EP2298778A4 - Dérivé d imidazothiazole ayant une structure cyclique de 4,7-diazaspiroý2.5¨octane - Google Patents

Dérivé d imidazothiazole ayant une structure cyclique de 4,7-diazaspiroý2.5¨octane

Info

Publication number
EP2298778A4
EP2298778A4 EP09762499A EP09762499A EP2298778A4 EP 2298778 A4 EP2298778 A4 EP 2298778A4 EP 09762499 A EP09762499 A EP 09762499A EP 09762499 A EP09762499 A EP 09762499A EP 2298778 A4 EP2298778 A4 EP 2298778A4
Authority
EP
European Patent Office
Prior art keywords
imidazothiazole
diazaspiro
derivate
cyclic structure
cyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09762499A
Other languages
German (de)
English (en)
Other versions
EP2298778A1 (fr
Inventor
Kouichi Uoto
Haruko Kawato
Yuuichi Sugimoto
Hiroyuki Naito
Masaki Miyazaki
Toru Taniguchi
Masashi Aonuma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of EP2298778A1 publication Critical patent/EP2298778A1/fr
Publication of EP2298778A4 publication Critical patent/EP2298778A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EP09762499A 2008-06-12 2009-06-10 Dérivé d imidazothiazole ayant une structure cyclique de 4,7-diazaspiroý2.5¨octane Withdrawn EP2298778A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008154036 2008-06-12
PCT/JP2009/060575 WO2009151069A1 (fr) 2008-06-12 2009-06-10 Dérivé d’imidazothiazole ayant une structure cyclique de 4,7-diazaspiro[2.5]octane

Publications (2)

Publication Number Publication Date
EP2298778A1 EP2298778A1 (fr) 2011-03-23
EP2298778A4 true EP2298778A4 (fr) 2011-10-05

Family

ID=41416775

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09762499A Withdrawn EP2298778A4 (fr) 2008-06-12 2009-06-10 Dérivé d imidazothiazole ayant une structure cyclique de 4,7-diazaspiroý2.5¨octane

Country Status (4)

Country Link
EP (1) EP2298778A4 (fr)
JP (1) JPWO2009151069A1 (fr)
TW (1) TW201002724A (fr)
WO (1) WO2009151069A1 (fr)

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US8629141B2 (en) 2011-05-11 2014-01-14 The Regents Of The University Of Michigan Spiro-oxindole MDM2 antagonists
TW201429969A (zh) 2012-12-20 2014-08-01 Merck Sharp & Dohme 作爲ｈｄｍ２抑制劑之經取代咪唑吡啶
US20170216286A1 (en) 2014-01-28 2017-08-03 Mayo Foundation For Medical Education And Research Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid
US10328058B2 (en) 2014-01-28 2019-06-25 Mayo Foundation For Medical Education And Research Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques
AU2015211021B2 (en) 2014-01-28 2020-07-02 Buck Institute For Research On Aging Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
CN105111155B (zh) * 2015-08-31 2018-12-14 武汉工程大学 一种4,7-二氮杂螺[2.5]辛烷-7-甲酸叔丁酯的合成方法
WO2017176958A1 (fr) 2016-04-06 2017-10-12 The Regents Of The University Of Michigan Intermédiaires monofonctionnels pour la dégradation d'une protéine cible dépendante du ligand
AU2017246452C1 (en) 2016-04-06 2021-06-03 The Regents Of The University Of Michigan MDM2 protein degraders
EP3458101B1 (fr) 2016-05-20 2020-12-30 H. Hoffnabb-La Roche Ag Conjugués anticorps-protac et procédés d'utilisation
CN108530375B (zh) * 2018-05-29 2020-04-21 南京药石科技股份有限公司 4-氧杂-7-氮杂螺[2.5]辛烷或其盐的中间体及制备方法
CN111943894A (zh) * 2019-05-17 2020-11-17 南京爱德程医药科技有限公司 一种4,7-二氮杂螺[2.5]辛烷类化合物的合成方法
CN111943893B (zh) * 2019-05-17 2024-07-26 南京爱德程医药科技有限公司 4,7-二氮杂螺[2,5]辛烷类化合物的合成方法
WO2023056069A1 (fr) 2021-09-30 2023-04-06 Angiex, Inc. Conjugués agent de dégradation-anticorps et leurs procédés d'utilisation
WO2023165523A1 (fr) * 2022-03-01 2023-09-07 上海璎黎药业有限公司 Dérivé méthoxy substitué par un cycle aromatique et son utilisation
WO2024240858A1 (fr) 2023-05-23 2024-11-28 Valerio Therapeutics Molécules protac dirigées contre un système de réparation de dommages à l'adn et leurs utilisations

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EP1167369A1 (fr) * 1999-04-06 2002-01-02 Yamanouchi Pharmaceutical Co. Ltd. Nouveaux derives de thiazolobenzimidazole
US6696441B1 (en) * 2000-08-11 2004-02-24 The Regents Of The University Of California Inhibition of p53-induced stress response
EP1486501A1 (fr) * 2002-03-20 2004-12-15 Yamanouchi Pharmaceutical Co. Ltd. Derive de thiazolobenzimidazole substitue par aminomethyle
WO2010082612A1 (fr) * 2009-01-16 2010-07-22 第一三共株式会社 Dérivé d'imidazothiazole comprenant une structure de noyau proline

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JP2005306839A (ja) * 2003-08-29 2005-11-04 Takeda Chem Ind Ltd 二環性ピペラジン化合物およびその用途
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JP4955646B2 (ja) 2005-03-16 2012-06-20 エフ．ホフマン−ラ ロシュ アーゲー シス−２，４，５−トリアリール−イミダゾリン及びそれらの抗癌薬としての使用
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SG174107A1 (en) 2006-08-30 2011-09-29 Univ Michigan New small molecule inhibitors of mdm2 and the uses thereof
AU2007332493A1 (en) * 2006-12-14 2008-06-19 Daiichi Sankyo Company, Limited Imidazothiazole derivatives
PL2134720T3 (pl) 2007-03-29 2011-04-29 Novartis Ag Heterocykliczne spiro-związki

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1167369A1 (fr) * 1999-04-06 2002-01-02 Yamanouchi Pharmaceutical Co. Ltd. Nouveaux derives de thiazolobenzimidazole
US6696441B1 (en) * 2000-08-11 2004-02-24 The Regents Of The University Of California Inhibition of p53-induced stress response
EP1486501A1 (fr) * 2002-03-20 2004-12-15 Yamanouchi Pharmaceutical Co. Ltd. Derive de thiazolobenzimidazole substitue par aminomethyle
WO2010082612A1 (fr) * 2009-01-16 2010-07-22 第一三共株式会社 Dérivé d'imidazothiazole comprenant une structure de noyau proline

Non-Patent Citations (1)

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Title
See also references of WO2009151069A1 *

Also Published As

Publication number Publication date
TW201002724A (en) 2010-01-16
EP2298778A1 (fr) 2011-03-23
JPWO2009151069A1 (ja) 2011-11-17
WO2009151069A1 (fr) 2009-12-17

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