EP2532941B2 - Procédé de conditionnement de mélanges NO/N2 avec étapes de purge et rinçage gazeux préalable - Google Patents

Procédé de conditionnement de mélanges NO/N2 avec étapes de purge et rinçage gazeux préalable Download PDF

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Publication number
EP2532941B2
EP2532941B2 EP12166496.5A EP12166496A EP2532941B2 EP 2532941 B2 EP2532941 B2 EP 2532941B2 EP 12166496 A EP12166496 A EP 12166496A EP 2532941 B2 EP2532941 B2 EP 2532941B2
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EP
European Patent Office
Prior art keywords
container
bar
gas
pressure
steps
Prior art date
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Active
Application number
EP12166496.5A
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German (de)
English (en)
French (fr)
Other versions
EP2532941B1 (fr
EP2532941A1 (fr
Inventor
Pierre de Villemeur
Joël Samirant
Celso Zerbinatti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Air Liquide Sante International SA
LAir Liquide SA pour lEtude et lExploitation des Procedes Georges Claude
Air Liquide Sante France SA
Original Assignee
Air Liquide Sante International SA
LAir Liquide SA pour lEtude et lExploitation des Procedes Georges Claude
Air Liquide Sante France SA
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Application filed by Air Liquide Sante International SA, LAir Liquide SA pour lEtude et lExploitation des Procedes Georges Claude, Air Liquide Sante France SA filed Critical Air Liquide Sante International SA
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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C5/00—Methods or apparatus for filling containers with liquefied, solidified, or compressed gases under pressures
    • F17C5/002—Automated filling apparatus
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2201/00—Vessel construction, in particular geometry, arrangement or size
    • F17C2201/05—Size
    • F17C2201/056—Small (<1 m3)
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2201/00—Vessel construction, in particular geometry, arrangement or size
    • F17C2201/05—Size
    • F17C2201/058—Size portable (<30 l)
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2203/00—Vessel construction, in particular walls or details thereof
    • F17C2203/06—Materials for walls or layers thereof; Properties or structures of walls or their materials
    • F17C2203/0634—Materials for walls or layers thereof
    • F17C2203/0636—Metals
    • F17C2203/0639—Steels
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2221/00—Handled fluid, in particular type of fluid
    • F17C2221/01—Pure fluids
    • F17C2221/014—Nitrogen
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2223/00—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel
    • F17C2223/01—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel characterised by the phase
    • F17C2223/0146—Two-phase
    • F17C2223/0153—Liquefied gas, e.g. LPG, GPL
    • F17C2223/0161—Liquefied gas, e.g. LPG, GPL cryogenic, e.g. LNG, GNL, PLNG
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2225/00—Handled fluid after transfer, i.e. state of fluid after transfer from the vessel
    • F17C2225/01—Handled fluid after transfer, i.e. state of fluid after transfer from the vessel characterised by the phase
    • F17C2225/0107—Single phase
    • F17C2225/0123—Single phase gaseous, e.g. CNG, GNC
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2225/00—Handled fluid after transfer, i.e. state of fluid after transfer from the vessel
    • F17C2225/03—Handled fluid after transfer, i.e. state of fluid after transfer from the vessel characterised by the pressure level
    • F17C2225/036—Very high pressure, i.e. above 80 bars
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
    • F17C2227/01—Propulsion of the fluid
    • F17C2227/0128—Propulsion of the fluid with pumps or compressors
    • F17C2227/0135—Pumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
    • F17C2227/03—Heat exchange with the fluid
    • F17C2227/0302—Heat exchange with the fluid by heating
    • F17C2227/0309—Heat exchange with the fluid by heating using another fluid
    • F17C2227/0311—Air heating
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
    • F17C2227/04—Methods for emptying or filling
    • F17C2227/044—Methods for emptying or filling by purging
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2265/00—Effects achieved by gas storage or gas handling
    • F17C2265/01—Purifying the fluid
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2270/00—Applications
    • F17C2270/02—Applications for medical applications
    • F17C2270/025—Breathing
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2270/00—Applications
    • F17C2270/05—Applications for industrial use
    • F17C2270/059—Mass bottling, e.g. merry belts

