EP2736536A4 - Cellules d'îlot sur matrice et petits agrégats de cellules d'îlot pour le traitement du diabète - Google Patents

Cellules d'îlot sur matrice et petits agrégats de cellules d'îlot pour le traitement du diabète

Info

Publication number: EP2736536A4
Authority: EP; European Patent Office
Prior art keywords: diabetes; matrix; treatment; islet cells; cell aggregates
Prior art date: 2011-07-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

EP12818108.8A

Other languages

German (de)

English (en)

Other versions

EP2736536A2 (fr

Inventor

Lisa A Stehno-Bittel

Karthik Ramachandran

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Kansas

Original Assignee

University of Kansas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-07-27

Filing date

2012-07-26

Publication date

2015-03-11

2012-07-26 Application filed by University of Kansas filed Critical University of Kansas

2012-07-26 Priority to EP18186206.1A priority Critical patent/EP3498300A1/fr

2014-06-04 Publication of EP2736536A2 publication Critical patent/EP2736536A2/fr

2015-03-11 Publication of EP2736536A4 publication Critical patent/EP2736536A4/fr

Status Ceased legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/507—Pancreatic cells
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/10—Mineral substrates
- C12N2533/12—Glass
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
- C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/72—Chitin, chitosan
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2535/00—Supports or coatings for cell culture characterised by topography

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Cell Biology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Food Science & Technology (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Tropical Medicine & Parasitology (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Obesity (AREA)
General Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Emergency Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

EP12818108.8A 2011-07-27 2012-07-26 Cellules d'îlot sur matrice et petits agrégats de cellules d'îlot pour le traitement du diabète Ceased EP2736536A4 (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
EP18186206.1A EP3498300A1 (fr)	2011-07-27	2012-07-26	Cellules d'îlots créées à partir de modèles et petits amas de cellules d'îlots pour le traitement du diabète

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201161512303P	2011-07-27	2011-07-27
US201213482671A	2012-05-29	2012-05-29
PCT/US2012/048352 WO2013016544A2 (fr)	2011-07-27	2012-07-26	Cellules d'îlot sur matrice et petits agrégats de cellules d'îlot pour le traitement du diabète

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
EP18186206.1A Division EP3498300A1 (fr)	2011-07-27	2012-07-26	Cellules d'îlots créées à partir de modèles et petits amas de cellules d'îlots pour le traitement du diabète

Publications (2)

Publication Number	Publication Date
EP2736536A2 EP2736536A2 (fr)	2014-06-04
EP2736536A4 true EP2736536A4 (fr)	2015-03-11

Family

ID=46275980

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EP12818108.8A Ceased EP2736536A4 (fr)	2011-07-27	2012-07-26	Cellules d'îlot sur matrice et petits agrégats de cellules d'îlot pour le traitement du diabète
EP18186206.1A Withdrawn EP3498300A1 (fr)	2011-07-27	2012-07-26	Cellules d'îlots créées à partir de modèles et petits amas de cellules d'îlots pour le traitement du diabète

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
EP18186206.1A Withdrawn EP3498300A1 (fr)	2011-07-27	2012-07-26	Cellules d'îlots créées à partir de modèles et petits amas de cellules d'îlots pour le traitement du diabète

Country Status (4)

Country	Link
EP (2)	EP2736536A4 (fr)
JP (1)	JP2014521335A (fr)
CA (1)	CA2842695C (fr)
WO (1)	WO2013016544A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2016513465A (ja) *	2013-03-15	2016-05-16	ミロマトリックスメディカルインコーポレイティド	膵島細胞の再細胞化のための灌流型脱細胞化肝臓の使用
JP6405752B2 (ja) *	2014-07-01	2018-10-17	大日本印刷株式会社	細胞培養容器
WO2019241499A1 (fr)	2018-06-13	2019-12-19	Miromatrix Medical Inc.	Charge de fistule et système de déploiement
DE102019217466A1 (de) *	2019-11-12	2021-05-12	Lpkf Laser & Electronics Ag	Reaktionsgefäße aus Glas, Herstellungsverfahren und Verfahren zur Analyse

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007087402A2 (fr) *	2006-01-24	2007-08-02	Brown University	Dispositif et procédé d'agrégation et d'encapsulation cellulaires
EP2286822A1 (fr) *	2009-08-17	2011-02-23	Universiteit Twente	Traitement du diabète
WO2011126921A2 (fr) *	2010-04-06	2011-10-13	University Of Kansas	Ilots de langerhans à matrice et petits amas d'îlots de langerhans pour le traitement du diabète

Family Cites Families (13)

