EP2259783A2 - 3-(2-diméthylaminométhyl-cyclohexyl)-phénol contre les douleurs polyneuropathiques - Google Patents

3-(2-diméthylaminométhyl-cyclohexyl)-phénol contre les douleurs polyneuropathiques

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Publication number
EP2259783A2
EP2259783A2 EP09708857A EP09708857A EP2259783A2 EP 2259783 A2 EP2259783 A2 EP 2259783A2 EP 09708857 A EP09708857 A EP 09708857A EP 09708857 A EP09708857 A EP 09708857A EP 2259783 A2 EP2259783 A2 EP 2259783A2
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EP
European Patent Office
Prior art keywords
pain
polyneuropathy
dosage form
use according
phenol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
EP09708857A
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German (de)
English (en)
Inventor
Thomas Christoph
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
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Gruenenthal GmbH
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Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to EP09708857A priority Critical patent/EP2259783A2/fr
Publication of EP2259783A2 publication Critical patent/EP2259783A2/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Definitions

  • the invention relates to the treatment of polyneuropathic pain, in particular in diabetic polyneuropathy or chemically induced polyneuropathy, by administration of 3- (2-dimethylaminomethylcyclohexyl) phenol, preferably of (1R, 2R) -3- (2-dimethylaminomethylcyclohexyl) phenol, or one of its pharmaceutically acceptable salts.
  • Neuropathy is a disease of the nervous system.
  • mononeuro- pathy individual nerves are affected.
  • Typical mononeuropathies are peripheral facial palsy, carpal tunnel syndrome, ulnar nerve lesion, radial nerve paresis and peroneal paresis.
  • polyneuropathy many nerves are affected simultaneously. About 3% of all people over the age of 60 suffer from polyneuropathy.
  • neuropathy may affect motor, sensory or autonomic nerves.
  • peripheral polyneuropathy There are two main forms: peripheral polyneuropathy and autonomic polyneuropathy.
  • Peripheral polyneuropathy affects the nervous system which can be influenced by the will, for example the nerves which are responsible for the sense of touch (sensible) or the muscular movement (motor). Overall, impairments of the sensory nerve fibers, which conduct information from the periphery to the spinal cord and brain, are observed earlier and more pronounced. The motor nerves, which are responsible for the movement of the muscles, can also be affected. Muscle cramps are common, massive paralysis rather rare.
  • Autonomic polyneuropathy affects the involuntary, non-willed nervous system (sympathetic and parasympathetic). For example, this autonomic nervous system regulates the changing pace of the heartbeat or gastrointestinal movements during digestion. Up to 50 percent of diabetics suffer from autonomic polyneuropathy after 20 years of illness. The symptoms depend on which organs of the body are affected:
  • CONFIRMATION COPY The disease can affect both the isolation of the nerve (myelin) and the cell process (axon). Symmetrical and asymmetrical shapes can occur. Symptoms vary depending on the type of nerve fiber and body region. Since the cell bodies (somata) of the sensory nerve cells in the ganglia are close to the spinal cord and the nerve processes are supplied from there, the longest nerve fibers, which have to be supplied to the toes by the organism, are most likely to be damaged. Often the disease begins with unpleasant sensations in the toes. As the disease progresses, patients often describe the distribution of discomfort as "glove-shaped" or "sock-shaped". The affected areas of the body may be tingling and uncomfortably disturbed by numbness, heavier forms may manifest themselves in polyneuropathic pain, which is often felt as burning pain. There may also be false sensations, such as cold, heat or swelling feeling occur.
  • the signs and symptoms of polyneuropathy can be divided into three groups: (i) small-fiber sensory (eg burning pain, cutaneous hyperesthesia, praesthesia, lancing pain, loss of pain and temperature perception, loss of visceral pain sensation, foot ulceration), (ii ) Large-fiber sensory (eg loss of vibration perception, ataxia due to loss of propioception, loss of reflexes, slowed nerve conduction velocity) and (iii) autonomic (eg, arrhythmia, resting tachycardia, loss of adequate heart rate adjustment, silent heart attacks, congestive heart failure, orthostatic hypotension, gustatory sweating , Hyperthermia, gastroparesis, neuropathic diarrhea, constipation, bladder dysfunction, erectile dysfunction, retrograde ejaculation).
