EP2346563A4 - Micro-aiguilles polymères à transition de phase - Google Patents
Micro-aiguilles polymères à transition de phaseInfo
- Publication number
- EP2346563A4 EP2346563A4 EP09818735A EP09818735A EP2346563A4 EP 2346563 A4 EP2346563 A4 EP 2346563A4 EP 09818735 A EP09818735 A EP 09818735A EP 09818735 A EP09818735 A EP 09818735A EP 2346563 A4 EP2346563 A4 EP 2346563A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- phase transition
- polymer micro
- micro needles
- needles
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10356008P | 2008-10-07 | 2008-10-07 | |
| PCT/CN2009/000510 WO2010040271A1 (fr) | 2008-10-07 | 2009-05-12 | Micro-aiguilles polymères à transition de phase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP2346563A1 EP2346563A1 (fr) | 2011-07-27 |
| EP2346563A4 true EP2346563A4 (fr) | 2012-02-29 |
| EP2346563B1 EP2346563B1 (fr) | 2018-08-29 |
Family
ID=42100193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP09818735.4A Not-in-force EP2346563B1 (fr) | 2008-10-07 | 2009-05-12 | Micro-aiguilles polymères à transition de phase |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9320878B2 (fr) |
| EP (1) | EP2346563B1 (fr) |
| JP (1) | JP5879126B2 (fr) |
| CN (1) | CN102202720B (fr) |
| CA (1) | CA2739876A1 (fr) |
| DK (1) | DK2346563T3 (fr) |
| ES (1) | ES2691388T3 (fr) |
| WO (1) | WO2010040271A1 (fr) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
| EP2146689B1 (fr) | 2007-04-16 | 2020-08-12 | Corium, Inc. | Réseaux de micro-aiguilles coulées dans un solvant contenant un actif |
| US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| JP6327852B2 (ja) | 2010-05-04 | 2018-05-23 | コリウム インターナショナル， インコーポレイテッド | 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス |
| JP5688752B2 (ja) * | 2010-07-22 | 2015-03-25 | コスメディ製薬株式会社 | 経皮吸収製剤およびその製造方法 |
| JP5808102B2 (ja) * | 2010-07-22 | 2015-11-10 | コスメディ製薬株式会社 | 抗原を含有する経皮免疫製剤およびその製造方法 |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| NZ611076A (en) | 2010-12-01 | 2015-09-25 | Alderbio Holdings Llc | Anti-ngf compositions and use thereof |
| WO2012115208A1 (fr) * | 2011-02-24 | 2012-08-30 | 久光製薬株式会社 | Composition d'analogue de glp-1 pour des dispositifs de micro aiguille |
| JP2014236758A (ja) * | 2011-09-30 | 2014-12-18 | テルモ株式会社 | センサ |
| WO2013063614A1 (fr) * | 2011-10-28 | 2013-05-02 | Sung-Yun Kwon | Timbre perforateur à solution solide dissolvable pour le traitement de la migraine |
| JP5990913B2 (ja) * | 2012-01-31 | 2016-09-14 | 凸版印刷株式会社 | 針状体の製造方法 |
| US20130216779A1 (en) | 2012-02-16 | 2013-08-22 | University Of Tennessee Research Foundation | Nanostructures from Laser-Ablated Nanohole Templates |
| CN102580232B (zh) * | 2012-02-23 | 2013-12-18 | 游学秋 | 一种丝素微针系统和丝素纳米颗粒及其制备方法 |
| JP6098059B2 (ja) * | 2012-07-20 | 2017-03-22 | 凸版印刷株式会社 | 針状体の製造方法および針状体 |
| US9764060B2 (en) | 2012-08-09 | 2017-09-19 | The Royal Institution For The Advancement Of Learning / Mcgill University | Dense hydrogels |
| US10980865B2 (en) | 2012-08-10 | 2021-04-20 | Aquavit Pharmaceuticals, Inc. | Direct application system and method for the delivery of bioactive compositions and formulations |
| JP6034398B2 (ja) * | 2012-11-13 | 2016-11-30 | 富士フイルム株式会社 | モールド成形体及び経皮吸収シートの製造方法 |
| CN104780967B (zh) * | 2012-11-13 | 2017-04-12 | 富士胶片株式会社 | 经皮吸收片的制造方法 |
| AU2013364053B2 (en) | 2012-12-21 | 2018-08-30 | Corium Pharma Solutions, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| WO2014121051A1 (fr) * | 2013-02-01 | 2014-08-07 | The Brigham And Women's Hospital, Inc. | Aiguilles adhésives dilatables |
