD Column: Phenomenex Synergi 2 ⁇ Hydro-RP Mercury 20 mm x 4 mm
  • Eluent A 1 l of water + 0.5 ml of 50% formic acid
  • eluent B 1 l of acetonitrile + 0.5 ml of 50% formic acid
  • Flow 0.0 min 1 ml / min ⁇ 2.5 min / 3.0 min / 4.5 min 2 ml / min
  • Oven 50 ° C .
  • UV detection 210 nm.
  • Device type MS Micromass ZQ
  • Device type HPLC HP 1100 Series
  • UV DAD Column: Phenomenex Synergi 2.5 ⁇ MAX-RP 10OA Mercury 20mm x 4mm
  • Eluent A 1 l of water + 0.5 ml of 50% formic acid
  • eluent B 1 l of acetonitrile + 0.5 ml of 50% formic acid
  • Flow 2 ml / min
  • Oven 50 ° C .
  • UV detection 210 nm.
  • Device type MS Micromass ZQ
  • Device type HPLC Waters Alliance 2795; Column: Merck Chromolith SpeedROD RP-18e 100 mm x 4.6 mm; Eluent A: water + 500 ⁇ l 50% formic acid / 1; Eluent B: acetonitrile + 500 ⁇ l 50% formic acid / 1; Gradient: 0.0 min 10% B ⁇ 7.0 min 95% B ⁇ 9.0 min 95% B; Flow: 0.0 min 1.0 ml / min ⁇ 7.0 min 2.0 ml / min ⁇ 9.0 min 2.0 ml / min; Oven: 35 ° C; UV detection: 210 nm.
  • Device type MS M-40 DCI (NH 3 ); Device type HPLC: HP 1100 with DAD detection; Column: Kromasil 100 RP-18, 60 mm x 2.1 mm, 3.5 ⁇ m; Eluent A: 5 ml HClO 4 (70% strength) / liter water, eluent B: acetonitrile; Gradient: 0 min 2% B ⁇ 0.5 min 2% B ⁇ 4.5 min 90% B ⁇ 6.5 min 90% B ⁇ 6.7 min 2% B ⁇ 7.5 min 2% B; Flow: 0.75 ml / min; Column temperature: 30 ° C .; UV detection: 210 nm.
  • Instrument Micromass Quattro Premier with Waters UPLC Acquity; Column: Thermo Hypersil GOLD 1.9 ⁇ 50mm x 1mm; Eluent A: 1 l of water + 0.5 ml of 50% formic acid, eluent B: 1 l of acetonitrile + 0.5 ml of 50% formic acid; Gradient: 0.0 min 90% A ⁇ 0.1 min 90% A ⁇ 1.5 min 10% A ⁇ 2.2 min 10% A; Flow: 0.33 ml / min; Oven: 50 ° C .; UV detection: 210 nm.
  • Device type HPLC Abimed / Gilson Pump 305/306; Manometric Module 806; UV Knauer Variable Wavelenght Monitor; Column: Gromsil Cl 8, 10 nm, 250 mm x 30 mm; Eluent A: 1 1 water + 0.5 ml 99% trifluoroacetic acid, eluent B: 1 liter acetonitrile; Gradient: 0.0 min 2% B ⁇ 10 min 2% B ⁇ 50 min 90% B; Flow: 20 ml / min; Volume: 628 ml A and 372 ml B.
  • Device type HPLC Agilent 1100 with DAD detection; Column: Merck Chromolith SpeedROD RP-18e, 50 mm x 4.6 mm; Eluent A: 0.05% H 3 PO 4 , eluent B: acetonitrile; Gradient: 0 min 5% B ⁇ 2.5 min 95% B ⁇ 3.0 min 95% B; Flow: 5 ml / min; Column temperature: 40 ° C; UV detection: 210 nm.
  • Device Type MS Waters ZQ
  • Device Type HPLC Agilent 1100 Series
  • UV DAD Column: Thermo Hypersil GOLD 3 ⁇ 20mm x 4mm
  • Eluent A 1 l of water + 0.5 ml of 50% formic acid
  • eluent B 1 l of acetonitrile + 0.5 ml of 50% formic acid
  • UV detection 210 nm.
  • Instrument Micromass GCT, GC 6890; Column: Restek RTX-35, 15 m ⁇ 200 ⁇ m ⁇ 0.33 ⁇ m; constant flow with helium: 0.88 ml / min; Oven: 70 ° C; Inlet: 250 ° C; Gradient: 70 0 C, 30 ° C / min ⁇ 310 0 C (3 min hold).
  • Example IA The title compound was prepared analogously to the procedure for Example IA from 4-hydroxybenzaldehyde and cyclohexene oxide.