Definitions

  • the invention relates to a method of conditioning a NO / N 2 gas mixture in a container, in particular one or more gas bottles, comprising several successive purge and gaseous rinsing steps.
  • Gaseous NO / N 2 mixtures are commonly used to treat pulmonary vasoconstriction in adults or children, particularly in neonates with primary pulmonary hypertension or in patients undergoing cardiac surgery.
  • NO / N 2 mixtures are conventionally packaged in steel gas cylinders. Typically, these bottles contain 100 to 1000 ppm by volume of NO and nitrogen (N 2 ) for the rest. These bottles usually have a water capacity of 2 to 50 liters, which allows to introduce a total load of up to 15 m 3 of NO / N 2 mixture.
  • the packaging that is to say the bottling of these mixtures, is done in gas conditioning centers, as for example in the documents FR 2914393 and US 20030012709 .
  • the packaging of these mixtures is not always easy to achieve industrially.
  • the gaseous mixture NO / N2 is sensitive to the presence of residual oxygen-type impurities that may be present in the bottles during their filling.
  • the problem is therefore to propose an improved packaging method making it possible to eliminate all or almost all the impurities, in particular oxygen, which may be in one or more gas cylinders to receive an NO type gas mixture. / N 2 .
  • the solution of the invention is then a method for conditioning a gaseous mixture NO / N 2 in at least one container, in particular one or more gas bottles, according to claim 1.
  • the pressures given are absolute pressures.
  • the Figure 1 schematizes an embodiment of a conditioning cycle applicable in the context of the gaseous mixture conditioning process NO / N 2 of the present invention.
  • this conditioning cycle comprises several successive steps, ranging over time from T0 to T13, which are applied to each bottle and which are detailed below.
  • the successive steps a) to c) of the process of the invention have been indicated on the Figure 1 .
  • the hoses of the installation are emptied in the open air, that is to say that the internal volume of the filling hoses is put in fluid communication with the ambient atmosphere to evacuate any residual overpressure .
  • the valve (s) of gas containers connected to the hoses are closed, therefore no gas exchange takes place with the container (s). This corresponds to step d) of the process.
  • a vacuum pump is used to put the inside of the hoses in connection vacuum, that is to say at a pressure below atmospheric pressure, for example of the order of 0.15 bar , which allows to evacuate the gas residual and / or air that are there.
  • connection vacuum that is to say at a pressure below atmospheric pressure, for example of the order of 0.15 bar , which allows to evacuate the gas residual and / or air that are there.
  • This phase is also realized closed tap. Vacuuming the hoses is a safety feature that makes it possible to check the correct connection of all hoses and the absence of leaks. Indeed, in case of leakage or incorrect connection of a hose vacuum will not be established stably. This corresponds to step e) of the process schematized in Figure 1 .
  • the operator opens the valve of each bottle and the residual pressure present in each bottle then goes up to the pressure sensor, which detects said rise in pressure.
  • the residual pressure of the bottle is of the order of about 3 to 4 bar absolute.
  • each bottle is vented, that is to say that is allowed to escape the gas contained in the bottle to the outside atmosphere simply by the effect of the pressure difference between inside and outside. outside of the bottle so as to bring the internal pressure of the bottle to atmospheric pressure.
  • the bottle is rinsed with nitrogen during which its internal pressure is increased to about 10 bar.
  • the addition of nitrogen is via a gas pipeline and / or nitrogen storage under pressure so as to bring the internal pressure of the bottle to the desired pressure. This corresponds to step c) of the process of the invention.
  • the bottle is purged by depressurizing its internal volume by withdrawing the residual gas therein by means of a vacuum pump until an internal negative pressure of less than 0.2 bar abs, preferably less than 0.1 bar, for example of the order of 0.05 bar. This corresponds to a new step b) of the process of the invention.
  • the bottle is re-rinsed with nitrogen until its internal pressure is approximately 10 bar, as between T4 and T5. This corresponds to a new step c) of the process of the invention.
  • the bottle undergoes a new exhaust towards the ambient atmosphere as during times T5 and T6.
  • the gaseous residual pressure is then maintained at approximately 1.35 bar to prevent untimely entry of atmospheric contaminants. This corresponds to a new step a) of the process of the invention.
