EP2436692A3 - Protéines hybrides hypoallergéniques d'allergènes d'acarien de groupe majeur 1 et 2 utiles pour le traitement d'allergies - Google Patents

Protéines hybrides hypoallergéniques d'allergènes d'acarien de groupe majeur 1 et 2 utiles pour le traitement d'allergies Download PDF

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Publication number
EP2436692A3
EP2436692A3 EP11179771A EP11179771A EP2436692A3 EP 2436692 A3 EP2436692 A3 EP 2436692A3 EP 11179771 A EP11179771 A EP 11179771A EP 11179771 A EP11179771 A EP 11179771A EP 2436692 A3 EP2436692 A3 EP 2436692A3
Authority
EP
European Patent Office
Prior art keywords
treatment
allergies
hybrid proteins
allergens
major group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP11179771A
Other languages
German (de)
English (en)
Other versions
EP2436692B1 (fr
EP2436692A2 (fr
Inventor
Juan Andres Asturias Ortega
Iñaki Ibarrola Lopez De Davalillo
Maria Carmen Arilla Rodriguez
Alberto Martinez Garate
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roxall Medicina Espana SA
Original Assignee
Bial Industrial Farmaceutica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bial Industrial Farmaceutica SA filed Critical Bial Industrial Farmaceutica SA
Publication of EP2436692A2 publication Critical patent/EP2436692A2/fr
Publication of EP2436692A3 publication Critical patent/EP2436692A3/fr
Application granted granted Critical
Publication of EP2436692B1 publication Critical patent/EP2436692B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Insects & Arthropods (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP11179771.8A 2008-03-25 2009-03-24 Protéines hybrides hypoallergéniques d'allergènes d'acarien de groupe majeur 1 et 2 utiles pour le traitement d'allergies Not-in-force EP2436692B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200800827 2008-03-25
EP09724998A EP2268662A2 (fr) 2008-03-25 2009-03-24 Protéines hybrides hypoallergéniques d allergènes majeurs de mites de groupe 1 et 2 pour utilisation dans le traitement d allergies

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP09724998A Division EP2268662A2 (fr) 2008-03-25 2009-03-24 Protéines hybrides hypoallergéniques d allergènes majeurs de mites de groupe 1 et 2 pour utilisation dans le traitement d allergies
EP09724998.1 Division 2009-03-24

Publications (3)

Publication Number Publication Date
EP2436692A2 EP2436692A2 (fr) 2012-04-04
EP2436692A3 true EP2436692A3 (fr) 2012-06-27
EP2436692B1 EP2436692B1 (fr) 2017-08-02

Family

ID=41110539

Family Applications (3)

Application Number Title Priority Date Filing Date
EP11179765.0A Not-in-force EP2436691B1 (fr) 2008-03-25 2009-03-24 Protéines hybrides hypoallergéniques d'allergènes d'acarien de groupe majeur 1 et 2 utiles pour le traitement d'allergies
EP09724998A Ceased EP2268662A2 (fr) 2008-03-25 2009-03-24 Protéines hybrides hypoallergéniques d allergènes majeurs de mites de groupe 1 et 2 pour utilisation dans le traitement d allergies
EP11179771.8A Not-in-force EP2436692B1 (fr) 2008-03-25 2009-03-24 Protéines hybrides hypoallergéniques d'allergènes d'acarien de groupe majeur 1 et 2 utiles pour le traitement d'allergies

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP11179765.0A Not-in-force EP2436691B1 (fr) 2008-03-25 2009-03-24 Protéines hybrides hypoallergéniques d'allergènes d'acarien de groupe majeur 1 et 2 utiles pour le traitement d'allergies
EP09724998A Ceased EP2268662A2 (fr) 2008-03-25 2009-03-24 Protéines hybrides hypoallergéniques d allergènes majeurs de mites de groupe 1 et 2 pour utilisation dans le traitement d allergies

Country Status (9)

