EP2591643A1 - Cyclotron comprenant un moyen de modification du profil de champ magnétique et procédé associé - Google Patents
Cyclotron comprenant un moyen de modification du profil de champ magnétique et procédé associéInfo
- Publication number
- EP2591643A1 EP2591643A1 EP11729981.8A EP11729981A EP2591643A1 EP 2591643 A1 EP2591643 A1 EP 2591643A1 EP 11729981 A EP11729981 A EP 11729981A EP 2591643 A1 EP2591643 A1 EP 2591643A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- mass
- ratio
- cyclotron
- magnetic field
- charge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H13/00—Magnetic resonance accelerators; Cyclotrons
- H05H13/005—Cyclotrons
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H13/00—Magnetic resonance accelerators; Cyclotrons
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H7/00—Details of devices of the types covered by groups H05H9/00, H05H11/00, H05H13/00
- H05H7/04—Magnet systems, e.g. undulators, wigglers; Energisation thereof
Definitions
- the present invention relates to a cyclotron and a method for modifying the magnetic field profile in the cyclotron according to the "mass-to-mass" ratio of a particle to accelerate.
- Cyclotrons are circular accelerators for accelerating charged particles such as positive ions (protons, deuterons, helions, alpha particles, etc.) or negative ions (H-, D-, etc.), which are used inter alia for the production of radioactive isotopes, for radiotherapy, or for experimental purposes.
- An isochronous cyclotron generally comprises:
- an electromagnet comprising an upper pole and a lower pole, arranged symmetrically with respect to a median plane, perpendicular to the central axis of the cyclotron, and separated by an air gap provided for the circulation of the charged particles, each of said poles comprising several areas arranged so as to have an alternation of narrow-gap areas commonly referred to as “hills” and wide-gap areas commonly referred to as “valleys";
- B (R) is the average magnetic field around a circle of radius R;
- BO the magnetic field in the center of the cyclotron
- q the charge of the particle
- mi will be considered in first approximation as the mass of the particle m given by the product of the mass number A by the mass of the nucleons m N.
- the sectors are machined so as to accelerate a type of particle ratio "charge on mass" q / m very precise.
- FIG. 1 shows the average magnetic field profiles ⁇ B> as a function of the average radius ⁇ R> of the particle in the cyclotron for the acceleration of particles of ratio q / m equal to 1 and particles of "charge on mass" ratio »Q / m equal to 1 ⁇ 2.
- a mechanical means supports ferromagnetic plates which extend, in two opposite valleys, from an area near the center of the cyclotron to the periphery of the cyclotron.
- said mechanical means positions said ferromagnetic plates near the median plane of the cyclotron to provide an additional field to obtain the required isochronous magnetic field profile.
- said ferromagnetic plates are distant from the median plane so as to reduce or eliminate the intensity of the additional magnetic field and to obtain the field profile Isochronous magnet required for acceleration of deuterons.
- the profile of the average magnetic field as a function of the average radius varies by increasing by about 1% by "step" of 10 MeV.
- the profile of the average magnetic field as a function of the average radius increases by about 0.5% in steps of 10 MeV for the case of deuterons.
- the variation of the average magnetic field from the center of the cyclotron to the end of the poles is 1% for the proton and 0.25% for the deuteron.
- said ferromagnetic plates as employed in Cyclone 18/9 and Cyclone 30/15 are sufficient to produce the additional magnetic field necessary for proton acceleration.
- the variation in the average magnetic field profile from the center of the cyclotron to the end of the poles should be about 7% for the first time.
- This document explains the different solutions that have been envisaged in order to obtain a cyclotron that can operate according to two different isochronous magnetic fields so as to accelerate a type of particles of desired q / m ratio.
- This cyclotron C70 comprises hills divided into three superimposed parts and parallel to the median plane:
- the object of the present invention is to provide a cyclotron capable of accelerating different types of "charge on mass" ratios q / m, not having the disadvantages of the prior art.