  • small-fiber sensory eg burning pain, cutaneous hyperesthesia, praesthesia, lancing pain, loss of pain and temperature perception, loss of visceral pain sensation, foot ulceration
  • Large-fiber sensory eg loss of vibration perception,
  • fiber type A- ⁇ (I) 13-20 ⁇ m, myelinated: proprioception of the limbs;
  • Fiber type A-ß (M) (6-12 ⁇ m, myelinated): Proprioception of the limbs, vibration, pressure;
  • Fiber type A- ⁇ (III) (1-5 ⁇ m, myelinated): mechanical, sharp, stabbing pain, intense pressure on the skin (via mechanical nociceptors) and extreme temperature (via thermal nociceptors);
  • Fiber type C (IV) (0.2-1, 5 ⁇ m, unmyelinated): burning, persistent, diffuse pain, temperature-triggered pain, mechanical burning pain over polymodal nociceptors at high intensity of thermal or chemical stimuli. Satisfactory control of pain in polyneuropathy by administration of conventional analgesics is limited (H. Chen et al., Mayo Clin Proc., 2004, 79, 1533-45, M. Namaka et al., Clin Ther., 2004, 26, 951 -79). Placebo-controlled trials in the treatment of pain in polyneuropathy have resulted in the following NNT scores (Numbers Needed to Treat ⁇ Number of patients requiring treatment with the drug for more than 50% pain relief):
  • the effectiveness of a drug in the treatment of pain can in principle be expressed in several ways. In addition to relieving pain on a pain scale, sometimes also, an increase in the average pain threshold and / or a reduction in the number of pain-sensitive tender points (tender points) are observed, which is particularly advantageous.
  • the object of the invention is to provide medicaments which have advantages over conventional medicaments.
  • the medicinal products should enable the treatment of polyneuropathic pain and thereby provide as much pain relief as possible with the least possible side effects.
  • the invention relates to the use of the active ingredient 3- (2-dimethylaminomethylcyclohexyl) phenol or one of its pharmaceutically acceptable salts for the preparation of a pharmaceutical composition for the treatment of polyneuropathic pain.
  • Another aspect of the invention relates to 3- (2-dimethylaminomethylcyclohexyl) phenol or one of its pharmaceutically acceptable salts for the treatment of polyneuropathic pain.
  • the active ingredient is in the form of the (1R, 2R) stereoisomer, ie as (1R, 2R) -3- (2-dimethylaminomethylcyclohexyl) phenol (faxeladol).
  • the other stereoisomers ie (1 R.2S), (1 S.2R) and (1S.2S) are suitable.
  • the active ingredient may be present as a free base or as a pharmaceutically acceptable salt.
  • Preferred pharmaceutically acceptable salts are salts of inorganic acids, for example the hydrochloride, hydrobromide, sulfate, hydrogen sulfate, dihydrogen phosphate, hydrogen phosphate and phosphate; and organic acid salts, eg, methanesulfonate, hexane-1-sulfonate, formate, acetate, oxalate, succinate, malate, tartrate, mandelate, fumarate, maleate, lactate, citrate, glutamate, saccharinate, sebacinate, monomethyl sebacinate, 5-oxo-prolinate , Nicotinate, benzoate, aminobenzoate, methylbenzoate, trimethylbenzoate, ⁇ -liponate, N-acetylglycinate, N-acetylalaninate, N-acetylcysteinate, N-acetylisoleucinate, N-acetylleucinate, N-acetylmethioninate,
  • the active ingredient is formulated in a pharmaceutical composition.
  • the pharmaceutical composition of the invention may e.g. be firm, pasty or liquid.
  • it contains pharmaceutically acceptable excipients, for example fillers, binders, solvents, lubricants and / or disintegrants.
  • excipients for example fillers, binders, solvents, lubricants and / or disintegrants.
  • suitable auxiliaries are known to the person skilled in the art. In this context, reference may be made, for example, to H. P. Fiedler, Lexikon der Hilfsstoffe für Pharmazie, Kosmetik und Nachbar withe, Editio Cantor Aulendorf.
  • the drug content of the pharmaceutical composition is in the range of 0.001 to 99.999 wt%, more preferably 0.1 to 95 wt%, even more preferably 1.0 to 80 wt%, most preferably 2.5 to 65 wt%. % and in particular 5.0 to 50% by weight, based on the total weight of the pharmaceutical composition.