Country Link
US (2) US8951530B2 (fr)
EP (3) EP2436691B1 (fr)
JP (2) JP5793073B2 (fr)
CN (2) CN107118265A (fr)
BR (1) BRPI0908848A2 (fr)
CA (1) CA2718994C (fr)
ES (2) ES2638271T3 (fr)
MX (1) MX2010010353A (fr)
WO (1) WO2009118642A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103327988B (zh) * 2010-06-03 2016-06-08 阿尔卡贝洛股份公司 包含螨过敏原提取物的药品及其制备方法
EP2460824A1 (fr) * 2010-12-01 2012-06-06 Biomay Ag Polypeptides hypoallergéniques pour le traitement de l'allergie aux acariens
CN102676568A (zh) * 2012-05-08 2012-09-19 崔玉宝 一种生产重组粉尘螨变应原Der f1和Der f2融合蛋白的方法
ES2601220T3 (es) 2012-09-20 2017-02-14 Universidad De Cartagena Proteínas de fusión con representación de diferentes alérgenos: propuesta de vacuna para alergia a los ácaros
WO2016088765A1 (fr) * 2014-12-02 2016-06-09 大鵬薬品工業株式会社 Nouvelle protéine de dermatophagoides farinae
NL2014882B1 (en) * 2015-05-29 2017-01-31 Citeq B V Allergy-specific immunotherapy compositions for use in the treatment of house-dust mite allergy.
KR20180061338A (ko) * 2015-09-30 2018-06-07 베링거잉겔하임베트메디카게엠베하 동물에서의 개선된 모듈러 항원 수송 분자 및 이의 용도
KR101858840B1 (ko) * 2016-01-15 2018-05-16 단국대학교 천안캠퍼스 산학협력단 집먼지진드기 유래 알레르겐에 의한 과민반응 면역조절제
GB201602850D0 (en) * 2016-02-18 2016-04-06 Bial Ind Farmaceutica S A Fusion proteins
CN108265056B (zh) * 2016-12-31 2019-08-30 江苏众红生物工程创药研究院有限公司 一种重组户尘螨1类变应原蛋白及其制备方法和应用
CN109852652B (zh) * 2017-11-30 2023-05-02 江苏众红生物工程创药研究院有限公司 重组尘螨Ⅰ型变应原Der p1和Der f1蛋白的制备与应用
EP3569612A1 (fr) * 2018-05-18 2019-11-20 Biomay Ag Traitement et prévention d'allergies aux acariens
CN113831400A (zh) * 2021-07-29 2021-12-24 沈阳医学院 一种尘螨致敏蛋白Der p 1的分离纯化方法
CN116063442A (zh) * 2022-09-28 2023-05-05 深圳市龙岗区耳鼻咽喉医院 Der p2的3个B细胞表位肽及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1440979A1 (fr) * 2003-01-21 2004-07-28 BIOMAY Produktions- und Handels- Aktiengesellschaft Procédé de préparation de protéines mosaiques hypoallergéniques
WO2006058359A2 (fr) * 2004-12-02 2006-06-08 Biomay Ag Derives d'allergenes proteiniques
US20070065468A1 (en) * 2005-08-29 2007-03-22 National University Of Singapore Chimeric allergens for immunotherapy
EP1908777A1 (fr) * 2006-10-06 2008-04-09 Stallergenes Sa Protéines de fusion d'acarien

Family Cites Families (11)

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WO1988010297A1 (fr) * 1987-06-17 1988-12-29 Princess Margaret Children's Medical Research Foun Clonage d'allergenes d'acariens
US5433948A (en) * 1990-02-13 1995-07-18 Thomas; Wayne R. Cloning and sequencing of allergens of dermatophagoides (house dust mite)
US7288256B1 (en) * 1991-10-16 2007-10-30 Merck Patent Gmbh T cell epitopes of the major allergens from dermatophagoides (house dust mite)
GB9724531D0 (en) 1997-11-19 1998-01-21 Smithkline Biolog Novel compounds
EP1221317A1 (fr) 2000-12-28 2002-07-10 SHAN-Beteiligungsgesellschaft m.b.H. Vaccins comprenant des polypeptides hybrides constitué d'au moins deux allergènes différents
FR2841906B1 (fr) 2002-07-05 2006-08-18 Stallergenes Sa Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes
CN1780852A (zh) * 2003-04-25 2006-05-31 诺和酶股份有限公司 组1螨多肽变体
ITRM20040103A1 (it) 2004-02-27 2004-05-27 Consiglio Nazionale Ricerche Proteine di fusione comprendenti allergeni della famiglia delle ns-ltps, loro usi e composizioni farmaceutiche che le comprendono.
CN100374152C (zh) * 2005-12-23 2008-03-12 中国农业大学 一种过敏性反应抑制剂
GB0607377D0 (en) 2006-04-12 2006-05-24 Glaxosmithkline Biolog Sa Novel Methods
EP1908776A1 (fr) * 2006-10-06 2008-04-09 Stallergenes Sa Proteines de fusion provenant de mite

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1440979A1 (fr) * 2003-01-21 2004-07-28 BIOMAY Produktions- und Handels- Aktiengesellschaft Procédé de préparation de protéines mosaiques hypoallergéniques
WO2006058359A2 (fr) * 2004-12-02 2006-06-08 Biomay Ag Derives d'allergenes proteiniques
US20070065468A1 (en) * 2005-08-29 2007-03-22 National University Of Singapore Chimeric allergens for immunotherapy
EP1908777A1 (fr) * 2006-10-06 2008-04-09 Stallergenes Sa Protéines de fusion d'acarien

