EP2616468A4 - Verschmolzene heteroarlye und anwendungen davon - Google Patents

Verschmolzene heteroarlye und anwendungen davon

Info

Publication number
EP2616468A4
EP2616468A4 EP11824596.8A EP11824596A EP2616468A4 EP 2616468 A4 EP2616468 A4 EP 2616468A4 EP 11824596 A EP11824596 A EP 11824596A EP 2616468 A4 EP2616468 A4 EP 2616468A4
Authority
EP
European Patent Office
Prior art keywords
heteroaryles
condensed
condensed heteroaryles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11824596.8A
Other languages
English (en)
French (fr)
Other versions
EP2616468A1 (de
Inventor
Weiguo Su
Weihan Zhang
Haibin Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hutchmed Ltd
Original Assignee
Hutchison Medipharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchison Medipharma Ltd filed Critical Hutchison Medipharma Ltd
Publication of EP2616468A1 publication Critical patent/EP2616468A1/de
Publication of EP2616468A4 publication Critical patent/EP2616468A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP11824596.8A 2010-09-16 2011-09-15 Verschmolzene heteroarlye und anwendungen davon Withdrawn EP2616468A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2010076996 2010-09-16
PCT/CN2011/079684 WO2012034526A1 (en) 2010-09-16 2011-09-15 Fused heteroaryls and their uses

Publications (2)

Publication Number Publication Date
EP2616468A1 EP2616468A1 (de) 2013-07-24
EP2616468A4 true EP2616468A4 (de) 2014-02-26

Family

ID=45831015

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11824596.8A Withdrawn EP2616468A4 (de) 2010-09-16 2011-09-15 Verschmolzene heteroarlye und anwendungen davon

Country Status (13)