- Another object of the present invention is to provide a cyclotron a magnetic field profile correction means according to the q / m ratio of the type particles to accelerate, said means allowing a simpler embodiment than the means of the prior art.
- Another object of the present invention is to provide a cyclotron a magnetic field profile correction means in the q / m ratio of the type of particles to accelerate, said means being able to produce enough additional magnetic field in the case cyclotrons of medium to high energy.
- Another object of the present invention is to provide a cyclotron a magnetic field profile correction means not disturbing the internal vacuum of the cyclotron.
- the present invention relates to a cyclotron capable of producing a first accelerated charged particle beam defined by a first "charge on mass” ratio (q / m) or a second accelerated charged particle beam defined by a second ratio " mass load "(q / m)” less than said first "mass load” ratio (q / m), said cyclotron comprising:
- an electromagnet comprising two poles, preferably an upper pole and a lower pole, arranged symmetrically with respect to a median plane perpendicular to the central axis of the cyclotron and separated by an air gap provided for the circulation of charged particles, each of said poles comprising a plurality of sectors arranged so as to have alternating zones with a narrow gap called "Hills” and wide gap areas called “valleys";
- means for modifying the magnetic field profile according to the "mass-to-mass" ratio of the particles to be accelerated comprising a ferromagnetic part present in one of said valleys and extending radially from a region close to the center towards the periphery of the cyclotron, said part ferromagnetic circuit forming a magnetic circuit with the bottom of said valley, so as to create an additional magnetic field sufficiently large for particle acceleration of said first beam having said first load to mass ratio (q / m); characterized by :
- a secondary induction coil arranged around said ferromagnetic part so as to be able to induce a magnetic field opposing the magnetic field induced in said ferromagnetic part by said main induction coil and to reduce the additional magnetic field contribution provided by said piece ferromagnetic material for accelerating particles of said second beam having said second mass to mass ratio (q / m).
- the secondary induction coil is disposed around said ferromagnetic part parallel to said main induction coil.
- said ferromagnetic part comprises: a first portion, extending from the center to the periphery of said cyclotron, forming an air gap, and; a second part comprising a pillar made of a ferromagnetic material supporting said first part.
- said secondary induction coil surrounds said pillar.
- the cyclotron comprises means for modifying the magnetic field profile located in two opposite valleys.
- the cyclotron is characterized by:
- a mechanical device for moving said ferromagnetic part away from the median plane when it is desired to accelerate particles having the second "mass-to-mass” ratio (q / m) or to bring said ferromagnetic part closer to the median plane when it is desired accelerate particles having the first "charge to mass” ratio (q / m).
- the present invention relates to a method for producing an accelerated charged particle beam and characterized in that:
- the intensity of current in said secondary induction coil is adjusted or adjusted according to the report "charge on mass” particles to accelerate.
- the method is characterized in that:
- the method is characterized in that:
- a current is applied in said secondary induction coil so as to induce a magnetic field opposed to said main induction field if one passes from the acceleration of a first particle beam having the first ratio "charge on mass "(q / m) at the acceleration of a second particle beam having the second" mass-to-mass "ratio (q / m).
- the method is characterized in that:
- the closure of the passage of the current in the secondary induction coil is provided if the acceleration of a second particle beam is switched having the second "mass-to-mass" (q / m) ratio to the acceleration of a first particle beam having the "mass-to-mass” ratio (q / m).
- the method is characterized in that a particle beam is accelerated on a target comprising a radioisotope precursor.
- the present invention also relates to a use of a cyclotron as described above or the method as described above for the production of radioisotopes.
- FIG. 1 represents the profile of the average magnetic field ⁇ B> to be applied in an isochronous cyclotron as a function of the average radius ⁇ R> of the particle, for the acceleration of protons and deuterons.
- Figure 2 shows a schematic sectional view along a plane perpendicular to the median plane of a cyclotron according to a first embodiment of the present invention.
- Figure 3 shows a schematic sectional view along the median plane of a cyclotron according to a second embodiment of the present invention.