  • Triphenylphosphine in 50 ml of THF was added dropwise at about 10 ° C. to 6.3 ml (30 mmol) of diisopropyl azodicarboxylate.
  • 1 g (6 mmol) of 4-nitrobenzoic acid and, after the addition had been added a further 4 g (24 mmol) of 4-nitrobenzoic acid were added and the mixture was stirred at RT overnight.
  • 6.4 g (24 mmol) of triphenylphosphine and 5.2 ml (24.7 mmol) of diisopropyl azodicarboxylate were again added and the mixture was stirred at RT for a further night.
  • the title compound was obtained analogously to the procedure for Example 19A from the compound from Example 13A. Purification was carried out by dissolving the residue obtained after treatment with 2N hydrochloric acid in dilute sodium hydroxide solution, extracting with ethyl acetate, acidifying the aqueous phase with dilute hydrochloric acid and extracting once more with ethyl acetate. The second ethyl acetate phase was concentrated and the residue was dried under high vacuum. This crude product was used without further purification in the next stage.
  • Example 17A To the reaction solution obtained in Example 17A was added 0.92 g (9.15 mmol) of 2-cyanothioacetamide and 0.92 ml (8.32 mmol) of 4-methylmorpholine and heated under reflux for 18 h. The resulting precipitate was filtered off, washed with a little ethanol and dried.
  • Example 18A To the reaction solution obtained in Example 18A, 0.68 g (6.78 mmol) of 2-cyanothioacetamide and 0.69 ml (6.17 mmol) of 4-methylmorpholine were added and heated under reflux for 18 hours. The solvent was then distilled off in vacuo and the residue was processed further without further purification.
  • the title compound was prepared analogously to the procedure of Example 30 from the starting compounds 22A and 35A.
  • the title compound was prepared analogously to the procedure of Example 30 from the starting compounds 22A and 38A.
  • Example 23A The reaction solution obtained in Example 23A was admixed with 1 ml of DMF, 43 mg (0.25 mmol) of 3-chloromethylpyridine hydrochloride and 70 mg (0.5 mmol) of potassium carbonate and stirred at 50 ° C. overnight. Then, 0.2 ml of 5 N acetic acid was added and the solution was purified directly by preparative HPLC. The product-containing fractions were purified by repeated preparative HPLC. The resulting solid (21.6 mg) was dissolved in hot ethanol, treated with water and partially concentrated. The resulting precipitate was filtered off, washed with water and dried under high vacuum.
  • Cells of the permanent line CHO are stably transfected with the cDNA for the adenosine receptor subtypes Al, A2a and A2b.
  • the adenosine Al receptors are coupled to G proteins, while the adenosine A2a and A2b receptors via G s proteins to adenylate cyclase. Accordingly, cAMP production in the cell is inhibited or stimulated. Via a cAMP-dependent promoter, the expression of the luciferase is then modulated.
  • the luciferase test is optimized with the aim of high sensitivity and reproducibility, low variance and suitability for implementation on a robotic system by varying several test parameters, such as cell density, growing phase and test incubation, forskolin concentration and medium composition.
  • test parameters such as cell density, growing phase and test incubation, forskolin concentration and medium composition.
  • the stock cultures are grown in DMEM / F12 medium with 10% FCS (fetal calf serum) at 37 ° C under 5% CO 2 and split 1:10 each after 2-3 days.
  • Test cultures are seeded at 2,000 cells per well in 384-well plates and grown at 37 ° C for approximately 48 hours. Then the medium is replaced by a physiological saline solution (130 mM sodium chloride, 5 mM potassium chloride, 2 mM calcium chloride, 20 mM HEPES, 1 mM magnesium chloride hexahydrate, 5 mM sodium hydrogen carbonate, pH 7.4).
  • DMSO substances to be tested are in a dilution series of 5 x 10 * 11 M to 3 x 10 -6 M (final concentration) to the test cultures pipetted (maximum DMSO final concentration in test mixture: 0.5%). Ten minutes later, forskolin is added to the Al cells, and then all cultures are incubated for four hours at 37 ° C.
  • the reference compound used in these experiments is the adenosine-analogous compound NECA (5-N-ethylcarboxamido-adenosine), which binds with high affinity to all adenosine receptor subtypes and a has an agonistic activity [Klotz, KN, Hessling, J., Hegler, J., Owman, C, KuIl, B., Fredholm, BB, Lohse, MJ, "Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells ", Naunyn Schmiedeberg's Arch. Pharmacol. 357. 1-9 (1998)].
  • NECA adenosine-analogous compound
  • Table 1 shows the EC 5 o values of representative embodiments for the receptor stimulation on adenosine A1, A2a and A2b receptor subtypes:
  • the caudal artery is prepared and clamped in a conventional apparatus for measuring isolated vessels.
  • the vessels are perfused in a heat bath and contracted with phenylephrine.