  • the pharmaceutical composition according to the invention may optionally contain other active substances which may, for example, be selected from the group consisting of selective serotonin and norepinephrine reuptake inhibitors, ⁇ 2 ⁇ Ligands, tricyclic antidepressants, opioids and other analgesics.
  • active substances may, for example, be selected from the group consisting of selective serotonin and norepinephrine reuptake inhibitors, ⁇ 2 ⁇ Ligands, tricyclic antidepressants, opioids and other analgesics.
  • a COX II inhibitor is not simultaneously contained, preferably no further active ingredient at all.
  • the pharmaceutical composition is present as a dosage form.
  • the dosage form according to the invention can be, for example, solid, pasty or liquid.
  • the dosage form according to the invention is formulated for systemic, parenteral, topical or local administration.
  • the dosage form according to the invention is formulated for oral or buccal administration.
  • other forms of administration are also possible, for example for buccal, sublingual, transmucosal, rectal, intralumbar, intraperitoneal, transdermal, intravenous, intramuscular, intragluteal, intracutaneous and subcutaneous administration.
  • the dosage form preferably contains suitable additives and / or auxiliaries.
  • suitable additives and / or auxiliaries in the context of the invention are all substances known to the person skilled in the art from the prior art for achieving galenic formulations.
  • the choice of these excipients and the amounts to be used depend on how the dosage form is to be administered, i. oral, intravenous, intraperitoneal, intradermal, intramuscular, intranasal, buccal or local.
  • preparations in the form of tablets, chewable tablets, dragees, capsules, granules, drops, juices or syrups are suitable, for parenteral, topical and inhalative administration solutions, suspensions, readily reconstitutable dry preparations and sprays.
  • parenteral, topical and inhalative administration solutions, suspensions, readily reconstitutable dry preparations and sprays are suitable.
  • suppositories for rectal use are examples of suitable percutaneous administration forms.
  • the dosage form may be in the form of a simple tablet and a coated tablet (e.g., a coated tablet or dragee).
  • the tablets are usually round and biconvex, but oblong forms are also possible.
  • Granules, spheroids, pellets or microcapsules filled in sachets or capsules or compressed into disintegrating tablets are also possible.
  • excipients and additives for the oral administration forms are disintegrants, lubricants, binders, fillers, mold release agents, optionally solvents, flavorings, sugars, in particular vehicles, diluents, dyes, antioxidants, etc.
  • Waxes or fatty acid esters may be used for suppositories and excipients, preservatives, suspending agents etc. may be used for parenteral application agents.
  • Excipients may be, for example: water, ethanol, 2-propanol, glycerol, ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, glucose, fructose, lactose, sucrose, dextrose, molasses, starch, modified starch, gelatin, sorbitol, inositol, mannitol, microcrystalline cellulose , Methylcellulose, carboxymethylcellulose, cellulose acetate, shellac, cetyl alcohol, polyvinylpyrrolidone, paraffins, waxes, natural and synthetic gums, acacia, alginates, dextran, saturated and unsaturated fatty acids, stearic acid, magnesium stearate, zinc stearate, glyceryl ste
  • a solid formulation such as a tablet
  • the active ingredient of the drug with a pharmaceutical carrier, e.g. conventional tablet ingredients, such as corn starch, lactose, sucrose, sorbitol, talc, magnesium stearate, dicalcium phosphate or pharmaceutically acceptable gums, and pharmaceutical diluents, e.g. Water, granulated to form a solid composition containing the active ingredient in a homogeneous distribution.
  • a homogeneous distribution is understood here to mean that the active ingredient is distributed uniformly over the entire composition, so that it can be readily subdivided into equally effective unit dose forms, such as tablets, capsules, dragees.
  • the solid composition is then subdivided into unit dose forms.
  • the tablets or pills may also be coated or otherwise compounded to provide a sustained release dosage form.
  • Suitable coating agents are i.a. polymeric acids and mixtures of polymeric acids with materials such as e.g. Shellac, cetyl alcohol and / or cellulose acetate.
  • the dosage form according to the invention is formulated for one, two or three times daily administration. Delayed release of the active ingredient can be achieved, for example, by retarding with the aid of a matrix, a coating or osmotic-release systems (cf., for example, WO 2005/009329).
