EP2644183A2 - Composite dentaire polymérisable doté de propriétés d'utilisation améliorées, procédé de réglage des propriétés d'utilisation de composites dentaires polymérisables et composite dentaire optimisé selon ce procédé - Google Patents

Composite dentaire polymérisable doté de propriétés d'utilisation améliorées, procédé de réglage des propriétés d'utilisation de composites dentaires polymérisables et composite dentaire optimisé selon ce procédé Download PDF

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Publication number
EP2644183A2
EP2644183A2 EP13158314.8A EP13158314A EP2644183A2 EP 2644183 A2 EP2644183 A2 EP 2644183A2 EP 13158314 A EP13158314 A EP 13158314A EP 2644183 A2 EP2644183 A2 EP 2644183A2
Authority
EP
European Patent Office
Prior art keywords
filler
alkyl
grm
soco
dental
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13158314.8A
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German (de)
English (en)
Other versions
EP2644183B9 (fr
EP2644183B1 (fr
EP2644183A3 (fr
Inventor
Andreas Dr. Utterodt
Kurt Reischl
Nelli Schönhof
Michael Eck
Christine Hiersekorn
Jutta Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kulzer GmbH
Original Assignee
Heraeus Kulzer GmbH
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Filing date
Publication date
Application filed by Heraeus Kulzer GmbH filed Critical Heraeus Kulzer GmbH
Publication of EP2644183A2 publication Critical patent/EP2644183A2/fr
Publication of EP2644183A3 publication Critical patent/EP2644183A3/fr
Application granted granted Critical
Publication of EP2644183B1 publication Critical patent/EP2644183B1/fr
Publication of EP2644183B9 publication Critical patent/EP2644183B9/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/70—Preparations for dentistry comprising inorganic additives
    • A61K6/71—Fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/70—Preparations for dentistry comprising inorganic additives
    • A61K6/71—Fillers
    • A61K6/77—Glass
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N19/00—Investigating materials by mechanical methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N19/00—Investigating materials by mechanical methods
    • G01N19/04—Measuring adhesive force between materials, e.g. of sealing tape, of coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Definitions

