EP2352591A4 - Système de cristallisation microcapillaire de type nanovolume - Google Patents

Système de cristallisation microcapillaire de type nanovolume

Info

Publication number
EP2352591A4
EP2352591A4 EP09763807A EP09763807A EP2352591A4 EP 2352591 A4 EP2352591 A4 EP 2352591A4 EP 09763807 A EP09763807 A EP 09763807A EP 09763807 A EP09763807 A EP 09763807A EP 2352591 A4 EP2352591 A4 EP 2352591A4
Authority
EP
European Patent Office
Prior art keywords
nanovolume
microcapillary
type
crystallization system
crystallization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09763807A
Other languages
German (de)
English (en)
Other versions
EP2352591A2 (fr
Inventor
Cory Gerdts
Mark Elliott
Peter Nollert-Von-Specht
Lansing J Stewart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emerald Biostructures Inc
Original Assignee
Emerald Biostructures Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emerald Biostructures Inc filed Critical Emerald Biostructures Inc
Publication of EP2352591A2 publication Critical patent/EP2352591A2/fr
Publication of EP2352591A4 publication Critical patent/EP2352591A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/23—Mixing by intersecting jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/06—Crystallising dishes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Peptides Or Proteins (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
EP09763807A 2008-06-13 2009-06-15 Système de cristallisation microcapillaire de type nanovolume Withdrawn EP2352591A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6153608P 2008-06-13 2008-06-13
PCT/US2009/047414 WO2009152520A2 (fr) 2008-06-13 2009-06-15 Système de cristallisation microcapillaire de type nanovolume

Publications (2)

Publication Number Publication Date
EP2352591A2 EP2352591A2 (fr) 2011-08-10
EP2352591A4 true EP2352591A4 (fr) 2013-01-23

Family

ID=41417428

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09763807A Withdrawn EP2352591A4 (fr) 2008-06-13 2009-06-15 Système de cristallisation microcapillaire de type nanovolume

Country Status (3)

Country Link
EP (1) EP2352591A4 (fr)
JP (2) JP2011525166A (fr)
WO (1) WO2009152520A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US12090480B2 (en) 2008-09-23 2024-09-17 Bio-Rad Laboratories, Inc. Partition-based method of analysis
CA2738578C (fr) 2008-09-23 2021-05-04 Quantalife, Inc. Systeme de dosage base sur des gouttelettes
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US12162008B2 (en) 2008-09-23 2024-12-10 Bio-Rad Laboratories, Inc. Partition-based method of analysis
GB0907504D0 (en) * 2009-04-30 2009-06-10 Imp Innovations Ltd Method of producing crystalline protein
CA2767182C (fr) 2010-03-25 2020-03-24 Bio-Rad Laboratories, Inc. Generation de gouttelettes pour dosages sur gouttelettes
US12097495B2 (en) 2011-02-18 2024-09-24 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
CN113856235A (zh) * 2021-09-29 2021-12-31 浙江大华技术股份有限公司 降温结晶控制方法、装置、电子设备和系统

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004104228A1 (fr) * 2002-10-04 2004-12-02 California Institute Of Technology Cristallographie de proteines microfluidiques
WO2008000276A2 (fr) * 2006-06-28 2008-01-03 Microlytic Aps Dispositif et procédé pour favoriser une cristallisation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585070A (en) * 1994-04-29 1996-12-17 Phoenix International Life Sciences Inc. Method for extraction, extraction cartridge and automated extraction processing system
US7459022B2 (en) * 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
NZ533466A (en) * 1999-06-28 2005-10-28 California Inst Of Techn Microfabricated elastomeric valve and pump systems
US7129091B2 (en) * 2002-05-09 2006-10-31 University Of Chicago Device and method for pressure-driven plug transport and reaction
EP1578950A4 (fr) * 2002-10-18 2007-08-08 Univ California Procedes de determination de structures cristallographiques par analyse des echanges d'hydrogene
EP1730489B1 (fr) * 2004-01-25 2020-03-04 Fluidigm Corporation Dispositifs de formation de cristaux et systemes et procedes de fabrication et d'utilisation de ceux-ci
US9477233B2 (en) * 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
US7655470B2 (en) * 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US20060027780A1 (en) * 2004-07-12 2006-02-09 Decode Biostructures, Inc. Crystallization solutions
JP2008538077A (ja) * 2005-03-16 2008-10-09 ユニバーシティ オブ シカゴ マイクロフルイディックシステム

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004104228A1 (fr) * 2002-10-04 2004-12-02 California Institute Of Technology Cristallographie de proteines microfluidiques
WO2008000276A2 (fr) * 2006-06-28 2008-01-03 Microlytic Aps Dispositif et procédé pour favoriser une cristallisation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAOUTHAR DHOUIB ET AL: "Microfluidic chips for the crystallization of biomacromolecules by counter-diffusion and on-chip crystal X-ray analysis", LAB ON A CHIP, vol. 9, no. 10, 1 January 2009 (2009-01-01), pages 1412, XP055046156, ISSN: 1473-0197, DOI: 10.1039/b819362b *
LOUNACI ET AL: "Microfluidic device for protein crystallization under controlled humidity", MICROELECTRONIC ENGINEERING, ELSEVIER PUBLISHERS BV., AMSTERDAM, NL, vol. 84, no. 5-8, 6 May 2007 (2007-05-06), pages 1758 - 1761, XP022062111, ISSN: 0167-9317, DOI: 10.1016/J.MEE.2007.01.269 *

Also Published As

Publication number Publication date
JP2011525166A (ja) 2011-09-15
WO2009152520A3 (fr) 2010-02-18
JP2014240343A (ja) 2014-12-25
EP2352591A2 (fr) 2011-08-10
WO2009152520A2 (fr) 2009-12-17

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20110420

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DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: EMERALD BIOSTRUCTURES INC.

A4 Supplementary search report drawn up and despatched

Effective date: 20130102

RIC1 Information provided on ipc code assigned before grant

Ipc: C07K 1/30 20060101ALI20121218BHEP

Ipc: B01L 3/06 20060101AFI20121218BHEP

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