EP2490530A4 - Composés et méthodes pour le traitement d'infections bactériennes - Google Patents

Composés et méthodes pour le traitement d'infections bactériennes

Info

Publication number
EP2490530A4
EP2490530A4 EP10825785.8A EP10825785A EP2490530A4 EP 2490530 A4 EP2490530 A4 EP 2490530A4 EP 10825785 A EP10825785 A EP 10825785A EP 2490530 A4 EP2490530 A4 EP 2490530A4
Authority
EP
European Patent Office
Prior art keywords
compounds
treatment
methods
bacterial infections
infections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10825785.8A
Other languages
German (de)
English (en)
Other versions
EP2490530A1 (fr
Inventor
James W Janetka
Zhenfu Han
Scott Hultgren
Jerry Pinkner
Corinne Cusumano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Priority to EP18214928.6A priority Critical patent/EP3492483A1/fr
Publication of EP2490530A1 publication Critical patent/EP2490530A1/fr
Publication of EP2490530A4 publication Critical patent/EP2490530A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP10825785.8A 2009-10-22 2010-10-22 Composés et méthodes pour le traitement d'infections bactériennes Withdrawn EP2490530A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP18214928.6A EP3492483A1 (fr) 2009-10-22 2010-10-22 Composés et méthodes pour le traitement d'infections bactériennes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25413509P 2009-10-22 2009-10-22
US32173810P 2010-04-07 2010-04-07
US38453510P 2010-09-20 2010-09-20
PCT/US2010/053848 WO2011050323A1 (fr) 2009-10-22 2010-10-22 Composés et méthodes pour le traitement d'infections bactériennes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP18214928.6A Division EP3492483A1 (fr) 2009-10-22 2010-10-22 Composés et méthodes pour le traitement d'infections bactériennes

Publications (2)

Publication Number Publication Date
EP2490530A1 EP2490530A1 (fr) 2012-08-29
EP2490530A4 true EP2490530A4 (fr) 2014-01-22

Family

ID=43900714

Family Applications (2)

Application Number Title Priority Date Filing Date
EP10825785.8A Withdrawn EP2490530A4 (fr) 2009-10-22 2010-10-22 Composés et méthodes pour le traitement d'infections bactériennes
EP18214928.6A Withdrawn EP3492483A1 (fr) 2009-10-22 2010-10-22 Composés et méthodes pour le traitement d'infections bactériennes

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP18214928.6A Withdrawn EP3492483A1 (fr) 2009-10-22 2010-10-22 Composés et méthodes pour le traitement d'infections bactériennes

Country Status (2)

Country Link
EP (2) EP2490530A4 (fr)
WO (1) WO2011050323A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5693452B2 (ja) 2008-08-04 2015-04-01 シーエイチディーアイ ファウンデーション，インコーポレーテッド 特定のキヌレニン−３−モノオキシゲナーゼインヒビター、医薬組成物およびそれらの使用方法
WO2012109263A1 (fr) 2011-02-07 2012-08-16 The Washington University Composés mannosides et leurs procédés d'utilisation
NZ601176A (en) * 2009-12-14 2014-03-28 Univ Basel Mannose derivatives as antagonists of bacterial adhesion
MX2012008346A (es) 2010-01-25 2012-11-12 Chdi Foundation Inc Determinados inhibidores de cinurenina-3-monooxigenasa, composiciones farmceuticas y metodos de uso de los mismos.
WO2012164074A1 (fr) * 2011-06-03 2012-12-06 University Of Basel Dérivés de mannose phosphate en tant qu'antagonistes de l'adhésion bactérienne
MX2014002459A (es) 2011-08-30 2014-04-10 Chdi Foundation Inc Inhibidores de quinurenina-3-monooxigenasa, composiciones farmaceuticas y metodos de uso de los mismos.
SI2750677T1 (sl) 2011-08-30 2017-10-30 Chdi Foundation, Inc. Inhibitorji kinurenin-3-monooksigenaze, farmacevtski sestavki in postopki njihove uporabe
CA2894536C (fr) 2012-12-18 2020-07-28 Vertex Pharmaceuticals Incorporated Derives de mannose pour le traitement d'infections bacteriennes
MX2015012472A (es) * 2013-03-12 2016-02-10 Vertex Pharma Derivados de manosa para el tratamiento de infecciones bacterianas.
CN111423479A (zh) 2013-05-30 2020-07-17 华盛顿大学 用于治疗细菌性感染的化合物和方法
CN106715421A (zh) 2014-07-17 2017-05-24 Chdi基金会股份有限公司 用于治疗hiv相关病症的方法和组合物
CN104119407B (zh) * 2014-07-31 2017-07-28 济南尚博生物科技有限公司 一种甲基‑2,3,4‑三氧‑苄基‑β‑D‑吡喃核糖苷的合成方法
CN105622685B (zh) * 2015-12-31 2019-08-23 杭州科本药业有限公司 一种糖基苯并咪唑化合物及其制备方法和应用
JP2019509315A (ja) 2016-03-23 2019-04-04 フィンブリオン セラピューティックス， インコーポレイテッドＦｉｍｂｒｉｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 疾患の処置に有用なＦｉｍＨのマンノース由来アンタゴニスト
EP3697924A1 (fr) 2017-10-16 2020-08-26 Enterome Nouveaux outils pour évaluer l'efficacité thérapeutique des bloqueurs fimh
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
TWI821328B (zh) 2018-07-10 2023-11-11 英商葛蘭素史克智慧財產發展有限公司 新穎化合物
ES2974634T3 (es) 2018-12-21 2024-06-28 Celgene Corp Inhibidores de tienopiridinas de RIPK2
US12297223B2 (en) 2019-05-07 2025-05-13 Glaxosmithkline Intellectual Property Development Limited Compounds
US12351597B2 (en) 2019-06-19 2025-07-08 Glaxosmithkline Intellectual Property Development Limited Substituted biphenyl or phenylheteroaryl-mannosides as antagonists of FimH
CN111423478A (zh) * 2020-04-16 2020-07-17 山东大学 一种含有炔丙基的木糖及其合成方法
CN117986219A (zh) * 2022-08-22 2024-05-07 三峡大学 一种6-芳/烷硫基-2h-吡喃-3-酮类化合物制备硫糖苷的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383092A2 (fr) * 1989-02-13 1990-08-22 Bayer Corporation Substrats enzymatiques chromogéniques à base de mérocyanine
US20070167378A1 (en) * 2003-10-08 2007-07-19 Saraiva Maria Joao M Compounds useful for the treatment of diseases associated with the formation of amyloid fibrils