  • the degree of contraction is determined by a contraction knife.
  • test substances are given and measured the decrease in the contraction of the vessels.
  • a decrease in contraction corresponds to a dilatation of the vessels.
  • the EC 50 value of a test substance with regard to its relaxing properties is the concentration at which the contraction of the vessels is reduced by 50%.
  • Guards SH spontaneous hypertensive rats carrying an internal transmitter capable of measuring both blood pressure and heart rate permanently (telemetric detection of hemodynamic parameters) are given test substances in different dosages orally. Subsequently, blood pressure and heart rate and their changes are recorded over 24 hours.
  • Guards Claw monkeys carrying an internal transmitter which can permanently measure both blood pressure and heart rate (telemetric detection of hemodynamic parameters), test substances are administered orally in various concentrations. Subsequently, blood pressure and heart rate and their changes are recorded over 6-24 hours.
  • the substance to be examined is administered to animals (eg mouse, rat, dog) intravenously as a solution, the oral administration is carried out as a solution or suspension via a gavage. After substance administration, the animals are bled at fixed times. This is heparinized and then plasma is recovered therefrom by centrifugation. The substance is in the Plasma quantified analytically by LC / MS-MS. From the plasma concentration-time curves determined in this way, the pharmacokinetic parameters such as AUC (area under the concentration-time curve), C n13x (maximum plasma concentration), T m (half-life) and CL (clearance) are calculated by means of a validated pharmacokinetic calculation program.
  • PBS buffer pH 6.5: 90.00 g NaCl pa (for example from Merck, Item No. 1.06404.1000), 13.61 g KH 2 PO 4 pa (for example from Merck, Item No. 1,04873,1000) and 83.35 g of 1N sodium hydroxide solution (eg from Bernd Kraft GmbH, Item No. 01030.4000) are weighed into a 1 liter volumetric flask, made up to 1 liter with distilled water and stirred for 1 hour. After that, with 1 N
  • Hydrochloric acid for example from Merck, Item No. 1.09057.1000
  • the pH is adjusted to 6.5.
  • PEG / water solution 70:30 v / v: 70 ml of polyethylene glycol 400 (for example from Merck, Item No. 8.17003.1000) and 30 ml of distilled water are homogenized in a 100 ml volumetric flask.
  • PEG / PBS buffer pH 6.5 (20:80 v / v): 20 ml of polyethylene glycol 400 (eg from Merck, Item No. 8.17003.1000) and 80 ml of PBS buffer pH 6.5 are dissolved in a 100 ml. Homogenized volumetric flask.
  • Dimethylsulfoxide e.g., Baker Co., Art No. 71572500
  • At least 4 mg of the test substance are accurately weighed into a wide-mouth 10 mm Screw V-Vial (Glastechnik Gräfenroda GmbH, Item No. 8004-WM-H / V15 ⁇ ) with a matching screw cap and septum in a pipetting robot with DMSO until added to a concentration of 50 mg / ml and shaken for 10 minutes.
  • Preparation of the starting solution for calibration solutions (stock solution): On a microtiter plate, 10 ⁇ l of the original solution are transferred using a pipetting robot and made up to a concentration of 600 ⁇ g / ml with DMSO. The sample is shaken until completely dissolved.
  • Calibration solution 1 (20 ⁇ g / ml): Mix 34.4 ⁇ l of the stock solution with 1000 ⁇ l of DMSO and homogenize.
  • Calibration solution 2 (2.5 ⁇ g / ml): 100 ⁇ l of the calibration solution 1 are mixed with 700 ⁇ l of DMSO and homogenized.
  • Sample solution for solubility up to 5 g / liter in PBS buffer pH 6.5 Transfer 10 ⁇ l of the original solution into a microtiter plate and add 1000 ⁇ l of PBS buffer pH 6.5.
  • Agilent 1100 with DAD (Gl 315A), quat. Pump (Gl 31 IA), autosampler CTC HTS PAL, degasser (G1322A) and column thermostat (G1316A); Column: Phenomenex Gemini C18, 50 mm x 2 mm, 5 ⁇ ; Temperature: 40 ° C .; Eluent A: water / phosphoric acid pH 2; Eluent B: acetonitrile; Flow rate: 0.7 ml / min; Gradient: 0-0.5 min 85% A, 15% B; Ramp: 0.5-3 min 10% A, 90% B; 3-3.5 min 10% A, 90% B; Ramp: 3.5-4 min 85% A, 15% B; 4-5 minutes 85% A, 15% B.