- Figure 4 shows a schematic sectional view along a plane perpendicular to the median plane of a cyclotron according to a second embodiment of the present invention.
- FIG. 5 represents a three-dimensional view of a portion of a cyclotron according to a third embodiment of the present invention.
- Figure 6 shows a schematic sectional view along a plane perpendicular to the median plane of a cyclotron according to a third embodiment of the present invention.
- the device of the present invention is a cyclotron capable of producing a beam of accelerated charged particles defined by a "mass-to-mass” ratio (q / m) or an accelerated particle beam defined by a “mass-to-mass” ratio. (q / m) 'lower than said ratio "load on mass” (q / m). Said cyclotron is able to accelerate particles with a "mass-to-mass" ratio (q / m), for example equal to 1, such as protons, or particles of ratio (q / m), equal to 1 ⁇ 2, such as particles.
- Said cyclotron according to the present invention is represented in FIGS. 2 to 6.
- Said cyclotron comprises a magnetic circuit comprising:
- an electromagnet comprising two poles, an upper pole and a lower pole, said poles being arranged symmetrically with respect to a median plane 13 perpendicular to the central axis 12 of the cyclotron, and separated by an air gap 14 provided for particle circulation charged, each of said poles comprising several sectors arranged so as to have alternating zones with narrow air gap called “hills” 5 and wide air gap areas called “valleys”4; flux returns 7 for closing said magnetic circuit;
- a main induction coil 6 for creating a substantially constant main induction field in the gap 14 between said poles and;
- Said cyclotron is characterized in that said means for modifying the magnetic field profile comprises:
- a ferromagnetic part 2 generally made of soft iron, present in one of said valleys 4 and extending from a region close to the center towards the periphery of the cyclotron, said ferromagnetic part 2 forming a magnetic circuit with the bottom of said valley, of to create an additional magnetic field large enough for the acceleration of particles "mass-to-mass" ratio (q / m);
- said ferromagnetic part 2 may take different forms as long as part or all of it extends from the center to the periphery of the cyclotron.
- said ferromagnetic part 2 can comprise:
- a first portion extending from the center to the periphery of the cyclotron forming an air gap and; a second part comprising a ferromagnetic pillar 3, connected to the flux returns 7 and supporting said first part.
- Said cyclotron may comprise for example two magnetic field profile modification means located in opposite valleys 4. Two other opposite valleys include acceleration electrodes commonly referred to as “dice” (not shown).
- said cyclotron may comprise four hills 5, each of these hills 5 being separated from each other by valleys 4.
- the sectors of the cyclotron are arranged in a symmetrical manner. order 4, with two opposite valleys 4 comprising said means for modifying the magnetic field and two other valleys comprising the dice.
- said means making it possible to reduce the contribution of the additional magnetic field comprises:
- said means making it possible to reduce the contribution of the additional magnetic field comprises a secondary induction coil 1 arranged around said ferromagnetic part 2 in parallel manner with said coil. main induction 6. Said secondary induction coil 1 is connected to a power supply device 11 for passing a counter current inducing a magnetic field opposing the magnetic field induced in said ferromagnetic part by said main induction coil 6.
- said ferromagnetic part 2 comprises:
- a second part comprising a ferromagnetic pillar 3, connected to the flux returns 7 and supporting said first part,
- said secondary induction coil 1 surrounding said pillar 3 and is arranged parallel to said main induction coil 6.
- the secondary induction coil 1 may be surrounded by a cooling element
- the cyclotron according to the present invention comprises:
- a second part comprising a pillar made of a ferromagnetic material supporting said first part.
- the cyclotron according to the present invention comprises means for correcting the magnetic field profile located in two opposite valleys.
- said means for reducing the additional magnetic field contribution provided by said ferromagnetic part comprises:
- a mechanical device for moving said ferromagnetic part away from the median plane when it is desired to accelerate particles having the second "mass-to-mass” ratio (q / m) or to bring said ferromagnetic part closer to the median plane when one wish to accelerate particles having the first "charge on mass” ratio (q / m).