  • the invention relates to a novel method for adjusting the performance of polymerizable flowable, usually uncured dental composites, dental composites with improved or optimized performance properties, in particular dental composite produced by the method.
  • the prior art discloses many dental composites that are universally applicable, i. meet the requirements for the restoration of hard tooth substance in all classes of cavities I, II, III, IV and V according to G. V. BLACK.
  • From the material class of the dental composite only the inorganic-organic hybrid materials with larger proportions of inorganic fillers, such as e.g. Dental glass or mineral nano-agglomerates.
  • the microfilled composites with prepolymer fillers introduced in the 1980s are not suitable for use in the posterior teeth (classes I and II) due to the limited wear resistance (abrasion resistance) and fracture resistance (flexural strength).
  • a high filler content is advantageous in order to achieve very good mechanical properties of the cured composite and at the same time to reduce the polymerization shrinkage that occurs during curing. These properties are also crucial for the long-term success of treatment with dental composites.
  • the invention relates to a method for adjusting or improving or optimizing the performance properties of dental composites, especially those with a high proportion of filler, by relating and optimizing the texturing and tackiness parameters.
  • the invention also relates to dental composites, in particular dental composites optimized according to the method, which have improved performance characteristics, in particular with regard to the parameters texturing and tackiness.
  • the components A1 and A2 described below are used as additives or filler content in the dental composites.
  • dental composites adjusted or optimized according to the method of the invention have an optimum balance of plasticity and tackiness with simultaneously very good material properties.
  • Outstanding material properties in particular the low shrinkage force with high flexural strength, are described by composites based on the crosslinker TCD-di-HEA ( EP 1 719 497 A1 .
  • EP 2 193 776 A2 are described by composites based on the crosslinker TCD-di-HEA ( EP 1 719 497 A1 . EP 2 193 776 A2 ).
  • the urethane crosslinkers TCD-di-HEA, HEMA-TMDI
  • a preferably soft plasticity automatically leads in such systems to an undesirably strong stickiness.
  • Component A1 Pre-polymer filler
  • pre-polymer fillers also known as splitter polymers or splinter polymers
  • the intrinsic viscosity will be lower.
  • the inventors found a surprisingly significantly lower tack on the composite surface (as can be quantified by measuring the peel force, as described below).
  • the tackiness can be adjusted within a wide range, without causing any major changes in the intrinsic viscosity.
  • the mechanical properties remain surprisingly stable, although the polymer particles are significantly softer.
  • Component A2 hydroxy-functionalized additives
  • liquid hydroxy-functionalized additives having a molecular weight ⁇ 250 g / mol, preferably according to the structural formula (I) given below, on the reduction in plasticity (which corresponds to a reduction of the intrinsic viscosity).
  • plasticity which corresponds to a reduction of the intrinsic viscosity
  • C 1 -C 15 -alkyl can be linear or branched and is, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, hexyl, heptyl, octyl, nonyl, decyl , Dodecyl or pentadecyl.
  • C 1 C 12 alkyl, C 1 -C 8 alkyl, C 1 -C 6 alkyl and C 1 -C 4 alkyl may have the same meanings as stated above, up to the corresponding number of carbon atoms.
  • C 2 -C 14 -alkyl interrupted by one or more O atoms is interrupted, for example, by 1 to 5, eg 1 to 3 or 1 or 2 times by -O-.
  • There are, for example, structural units such as -O (CH 2 ) 2 OH, -O (CH 2 ) 2 OCH 3 , -O (CH 2 CH 2 O) 2 CH 2 CH 3 , -CH 2 -O-CH 3 , - CH 2 CH 2 O-CH 2 CH 3 , - [CH 2 CH 2 O] y -CH 3 , where y 1 to 5, - (CH 2 CH 2 O) 5 CH 2 CH 3 , -CH 2 -CH (CH 3 ) -O-CH 2 -CH 2 CH 3 or -CH 2 -CH (CH 3 ) -O-CH 2 -CH 3 .
  • low molecular weight compounds below 250 are, in addition to water, low molecular weight alcohols such as ethanol, propanol, isopropanol, n-butanol, polyhydric alcohols, e.g. Glycols such as ethylene glycol, glycerol or polyethylene glycols, but also methacryl-functional silanes,
  • ethanol e.g. ethanol, glycerol, polyethylene glycol 200, and methacrylic functional silanes, e.g. the gamma (methacryloxy) propyltrimethoxysilane (CAS number: 2530-85-0) known as "MEMO” or "Silane A174", as well as water.
  • methacrylic functional silanes e.g. the gamma (methacryloxy) propyltrimethoxysilane (CAS number: 2530-85-0) known as "MEMO” or "Silane A174", as well as water.
  • Such composites are preferably produced or optimized by the process according to the invention, or they are obtained by improving existing formulations.
  • the performance characteristics of a composite are a complex combination of thixotropy, intrinsic viscosity and tackiness. These properties are also an important success factor for restorative therapy and can be adjusted appropriately with the method according to the invention.
  • test methods were developed to measurably record the composite properties (flow behavior / pseudoplasticity and tackiness).
  • the texturing is e.g. determined by a fluidity measurement.
  • a standardized shear is performed so that the condition of the composite is simulated during processing and after extrusion from the packaging.
  • the consistency of the composite is determined (for example, by penetration through a defined needle (probe) at a defined penetration rate by resistance (corresponding to weight) (although the consistency can be determined at rest without preparatory shear, this is practical Processing hardly relevant).
  • the result is a numerical value IG (corresponding to a weight force), which can be found in the tables and diagrams of the examples.
  • Tackiness (initial tackiness) is determined by measuring the peel force from the composite surface.
  • a metal test stamp defined on the prepared material is placed and deducted defined after a short residence time, the adhesion is measured as a force.
  • IK corresponding to a weight force
  • compositions which have been found to be advantageous in utility properties have IG / IK quotients of 2-5, particularly advantageous from 2-3.
  • This empirically determined basis allows both the Art to optimize the additives as well as their quantitative proportion of the composition, and also to determine the optimum ratio between glass filler and splinter polymer, (see Example 7).
  • flowable dental composite is preferably understood to mean a deformable material, but not necessarily a thin-bodied dental material.
  • degree of "flowability" of suitable materials is generally determined by employing strength / consistency and tackiness measurement methods.
  • Measured is the stickiness (gripping force) in grams, which is required when deducting a measuring punch, which is pressed onto the sample with a defined force.
  • the force in grams, which is opposite to a specified penetration depth of a measuring punch, is measured.
  • One of them (without splinter polymer) is composed as follows: 1% TEGDMA, 6% HEMA-TMDI, 15% TCD-di-HEA, 6% SiO 2 72% dental glass. It can be seen from the components not explicitly listed in the compositions of the tables.
  • Measured is the stickiness (gripping force) in grams, which is required when deducting a measuring punch, which is pressed onto the sample with a defined force.
  • Device Force-displacement measuring device with defined test stamp
  • the measuring punch On the sample freshly homogenized with a centrifugal mixer, the measuring punch is put on defined and the withdrawal force is determined. As a result, the mean value of the adhesive force is given in pounds or grams [g].
  • Device Force-displacement measuring device with defined test stamp.
  • the computationally determined values IG / IK were marked with the symbol - for less suitable, * for acceptable) and! marked for approved (or regarded as optimized).
  • Example 2 show compositions with different proportions of glass and splinters and an increasing water content, wherein the water is defined Amounts added as an additive.
  • the evaluation results with regard to the functional properties are again marked with the symbols!, *, ⁇ and ⁇ .
  • Example 3 shows, analogously to Example 1, the influence of the additives PEG and MEMO.
  • Measurement results textures analyzes Material Bemermerkung Water [%] Prepolymer [%] Glass [% ] F% IG IK Bemermerkieux IG Coefficient IG / IK Force, g Staff w Force, g Staff w acceptance range 110-170 1.25 to 5.6 SOCO 120-170 30-100 release area 125-160 1.7 to 4.16 GRM SOCO GRM VP 050711 KR1 o. H 2 O - Std.
  • Measurement results textures analyzes material Prepolymer [%] Glass[%] F% IG IK Remarks IG Coefficient IG / IK Force, g Stabw Force g Stabw SOCO 130-170 30-100 release area 130-170 1.3 to 5.67 GRM SOCO GRM VP 250711 Rei glycerin SOCO GRM VP 100811 Rei1 0.5% glycerol 2 67 69 135! 3 87! 5 135!
  • Example 3a Influence by hydroxy-functional additives - matrix evaluation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Dental Preparations (AREA)
EP13158314.8A 2012-03-28 2013-03-08 Composite dentaire polymérisable doté de propriétés d'utilisation améliorées, procédé de réglage des propriétés d'utilisation de composites dentaires polymérisables et composite dentaire optimisé selon ce procédé Active EP2644183B9 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102012006152A DE102012006152A1 (de) 2012-03-28 2012-03-28 Polymerisierbare Dentalkomposite mit verbesserten Gebrauchseigenschaften, Verfahren zur Einstellung der Gebrauchseigenschaften polymerisierbarer Dentalkompositen, und nach diesen Verfahren optimierte Dentalkomposite