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420127B1 (en) * 1994-11-18 2002-07-16 Washington University Compounds and pharmaceutical compositions for the treatment and prophylaxis of bacterial infections
US20080171706A1 (en) * 2004-03-23 2008-07-17 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Anti-Adhesive Compounds to Prevent and Treat Bacterial Infections

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383092A2 (fr) * 1989-02-13 1990-08-22 Bayer Corporation Substrats enzymatiques chromogéniques à base de mérocyanine
US20070167378A1 (en) * 2003-10-08 2007-07-19 Saraiva Maria Joao M Compounds useful for the treatment of diseases associated with the formation of amyloid fibrils

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
A. STOLL ET AL: "Das Furocumarin und die beta-D-Glucosido-furocumarinsäure aus den Samen von Coronilla-Arten. 23. Mitteilung über Herzglykoside", HELVETICA CHIMICA ACTA, vol. 33, no. 6, 1 January 1950 (1950-01-01), pages 1637 - 1647, XP055094084, ISSN: 0018-019X, DOI: 10.1002/hlca.19500330631 *
DENNIS A. SHUMAN ET AL: "Synthesis and biological activity of certain 8-mercaptopurine and 6-mercaptopyrimidine S-nucleosides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 12, no. 4, 1 July 1969 (1969-07-01), pages 653 - 657, XP055094096, ISSN: 0022-2623, DOI: 10.1021/jm00304a021 *
FAROUK M E ABDEL-MEGEID ET AL: "PREPARATION AND SOME REACTIONS OF D-GLUCOSYL DERIVATIVES OF 2-THIOXO-1,3,4-OXADIAZOLES AND 2-THIOXO- 1,3,4-THIADIAZOLES AND THEIR 2-OXO ANALOGUES*", CARBOHYDRATE RESEARCH, vol. 59, 1 January 1977 (1977-01-01), pages 95 - 102, XP055094075 *
NORIKO NAGAHORI ET AL: "Inhibition of Adhesion of Type 1 Fimbriated Escherichia coli to Highly Mannosylated Ligands Shin-Ichiro Nishimura, [b]", CHEMBIOCHEM, vol. 50, no. 3, 1 January 2002 (2002-01-01), pages 836 - 844, XP055094204 *
R BOGNAR: "N-GLYKOSYL-DERIVATE 'l-F.IL XIII. DER NACHTRÄGLICHE AUSBAU DES AGLYKONS. SYNTHESE VON N-GLYKOSYL- DERIVATEN DES 2-AMINO-THIAZOLS, 2-AMINO-1,3,4-THIADIAZOLS UND 5-AMINO-1,2,3,4-THIATRIAZOLS", CARBOHYDRATE RESEARCH, vol. 5, 1 January 1967 (1967-01-01), pages 320 - 328, XP055094071 *
See also references of WO2011050323A1 *
V. S. TAILE ET AL: "Synthesis and biological evaluation of novel 2-(4-O-[beta]-D-glucosidoxyphenyl)-4,5-disubstituted imidazoles", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 47, no. 4, 17 July 2010 (2010-07-17), pages 903 - 907, XP055094097, ISSN: 0022-152X, DOI: 10.1002/jhet.433 *
W. T. HASKINS: "Reliations between Rotatory Power and Structure in the Sugar Group. XXXV. Some 2'-Naohthyl 1-Thioglycopyranosides and their Acetates", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 69, no. 7, 19 July 1947 (1947-07-19), pages 1668 - 1672, XP055094092, ISSN: 0002-7863, DOI: 10.1021/ja01199a030 *
ZHENFU HAN ET AL: "Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-Substituted Biphenyl Mannosides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 8, 26 April 2012 (2012-04-26), pages 3945 - 3959, XP055065272, ISSN: 0022-2623, DOI: 10.1021/jm300165m *

Also Published As

Publication number Publication date
EP3492483A1 (fr) 2019-06-05
WO2011050323A1 (fr) 2011-04-28
EP2490530A1 (fr) 2012-08-29

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