Country Link
US (1) US9181264B2 (de)
EP (1) EP2616468A4 (de)
JP (1) JP5634609B2 (de)
KR (1) KR20130087020A (de)
AU (1) AU2011301518B2 (de)
BR (1) BR112013005855A2 (de)
CA (1) CA2810708A1 (de)
MX (1) MX2013002784A (de)
NZ (1) NZ607527A (de)
PH (1) PH12013500500A1 (de)
RU (1) RU2552114C2 (de)
SG (1) SG188302A1 (de)
WO (1) WO2012034526A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130310374A1 (en) * 2010-12-06 2013-11-21 Piramal Enterprises Limited` Substituted Imidazoquinoline Derivatives
EP2867236B1 (de) 2012-06-29 2017-06-14 Pfizer Inc Neue 4-(substituierte amino)-7h-pyrrolo[2,3-d]pyrimidine als lrrk2 hemmer
CA2897279C (en) * 2013-01-23 2020-12-29 Astrazeneca Ab Aminopyrazine derivatives and pharmaceutical compositions thereof for use in the treatment of cancer
US9227969B2 (en) 2013-08-14 2016-01-05 Novartis Ag Compounds and compositions as inhibitors of MEK
EP3083618B1 (de) 2013-12-17 2018-02-21 Pfizer Inc Neuartige 3,4-disubstituierte-1h-pyrrolo[2,3-b]pyridine und 4,5-disubstituierte 7h-pyrrolo[2,3-c]pyridazine als lrrk2-hemmer
AU2015290007B2 (en) * 2014-07-14 2019-11-21 Advenchen Pharmaceuticals, Nanjing Ltd. Fused quinoline compunds as pi3k, mTor inhibitors
CN114805352B (zh) * 2015-07-11 2023-09-15 南京爱德程医药科技有限公司 作为pi3k/mtor抑制剂的吡咯并吡啶取代的稠合喹啉化合物
RU2722149C1 (ru) * 2015-09-14 2020-05-27 Пфайзер Инк. Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2
CN108699065B (zh) * 2015-12-18 2021-08-31 诺华股份有限公司 作为激酶抑制剂的三环类化合物和组合物
JP7247092B2 (ja) * 2017-01-09 2023-03-28 上海瑛派▲薬▼▲業▼有限公司 キナーゼ阻害剤としての置換された縮合ヘテロアリール化合物及びその用途
KR102143320B1 (ko) 2018-08-28 2020-08-12 주식회사 스템랩 합성 메신저 rna를 이용하여 소변세포를 신경줄기세포로 직접 역분화하는 방법
CN109810112B (zh) * 2019-02-01 2021-03-23 华侨大学 一种吲哚并[2,1-a]酞嗪衍生物的制备方法
CN109912606B (zh) * 2019-04-16 2021-05-04 新乡医学院 一种嘧啶并吲唑类化合物的合成方法
MX2024000357A (es) * 2021-07-07 2024-02-12 Incyte Corp Compuestos triciclicos como inhibidores de homologo de oncogen viral de sarcoma de rata kirsten (kras).
WO2025247391A1 (en) * 2024-05-31 2025-12-04 Hutchmed Limited Novel pi3k and/or pikk inhibitors, antibody-drug conjugates comprising the same and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005054237A1 (en) * 2003-11-21 2005-06-16 Novartis Ag 1h-imidazoquinoline derivatives as protein kinase inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN160956B (de) * 1982-10-18 1987-08-22 Pfizer
DK0783504T3 (da) * 1994-09-16 2000-08-14 Novo Nordisk As (1,2,4)triazolo (4,3-a)guinoxalinon-derivater, deres fremstilling og anvendelse som antagonister af ampa-receptorer
AR046845A1 (es) * 2003-11-21 2005-12-28 Novartis Ag Derivados de 1h-imidazo[4,5-c]quinolina para tratamiento de enfermedades dependientes de las proteino-quinasas
WO2007075468A1 (en) 2005-12-16 2007-07-05 Coley Pharmaceutical Group, Inc. Substituted imidazoquinolines, imidazonaphthyridines, and imidazopyridines, compositions, and methods
JP2010535844A (ja) 2007-08-14 2010-11-25 ノバルティス アーゲー Ｇａｂａアルファリガンドとしてのピラゾロキノリンおよびピラゾロナフチリジン誘導体
US20110212053A1 (en) * 2008-06-19 2011-09-01 Dapeng Qian Phosphatidylinositol 3 kinase inhibitors
WO2010038165A1 (en) * 2008-09-30 2010-04-08 Pfizer Inc. Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions
US20100078444A1 (en) 2008-09-30 2010-04-01 Thomas Gerard Shannon Compressed tissue product
WO2010054253A1 (en) * 2008-11-07 2010-05-14 Biotie Therapies Gmbh Triazine derivatives as inhibitors of phosphodiesterases
WO2010054260A1 (en) * 2008-11-07 2010-05-14 Biotie Therapies Gmbh Imidazo[5,1-c][1,2,4]benzotriazine derivatives as inhibitors of phosphodiesterases
IL266563B (en) 2009-10-06 2022-09-01 Millennium Pharm Inc Heterocyclic compounds useful as pdk1 inhibitors
TW201204727A (en) * 2010-03-10 2012-02-01 Kalypsys Inc Heterocyclic inhibitors of histamine receptors for the treatment of disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005054237A1 (en) * 2003-11-21 2005-06-16 Novartis Ag 1h-imidazoquinoline derivatives as protein kinase inhibitors

Also Published As

Publication number Publication date
MX2013002784A (es) 2013-04-24
KR20130087020A (ko) 2013-08-05
BR112013005855A2 (pt) 2016-05-17
AU2011301518B2 (en) 2014-07-03
US9181264B2 (en) 2015-11-10
RU2552114C2 (ru) 2015-06-10
NZ607527A (en) 2015-04-24
JP5634609B2 (ja) 2014-12-03
RU2013108348A (ru) 2014-10-27
PH12013500500A1 (en) 2013-05-06
AU2011301518A1 (en) 2013-03-14
WO2012034526A1 (en) 2012-03-22
US20130190307A1 (en) 2013-07-25
CA2810708A1 (en) 2012-03-22
JP2013537204A (ja) 2013-09-30
SG188302A1 (en) 2013-04-30
EP2616468A1 (de) 2013-07-24

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20140124

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 471/04 20060101AFI20140120BHEP

Ipc: A61K 31/4745 20060101ALI20140120BHEP

Ipc: A61K 31/4985 20060101ALI20140120BHEP

Ipc: A61P 35/00 20060101ALI20140120BHEP

Ipc: C07D 471/14 20060101ALI20140120BHEP

Ipc: C07D 487/04 20060101ALI20140120BHEP

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