  • the dosage form according to the invention under in vitro conditions after 1 h at least 5 wt .-%, more preferably at least 10 wt .-%, more preferably at least 15 wt .-%, most preferably at least 20 wt .-% and in particular at least 25 wt. -% of the active substance originally contained in the dosage form.
  • the dosage form according to the invention under in vitro conditions after 1 h at most 95 wt .-%, more preferably at most 90 wt .-%, more preferably at most 85 wt .-%, most preferably at most 80 wt .-% and in particular at most 75 wt. -% of the active substance originally contained in the dosage form.
  • Suitable methods for determining the in vitro release rate are known to the person skilled in the art.
  • the determination under sink conditions at 75 U / min in a buffer (according to Ph. Eur.) At a pH of 6.8 at 37 ° C and under UV spectroscopic detection using a Blattrühepparatur or Drehkörbchenmethode.
  • the dosage form according to the invention preferably contains the active ingredient in a dosage in the range of 1.0 to 1000 mg, more preferably 5.0 to 900 mg, even more preferably 10 to 800 mg, most preferably 15 to 700 mg and in particular 20 to 600 mg, in each case on the free base.
  • the dosage form is formulated for oral administration;
  • the dosage form is a solid and / or compressed and / or film-coated dosage form; and or
  • the dosage form releases the active substance from a matrix with a delay
  • the dosage form contains the active substance in an amount of 0.001 to 99.999% by weight, more preferably 0.1 to 99.9% by weight, even more preferably 1.0 to 99.0% by weight, more preferably 2.5 up to 80% by weight, most preferably 5.0 to 50% by weight and in particular 7.5 to 40% by weight, based on the total weight of the dosage form; and or
  • the dosage form contains the dosage form a pharmaceutically acceptable carrier and / or pharmaceutically acceptable excipients; and or the dosage form has a total mass in the range from 25 to 2,000 mg, more preferably 50 to 1,800 mg, even more preferably 60 to 1,600 mg, even more preferably 70 to 1,400 mg, most preferably 80 to 1,200 mg and especially 100 to 1,000 mg, and / or
  • the dosage form is selected from the group consisting of tablets, capsules, pellets and granules.
  • Another aspect of the invention relates to a dosage form as described above for the treatment of polyneuropathic pain.
  • the active ingredient 3- (2-dimethylaminomethylcyclohexyl) phenol and its pharmaceutically acceptable salts are suitable for the treatment of polyneuropathic pain.
  • the pain is peripheral polyneuropathic pain or central polyneuropathic pain.
  • Polyneuropathy or polyneuropathic pain is preferably acute (up to four weeks), subacute (four to eight weeks) or chronic (more than eight weeks).
  • the motor, sensory, autonomous, sensorimotor or central nervous system is preferably affected.
  • the symptoms are distributed symmetrically or asymmetrically.
  • the pain can be mild, moderate, moderate, strong or very strong.
  • the neuropathic pain scale (NPS) can serve as a measure (see B.S. Galer et al., Neurology 1997, 48, 332-8).
  • causes of peripheral polyneuropathic pain are diabetic polyneuropathy, postherpetic neuralgia, radioculopathy, posttraumatic neuralgia, by chemical substances, e.g. Chemotherapy-induced polyneuropathy, phantom limb pain, complex regional syndrome, HIV-induced sensory polyneuropathy, and alcoholic polyneuropathy.
  • causes of central polyneuropathic pain include compressive myelopathy due to narrowed canal stenosis, posstraumatic spinal pain, stroke pain, postischemic myelopathy, radiation-induced myelopathy, multiple sclerosis-induced myelopathia, and HIV-induced myelopathy.
  • the polyneuropathic pain causing polyneuropathy is associated with a disease selected from the group consisting of diabetes, diabetes mellitus, vasculitis, uremia, hypotyrodism, alcohol abuse, postherpetic neuralgia, idiopathic neuropathy, chronic inflammatory demyelinating neuropathy, multifocal motor neuropathy, hereditary Polyneuropathy, Guillain-Barre syndrome, intoxication [eg by alcohol, heavy metals ⁇ in particular Pb 1 Hg 1 As ⁇ , hydrocarbons resulting from chemotherapy with cytostatic drugs], porphyria, infectious diseases, cancers [eg myeloma, amyloid, leukemia, lymphoma], pernicious anemia, vitamin E deficiency, Refsum disease, Bassen branch Syndrome, Fabry disease, vasculitis and amyloidosis.
