EP2254899A4 - BLOCKING METASTASES OF CANCER CELLS AND NOVEL COMPOSITIONS THEREFOR - Google Patents

BLOCKING METASTASES OF CANCER CELLS AND NOVEL COMPOSITIONS THEREFOR

Info

Publication number
EP2254899A4
EP2254899A4 EP09721583A EP09721583A EP2254899A4 EP 2254899 A4 EP2254899 A4 EP 2254899A4 EP 09721583 A EP09721583 A EP 09721583A EP 09721583 A EP09721583 A EP 09721583A EP 2254899 A4 EP2254899 A4 EP 2254899A4
Authority
EP
European Patent Office
Prior art keywords
metastases
blocking
cancer cells
novel compositions
compositions therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09721583A
Other languages
German (de)
French (fr)
Other versions
EP2254899A1 (en
Inventor
Pui-Kwong Chan
May Sung Mak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pacific Arrow Ltd
Original Assignee
Pacific Arrow Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2008/002086 external-priority patent/WO2008133766A1/en
Priority claimed from US12/344,682 external-priority patent/US8841265B2/en
Application filed by Pacific Arrow Ltd filed Critical Pacific Arrow Ltd
Publication of EP2254899A1 publication Critical patent/EP2254899A1/en
Publication of EP2254899A4 publication Critical patent/EP2254899A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP09721583A 2008-02-15 2009-02-13 BLOCKING METASTASES OF CANCER CELLS AND NOVEL COMPOSITIONS THEREFOR Withdrawn EP2254899A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/US2008/002086 WO2008133766A1 (en) 2007-02-16 2008-02-15 Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
US3827708P 2008-03-20 2008-03-20
US5430808P 2008-05-19 2008-05-19
US12/344,682 US8841265B2 (en) 2003-10-09 2008-12-29 Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof
PCT/US2009/034115 WO2009117196A1 (en) 2008-02-15 2009-02-13 Blocking the metastasis of cancer cells and the uses of new compounds thereof

Publications (2)

Publication Number Publication Date
EP2254899A1 EP2254899A1 (en) 2010-12-01
EP2254899A4 true EP2254899A4 (en) 2012-05-30

Family

ID=41091216

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09721583A Withdrawn EP2254899A4 (en) 2008-02-15 2009-02-13 BLOCKING METASTASES OF CANCER CELLS AND NOVEL COMPOSITIONS THEREFOR

Country Status (5)

Country Link
EP (1) EP2254899A4 (en)
CN (1) CN101998964B (en)
AU (1) AU2009226063A1 (en)
CA (1) CA2715501A1 (en)
WO (1) WO2009117196A1 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201136604A (en) 2009-12-14 2011-11-01 Oncotherapy Science Inc TMEM22 peptides and vaccines including the same
KR101873607B1 (en) * 2010-07-16 2018-07-02 퍼시픽 애로우 리미티드 New compounds for treating cancer and other diseases
EP2593111B1 (en) * 2010-07-16 2017-09-27 Pacific Arrow Limited New compounds for treating cancer and other diseases
GB201016902D0 (en) 2010-10-07 2010-11-24 Chamberlain Luke A boiler assembly comprising a removable boiler unit
WO2013061328A2 (en) 2011-10-27 2013-05-02 Yeda Research And Development Co. Ltd. Method of treating cancer
CN102864234B (en) * 2012-09-29 2014-03-19 山东大学齐鲁医院 Molecular marker for identifying susceptibility of ovarian cancer
CN102851388B (en) * 2012-09-29 2014-03-19 山东大学齐鲁医院 Molecular marker for identifying susceptibility of ovarian cancer, kit and identifying method thereof
CN104062432B (en) * 2013-03-22 2016-01-20 中山大学 The application of ang2 in preparation ECTC vascular group diagnosing cancer of liver reagent and medicine
WO2015157476A2 (en) * 2014-04-10 2015-10-15 Academia Sinica Pdia4 protein as a target for diagnosis, monitoring and treatment of diabetes
CN103992236B (en) * 2014-04-29 2016-05-18 于非 A kind of New Target tropism antineoplastic and preparation method thereof and application
CN105467127B (en) * 2015-03-23 2017-06-06 复旦大学 The application process and its detection kit of a kind of human colon carcinoma protein markers COL6A3
WO2018045509A1 (en) * 2016-09-07 2018-03-15 武汉华大吉诺因生物科技有限公司 Polypeptide and application thereof
WO2018219342A1 (en) * 2017-06-01 2018-12-06 立森印迹诊断技术有限公司 Imprinted gene graded model and diagnostic method and application
CN107312855B (en) * 2017-07-24 2020-12-25 青岛泱深生物医药有限公司 Gene related to laryngeal squamous cell carcinoma and application thereof
CN107543926A (en) * 2017-08-25 2018-01-05 复旦大学附属金山医院 A kind of application of new Diagnosis of Breast invasive ductal carcinoma
TW201919644A (en) * 2017-09-29 2019-06-01 台灣浩鼎生技股份有限公司 Method for treating leukemia
CN108103194B (en) * 2017-12-27 2021-05-18 中国医学科学院药用植物研究所 A target for inhibiting gastric cancer cell MGC-803 and its application
CN108220421B (en) * 2018-01-05 2019-04-05 智海基因科技南京有限公司 The diagnostic kit and related gene of oneself immunity hepatitis are preparing the application in the kit
CN110272997B (en) * 2018-03-14 2023-04-28 华中科技大学同济医学院附属同济医院 Use of a C/EBPβ gene or protein
CN108728539A (en) * 2018-06-05 2018-11-02 浙江大学 A kind of application of HoxD10 genes in gastric cancer
CN108840923B (en) * 2018-06-22 2021-08-03 上海交通大学医学院附属仁济医院 A kind of polypeptide targeting PD-L1 and its application
CN108642181B (en) * 2018-06-25 2021-09-10 遵义医科大学附属医院 Application of long-chain non-coding RNA SLC25A25-AS1
CN111217900A (en) * 2018-11-27 2020-06-02 上海交通大学 Transcription regulation factor for angiogenesis and application thereof
CN111289749B (en) * 2018-12-10 2023-04-14 北京蛋白质组研究中心 Application of C-type 1 Niemann-Pickin detection substance in the preparation of products for screening hepatocellular carcinoma
CN109402119A (en) * 2018-12-11 2019-03-01 宁夏医科大学总医院 A kind of circular rna hsa_circTGFBI_001 and its specificity amplification primer and application
CN109402125A (en) * 2018-12-11 2019-03-01 宁夏医科大学总医院 A kind of circular rna hsa_circTGFBI_007 and its specificity amplification primer and application
CN110672848A (en) * 2019-10-25 2020-01-10 四川大学华西医院 Application of APEH autoantibody detection reagent in preparation of lung cancer screening kit
CN111153956B (en) * 2019-12-06 2020-12-11 江苏一片叶高新科技有限公司 A kind of tea saponin compound, preparation method and application
CN110938630B (en) * 2019-12-20 2023-07-28 中国人民解放军第四军医大学 Application of human B3GNT5 gene and related products
CN111166769B (en) * 2020-03-18 2022-01-11 山东大学 Application of dermal fibroblast in treating melanoma
CN111979328B (en) * 2020-09-07 2022-10-14 复旦大学附属中山医院 Biomarker for predicting liver cancer lung metastasis and application thereof
CN112011620B (en) * 2020-09-23 2021-04-27 山东大学第二医院 Application of circ-SLC38A1 as target in medicine for inhibiting bladder cancer cells
CN112481373B (en) * 2020-12-21 2022-01-28 华北理工大学 circRNA detection kit for auxiliary diagnosis of autism
CN115404272B (en) * 2021-05-28 2025-06-27 中国医学科学院基础医学研究所 Use of ADAMTS1 gene polymorphisms for predicting the risk of Alzheimer's disease
CN114015689B (en) * 2021-10-26 2024-06-07 江苏大学 ShRNA sequence for specifically inhibiting GOS2 gene expression and application thereof
CN114984187B (en) * 2022-07-20 2024-07-26 南通大学 Application of transmembrane protein Tmem63b in preparation of medicine for treating peripheral nerve demyelinating diseases
CN115806575B (en) * 2022-10-19 2025-04-08 中南林业科技大学 A terpenoid compound and its extraction method and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038700A1 (en) * 1998-12-22 2000-07-06 Janssen Pharmaceutica N.V. Antiprotozoal saponins
US20070161580A1 (en) * 2003-10-09 2007-07-12 Chan Pui-Kwong Anti-Tumor Compounds With Angeloyl Groups