| CA2903748C (fr) | 2013-03-12 | 2021-11-02 | Corium International, Inc. | Applicateurs de microprojection |
| AU2014237279B2 (en) | 2013-03-15 | 2018-11-22 | Corium Pharma Solutions, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| BR112015022625B1 (pt) | 2013-03-15 | 2023-01-31 | Corium, Inc | Aparelho de microestrutura para entrega de agente terapêutico |
| WO2014150285A2 (fr) | 2013-03-15 | 2014-09-25 | Corium International, Inc. | Applicateurs de microprojection d'impacts multiples et procédés d'utilisation |
| US9962534B2 (en) * | 2013-03-15 | 2018-05-08 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| JP6110562B2 (ja) * | 2013-05-06 | 2017-04-05 | ユービック インコーポレイテッド | 遠心力を利用したマイクロ構造体の製造方法およびそれから製造されたマイクロ構造体 |
| PT3003246T (pt) * | 2013-05-31 | 2021-02-22 | Victor Bronshtein | Composições poliméricas contendo produtos biofarmacêuticos estáveis à temperatura ambiente e métodos para a formulação dos mesmos |
| WO2015012252A1 (fr) * | 2013-07-22 | 2015-01-29 | 凸版印刷株式会社 | Corps à pointes |
| US10195410B2 (en) | 2013-07-22 | 2019-02-05 | Tuo Jin | Fabrication process of phase-transition microneedle patch |
| US20160310412A1 (en) * | 2013-12-16 | 2016-10-27 | Takeda Pharmaceutical Company Limited | Microneedle |
| US20160279401A1 (en) | 2015-03-27 | 2016-09-29 | Allergan, Inc. | Dissolvable microneedles for skin treatment |
| CN104069484A (zh) * | 2014-03-28 | 2014-10-01 | 上海交通大学 | 干扰素微针及其制备方法和应用 |
| CN103893018B (zh) * | 2014-04-16 | 2016-02-03 | 华熙福瑞达生物医药有限公司 | 一种可溶性透明质酸微针贴片 |
| US11040182B2 (en) * | 2014-08-18 | 2021-06-22 | Noven Pharmaceuticals, Inc. | Microneedle device and methods |
| WO2016036866A1 (fr) | 2014-09-04 | 2016-03-10 | Corium International, Inc. | Matrice de microstructures, procédé de production et procédés d'utilisation |
| KR101831948B1 (ko) * | 2015-02-13 | 2018-02-23 | 주식회사 엔도더마 | 가교된 히알루론산 하이드로젤을 이용한 마이크로구조체 및 이의 제조방법 |
| JP6369992B2 (ja) * | 2015-03-19 | 2018-08-08 | ライオン株式会社 | 溶解型マイクロニードル製剤 |
| JP2017514646A (ja) * | 2015-04-03 | 2017-06-08 | ソーチョウ ユニバーシティー | 膨潤型シルクフィブロインマイクロニードル薬物送達システム及びその製造方法 |
| CN114515269A (zh) * | 2015-04-06 | 2022-05-20 | 株式会社Lg生活健康 | 微针及其制造方法 |
| CN113350489A (zh) * | 2015-04-21 | 2021-09-07 | 北卡罗来纳州立大学 | 使用缺氧敏感性纳米复合材料的葡萄糖响应性胰岛素递送系统 |
| US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| CN105031744B (zh) * | 2015-06-29 | 2018-01-02 | 苏州大学 | 一种增生性瘢痕用微针及其制备方法 |
| WO2017005375A1 (fr) * | 2015-07-08 | 2017-01-12 | Leo Laboratories Limited | Procédé permettant d'améliorer l'administration de médicaments à travers la peau |
| KR101629007B1 (ko) * | 2015-07-16 | 2016-06-13 | (주)비엔에스메디븐스 | 접촉각 조절이 가능한 마이크로니들 패치의 베이스필름 |
| WO2017044898A1 (fr) | 2015-09-11 | 2017-03-16 | Ultra Small Fibers, LLC | Supports de filtre et dispositifs filtrants à nanofibres ajustables |
| WO2017053872A1 (fr) * | 2015-09-25 | 2017-03-30 | Steven Craig Anderson | Appareil et procédé d'adhésion |
| CN108601727B (zh) * | 2016-02-15 | 2021-10-22 | 上海交通大学 | 一种快速打印微针贴剂的方法 |
| KR102413032B1 (ko) * | 2016-03-01 | 2022-06-24 | 노쓰 캐롤라이나 스테이트 유니버시티 | 마이크로니들 패치-보조된 전달에 의한 향상된 암 면역요법 |
| CN105617526B (zh) * | 2016-03-11 | 2020-01-31 | 苏州大学 | 一种溶胀型丝素蛋白微针给药系统及其制备方法 |
| KR101973801B1 (ko) * | 2016-06-16 | 2019-04-30 | 주식회사 엔도더마 | 용해 특성이 우수한 히알루론산 마이크로구조체 |
| WO2018004191A1 (fr) * | 2016-06-29 | 2018-01-04 | 서울대학교 산학협력단 | Dispositif de biodétection et dispositif d'administration de médicament |
| CN106166325A (zh) * | 2016-06-29 | 2016-11-30 | 莆田学院 | 一种聚乙烯醇水凝胶微针的制备方法 |
| KR101843263B1 (ko) * | 2016-06-29 | 2018-03-29 | 서울대학교산학협력단 | 약물 전달 장치 |