Publications (4)

Publication Number Publication Date
EP2644183A2 true EP2644183A2 (fr) 2013-10-02
EP2644183A3 EP2644183A3 (fr) 2016-10-19
EP2644183B1 EP2644183B1 (fr) 2020-12-16
EP2644183B9 EP2644183B9 (fr) 2021-06-30

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Family Applications (1)

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EP13158314.8A Active EP2644183B9 (fr) 2012-03-28 2013-03-08 Composite dentaire polymérisable doté de propriétés d'utilisation améliorées, procédé de réglage des propriétés d'utilisation de composites dentaires polymérisables et composite dentaire optimisé selon ce procédé

Country Status (7)

Country Link
US (1) US9326918B2 (fr)
EP (1) EP2644183B9 (fr)
JP (1) JP5896949B2 (fr)
CN (1) CN103356390B (fr)
BR (1) BR102013007144A2 (fr)
DE (1) DE102012006152A1 (fr)
ES (1) ES2852823T3 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019068618A3 (fr) * 2017-10-04 2019-06-20 Kulzer Gmbh Matériau composite dentaire et ébauches à fraiser de ce matériau composite
WO2019068611A3 (fr) * 2017-10-04 2019-06-20 Kulzer Gmbh Matériau composite dentaire et ébauches à fraiser de ce matériau composite

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7521898B2 (ja) * 2017-12-01 2024-07-24 クラレノリタケデンタル株式会社 歯科用修復材組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1719497A1 (fr) 2005-05-04 2006-11-08 Heraeus Kulzer GmbH Matériau composite à force de retrait faible
EP2193776A2 (fr) 2007-07-20 2010-06-09 Heraeus Kulzer GmbH Composite dentaire doté d'une tension de réduction moindre et d'une haute résistance à la flexion