Non-Patent Citations (10)

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Title
AKDIS ET AL: "Mechanisms of allergen-specific immunotherapy", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY - YEARLY BOOK, INC, US, vol. 119, no. 4, 5 April 2007 (2007-04-05), pages 780 - 789, XP022020511, ISSN: 0091-6749 *
BANNON GARY A ET AL: "Evaluation of available IgE-binding epitope data and its utility in bioinformatics", MOLECULAR NUTRITION & FOOD RESEARCH, WILEY - VCH VERLAG, WEINHEIM, DE, vol. 50, no. 7, 1 July 2006 (2006-07-01), pages 638 - 644, XP002448731, ISSN: 1613-4125 *
BHALLA ET AL: "Biotechnology-based allergy diagnosis and vaccination", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 26, no. 3, 28 January 2008 (2008-01-28), pages 153 - 161, XP022487059, ISSN: 0167-7799 *
CHEN ET AL: "Reduction of the in vivo allergenicity of Der p 2, the major house-dust mite allergen, by genetic engineering", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 45, no. 9, 4 March 2008 (2008-03-04), pages 2486 - 2498, XP022540428, ISSN: 0161-5890 *
CRAMERI R ET AL: "Novel vaccines and adjuvants for allergen-specific immunotherapy", CURRENT OPINION IN IMMUNOLOGY, ELSEVIER, OXFORD, GB, vol. 18, no. 6, 1 December 2006 (2006-12-01), pages 761 - 768, XP025078999, ISSN: 0952-7915, [retrieved on 20061201] *
DATABASE Geneseq [online] 12 July 2007 (2007-07-12), "Chimeric dust mite allergen protein B5D2D1proD1 - SEQ ID 2.", XP002675792, retrieved from EBI accession no. GSP:AFH52734 Database accession no. AFH52734 *
GONZALEZ-RIOJA ET AL: "Genetically engineered hybrid proteins from Parietaria judaica pollen for allergen-specific immunotherapy", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY - YEARLY BOOK, INC, US, vol. 120, no. 3, 31 August 2007 (2007-08-31), pages 602 - 609, XP022212638, ISSN: 0091-6749 *
HOLM JENS ET AL: "Allergy vaccine engineering: Epitope modulation of recombinant Bet v 1 reduces IgE binding but retains protein folding pattern for induction of protective blocking-antibody responses", JOURNAL OF IMMUNOLOGY, vol. 173, no. 8, 15 October 2004 (2004-10-15), pages 5258 - 5267, XP009123652, ISSN: 0022-1767 *
MANTYJARVI R RAUTIAINEN J VIRTANEN T: "Lipocalins as allergens", BIOCHIMICA ET BIOPHYSICA ACTA - PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGIE, ELSEVIER SCIENCE BV, AMSTERDAM, NL, vol. 1482, no. 1-2, 18 October 2000 (2000-10-18), pages 308 - 317, XP004279083, ISSN: 0167-4838 *
WALLNER ET AL: "Allergy multivaccines created by DNA shuffling of tree pollen allergens", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY - YEARLY BOOK, INC, US, vol. 120, no. 2, 29 July 2007 (2007-07-29), pages 374 - 380, XP022199094, ISSN: 0091-6749 *

Also Published As

Publication number Publication date
EP2436692B1 (fr) 2017-08-02
JP2011517407A (ja) 2011-06-09
JP6068544B2 (ja) 2017-01-25
EP2436691A3 (fr) 2012-06-27
BRPI0908848A2 (pt) 2015-12-01
WO2009118642A2 (fr) 2009-10-01
CN101977929B (zh) 2016-10-19
CA2718994A1 (fr) 2009-10-01
EP2436691A2 (fr) 2012-04-04
JP5793073B2 (ja) 2015-10-14
CN107118265A (zh) 2017-09-01
CA2718994C (fr) 2017-06-13
WO2009118642A3 (fr) 2009-12-03
EP2436692A2 (fr) 2012-04-04
EP2268662A2 (fr) 2011-01-05
EP2436691B1 (fr) 2017-08-02
US20150152148A1 (en) 2015-06-04
ES2638308T3 (es) 2017-10-19
ES2638271T3 (es) 2017-10-19
US20110052640A1 (en) 2011-03-03
CN101977929A (zh) 2011-02-16
JP2015164424A (ja) 2015-09-17
MX2010010353A (es) 2010-10-05
US8951530B2 (en) 2015-02-10

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