| CN106113365B (zh) * | 2016-06-29 | 2018-02-13 | 莆田学院 | 一种聚乙烯醇海绵微针的制备方法 |
| CN106267191A (zh) * | 2016-09-03 | 2017-01-04 | 山西纳安生物科技有限公司 | 纳米抗体生物药透皮给药制剂系统及制备方法和应用 |
| WO2018085809A1 (fr) | 2016-11-07 | 2018-05-11 | North Carolina State University | Patch chargé de vésicules doublement sensibles destiné à une amélioration de l'apport d'insuline en réaction au glucose |
| EP3541358A1 (fr) | 2016-11-21 | 2019-09-25 | Eirion Therapeutics, Inc. | Administration transdermique de grands agents |
| KR102401856B1 (ko) | 2017-02-17 | 2022-05-26 | 알레간 인코포레이티드 | 활성 성분을 갖는 마이크로니들 어레이 |
| WO2018208223A1 (fr) * | 2017-05-10 | 2018-11-15 | Chee Yen Lim | Procédé de fabrication de patchs à micro-aiguilles |
| TWI633901B (zh) * | 2017-05-16 | 2018-09-01 | 怡定興科技股份有限公司 | 醫美微針貼片之製作方法 |
| CN107349175A (zh) * | 2017-06-06 | 2017-11-17 | 浙江理工大学 | 一种负载脂肪褐变剂的微针贴片及其制备方法 |
| DE102017112573A1 (de) * | 2017-06-07 | 2018-12-13 | Lts Lohmann Therapie-Systeme Ag | Mikronadelsystem zur Applikation von Glukagon-ähnlichen-Peptid Analoga |
| CN107096013B (zh) * | 2017-06-09 | 2020-10-27 | 广州新济薇娜生物科技有限公司 | 鲑鱼降钙素可溶性微针贴片及其制备方法 |
| CN108742718B (zh) * | 2018-03-23 | 2021-04-16 | 苏州德锐特成像技术有限公司 | 一种可快速溶胀的自粘附微针贴片及其制备方法 |
| KR102767779B1 (ko) * | 2018-04-13 | 2025-02-13 | 노쓰 캐롤라이나 스테이트 유니버시티 | 모발 성장 촉진을 위한 마이크로니들 패치의 사용 |
| CN108837299B (zh) * | 2018-07-18 | 2020-08-07 | 武汉大学 | 一种智能调节血糖的微针贴片及其制备方法 |
| JP7197886B2 (ja) * | 2018-08-01 | 2022-12-28 | 国立大学法人 新潟大学 | 線維化コラーゲンゲル作製用鋳型材料 |
| DE102018215324A1 (de) * | 2018-09-10 | 2020-03-12 | Lts Lohmann Therapie-Systeme Ag | Vorrichtung und Verfahren zur Herstellung von Mikrostrukturen |
| CN110947085A (zh) * | 2018-09-27 | 2020-04-03 | 中科微针（北京）科技有限公司 | 一种加速聚乙烯醇可溶性微针成型和速溶给药的方法及制备的微针 |
| CA3117492A1 (fr) * | 2018-10-31 | 2020-05-07 | The Regents Of The University Of California | Micro-aiguilles biodegradables pour administration transdermique d'agents therapeutiques |
| CN109528695B (zh) * | 2019-01-12 | 2022-04-19 | 蚌埠医学院 | 一种治疗类风湿性关节炎的微针透皮给药贴片及其制备方法 |
| CN109701152A (zh) * | 2019-01-14 | 2019-05-03 | 浙江工业大学 | 一种装载药物的可溶性微针贴片及其制备方法 |
| KR102187439B1 (ko) * | 2019-01-30 | 2020-12-07 | 주식회사 라파스 | 마이크로니들 패취를 이용한 최소 침습적 피부 생체 검사 방법 |
| CN110090044B (zh) * | 2019-04-23 | 2021-01-19 | 西安交通大学 | 一种用于采集皮肤间质液的水凝胶微针贴片及其制备方法和使用方法 |
| CN110151736A (zh) * | 2019-07-04 | 2019-08-23 | 蚌埠医学院 | 贴剂及其制备方法 |
| WO2021007344A1 (fr) * | 2019-07-08 | 2021-01-14 | Board Of Regents Of The University Of Nebraska | Administration de médicaments à l'aide de réseaux de micro-aiguilles |
| CN110270007A (zh) * | 2019-07-15 | 2019-09-24 | 上海交通大学 | 一种担载生物分子微针及其制备方法 |
| EP3838261A1 (fr) * | 2019-12-20 | 2021-06-23 | Ares Trading S.A. | Ensemble de micro-aiguilles, actionneur et procédé d'utilisation |
| US11202753B1 (en) | 2020-03-06 | 2021-12-21 | Aquavit Pharmaceuticals, Inc. | Systems and methods for generating immune responses in subjects using microchannel delivery devices |
| BR112022022039A2 (pt) | 2020-04-28 | 2022-12-13 | Ticona Llc | Conjunto de microagulhas |
| CN112023033B (zh) * | 2020-04-29 | 2023-08-25 | 中山大学·深圳 | 一种同时实现卡介苗接种及其诊断的两段式微针阵列药贴及其制备方法 |
| CN114324196B (zh) * | 2020-09-29 | 2024-06-11 | 华中科技大学 | 用于增强皮肤光透明性的可溶性聚合物微针的制备及应用 |
| CN114272511B (zh) * | 2021-01-12 | 2023-08-01 | 广州新济药业科技有限公司 | 司美格鲁肽可溶性微针贴片及其制备方法 |
| CN113599501B (zh) * | 2021-08-25 | 2022-11-29 | 北京三元基因药业股份有限公司 | 一种稳定的干扰素微针制剂及其制备方法与应用 |
| WO2023034056A1 (fr) * | 2021-09-03 | 2023-03-09 | Bionaut Labs Ltd. | Oligonucléotides encapsulés dans une matrice d'hydrogel et procédés de formulation et d'utilisation d'oligonucléotides encapsulés |