  • the bottle is further rinsed with nitrogen until its internal pressure is about 10 bar, as before. This corresponds to a new step c) of the process of the invention.
  • a gaseous premix of NO and N 2 containing an NO content of less than 10% by volume until reaching a first filling pressure P1 with P1> 1 bar, typically a P1 pressure of the order of 2 to 10 bar abs, preferably from 3 to 5 bar abs about.
  • the gaseous premix consisting of NO and N 2 contains a NO content of the order of 4% by volume.
  • nitrogen containing gas is introduced into the vessel containing the NO / N 2 premix at the first pressure P1 until a final NO / N 2 gas mixture containing a content of NO less than or equal to at 1200 ppm by volume, for example a final NO content of 200 to 800 ppm, and a second pressure P2 between P1 and 800 bar, for example here a pressure of 180 to 200 bar.
  • This method can be implemented by means of a packaging installation such as that schematized in Figure 2 equipped with a ramp 14 for packaging gas containers, that is to say, gas cylinders, comprising connecting means 15 for filling several containers 11 to 13 at a time, typically from 2 to 20 bottles concomitantly .
  • a packaging installation such as that schematized in Figure 2 equipped with a ramp 14 for packaging gas containers, that is to say, gas cylinders, comprising connecting means 15 for filling several containers 11 to 13 at a time, typically from 2 to 20 bottles concomitantly .
  • the nitrogen is stored in the tank 1 in liquid form and then withdrawn in liquid form by a cryogenic pump 2 which compresses it to a pressure of the order of 100 to 300 bar, before sending it to an atmospheric heater 3 where it is vaporized to obtain nitrogen gas.
  • a cryogenic pump 2 which compresses it to a pressure of the order of 100 to 300 bar, before sending it to an atmospheric heater 3 where it is vaporized to obtain nitrogen gas.
  • it comprises a pipe or main line 20 for conveying nitrogen from a tank 1 to the ramp 14 of conditioning.
  • the pressure in the line varies between about 100 bar immediately downstream of the collapse of the buffer capacity in the bottles and about 260 bar which corresponds to the stopping threshold of the pump.
  • the nitrogen gas is then conveyed via line 20 to a purification device 6 for removing traces of O 2 and H 2 O, for example a suitable molecular sieve, for example of the zeolite, silica gel, alumina or analog, or mixtures thereof.
  • a purification device 6 for removing traces of O 2 and H 2 O, for example a suitable molecular sieve, for example of the zeolite, silica gel, alumina or analog, or mixtures thereof.
  • the line 20 is also fluidly connected to a buffer capacity 4 for storing a portion of the nitrogen gas, as well as backup frames 5 each comprising several bottles of nitrogen.
  • the installation also comprises a cabinet 16 comprising a plurality of bottles 9 of a premix of NO / N2 containing here 4% by volume of NO, which bottles 9 are fluidly connected to the line 20 by a feed line 22.
  • premix NO / N 2 a premix of NO / N2 containing here 4% by volume of NO, which bottles 9 are fluidly connected to the line 20 by a feed line 22.
  • premix NO / N 2 .
  • the lines of NO / N2 22 and nitrogen 20 are not directly connected to each other but are connected to the block vanness 8 which in turn is connected by line 21 to the one or ramps 14.
  • the valves of the valve block 8 make it possible to choose the fluid with which the bottles 11 to 13 of the ramp 14 are filled.
  • the nitrogen lines 20 and premix lines NO / N 2 22 are thus fluidly connected firstly by the valve block 8, then a common section 21 to the filling ramp 14.
  • the valve block 8 comprises valves, control elements controlled by the control device 10.
  • Flow meters 7 make it possible to measure the quantity of N 2 and NO flowing in lines 20 and 22, and to transmit the measured information to a control device 10, such as a computer or the like.
  • the installation also includes a vent line 17 for evacuating gases to the ambient atmosphere, especially during the purge steps during which the internal volume of the container is in fluid communication with the ambient atmosphere.
  • a vacuum pump (not shown) makes it possible to operate the evacuation (s) of the containers, that is to say to reduce their internal pressure until a pressure lower than atmospheric pressure is obtained, ie ⁇ 1 bar absolute.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Vacuum Packaging (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
EP12166496.5A 2011-06-09 2012-05-03 Procédé de conditionnement de mélanges NO/N2 avec étapes de purge et rinçage gazeux préalable Active EP2532941B2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1155038A FR2976260B1 (fr) 2011-06-09 2011-06-09 Procede de conditionnement de melanges no/n2 avec etapes de purge et rincage gazeux prealable