  • a disease selected from the group consisting of diabetes, diabetes mellitus, vasculitis, uremia, hypotyrodism, alcohol
  • Diabetic polyneuropathy and postherpetic neuralgia are particularly preferred. If it is an infectious disease, it is preferably selected from the group consisting of mononucleosis, ehrlichiosis, typhus, diphtheria, leprosy, HIV, syphilis and Lyme disease.
  • the polyneuropathic pain is preferably pain which has as its cause a polyneuropathy within the meaning of ICD-10 (International Statistical Classification of Diseases and Related Health Problems, WHO edition, preferably as of 2008).
  • Polyneuropathy is preferably selected from paraneoplastic polyneuropathy, hereditary and idiopathic neuropathy [G60], polyneuritis [G61], other polyneuropathies [G62], polyneuropathy in diseases classified elsewhere [G63], neuralgia or the like. [M79.2-], Neuritis o.n.A. [M79.2-], peripheral neuritis during pregnancy [O26.83] and radiculitis o.n.A. [M54.1-].
  • hereditary or idiopathic neuropathy is preferably selected from the group consisting of hereditary sensorimotor neuropathy [G60.0] (Charcot-Marie-Tooth-Hoffmann syndrome, Dejerine-Sottas disease, hereditary sensorimotor Neuropathy, type I-IV, hypertrophic neuropathy of infancy, peroneal muscle atrophy (axonal type) (hypertrophic form), Roussy-Levy syndrome); Refsum disease [G60.1]; Neuropathy associated with hereditary ataxia [G60.2]; idiopathic progressive neuropathy [G60.3]; other hereditary and idiopathic neuropathy [G60.8] (Morvan's disease, Nelaton's syndrome, sensory neuropathy: dominant inheritance or recessive inheritance); and hereditary and idiopathic neuropathy, unspecified [G60.9].
  • G60.0 Hereditary sensorimotor neuropathy
  • Nelaton's syndrome Nelaton's syndrome, sensory neuropathy: dominant
  • polyneuritis preferably selected from the group consisting of Guillain-Barre syndrome (polyradiculoneuropathy) [G61.0] (acute (post-) infectious polyneuritis); Serum polyneuropathy [G61.1], other polyneuritis [G61.8] and polyneuritis, unspecified [G61.9].
  • G61.0 acute (post-) infectious polyneuritis
  • Serum polyneuropathy G61.1
  • other polyneuritis G61.8
  • polyneuritis unspecified [G61.9].
  • polyneuropathy In the case of other polyneuropathy [G62], it is preferably selected from the group consisting of drug-induced polyneuropathy [G62.0], alcoholic polyneuropathy [G62.1], polyneuropathy by other toxic agents [G62.2], others specified polyneuropathy [G62.8] (radiation-induced polyneuropathy, Critical disease polyneuropathy [G62.80], other specified polyneuropathy [G62.88]) and polyneuropathy, unspecified [G62.9] (neuropathy onA).
  • polyneuropathy in diseases classified elsewhere [G63] it is preferably selected from the group consisting of polyneuropathy in infectious and parasitic diseases classified elsewhere [G63.0] (polyneuropathy in: diphtheria [A36.8fl, infectious mononucleosis [A36.8 B27.f], leprosy [A30 " t], Lyme disease [A69.2fl, mumps [B26.8fl, after zoster [B02.2t], late syphilis [A52.1fl, late syphilis, congenital [A50.4f], tuberculosis Polyneuropathy in neoplasms [G63.1] [C0 ⁇ - D48f]; diabetic polyneuropathy [G63.2] [E10 ⁇ -E14t, fourth digit .4]; polyneuropathy in other endocrine and metabolic diseases [G63.3 ] [EOE-EOTf, E15-E16f, E20
  • the polyneuropathic pain is associated with diabetic polyneuropathy [G63.2]. More than half of all diabetics develop nerve damage (polyneuropathy) if they have been suffering from diabetes for more than ten years. If you take all type 1 and type 2 diabetics together, about 30 percent suffer from it.
  • the polyneuropathic pain is induced by toxic agents (chemically induced polyneuropathy), preferably by drugs (e.g., chemotherapeutics) [G62.0] or alcohol [G62.1].
