EP2254899A4 - Blockierung der metastase von krebszellen sowie anwendungen der daraus gewonnenen neuen verbindungen - Google Patents

Blockierung der metastase von krebszellen sowie anwendungen der daraus gewonnenen neuen verbindungen

Info

Publication number
EP2254899A4
EP2254899A4 EP09721583A EP09721583A EP2254899A4 EP 2254899 A4 EP2254899 A4 EP 2254899A4 EP 09721583 A EP09721583 A EP 09721583A EP 09721583 A EP09721583 A EP 09721583A EP 2254899 A4 EP2254899 A4 EP 2254899A4
Authority
EP
European Patent Office
Prior art keywords
metastases
blocking
cancer cells
novel compositions
compositions therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09721583A
Other languages
English (en)
French (fr)
Other versions
EP2254899A1 (de
Inventor
Pui-Kwong Chan
May Sung Mak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pacific Arrow Ltd
Original Assignee
Pacific Arrow Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2008/002086 external-priority patent/WO2008133766A1/en
Priority claimed from US12/344,682 external-priority patent/US8841265B2/en
Application filed by Pacific Arrow Ltd filed Critical Pacific Arrow Ltd
Publication of EP2254899A1 publication Critical patent/EP2254899A1/de
Publication of EP2254899A4 publication Critical patent/EP2254899A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP09721583A 2008-02-15 2009-02-13 Blockierung der metastase von krebszellen sowie anwendungen der daraus gewonnenen neuen verbindungen Withdrawn EP2254899A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/US2008/002086 WO2008133766A1 (en) 2007-02-16 2008-02-15 Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
US3827708P 2008-03-20 2008-03-20
US5430808P 2008-05-19 2008-05-19
US12/344,682 US8841265B2 (en) 2003-10-09 2008-12-29 Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof
PCT/US2009/034115 WO2009117196A1 (en) 2008-02-15 2009-02-13 Blocking the metastasis of cancer cells and the uses of new compounds thereof

Publications (2)

Publication Number Publication Date
EP2254899A1 EP2254899A1 (de) 2010-12-01
EP2254899A4 true EP2254899A4 (de) 2012-05-30

Family

ID=41091216

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09721583A Withdrawn EP2254899A4 (de) 2008-02-15 2009-02-13 Blockierung der metastase von krebszellen sowie anwendungen der daraus gewonnenen neuen verbindungen

Country Status (5)

Country Link
EP (1) EP2254899A4 (de)
CN (1) CN101998964B (de)
AU (1) AU2009226063A1 (de)
CA (1) CA2715501A1 (de)
WO (1) WO2009117196A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201136604A (en) 2009-12-14 2011-11-01 Oncotherapy Science Inc TMEM22 peptides and vaccines including the same
KR101873607B1 (ko) * 2010-07-16 2018-07-02 퍼시픽 애로우 리미티드 암 및 다른 질환들을 치료하기 위한 화합물
EP2593111B1 (de) * 2010-07-16 2017-09-27 Pacific Arrow Limited Neue verbindungen zur behandlung von krebs und anderen krankheiten
GB201016902D0 (en) 2010-10-07 2010-11-24 Chamberlain Luke A boiler assembly comprising a removable boiler unit
WO2013061328A2 (en) 2011-10-27 2013-05-02 Yeda Research And Development Co. Ltd. Method of treating cancer
CN102864234B (zh) * 2012-09-29 2014-03-19 山东大学齐鲁医院 一种用于鉴别卵巢癌易感性的分子标记
CN102851388B (zh) * 2012-09-29 2014-03-19 山东大学齐鲁医院 一种用于鉴别卵巢癌易感性的分子标记、试剂盒及其鉴别方法
CN104062432B (zh) * 2013-03-22 2016-01-20 中山大学 ang2在制备ECTC血管类型肝癌诊断试剂及治疗药物中的应用
WO2015157476A2 (en) * 2014-04-10 2015-10-15 Academia Sinica Pdia4 protein as a target for diagnosis, monitoring and treatment of diabetes
CN103992236B (zh) * 2014-04-29 2016-05-18 于非 一种新型靶向性抗肿瘤药物及其制备方法与应用
CN105467127B (zh) * 2015-03-23 2017-06-06 复旦大学 一种人结肠癌蛋白质标志物col6a3的应用方法及其检测试剂盒
WO2018045509A1 (zh) * 2016-09-07 2018-03-15 武汉华大吉诺因生物科技有限公司 多肽及其应用
WO2018219342A1 (zh) * 2017-06-01 2018-12-06 立森印迹诊断技术有限公司 一种印记基因分级模型和诊断方法及其应用
CN107312855B (zh) * 2017-07-24 2020-12-25 青岛泱深生物医药有限公司 一种与喉鳞癌相关的基因及其应用
CN107543926A (zh) * 2017-08-25 2018-01-05 复旦大学附属金山医院 一种新的诊断乳腺浸润性导管癌的应用
TW201919644A (zh) * 2017-09-29 2019-06-01 台灣浩鼎生技股份有限公司 治療血癌的方法
CN108103194B (zh) * 2017-12-27 2021-05-18 中国医学科学院药用植物研究所 一种抑制胃癌细胞mgc-803的靶点及其应用
CN108220421B (zh) * 2018-01-05 2019-04-05 智海基因科技南京有限公司 自身免疫性肝炎的诊断试剂盒及相关基因在制备该试剂盒中的应用
CN110272997B (zh) * 2018-03-14 2023-04-28 华中科技大学同济医学院附属同济医院 一种C/EBPβ基因或者蛋白的用途
CN108728539A (zh) * 2018-06-05 2018-11-02 浙江大学 一种HoxD10基因在胃癌中的应用
CN108840923B (zh) * 2018-06-22 2021-08-03 上海交通大学医学院附属仁济医院 一种靶向pd-l1的多肽及其应用
CN108642181B (zh) * 2018-06-25 2021-09-10 遵义医科大学附属医院 长链非编码rna slc25a25-as1的应用
CN111217900A (zh) * 2018-11-27 2020-06-02 上海交通大学 一种血管新生的转录调控因子及其用途
CN111289749B (zh) * 2018-12-10 2023-04-14 北京蛋白质组研究中心 C型1类尼曼-匹克蛋白检测物在制备筛查肝细胞癌产品中的应用
CN109402119A (zh) * 2018-12-11 2019-03-01 宁夏医科大学总医院 一种环状RNA hsa_circTGFBI_001及其特异性扩增引物和应用
CN109402125A (zh) * 2018-12-11 2019-03-01 宁夏医科大学总医院 一种环状RNA hsa_circTGFBI_007及其特异性扩增引物和应用
CN110672848A (zh) * 2019-10-25 2020-01-10 四川大学华西医院 Apeh自身抗体检测试剂在制备肺癌筛查试剂盒中的用途
CN111153956B (zh) * 2019-12-06 2020-12-11 江苏一片叶高新科技有限公司 一种茶皂苷类化合物、制备方法及应用
CN110938630B (zh) * 2019-12-20 2023-07-28 中国人民解放军第四军医大学 人b3gnt5基因的用途及相关产品
CN111166769B (zh) * 2020-03-18 2022-01-11 山东大学 真皮成纤维细胞在治疗黑色素瘤中的应用
CN111979328B (zh) * 2020-09-07 2022-10-14 复旦大学附属中山医院 一种预测肝癌肺转移的生物标志物及其应用
CN112011620B (zh) * 2020-09-23 2021-04-27 山东大学第二医院 circ-SLC38A1作为靶点在抑制膀胱癌细胞药物中的应用
CN112481373B (zh) * 2020-12-21 2022-01-28 华北理工大学 一种用于孤独症辅助诊断的circRNA检测试剂盒
CN115404272B (zh) * 2021-05-28 2025-06-27 中国医学科学院基础医学研究所 Adamts1基因多态性用于预测阿尔茨海默病风险的用途
CN114015689B (zh) * 2021-10-26 2024-06-07 江苏大学 一种特异性抑制GOS2基因表达的shRNA序列及其应用
CN114984187B (zh) * 2022-07-20 2024-07-26 南通大学 跨膜蛋白Tmem63b在制备治疗周围神经脱髓鞘类疾病的药物中的应用
CN115806575B (zh) * 2022-10-19 2025-04-08 中南林业科技大学 一种萜类化合物及其提取方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038700A1 (en) * 1998-12-22 2000-07-06 Janssen Pharmaceutica N.V. Antiprotozoal saponins
US20070161580A1 (en) * 2003-10-09 2007-07-12 Chan Pui-Kwong Anti-Tumor Compounds With Angeloyl Groups