  • Agilent 1100 with DAD (Gl 315A), quat. Pump (G1311A), autosampler CTC HTS PAL, degasser (G1322A) and column thermostat (G1316A); Column: VDSoptilab Kromasil 100 C18, 60 mm x 2.1 mm, 3.5 ⁇ ; Temperature: 30 ° C .; Eluent A: water + 5 ml perchloric acid / liter; Eluent B: acetonitrile; Flow rate: 0.75 ml / min; Gradient: 0-0.5 min 98% A, 2% B; Ramp: 0.5-4.5 min 10% A, 90% B; 4.5-6 min 10% A, 90% B; Ramp: 6.5-6.7 min 98% A, 2% B; 6.7-7.5 min 98% A, 2% B.
  • the compounds according to the invention can be converted into pharmaceutical preparations as follows:
  • the mixture of compound of the invention, lactose and starch is granulated with a 5% solution (m / m) of the PVP in water.
  • the granules are mixed after drying with the magnesium stearate for 5 minutes.
  • This mixture is compressed with a conventional tablet press (for the tablet format see above).
  • a pressing force of 15 kN is used as a guideline for the compression.
  • a single dose of 100 mg of the compound of the invention corresponds to 10 ml of oral suspension.
  • the rhodigel is suspended in ethanol, the compound according to the invention is added to the suspension. While stirring, the addition of water. Until the completion of the swelling of Rhodigels is stirred for about 6 h.
  • a single dose of 100 mg of the compound according to the invention corresponds to 20 g of oral solution.
  • the compound of the invention is suspended in the mixture of polyethylene glycol and polysorbate with stirring. The stirring is continued until complete dissolution of the compound according to the invention.
  • the compound of the invention is dissolved in a concentration below saturation solubility in a physiologically acceptable solvent (e.g., isotonic saline, glucose solution 5% and / or PEG 400 solution 30%).
  • a physiologically acceptable solvent e.g., isotonic saline, glucose solution 5% and / or PEG 400 solution 30%.
  • the solution is sterile filtered and filled into sterile and pyrogen-free injection containers.

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Abstract

L'invention concerne : de nouveaux dérivés de 4-phényl-3,5-dicyanopyridine substitués par un groupe cycloalkoxy, de formule (1) ; des procédés pour leur fabrication ; leur utilisation pour le traitement et/ou la prévention de maladies et leur utilisation pour la fabrication de médicaments pour le traitement et/ou la prévention de maladies, de préférence pour le traitement et/ou la prévention d'affections cardiovasculaires et métaboliques.
EP09711052A 2008-02-13 2009-01-31 4-phényl-3,5-dicyanopyridines substituées par un groupe cycloalkoxy, et leur utilisation Withdrawn EP2242741A1 (fr)

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DE102008008838A DE102008008838A1 (de) 2008-02-13 2008-02-13 Cycloalkoxy-substituierte 4-Phenyl-3,5-dicyanopyridine und ihre Verwendung
PCT/EP2009/000645 WO2009100827A1 (fr) 2008-02-13 2009-01-31 4-phényl-3,5-dicyanopyridines substituées par un groupe cycloalkoxy, et leur utilisation

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DE102010030688A1 (de) 2010-06-30 2012-01-05 Bayer Schering Pharma Aktiengesellschaft Substituierte Dicyanopyridine und ihre Verwendung
EP2567959B1 (fr) 2011-09-12 2014-04-16 Sanofi Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
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WO2018153898A1 (fr) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Agonistes partiels sélectifs du récepteur a1 de l'adénosine en combinaison avec des antagonistes du récepteur des minéralocorticoïdes
WO2018153899A1 (fr) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Agonistes partiels sélectifs du récepteur a1 de l'adénosine en combinaison avec des stimulateurs et/ou activateurs de la guanylate cyclase soluble (sgc)
WO2018153895A1 (fr) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Agonistes partiels sélectifs du récepteur a1 de l'adénosine en combinaison avec un inhibiteur de l'endopeptidase neutre et/ou un antagoniste du récepteur de l'angiotensine ii
WO2018153897A1 (fr) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Agonistes partiels sélectifs du récepteur a1 de l'adénosine en combinaison avec des inhibiteurs des canaux hcn
WO2018153900A1 (fr) 2017-02-22 2018-08-30 Bayer Aktiengesellschaft Agonistes partiels sélectifs du récepteur a1 de l'adénosine en combinaison avec des inhibiteurs de sglt-2
EP4479399A4 (fr) * 2022-02-17 2026-03-18 Lucy Therapeutics Inc Ligands de l'adénosine pour le traitement de troubles neurologiques
WO2025214474A1 (fr) * 2024-04-11 2025-10-16 Shaoxing City Youluofei Pharmaceutical Co., Ltd. Ligands sélectifs du récepteur de l'adénosine

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US20110021487A1 (en) 2011-01-27
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CA2714656A1 (fr) 2009-08-20
WO2009100827A1 (fr) 2009-08-20

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