EP2801615A4 - Structure d'oligo-arn double hélice de type nanoparticule à efficacité élevée et son procédé de préparation - Google Patents

Structure d'oligo-arn double hélice de type nanoparticule à efficacité élevée et son procédé de préparation

Info

Publication number: EP2801615A4
Authority: EP; European Patent Office
Prior art keywords: oligo; nanoparticle; preparation; efficiency; rna structure
Prior art date: 2012-01-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP13733748.1A

Other languages

German (de)

English (en)

Other versions

EP2801615B1 (fr

EP2801615A1 (fr

EP2801615C0 (fr

Inventor

Jeiwook Chae

Boram Han

Han-Na Kim

Han Oh Park

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bioneer Corp

Original Assignee

Bioneer Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-01-05

Filing date

2013-01-04

Publication date

2015-08-19

2013-01-04 Application filed by Bioneer Corp filed Critical Bioneer Corp

2014-11-12 Publication of EP2801615A1 publication Critical patent/EP2801615A1/fr

2015-08-19 Publication of EP2801615A4 publication Critical patent/EP2801615A4/fr

2025-06-25 Application granted granted Critical

2025-06-25 Publication of EP2801615B1 publication Critical patent/EP2801615B1/fr

2025-06-25 Publication of EP2801615C0 publication Critical patent/EP2801615C0/fr

Status Active legal-status Critical Current

2033-01-04 Anticipated expiration legal-status Critical

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

EP13733748.1A 2012-01-05 2013-01-04 Structure d'oligo-arn double hélice de type nanoparticule à efficacité élevée et son procédé de préparation Active EP2801615B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR20120001711		2012-01-05
PCT/KR2013/000035 WO2013103249A1 (fr)	2012-01-05	2013-01-04	Structure d'oligo-arn double hélice de type nanoparticule à efficacité élevée et son procédé de préparation

Publications (4)

Publication Number	Publication Date
EP2801615A1 EP2801615A1 (fr)	2014-11-12
EP2801615A4 true EP2801615A4 (fr)	2015-08-19
EP2801615B1 EP2801615B1 (fr)	2025-06-25
EP2801615C0 EP2801615C0 (fr)	2025-06-25

Family

ID=48745281

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP13733748.1A Active EP2801615B1 (fr)	2012-01-05	2013-01-04	Structure d'oligo-arn double hélice de type nanoparticule à efficacité élevée et son procédé de préparation

Country Status (11)

Country	Link
US (1)	US9326941B2 (fr)
EP (1)	EP2801615B1 (fr)
JP (1)	JP6060178B2 (fr)
KR (1)	KR101752812B1 (fr)
CN (2)	CN107988227A (fr)
AU (1)	AU2013206989B2 (fr)
BR (1)	BR112014016562B1 (fr)
CA (1)	CA2860527C (fr)
ES (1)	ES3034830T3 (fr)
RU (1)	RU2577227C1 (fr)
WO (1)	WO2013103249A1 (fr)

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WO2013089522A1 (fr) *	2011-12-15	2013-06-20	(주)바이오니아	Nouveaux conjugués oligonucléotidiques et leur utilisation
CN110592082A (zh) *	2013-07-05	2019-12-20	柏业公司	呼吸疾病相关基因特异性siRNA、含有siRNA的双螺旋寡RNA结构及其用途
BR112016000160B1 (pt)	2013-07-05	2021-06-08	Bioneer Corporation	estrutura de oligonucleotídeo tipo nanopartícula melhorada tendo alta eficiência e método para a preparação da mesma
CN105705639A (zh)	2013-07-05	2016-06-22	柏业公司	登革病毒相关的基因特异性siRNA、包含该siRNA的双链寡RNA分子、和包含它们的用于抑制登革病毒复制的组合物
EP3128008B1 (fr) *	2014-04-04	2024-05-29	Bioneer Corporation	Oligo-arn à double brin et composition pharmaceutique le comprenant pour la prévention ou le traitement de la fibrose ou de maladies respiratoires
EP3368089B1 (fr)	2015-10-26	2025-11-05	Translate Bio Ma, Inc.	Formulations de nanoparticules pour l'administration de complexes d'acide nucléique
KR101861738B1 (ko) *	2016-08-24	2018-05-29	(주)바이오니아	마이크로 rna를 포함하는 이중나선 올리고 rna 구조체
CN110225770B (zh)	2016-12-14	2022-04-26	杨森生物科技公司	结合cd8a的纤连蛋白iii型结构域
EP3554535A4 (fr)	2016-12-14	2020-10-21	Janssen Biotech, Inc.	Domaines de fibronectine de type iii se liant à pd-l1
EP3554561B1 (fr)	2016-12-14	2023-06-28	Janssen Biotech, Inc.	Domaines de fibronectine de type iii à liaison au cd137
NL2021258B1 (en)	2018-06-14	2019-12-20	Illumina Inc	Device for luminescent imaging
US11781138B2 (en)	2019-10-14	2023-10-10	Aro Biotherapeutics Company	FN3 domain-siRNA conjugates and uses thereof
CN119119240A (zh)	2019-10-14	2024-12-13	Aro生物疗法公司	结合cd71的纤维粘连蛋白iii型结构域
WO2021076543A1 (fr)	2019-10-14	2021-04-22	Aro Biotherapeutics Company	Domaines de type iii de fibronectine de liaison à cd137
CA3214552A1 (fr)	2021-04-14	2022-10-20	Russell C. Addis	Domaines fibronectine de type iii de liaison a cd71
EP4323008A4 (fr)	2021-04-14	2026-02-25	Aro Biotherapeutics Company	Conjugués domaine fn3-arnsi et leurs utilisations
CN114480377A (zh) *	2022-01-27	2022-05-13	浙江浥眸生物科技有限公司	一种刷状核酸组装体和复合纳米粒子及其应用
KR20250173666A (ko)	2024-06-04	2025-12-11	서울시립대학교 산학협력단	핵산 코팅용 지질 조성물 및 이를 포함하는 핵산 전달체