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038700A1 (en) * 1998-12-22 2000-07-06 Janssen Pharmaceutica N.V. Antiprotozoal saponins
US20040138151A1 (en) * 1998-12-22 2004-07-15 Janssen Pharmaceutica N.V. Antiprotozoal saponins
US20070161580A1 (en) * 2003-10-09 2007-07-12 Chan Pui-Kwong Anti-Tumor Compounds With Angeloyl Groups

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GERMONPREZ, NILS ET AL: "Antileishmanial saponins from Maesa", XP002673641, retrieved from STN Database accession no. 2003:888935 *
GERMONPREZ NILS ET AL: "In vitro and in vivo anti-leishmanial activity of triterpenoid saponins isolated from Maesa balansae and some chemical derivatives", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 1, 13 January 2005 (2005-01-13), pages 32 - 37, XP002672062, ISSN: 0022-2623 *
GERMONPREZ, NILS ET AL: "Antileishmanial saponins from Maesa", TAP CHI HOA HOC , 41(SPEC.), 125-130 CODEN: TCHHDC; ISSN: 0378-2336, 2003 *
LOUIS MAES ET AL: "In Vitro and In Vivo Activities of a Triterpenoid Saponin Extract (PX-6518) from the Plant Maesa balansae against Visceral Leishmania Species", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 48, no. 1, 1 January 2004 (2004-01-01), pages 130 - 136, XP008140635, ISSN: 0066-4804, DOI: 10.1128/AAC.48.1.130-136.2004 *
LU Y ET AL: "Triterpenoid saponins from the roots of tea plant (Camellia sinensis var. assamica)", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 53, no. 8, 1 April 2000 (2000-04-01), pages 941 - 946, XP027262251, ISSN: 0031-9422, [retrieved on 20000401] *
ODA K ET AL: "Adjuvant and Haemolytic Activities of 47 Saponins Derived from Medicinal and Food Plants", BIOLOGICAL CHEMISTRY, WALTER DE GRUYTER GMBH & CO, BERLIN, DE, vol. 381, 1 January 2000 (2000-01-01), pages 67 - 74, XP003005996, ISSN: 1431-6730, DOI: 10.1515/BC.2000.009 *
See also references of WO2009117196A1 *

Also Published As

Publication number Publication date
WO2009117196A8 (en) 2009-11-26
WO2009117196A1 (en) 2009-09-24
AU2009226063A1 (en) 2009-09-24
CN101998964B (zh) 2015-05-06
CN101998964A (zh) 2011-03-30
EP2254899A1 (de) 2010-12-01
CA2715501A1 (en) 2009-09-24

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