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038700A1 (en) * 1998-12-22 2000-07-06 Janssen Pharmaceutica N.V. Antiprotozoal saponins
US20040138151A1 (en) * 1998-12-22 2004-07-15 Janssen Pharmaceutica N.V. Antiprotozoal saponins
US20070161580A1 (en) * 2003-10-09 2007-07-12 Chan Pui-Kwong Anti-Tumor Compounds With Angeloyl Groups

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GERMONPREZ, NILS ET AL: "Antileishmanial saponins from Maesa", XP002673641, retrieved from STN Database accession no. 2003:888935 *
GERMONPREZ NILS ET AL: "In vitro and in vivo anti-leishmanial activity of triterpenoid saponins isolated from Maesa balansae and some chemical derivatives", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 1, 13 January 2005 (2005-01-13), pages 32 - 37, XP002672062, ISSN: 0022-2623 *
GERMONPREZ, NILS ET AL: "Antileishmanial saponins from Maesa", TAP CHI HOA HOC , 41(SPEC.), 125-130 CODEN: TCHHDC; ISSN: 0378-2336, 2003 *
LOUIS MAES ET AL: "In Vitro and In Vivo Activities of a Triterpenoid Saponin Extract (PX-6518) from the Plant Maesa balansae against Visceral Leishmania Species", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 48, no. 1, 1 January 2004 (2004-01-01), pages 130 - 136, XP008140635, ISSN: 0066-4804, DOI: 10.1128/AAC.48.1.130-136.2004 *
LU Y ET AL: "Triterpenoid saponins from the roots of tea plant (Camellia sinensis var. assamica)", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 53, no. 8, 1 April 2000 (2000-04-01), pages 941 - 946, XP027262251, ISSN: 0031-9422, [retrieved on 20000401] *
ODA K ET AL: "Adjuvant and Haemolytic Activities of 47 Saponins Derived from Medicinal and Food Plants", BIOLOGICAL CHEMISTRY, WALTER DE GRUYTER GMBH & CO, BERLIN, DE, vol. 381, 1 January 2000 (2000-01-01), pages 67 - 74, XP003005996, ISSN: 1431-6730, DOI: 10.1515/BC.2000.009 *
See also references of WO2009117196A1 *

Also Published As

Publication number Publication date
WO2009117196A8 (en) 2009-11-26
WO2009117196A1 (en) 2009-09-24
AU2009226063A1 (en) 2009-09-24
CN101998964B (en) 2015-05-06
CN101998964A (en) 2011-03-30
EP2254899A1 (en) 2010-12-01
CA2715501A1 (en) 2009-09-24

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