- said means for reducing the additional magnetic field contribution provided by said ferromagnetic part comprises:
- a secondary induction coil disposed around said ferromagnetic part parallel to said main induction coil and connected to a power supply means for passing a current inducing a magnetic field opposing the magnetic field induced in said ferromagnetic part by said main coil.
- said secondary induction coil surrounds said pillar.
- the present invention also relates to a method for correcting the magnetic field profile in a cyclotron capable of producing a first accelerated charged particle beam defined by a first "charge on mass” ratio (q / m) or a second accelerated charged particle beam defined by a second "mass-to-mass” ratio (q / m) lower than said first "mass-to-mass” ratio (q / m), said cyclotron comprising a magnetic circuit comprising:
- an electromagnet comprising two poles, an upper pole and a lower pole, said poles being arranged symmetrically with respect to a median plane perpendicular to the central axis of the cyclotron, and separated by an air gap provided for the circulation of the charged particles, each said poles comprising a plurality of sectors arranged so as to have an alternation of narrow-gap zones called “hills” and wide-gap zones called “valleys", so as to ensure a refocusing of said beam in the median plane;
- a main induction coil for creating a substantially constant main induction field in the gap between said poles; a means for correcting the magnetic field profile according to the q / m ratio of the type of particle to be accelerated, characterized in that a magnetic field profile correction means is provided comprising:
- a ferromagnetic part comprised in one of said valleys and extending radially from a region close to the center towards the periphery of the cyclotron, said ferromagnetic piece forming a magnetic circuit with the bottom of said valley, so as to create an additional magnetic field sufficiently important for particle acceleration of the first beam having the first "charge to mass” ratio (q / m);
- said ferromagnetic part comprises:
- a second part comprising a pillar made of a ferromagnetic material and supporting said first part.
- said means for reducing the additional magnetic field contribution provided by said ferromagnetic part comprises:
- a secondary induction coil disposed around said ferromagnetic part in parallel to said main induction coil and connected to an electrical supply means making it possible to pass a current inducing a magnetic field opposing the magnetic field induced in said said ferromagnetic part by said main coil.
- one adjusts or adjusts the current intensity in said secondary induction coil according to the ratio "charge on mass” of the particle to accelerate.
- the method according to the invention comprises the step of producing a first accelerated particle beam defined by a first "charge on mass” ratio (q / m) by means of said cyclotron, without applying current in said secondary induction coil, or producing a second particle beam defined by a second "charge-to-mass” ratio (q / m) by said cyclotron by applying a current in said secondary induction coil in order to induce a magnetic field opposing said main induction field, the first ratio "load on mass” (q / m) being greater than the second ratio "load on mass” (q / m) '.
- the method according to the invention comprises the step of applying a current in said secondary induction coil so as to induce a magnetic field opposing said main induction field if one passes the acceleration of a first particle beam having the first "mass-to-mass" ratio (q / m) to the acceleration of a second particle beam having the second "mass-to-mass” ratio (q / m) ', or closing the passage of the current in said secondary induction coil if one passes from the acceleration of a second particle beam having the second ratio "charge on mass" (q / m)' to the acceleration a first particle beam having the ratio "charge on mass” (q / m).
- a particle beam is accelerated on a target comprising a radioisotope precursor.
- the present invention also relates to the use of said method or cyclotron for the production of radioisotope.
- the magnetic field profile must be modified so as to obtain a profile of field isochronous magnetic as shown in Figure 1. It must therefore reduce the additional magnetic field provided by said ferromagnetic part 2. This can be done by applying in said secondary induction coil 1 a counter current creating a magnetic field opposing to the main magnetic field induced by said main induction coil 6, so as to obtain the isochronous magnetic field necessary for the acceleration of deuterons or particles "mass to mass ratio" equal to 1 ⁇ 2.
- These "mass load” ratios of 1 and 1 ⁇ 2 are not a limitation of the present invention and other "mass-to-mass" ratios can be considered.