  • toxic agents chemically induced polyneuropathy
  • drugs e.g., chemotherapeutics
  • G62.0 chemotherapeutics
  • alcohol G62.1
  • chemotherapeutics e.g., chemotherapeutics
  • Various toxic agents are known which can induce polyneuropathy. Examples of drugs are cisplatin, didanosine, stavudine and zalcitabine.
  • Inhibition of cold allodynia at each time point of measurement was expressed as the percent pretreatment (% MPE) effect, with the pretest corresponding to 0% MPE and complete inhibition (0 eviction responses per 2 min) to 100% MPE.
  • the significance of a substance effect was determined on the basis of the percent inhibition values against the vehicle group by means of two-factorial analysis of variance and post hoc analysis according to Bonferroni, the ED 50 value via linear regression analysis for the individual measurement points or the area under the curve (AUC).
  • Rats were treated with vehicle (0.9% NaCl) or vincristine (200 ⁇ g / kg iv) (1 ml / kg) on five days (day 4, 6, 8, 10, 12) resulting in a cumulative vincristine dose of 1 mg / kg.
  • vehicle 0.9% NaCl
  • vincristine 200 ⁇ g / kg iv
  • ml / kg ml / kg
  • acetone 10 ⁇ l
  • the number of induced pull-out reactions was recorded over a period of 30 seconds.
  • the cumulative number of 5 stimulations was determined before and at various times after drug or vehicle delivery.
  • the significance of a substance effect was determined on the basis of the percentage inhibition values against the vehicle group by means of two-factorial analysis of variance and post hoc analysis according to Bonferroni, the ED 50 value via linear regression analysis for the individual measurement points.
  • the ED 50 value at the same time after administration (30 min) in the polyneuropathic pain model is 5.7 mg / kg ip and in the mononeuropathic pain model is 17.6 mg / kg ip, ie approximately in the polyneuropathic pain model a factor of 3 is more effective.
  • a multi-dose crossover study was performed to evaluate the analgesic efficacy of oral (1R, 2R) -3- (2-dimethylaminomethylcyclohexyl) phenol (Faxeladol) prolonged release (PR) compared to placebo in patients with painful polyneuropathy of various origins.
  • the study was conducted as a randomized, double-blind, multicenter, double-blind, crossover study of phase II placebo control.
  • Faxeladol PR 120 mg to 240 mg has been demonstrated in patients with a history of painful polyneuropathy. Faxeladol PR was clearly superior to placebo in reducing average pain intensity.

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  • Biomedical Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
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Abstract

L'invention concerne l'utilisation de l'agent actif 3-(2-diméthylaminométhyl-cyclohexyl)-phénol ou d'un de sels pharmaceutiquement acceptables pour la fabrication d'une composition pharmaceutique destinée au traitement des douleurs polyneuropathiques, notamment en cas de polyneuropathie diabétique.
EP09708857A 2008-02-04 2009-02-02 3-(2-diméthylaminométhyl-cyclohexyl)-phénol contre les douleurs polyneuropathiques Withdrawn EP2259783A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09708857A EP2259783A2 (fr) 2008-02-04 2009-02-02 3-(2-diméthylaminométhyl-cyclohexyl)-phénol contre les douleurs polyneuropathiques

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08002013A EP2085081A1 (fr) 2008-02-04 2008-02-04 3-(2-diméthylaminométhyle-cyclohexyl)-phénol contre la douleur polyneuropathique
EP09708857A EP2259783A2 (fr) 2008-02-04 2009-02-02 3-(2-diméthylaminométhyl-cyclohexyl)-phénol contre les douleurs polyneuropathiques
PCT/EP2009/000655 WO2009098008A2 (fr) 2008-02-04 2009-02-02 3-(2-diméthylaminométhyl-cyclohexyl)-phénol contre les douleurs polyneuropathiques

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EP2259783A2 true EP2259783A2 (fr) 2010-12-15

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EP09708857A Withdrawn EP2259783A2 (fr) 2008-02-04 2009-02-02 3-(2-diméthylaminométhyl-cyclohexyl)-phénol contre les douleurs polyneuropathiques

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US (1) US20090197960A1 (fr)
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EP2085081A1 (fr) 2009-08-05
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WO2009098008A2 (fr) 2009-08-13
WO2009098008A3 (fr) 2009-12-10

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