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WO2007021142A1 (fr) *	2005-08-17	2007-02-22	Bioneer Corporation	Conjugues siarn-polymeres hydrophiles pour l'administration intracellulaire de petits arn interferents et methode associee
WO2009045457A2 (fr) *	2007-10-02	2009-04-09	Rxi Pharmaceuticals Corp.	CONSTRUCTIONS D'ARNi À STRUCTURE TRIPARTITE
WO2010074540A2 (fr) *	2008-12-26	2010-07-01	주식회사 삼양사	Composition pharmaceutique contenant un médicament anionique et procédé de préparation associé
CA2871888A1 (fr) *	2009-05-14	2010-11-18	Bioneer Corporation	Conjugue et son procede de preparation sirna
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WO2013109057A1 (fr) *	2012-01-18	2013-07-25	(주)바이오니아	Complexe nanoparticule magnétique-samirna et son procédé de préparation

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2013
- 2013-01-04 JP JP2014551188A patent/JP6060178B2/ja active Active
- 2013-01-04 CA CA2860527A patent/CA2860527C/fr active Active
- 2013-01-04 BR BR112014016562-9A patent/BR112014016562B1/pt active IP Right Grant
- 2013-01-04 RU RU2014132167/10A patent/RU2577227C1/ru active
- 2013-01-04 CN CN201711382331.6A patent/CN107988227A/zh active Pending
- 2013-01-04 KR KR1020147018685A patent/KR101752812B1/ko active Active
- 2013-01-04 US US14/370,035 patent/US9326941B2/en active Active
- 2013-01-04 WO PCT/KR2013/000035 patent/WO2013103249A1/fr not_active Ceased
- 2013-01-04 CN CN201380009937.9A patent/CN104114704A/zh active Pending
- 2013-01-04 ES ES13733748T patent/ES3034830T3/es active Active
- 2013-01-04 AU AU2013206989A patent/AU2013206989B2/en active Active
- 2013-01-04 EP EP13733748.1A patent/EP2801615B1/fr active Active

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Also Published As

Publication number	Publication date
EP2801615B1 (fr)	2025-06-25
WO2013103249A1 (fr)	2013-07-11
AU2013206989B2 (en)	2015-05-28
CA2860527A1 (fr)	2013-07-11
JP2015508998A (ja)	2015-03-26
US9326941B2 (en)	2016-05-03
CN104114704A (zh)	2014-10-22
JP6060178B2 (ja)	2017-01-18
EP2801615A1 (fr)	2014-11-12
KR101752812B1 (ko)	2017-06-30
ES3034830T3 (en)	2025-08-25
KR20140109927A (ko)	2014-09-16
CN107988227A (zh)	2018-05-04
US20150005364A1 (en)	2015-01-01
AU2013206989A1 (en)	2014-07-24
BR112014016562A8 (pt)	2017-07-04
BR112014016562B1 (pt)	2021-08-10
CA2860527C (fr)	2019-04-09
BR112014016562A2 (pt)	2017-06-13
EP2801615C0 (fr)	2025-06-25
RU2577227C1 (ru)	2016-03-10

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