- the present invention avoids resorting to a complex winding and machining system at the sector level.
- the second and third embodiments of the present invention make it possible to avoid the use of a mobile system to pass from an isochronous magnetic field necessary for the acceleration of one type of ratio report "charge on mass" q / m to another.
- Another substantial advantage of the second and third embodiments of the present invention is that in the case of rough poles machining, it is always possible to correct the magnetic field by varying the current in the secondary induction coil 1 so as to obtain the desired isochronous magnetic field with good accuracy.
- the present invention can be used to accelerate q / m ratio particles on a target for the production of radioisotopes.
- said cyclotron in a first use, can be used to accelerate particles of "charge to mass" ratio q / m equal to 1, such as for example protons on a target comprising a radioisotope precursor.
- the magnetic field in said cyclotron can be modified so as to accelerate particles of ratio "charge on mass" (q / m) equal to 1 ⁇ 2, such as for example deuterons, on a target comprising a precursor radioisotope.
Landscapes
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Optics & Photonics (AREA)
- Particle Accelerators (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE2010/0415A BE1019411A4 (fr) | 2010-07-09 | 2010-07-09 | Moyen de modification du profil de champ magnetique dans un cyclotron. |
| PCT/EP2011/061238 WO2012004225A1 (fr) | 2010-07-09 | 2011-07-04 | Cyclotron comprenant un moyen de modification du profil de champ magnétique et procédé associé |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP2591643A1 true EP2591643A1 (fr) | 2013-05-15 |
| EP2591643B1 EP2591643B1 (fr) | 2014-05-14 |
Family
ID=43597793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP11729981.8A Active EP2591643B1 (fr) | 2010-07-09 | 2011-07-04 | Cyclotron comprenant un moyen de modification du profil de champ magnétique et procédé associé |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9055662B2 (fr) |
| EP (1) | EP2591643B1 (fr) |
| JP (1) | JP5836369B2 (fr) |
| KR (1) | KR20130138171A (fr) |
| BE (1) | BE1019411A4 (fr) |
| CA (1) | CA2804336C (fr) |
| WO (1) | WO2012004225A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113009394A (zh) * | 2021-01-29 | 2021-06-22 | 江苏力磁医疗设备有限公司 | 一种静磁场发生装置 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3024306B1 (fr) * | 2014-11-19 | 2019-08-07 | Ion Beam Applications S.A. | Cyclotron a courant eleve |
| US9894747B2 (en) | 2016-01-14 | 2018-02-13 | General Electric Company | Radio-frequency electrode and cyclotron configured to reduce radiation exposure |
| EP3244707B1 (fr) * | 2016-05-13 | 2018-09-05 | Ion Beam Applications S.A. | Insert de pôle pour cyclotron |
| EP3244710B1 (fr) * | 2016-05-13 | 2018-09-05 | Ion Beam Applications S.A. | Cyclotron compact |
| US9961757B2 (en) | 2016-05-13 | 2018-05-01 | Ion Beam Applications S.A. | Peripheral hill sector design for cyclotron |
| KR102430822B1 (ko) * | 2016-10-06 | 2022-08-08 | 스미도모쥬기가이고교 가부시키가이샤 | 입자가속기 |
| JP6739393B2 (ja) * | 2017-04-18 | 2020-08-12 | 株式会社日立製作所 | 粒子線加速器および粒子線治療装置 |
| EP3496516B1 (fr) * | 2017-12-11 | 2020-02-19 | Ion Beam Applications S.A. | Régénérateur de cyclotron supraconducteur |