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Publication number	Priority date	Publication date	Assignee	Title
DK402984D0 (da)	1984-08-23	1984-08-23	Nordisk Insulinlab	Fremgangsmaade til formering af insulin-producerende celler
EP0363125A3 (fr)	1988-10-03	1990-08-16	Hana Biologics Inc.	Produit contenant des cellules pancréatiques endocrines aptes à proliférer et procédé
US5164000A (en)	1991-06-27	1992-11-17	Gamblin Rodger L	Lithographic printing fountain solution
US5280038A (en)	1992-03-13	1994-01-18	Virginia Commonwealth University	Histidine as a protective agent in cardiac surgery and myocardial ischemic syndrome
US5696109A (en)	1992-12-07	1997-12-09	Eukarion, Inc.	Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
US6703017B1 (en)	1994-04-28	2004-03-09	Ixion Biotechnology, Inc.	Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
US5670545A (en)	1996-02-09	1997-09-23	Board Of Regents Of The University Of Colorado	Method for the treatment of ischemic disease and reperfusion injury and the prevention of the adverse effects of reactive oxygen species
US6783954B2 (en)	1999-03-05	2004-08-31	Compugen Ltd.	VEGF nucleic acid and amino acid sequences
US6103255A (en) *	1999-04-16	2000-08-15	Rutgers, The State University	Porous polymer scaffolds for tissue engineering
US20070122904A1 (en) *	2000-09-29	2007-05-31	Unisearch Limited	Method and apparatus for culturing cells
US7786257B2 (en)	2000-12-18	2010-08-31	University Of Kansas	Signal-1/signal-2 bifunctional peptide inhibitors
WO2008111064A1 (fr) *	2007-03-12	2008-09-18	Technion Research & Development Foundation Ltd.	Ilots vascularisés et leurs procédés de fabrication
KR20130030309A (ko) *	2008-02-06	2013-03-26	가부시키가이샤 구라레	세포 배양 방법 및 스크리닝 방법

2012
- 2012-07-26 EP EP12818108.8A patent/EP2736536A4/fr not_active Ceased
- 2012-07-26 JP JP2014523006A patent/JP2014521335A/ja active Pending
- 2012-07-26 CA CA2842695A patent/CA2842695C/fr active Active
- 2012-07-26 EP EP18186206.1A patent/EP3498300A1/fr not_active Withdrawn
- 2012-07-26 WO PCT/US2012/048352 patent/WO2013016544A2/fr not_active Ceased

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007087402A2 (fr) *	2006-01-24	2007-08-02	Brown University	Dispositif et procédé d'agrégation et d'encapsulation cellulaires
EP2286822A1 (fr) *	2009-08-17	2011-02-23	Universiteit Twente	Traitement du diabète
WO2011126921A2 (fr) *	2010-04-06	2011-10-13	University Of Kansas	Ilots de langerhans à matrice et petits amas d'îlots de langerhans pour le traitement du diabète

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ALDERT H. PIERSMA: "Alternative Methods for Developmental Toxicity Testing", BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, vol. 98, no. 5, 1 May 2006 (2006-05-01), pages 427 - 431, XP055164713, ISSN: 1742-7835, DOI: 10.1111/j.1742-7843.2006.pto_373.x *
CHOI Y Y ET AL: "Controlled-size embryoid body formation in concave microwell arrays", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 31, no. 15, 1 May 2010 (2010-05-01), pages 4296 - 4303, XP026971506, ISSN: 0142-9612, [retrieved on 20100305] *
HWANG JIN WOOK ET AL: "Optimal size control of pancreatic islet cell clusters using concave-bottomed microwells.", JOURNAL OF CONTROLLED RELEASE : OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETY 30 NOV 2011, vol. 152 Suppl 1, 30 November 2011 (2011-11-30), pages e218 - e219, XP002734971, ISSN: 1873-4995 *
JIN WOOK HWANG ET AL: "Functional clustering of pancreatic islet cells using concave microwell array", MACROMOLECULAR RESEARCH, vol. 19, no. 12, 3 November 2011 (2011-11-03), pages 1320 - 1326, XP055164708, ISSN: 1598-5032, DOI: 10.1007/s13233-012-1202-4 *
KARTHIK RAMACHANDRAN ET AL: "Engineering Islets for Improved Performance by Optimized Reaggregation in a Micromold", TISSUE ENGINEERING PART A, vol. 19, no. 5-6, 1 March 2013 (2013-03-01), pages 604 - 612, XP055164716, ISSN: 1937-3341, DOI: 10.1089/ten.tea.2012.0553 *
KUNZ-SCHUGHART L A ET AL: "The use of 3-D cultures for high-throughput screening: The multicellular spheroid model", JOURNAL OF BIOMOLECULAR SCREENING, SAGE; LIEBERT, US, vol. 9, no. 4, 1 June 2004 (2004-06-01), pages 273 - 285, XP002694233, ISSN: 1087-0571, DOI: 10.1177/1087057104265040 *

Also Published As

Publication number	Publication date
WO2013016544A2 (fr)	2013-01-31
EP2736536A2 (fr)	2014-06-04
WO2013016544A3 (fr)	2013-04-25
CA2842695C (fr)	2021-01-12
WO2013016544A4 (fr)	2013-06-13
JP2014521335A (ja)	2014-08-28
CA2842695A1 (fr)	2013-01-31
EP3498300A1 (fr)	2019-06-19

Legal Events

Date	Code	Title	Description
2014-05-02	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2014-06-04	17P	Request for examination filed	Effective date: 20140227
2014-06-04	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2014-11-05	DAX	Request for extension of the european patent (deleted)
2015-03-04	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 9/00 20060101ALI20150129BHEP Ipc: A61K 9/16 20060101ALI20150129BHEP Ipc: A61K 47/48 20060101AFI20150129BHEP Ipc: A61K 47/30 20060101ALI20150129BHEP Ipc: C12N 5/071 20100101ALI20150129BHEP Ipc: A61P 3/10 20060101ALI20150129BHEP
2015-03-11	A4	Supplementary search report drawn up and despatched	Effective date: 20150210
2016-07-13	17Q	First examination report despatched	Effective date: 20160614
2017-01-19	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2018-05-31	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED
2018-06-11	REG	Reference to a national code	Ref country code: DE Ref legal event code: R003
2018-10-17	18R	Application refused	Effective date: 20180611

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