EP2714080A4 - Procédés de traitement du lupus érythémateux systémique, de la sclérodermie et de la myosite par un anticorps contre l'interféron alpha - Google Patents

Procédés de traitement du lupus érythémateux systémique, de la sclérodermie et de la myosite par un anticorps contre l'interféron alpha

Info

Publication number
EP2714080A4
EP2714080A4 EP12789521.7A EP12789521A EP2714080A4 EP 2714080 A4 EP2714080 A4 EP 2714080A4 EP 12789521 A EP12789521 A EP 12789521A EP 2714080 A4 EP2714080 A4 EP 2714080A4
Authority
EP
European Patent Office
Prior art keywords
myositis
scleroderma
alpha
methods
lupus erythematosus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12789521.7A
Other languages
German (de)
English (en)
Other versions
EP2714080A1 (fr
Inventor
Ryan Criste
Lorin Roskos
Wendy White
Dominique Ethgen
Rajesh Narwal
Gabriel Robbie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune LLC
Original Assignee
MedImmune LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MedImmune LLC filed Critical MedImmune LLC
Publication of EP2714080A1 publication Critical patent/EP2714080A1/fr
Publication of EP2714080A4 publication Critical patent/EP2714080A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP12789521.7A 2011-05-25 2012-05-23 Procédés de traitement du lupus érythémateux systémique, de la sclérodermie et de la myosite par un anticorps contre l'interféron alpha Withdrawn EP2714080A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161489949P 2011-05-25 2011-05-25
PCT/US2012/039098 WO2012162367A1 (fr) 2011-05-25 2012-05-23 Procédés de traitement du lupus érythémateux systémique, de la sclérodermie et de la myosite par un anticorps contre l'interféron alpha

Publications (2)

Publication Number Publication Date
EP2714080A1 EP2714080A1 (fr) 2014-04-09
EP2714080A4 true EP2714080A4 (fr) 2014-11-19

Family

ID=47217695

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12789521.7A Withdrawn EP2714080A4 (fr) 2011-05-25 2012-05-23 Procédés de traitement du lupus érythémateux systémique, de la sclérodermie et de la myosite par un anticorps contre l'interféron alpha

Country Status (9)

Country Link
EP (1) EP2714080A4 (fr)
JP (1) JP2014516970A (fr)
KR (1) KR20140043402A (fr)
CN (1) CN103732251A (fr)
BR (1) BR112013030242A2 (fr)
CA (1) CA2836926A1 (fr)
MX (1) MX2013013785A (fr)
RU (1) RU2013157177A (fr)
WO (1) WO2012162367A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2791170A1 (fr) 2011-12-16 2014-10-22 Synthon Biopharmaceuticals B.V. Composés et procédés pour traiter des maladies inflammatoires
WO2013101771A2 (fr) * 2011-12-30 2013-07-04 Genentech, Inc. Compositions et méthode pour le traitement de maladies auto-immunes
ES2745103T3 (es) * 2013-06-15 2020-02-27 Tocagen Inc Partículas inmunosupresivas similares a virus basadas en gammaretrovirus
CN103740755A (zh) * 2013-12-23 2014-04-23 中国农业大学 猪ifit1基因在抗prrs病毒中的应用
RU2580301C1 (ru) * 2015-04-21 2016-04-10 Людмила Николаевна Хон Способ лечения системной красной волчанки человека
CN107058521B (zh) * 2017-03-17 2019-12-27 中国科学院北京基因组研究所 一种检测人体免疫状态的检测系统
EP3853859A1 (fr) * 2018-10-11 2021-07-28 Vivia Biotech, S.L. Procédé de détermination de l'efficacité d'un traitement avec une combinaison de médicaments chez un sujet diagnostiqué d'une maladie et procédé de classification de l'utilité de combinaisons de médicaments dans le traitement dudit sujet
JP2022512796A (ja) 2018-10-26 2022-02-07 ヤンセン バイオテツク，インコーポレーテツド Ｉ型インターフェロンシグネチャー及び使用方法
JP2022527542A (ja) * 2019-04-04 2022-06-02 ヤンセン バイオテツク，インコーポレーテツド 抗ＩＦＮ－α／ω抗体の投与方法
AU2023335547A1 (en) 2022-08-29 2025-02-27 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Method for screening and preparing immunomodulator
KR20250057823A (ko) 2022-08-29 2025-04-29 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 Taci 폴리펩티드를 포함하는 융합 단백질 및 이의 용도