| CN116421544B (zh) * | 2022-01-13 | 2025-10-17 | 浙江大学 | 聚合物微针、微针片及含其的递送系统、制备方法、应用 |
| CN114366091B (zh) * | 2022-01-17 | 2023-08-22 | 礼诚(北京)国际生物医药科技有限公司 | 一种连续监测或检测体内分析物的微针贴片、其制备方法及相关装置 |
| CN114569583B (zh) * | 2022-03-14 | 2023-10-17 | 中山大学 | 一种快速分离型脂质体复合缓释微针及其制备方法 |
| CN114917465B (zh) * | 2022-03-23 | 2024-04-09 | 深圳大学 | 一种自发热微针载药贴片及其制备方法 |
| CN114948852B (zh) * | 2022-05-26 | 2024-05-17 | 深圳先进技术研究院 | 一种用于脑部疾病诊断和治疗的微针系统及其制备方法 |
| CN115430031B (zh) * | 2022-07-05 | 2024-06-07 | 哈尔滨工业大学 | 一种多功能美容微针贴片及其批量化制备方法 |
| CN115501474A (zh) * | 2022-09-16 | 2022-12-23 | 深圳高性能医疗器械国家研究院有限公司 | 可溶性微针贴膜的制备方法 |
| CN116141545A (zh) * | 2022-11-30 | 2023-05-23 | 广东工业大学 | 一种防止微针底部翘起的模具、模具制备方法和微针制备方法 |
| CN116807520A (zh) * | 2023-06-28 | 2023-09-29 | 南方医科大学 | 一种无损无痛微创提取组织液的方法 |
| CN117159442B (zh) * | 2023-09-08 | 2025-09-12 | 安徽医科大学 | 一种dna/pva双网络水凝胶微针及其制备方法 |
| CN120837831B (zh) * | 2025-09-23 | 2026-01-02 | 成都华航创微科技有限公司 | 一种微针制备装置及其应用方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020082543A1 (en) * | 2000-12-14 | 2002-06-27 | Jung-Hwan Park | Microneedle devices and production thereof |
| WO2004024224A1 (fr) * | 2002-09-16 | 2004-03-25 | Sung-Yun Kwon | Micro-perforateurs solides et leurs procede d'utilisation |
| WO2007030477A2 (fr) * | 2005-09-06 | 2007-03-15 | Theraject, Inc. | Perforateur a solution solide contenant des particules de medicament et/ou des particules a adsorption de medicament |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2607128T3 (es) * | 2002-06-25 | 2017-03-29 | Theraject, Inc. | Microperforador de rápida disolución para administración de medicamentos y otras aplicaciones |
| KR100563330B1 (ko) | 2003-01-16 | 2006-03-22 | 포스트마이크로 주식회사 | Ｌｉｇａ공정을 이용한 폴리머 재질의 미세 바늘 어레이제조방법 |
| US20080262444A1 (en) * | 2005-01-31 | 2008-10-23 | Bioserentach Co., Ltd. | Percutaneously Absorbable Preparation, Percutaneously Absorbable Preparation Holding Sheet, and Percutaneously Absorbable Preparation Holding Equipment |
| CA2627542A1 (fr) * | 2005-11-18 | 2007-05-24 | 3M Innovative Properties Company | Batteries de micro-aiguilles et procedes pour leur fabrication |
| CN1899264A (zh) | 2006-07-20 | 2007-01-24 | 上海交通大学 | 温度敏感型水凝胶释药体系及其制备方法 |
| WO2008011625A2 (fr) * | 2006-07-21 | 2008-01-24 | Georgia Tech Researh Corporation | Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide |
| EP2062611A4 (fr) * | 2006-08-18 | 2010-01-06 | Toppan Printing Co Ltd | Micro-aiguille et timbre à micro-aiguilles |
| CN100460028C (zh) | 2006-12-08 | 2009-02-11 | 中国科学院上海微系统与信息技术研究所 | 一种用于药物传输的微针阵列及其制作方法 |
| JP5241517B2 (ja) * | 2007-02-06 | 2013-07-17 | 久光製薬株式会社 | アレルギー診断用マイクロニードルデバイス |
| EP2146689B1 (fr) * | 2007-04-16 | 2020-08-12 | Corium, Inc. | Réseaux de micro-aiguilles coulées dans un solvant contenant un actif |
| JP5559054B2 (ja) * | 2007-09-28 | 2014-07-23 | ザ クイーンズ ユニヴァーシティ オブ ベルファスト | 送達装置および方法 |
-
2009
- 2009-05-12 DK DK09818735.4T patent/DK2346563T3/da active
- 2009-05-12 EP EP09818735.4A patent/EP2346563B1/fr not_active Not-in-force
- 2009-05-12 JP JP2011530349A patent/JP5879126B2/ja active Active
- 2009-05-12 CN CN200980139874.2A patent/CN102202720B/zh active Active
- 2009-05-12 CA CA2739876A patent/CA2739876A1/fr not_active Abandoned
- 2009-05-12 US US13/122,873 patent/US9320878B2/en not_active Expired - Fee Related
- 2009-05-12 ES ES09818735.4T patent/ES2691388T3/es active Active