Publications (3)

Publication Number Publication Date
EP2532941A1 EP2532941A1 (fr) 2012-12-12
EP2532941B1 EP2532941B1 (fr) 2014-07-02
EP2532941B2 true EP2532941B2 (fr) 2018-02-28

Family

ID=45998206

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12166496.5A Active EP2532941B2 (fr) 2011-06-09 2012-05-03 Procédé de conditionnement de mélanges NO/N2 avec étapes de purge et rinçage gazeux préalable

Country Status (7)

Country Link
US (1) US20120312416A1 (es)
EP (1) EP2532941B2 (es)
CN (1) CN102814155B (es)
BR (1) BR102012013702B8 (es)
ES (1) ES2501090T5 (es)
FR (1) FR2976260B1 (es)
ZA (1) ZA201203663B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2976259B1 (fr) * 2011-06-09 2013-07-05 Air Liquide Procede de conditionnement d'un melange gazeux no/n2
FR2976258B1 (fr) * 2011-06-09 2014-09-05 Air Liquide Installation de conditionnement de no a debitmetres massiques

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5485827A (en) † 1990-12-05 1996-01-23 The General Hospital Corporation Methods and devices for treating plumonary vasoconstriction and asthma
US6152192A (en) † 1998-02-11 2000-11-28 Welding Company Of America Controller for system for filling gas cylinders with single gas or gas mixture
US20030070724A1 (en) † 2001-09-26 2003-04-17 Shock Robert F. Computer controlled apparatus and method of filling cylinders with gas
US20100330207A1 (en) † 2009-06-30 2010-12-30 Ikaria Holdings, Inc. Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US5540251A (en) * 1994-02-01 1996-07-30 Mayeaux; Paul H. Precision gas blender
US5476115A (en) * 1994-03-10 1995-12-19 Praxair Technology, Inc. Automatic gas blending system
US5826632A (en) * 1997-05-30 1998-10-27 The Boc Group, Inc. Dynamic gas cylinder filling process
US7334708B2 (en) * 2001-07-16 2008-02-26 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Integral blocks, chemical delivery systems and methods for delivering an ultrapure chemical
US20060060139A1 (en) * 2004-04-12 2006-03-23 Mks Instruments, Inc. Precursor gas delivery with carrier gas mixing
US7328726B2 (en) * 2006-01-20 2008-02-12 Air Products And Chemicals, Inc. Ramp rate blender
FR2914393B1 (fr) * 2007-03-27 2009-07-17 Air Liquide Procede et dispositif de preparation de bouteilles de gaz sous pression.
US7621302B2 (en) * 2007-09-28 2009-11-24 Airgas, Inc. Coriolis dosing system for filling gas cylinders
FR2976259B1 (fr) * 2011-06-09 2013-07-05 Air Liquide Procede de conditionnement d'un melange gazeux no/n2

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5485827A (en) † 1990-12-05 1996-01-23 The General Hospital Corporation Methods and devices for treating plumonary vasoconstriction and asthma
US6152192A (en) † 1998-02-11 2000-11-28 Welding Company Of America Controller for system for filling gas cylinders with single gas or gas mixture
US20030070724A1 (en) † 2001-09-26 2003-04-17 Shock Robert F. Computer controlled apparatus and method of filling cylinders with gas
US20100330207A1 (en) † 2009-06-30 2010-12-30 Ikaria Holdings, Inc. Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BRANSON R.D. ET AL: "Inhaled nitric oxide: delivery systems and monitoring", RESPIRATORY CARE, vol. 44, no. 3, March 1999 (1999-03-01), pages 281 - 307 †

Also Published As

Publication number Publication date
FR2976260B1 (fr) 2013-07-05
EP2532941B1 (fr) 2014-07-02
CN102814155B (zh) 2016-09-07
US20120312416A1 (en) 2012-12-13
ES2501090T5 (es) 2018-04-18
ES2501090T3 (es) 2014-10-01
EP2532941A1 (fr) 2012-12-12
ZA201203663B (en) 2013-01-30
CN102814155A (zh) 2012-12-12
FR2976260A1 (fr) 2012-12-14
BR102012013702B1 (pt) 2022-04-26
BR102012013702B8 (pt) 2022-05-24
BR102012013702A2 (pt) 2013-07-30

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