| JP7002952B2 (ja) * | 2018-01-29 | 2022-01-20 | 株式会社日立製作所 | 円形加速器、円形加速器を備えた粒子線治療システム、及び円形加速器の運転方法 |
| US12096790B2 (en) * | 2019-07-04 | 2024-09-24 | Philip Morris Products S.A. | Inductive heating arrangement having an annular channel |
| JP7352412B2 (ja) * | 2019-08-28 | 2023-09-28 | 住友重機械工業株式会社 | サイクロトロン |
| EP3876679B1 (fr) * | 2020-03-06 | 2022-07-20 | Ion Beam Applications | Synchrocyclotron permettant d'extraire des faisceaux de différentes énergies et procédé correspondant |
| CN116017836B (zh) * | 2022-12-20 | 2024-01-19 | 北京核力同创科技有限公司 | 一种医用小型回旋加速器真空室结构 |
| US12532403B2 (en) * | 2023-10-31 | 2026-01-20 | Texas Instruments Incorporated | Miniaturized integrated cyclotron |
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| US1948384A (en) * | 1932-01-26 | 1934-02-20 | Research Corp | Method and apparatus for the acceleration of ions |
| US2504585A (en) * | 1945-01-26 | 1950-04-18 | Atomic Energy Commission | Cyclotron target |
| US2673928A (en) * | 1950-09-20 | 1954-03-30 | Gen Electric | Apparatus for imparting high energy to charged particles |
| NL143102B (nl) * | 1970-02-18 | 1974-08-15 | Kernforschung Gmbh Ges Fuer | Isochroon cyclotron. |
| US3789355A (en) * | 1971-12-28 | 1974-01-29 | Mobil Oil Corp | Method of and apparatus for logging while drilling |
| JPS59173306U (ja) * | 1983-05-04 | 1984-11-19 | 株式会社島津製作所 | サイクロトロン用ハ−モニツクコイル |
| JPS6251200A (ja) * | 1985-08-28 | 1987-03-05 | 株式会社日本製鋼所 | 等時性磁場分布を有するサイクロトロンの磁極構造 |
| US5773919A (en) * | 1986-10-02 | 1998-06-30 | Electron Power Systems | Electron spiral toroid |
| JPH074800Y2 (ja) * | 1987-08-24 | 1995-02-01 | 株式会社日本製鋼所 | サイクロトロンの電磁石の磁極構造 |
| US5052638A (en) * | 1989-03-30 | 1991-10-01 | Minovitch Michael Andrew | Electromagnetic ramjet |
| BE1005530A4 (fr) * | 1991-11-22 | 1993-09-28 | Ion Beam Applic Sa | Cyclotron isochrone |
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| US6777699B1 (en) * | 2002-03-25 | 2004-08-17 | George H. Miley | Methods, apparatus, and systems involving ion beam generation |
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2010
- 2010-07-09 BE BE2010/0415A patent/BE1019411A4/fr not_active IP Right Cessation
-
2011
- 2011-07-04 KR KR1020137001658A patent/KR20130138171A/ko not_active Withdrawn
- 2011-07-04 EP EP11729981.8A patent/EP2591643B1/fr active Active
- 2011-07-04 WO PCT/EP2011/061238 patent/WO2012004225A1/fr not_active Ceased
- 2011-07-04 CA CA2804336A patent/CA2804336C/fr active Active
- 2011-07-04 US US13/809,127 patent/US9055662B2/en active Active
- 2011-07-04 JP JP2013517338A patent/JP5836369B2/ja active Active
Non-Patent Citations (1)
| Title |
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| See references of WO2012004225A1 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113009394A (zh) * | 2021-01-29 | 2021-06-22 | 江苏力磁医疗设备有限公司 | 一种静磁场发生装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013534700A (ja) | 2013-09-05 |
| US9055662B2 (en) | 2015-06-09 |
| CA2804336A1 (fr) | 2012-01-12 |
| EP2591643B1 (fr) | 2014-05-14 |
| CA2804336C (fr) | 2017-05-16 |
| KR20130138171A (ko) | 2013-12-18 |
| BE1019411A4 (fr) | 2012-07-03 |
| US20130141019A1 (en) | 2013-06-06 |
| JP5836369B2 (ja) | 2015-12-24 |
| WO2012004225A1 (fr) | 2012-01-12 |
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