- 2009-05-12 WO PCT/CN2009/000510 patent/WO2010040271A1/fr not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020082543A1 (en) * | 2000-12-14 | 2002-06-27 | Jung-Hwan Park | Microneedle devices and production thereof |
| WO2004024224A1 (fr) * | 2002-09-16 | 2004-03-25 | Sung-Yun Kwon | Micro-perforateurs solides et leurs procede d'utilisation |
| WO2007030477A2 (fr) * | 2005-09-06 | 2007-03-15 | Theraject, Inc. | Perforateur a solution solide contenant des particules de medicament et/ou des particules a adsorption de medicament |
Non-Patent Citations (1)
| Title |
|---|
| See also references of WO2010040271A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5879126B2 (ja) | 2016-03-08 |
| DK2346563T3 (da) | 2019-01-02 |
| CN102202720B (zh) | 2015-12-16 |
| US9320878B2 (en) | 2016-04-26 |
| US20110195124A1 (en) | 2011-08-11 |
| ES2691388T3 (es) | 2018-11-27 |
| EP2346563B1 (fr) | 2018-08-29 |
| WO2010040271A1 (fr) | 2010-04-15 |
| JP2012505164A (ja) | 2012-03-01 |
| CA2739876A1 (fr) | 2010-04-15 |
| EP2346563A1 (fr) | 2011-07-27 |
| CN102202720A (zh) | 2011-09-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2346563T3 (da) | Polymere faseovergangsmikronåle | |
| EP2286586A4 (fr) | Visioconférence à regard précis | |
| BRPI0822184A2 (pt) | Agulha múltipla | |
| DK2452709T3 (da) | Kanyledel | |
| IT1397181B1 (it) | Componente micromeccanico | |
| EP2391658A4 (fr) | Polymères à empreintes moléculaires | |
| BRPI1008760A2 (pt) | ensaios homogêneos de fase de solução | |
| EP2296708A4 (fr) | Vecteur polymère | |
| IT1400768B1 (it) | Componente micromeccanico | |
| BRPI0915738A2 (pt) | composição de polímero reticulável | |
| EP2040758A4 (fr) | Polymeres biosensibles | |
| DE602008005522D1 (de) | Polymerlösungen | |
| EP2520630A4 (fr) | Composition adhésive à base de polyester | |
| DE602008001230D1 (de) | Verbesserte Polymerzusammensetzung | |
| EP2478049A4 (fr) | Support polymère | |
| BRPI0917414A2 (pt) | centrífuga | |
| DK2346819T3 (da) | Naphthyleddikesyre | |
| EP2352043A4 (fr) | Film à déphasage | |
| DK2467520T3 (da) | Polymerfiberbaner med forbedret ydelse | |
| EP2478066A4 (fr) | Polymères triblocs bab à caractéristiques améliorées de libération | |
| BRPI0920932A2 (pt) | centrífuga | |
| EP2770011A4 (fr) | Polymère biodégradable à biodégradabilité contrôlée | |
| IT1397180B1 (it) | Componente micromeccanico | |
| EP2270920A4 (fr) | Ligne microruban | |
| EP2358763A4 (fr) | Composition de polymère |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20110506 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR |
|
| AX | Request for extension of the european patent |
Extension state: AL BA RS |
|
| DAX | Request for extension of the european patent (deleted) | ||
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20120201 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61M 37/00 20060101ALI20120126BHEP Ipc: A61K 39/00 20060101ALI20120126BHEP Ipc: A61M 31/00 20060101AFI20120126BHEP |
|
| 17Q | First examination report despatched |
Effective date: 20130118 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R079 Ref document number: 602009054204 Country of ref document: DE Free format text: PREVIOUS MAIN CLASS: A61M0031000000 Ipc: A61K0009000000 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61M 37/00 20060101ALI20161209BHEP Ipc: A61K 9/00 20060101AFI20161209BHEP |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
| GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: GRANT OF PATENT IS INTENDED |
|
| INTG | Intention to grant announced |
Effective date: 20180309 |
|
| GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
| GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE PATENT HAS BEEN GRANTED |
|
| AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR |
|
| REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
| REG | Reference to a national code |
Ref country code: AT Ref legal event code: REF Ref document number: 1034295 Country of ref document: AT Kind code of ref document: T Effective date: 20180915 |
|
| REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 602009054204 Country of ref document: DE |
|
| REG | Reference to a national code |
Ref country code: NL Ref legal event code: FP |
|
| REG | Reference to a national code |
Ref country code: ES Ref legal event code: FG2A Ref document number: 2691388 Country of ref document: ES Kind code of ref document: T3 Effective date: 20181127 |
|
| REG | Reference to a national code |
Ref country code: SE Ref legal event code: TRGR |
|
| REG | Reference to a national code |
Ref country code: DK Ref legal event code: T3 Effective date: 20181217 |
|
| REG | Reference to a national code |
Ref country code: LT Ref legal event code: MG4D |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: NV Representative=s name: CRONIN INTELLECTUAL PROPERTY, CH |
|
| REG | Reference to a national code |
Ref country code: NO Ref legal event code: T2 Effective date: 20180829 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181130 Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181229 Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181129 |
|
| REG | Reference to a national code |
Ref country code: AT Ref legal event code: MK05 Ref document number: 1034295 Country of ref document: AT Kind code of ref document: T Effective date: 20180829 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 Ref country code: AT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R097 Ref document number: 602009054204 Country of ref document: DE |
|
| PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
| 26N | No opposition filed |
Effective date: 20190531 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190512 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190512 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181229 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R082 Ref document number: 602009054204 Country of ref document: DE Representative=s name: ZEITLER VOLPERT KANDLBINDER PATENT- UND RECHTS, DE Ref country code: DE Ref legal event code: R081 Ref document number: 602009054204 Country of ref document: DE Owner name: BIODOSAGE TECH CO., LTD, CN Free format text: FORMER OWNER: JIN, TUO, SHANGHAI, CN Ref country code: DE Ref legal event code: R082 Ref document number: 602009054204 Country of ref document: DE Representative=s name: ZEITLER VOLPERT KANDLBINDER PATENTANWAELTE PAR, DE |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: NV Representative=s name: CABINET GERMAIN AND MAUREAU, CH Ref country code: CH Ref legal event code: PUE Owner name: BIODOSAGE TECH CO., LTD, CN Free format text: FORMER OWNER: JIN, TUO, CN |
|
| REG | Reference to a national code |
Ref country code: NO Ref legal event code: CHAD Owner name: BIODOSAGE TECH CO., CN |
|
| REG | Reference to a national code |
Ref country code: BE Ref legal event code: PD Owner name: BIODOSAGE TECH CO., LTD.; CN Free format text: DETAILS ASSIGNMENT: CHANGE OF OWNER(S), CESSION; FORMER OWNER NAME: JIN, TUO Effective date: 20201012 |
|
| REG | Reference to a national code |
Ref country code: ES Ref legal event code: PC2A Owner name: BIODOSAGE TECH CO., LTD Effective date: 20201023 |