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1401805A (en) * 1972-03-15 1975-07-30 Amalgamated Dental Co Ltd Dental filling materials
US4032673A (en) * 1974-02-22 1977-06-28 General Electric Company Method for applying an organic coating onto an inorganic coated steel sheet
JP2543516B2 (ja) * 1987-03-09 1996-10-16 三井石油化学工業株式会社 歯科用硬化性接着剤
DE4211040A1 (de) * 1992-04-03 1993-10-07 Muehlbauer Ernst Kg Automatisch anmischbares Mittel zur Anfertigung von Kronen und Brücken
JP3524233B2 (ja) * 1995-08-23 2004-05-10 株式会社ジーシー 歯科用無機有機複合充填材
US6472454B1 (en) * 1999-10-22 2002-10-29 Kerr Corporation Endodontic dental compositions
FI20010222A0 (fi) * 2001-02-06 2001-02-06 Yli Urpo Antti Lääketieteellisesti hammashoidolliset polymeerikomposiitit ja -koostumukset
US6787629B2 (en) * 2001-11-02 2004-09-07 Pentron Clinical Technologies, Llc Dental resin materials, method of manufacture, and uses thereof
US7132469B2 (en) * 2002-06-28 2006-11-07 Reinforced Polymers, Inc. Molding compositions with solid thermoplastic elastomer thickeners and products obtained therefrom
DE10335181B4 (de) * 2003-07-30 2011-01-13 Heraeus Kulzer Gmbh Künstliche Zähne mit hoher Abrasionsfestigkeit im Schmelz oder Schneidebereich
US20050272008A1 (en) * 2004-02-20 2005-12-08 Larry Stites Dental prosthetic reinforced with zirconia ceramic
EP1570831A1 (fr) * 2004-03-02 2005-09-07 Ernst Mühlbauer GmbH & Co.KG Matériau dentaire polymérisable contenant une charge
DE602004022551D1 (de) * 2004-09-24 2009-09-24 3M Espe Ag Dentalklebstoffzusammensetzung
US7741381B2 (en) * 2005-03-18 2010-06-22 Tokuyama Corporation Curable composition
DE102005018351B4 (de) * 2005-04-20 2008-05-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verwendung widerstandsfähiger, langlebiger Komposite im Dentalbereich
JP4794201B2 (ja) 2005-04-25 2011-10-19 株式会社松風 ２ペースト型グラスアイオノマー系セメント
BRPI0618948A2 (pt) * 2005-11-22 2011-09-13 Smithkline Beecham Corp revestimento adesivo
WO2007088628A1 (fr) * 2006-02-03 2007-08-09 Kabushiki Kaisha Shofu ciment en resine composite a usage dentaire, appret a usage dentaire et kit adhesif a usage dentaire les contenant
EP1872767A1 (fr) * 2006-06-30 2008-01-02 Ernst Mühlbauer GmbH & Co.KG Matériau dentaire polymérisable
GB0618963D0 (en) * 2006-09-26 2006-11-08 Ucl Business Plc Formulations and composites with reactive fillers
CN102083403B (zh) * 2008-04-28 2013-10-09 可乐丽则武齿科株式会社 牙科用组合物及复合树脂
JP2010065006A (ja) * 2008-09-12 2010-03-25 Gc Corp シーラー用セメント
JP5489494B2 (ja) 2009-03-09 2014-05-14 株式会社トクヤマデンタル 歯科用光硬化性材料
US8292625B2 (en) * 2010-07-23 2012-10-23 Pulpdent Corporation Radically curable urethane dimethacrylates and compositions thereof for tougher dental prosthetics
EP2450025B1 (fr) * 2010-11-08 2012-11-28 VOCO GmbH Dérivés d'acide phosphorique polymérisables comprenant un élément structurel polyalicyclique

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1719497A1 (fr) 2005-05-04 2006-11-08 Heraeus Kulzer GmbH Matériau composite à force de retrait faible
EP2193776A2 (fr) 2007-07-20 2010-06-09 Heraeus Kulzer GmbH Composite dentaire doté d'une tension de réduction moindre et d'une haute résistance à la flexion

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019068618A3 (fr) * 2017-10-04 2019-06-20 Kulzer Gmbh Matériau composite dentaire et ébauches à fraiser de ce matériau composite
WO2019068611A3 (fr) * 2017-10-04 2019-06-20 Kulzer Gmbh Matériau composite dentaire et ébauches à fraiser de ce matériau composite
US11219505B2 (en) 2017-10-04 2022-01-11 Kulzer Gmbh Dental composite material and mill blanks consisting of said composite material
US11311357B2 (en) 2017-10-04 2022-04-26 Kulzer Gmbh Dental composite material and mill blanks consisting of said composite material

Also Published As

Publication number Publication date
JP5896949B2 (ja) 2016-03-30
CN103356390B (zh) 2016-02-10
US9326918B2 (en) 2016-05-03
EP2644183B9 (fr) 2021-06-30
CN103356390A (zh) 2013-10-23
DE102012006152A1 (de) 2013-10-02
JP2013203741A (ja) 2013-10-07
US20130261218A1 (en) 2013-10-03
BR102013007144A2 (pt) 2015-06-16
EP2644183B1 (fr) 2020-12-16
EP2644183A3 (fr) 2016-10-19
ES2852823T3 (es) 2021-09-14

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