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009061818A1 (fr) * 2007-11-05 2009-05-14 Medimmune, Llc Procédés de traitement de la sclérodermie
WO2009135861A2 (fr) * 2008-05-07 2009-11-12 Novo Nordisk A/S Anticorps humanisés contre l'interféron-alpha humain
WO2010042705A1 (fr) * 2008-10-09 2010-04-15 Medimmune, Llc Formulation d'anticorps
WO2012149228A1 (fr) * 2011-04-26 2012-11-01 Genentech, Inc. Compositions et méthode de traitement de maladies auto-immunes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087726B2 (en) * 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
KR101225299B1 (ko) * 2003-12-10 2013-01-24 메다렉스, 인코포레이티드 인터페론 알파 항체 및 그의 용도
KR20080025174A (ko) * 2005-06-23 2008-03-19 메디뮨 인코포레이티드 응집 및 단편화 프로파일이 최적화된 항체 제제

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009061818A1 (fr) * 2007-11-05 2009-05-14 Medimmune, Llc Procédés de traitement de la sclérodermie
WO2009135861A2 (fr) * 2008-05-07 2009-11-12 Novo Nordisk A/S Anticorps humanisés contre l'interféron-alpha humain
WO2010042705A1 (fr) * 2008-10-09 2010-04-15 Medimmune, Llc Formulation d'anticorps
WO2012149228A1 (fr) * 2011-04-26 2012-11-01 Genentech, Inc. Compositions et méthode de traitement de maladies auto-immunes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HIGGS BRANDON W ET AL: "IFN-alpha/beta as a therapeutic target in SLE, myositis, and RA: A transcript profiling analysis of whole blood from several autoimmune diseases", ARTHRITIS & RHEUMATISM, WILEY, US, vol. 58, no. 9, Suppl. S, 1 September 2008 (2008-09-01), pages S667 - S668, XP009147410, ISSN: 0004-3591 *
MCBRIDE ET AL: "Dose-Dependent Modulation of Interferon Regulated Genes with Administration of Single and Repeat Doses of Rontalizumab in a Phase I, Placebo Controlled, Double Blind, Dose Escalation Study in SLE", INTERNET CITATION, 2009, pages 2072, XP002697717, ISSN: 0004-3591, Retrieved from the Internet <URL:http://www.blackwellpublishing.com/acrmeeting/abstract.asp?MeetingID=761&id=81694> [retrieved on 20130527] *
RONAN J WALSH ET AL: "Type I interferon-inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis", ARTHRITIS & RHEUMATISM, WILEY, US, vol. 56, no. 11, 1 November 2007 (2007-11-01), pages 3784 - 3792, XP008127186, ISSN: 0004-3591, DOI: 10.1002/ART.22928 *
See also references of WO2012162367A1 *
YAO Y ET AL: "Neutralization of interferon-[alpha]/[beta]-inducible genes and downstream effect in a phase I trial of an anti-interferon-[alpha] monoclonal antibody in systemic lupus erythematosus", ARTHRITIS & RHEUMATISM, WILEY, US, vol. 60, no. 6, 1 June 2009 (2009-06-01), pages 1785 - 1796, XP009147413, ISSN: 0004-3591, [retrieved on 20090528], DOI: 10.1002/ART.24557 *

Also Published As

Publication number Publication date
WO2012162367A1 (fr) 2012-11-29
MX2013013785A (es) 2014-07-28
JP2014516970A (ja) 2014-07-17
CN103732251A (zh) 2014-04-16
EP2714080A1 (fr) 2014-04-09
BR112013030242A2 (pt) 2016-12-06
KR20140043402A (ko) 2014-04-09
RU2013157177A (ru) 2015-06-27
CA2836926A1 (fr) 2012-11-29

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