|
| REG | Reference to a national code |
Ref country code: GB Ref legal event code: 732E Free format text: REGISTERED BETWEEN 20201022 AND 20201028 |
|
| REG | Reference to a national code |
Ref country code: NL Ref legal event code: PD Owner name: BIODOSAGE TECH CO., LTD; CN Free format text: DETAILS ASSIGNMENT: CHANGE OF OWNER(S), ASSIGNMENT; FORMER OWNER NAME: JIN, TUO Effective date: 20201103 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20090512 Ref country code: MT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: SE Payment date: 20210527 Year of fee payment: 13 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20180829 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: NL Payment date: 20220530 Year of fee payment: 14 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: NO Payment date: 20220428 Year of fee payment: 14 Ref country code: IT Payment date: 20220511 Year of fee payment: 14 Ref country code: GB Payment date: 20220427 Year of fee payment: 14 Ref country code: ES Payment date: 20220617 Year of fee payment: 14 Ref country code: DE Payment date: 20220429 Year of fee payment: 14 Ref country code: DK Payment date: 20220523 Year of fee payment: 14 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: CH Payment date: 20220428 Year of fee payment: 14 Ref country code: BE Payment date: 20220519 Year of fee payment: 14 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20230419 Year of fee payment: 15 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R082 Ref document number: 602009054204 Country of ref document: DE Representative=s name: KANDLBINDER, MARKUS, DIPL.-PHYS., DE |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 602009054204 Country of ref document: DE |
|
| REG | Reference to a national code |
Ref country code: NO Ref legal event code: MMEP |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
| REG | Reference to a national code |
Ref country code: SE Ref legal event code: EUG Ref country code: DK Ref legal event code: EBP Effective date: 20230531 |
|
| REG | Reference to a national code |
Ref country code: NL Ref legal event code: MM Effective date: 20230601 |
|
| GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20230512 |
|
| REG | Reference to a national code |
Ref country code: BE Ref legal event code: MM Effective date: 20230531 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20230513 Ref country code: NO Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20230531 Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20230531 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20230531 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NL Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20230601 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20230512 Ref country code: DK Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20230531 Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20231201 Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20230512 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20230531 |
|
| REG | Reference to a national code |
Ref country code: ES Ref legal event code: FD2A Effective date: 20240628 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: ES Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20230513 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: ES Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20230513 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20240531 |