EP2810716A1 - Dispositif de pipetage - Google Patents

Dispositif de pipetage Download PDF

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Publication number
EP2810716A1
EP2810716A1 EP20130181354 EP13181354A EP2810716A1 EP 2810716 A1 EP2810716 A1 EP 2810716A1 EP 20130181354 EP20130181354 EP 20130181354 EP 13181354 A EP13181354 A EP 13181354A EP 2810716 A1 EP2810716 A1 EP 2810716A1
Authority
EP
European Patent Office
Prior art keywords
block
pipette
pipetting device
insert
receptacles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP20130181354
Other languages
German (de)
English (en)
Other versions
EP2810716B1 (fr
Inventor
Roland Bolliger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tecan Trading AG
Original Assignee
Tecan Trading AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecan Trading AG filed Critical Tecan Trading AG
Priority to EP16182942.9A priority Critical patent/EP3112028B1/fr
Publication of EP2810716A1 publication Critical patent/EP2810716A1/fr
Application granted granted Critical
Publication of EP2810716B1 publication Critical patent/EP2810716B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B01L3/0279—Interchangeable or disposable dispensing tips co-operating with positive ejection means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/021—Adjust spacings in an array of wells, pipettes or holders, format transfer between arrays of different size or geometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details

Definitions

  • Such pipetting devices typically comprise a block for holding a plurality of identically formed pipette tips having a tip axis and for connecting these pipette tips to a plurality of pipette cones of a multi-pipette head of a liquid handling apparatus.
  • a block comprises a plurality of cavities penetrating the block, which are arranged parallel to one another. Often, these cavities are arranged in an array corresponding to the array of wells of a standard microplate.
  • Such a block also comprises a plurality of cylindrical insertion openings arranged on a lower side of the block and forming a lower opening of the cavities.
  • each cylindrical insertion opening may preferably have a stop which is designed to act on a rear end of a pipette tip inserted.
  • Such a block further comprises a plurality of conical insertion openings arranged on an upper side of the block and forming an upper opening of the cavities, each of which is designed to sealably insert a pipette cone of a multi-pipette head.
  • such a pipetting device typically comprises a number of tubular pipette tips each having a wall extending along the tip axis and having a forward opening transport port for receiving and dispensing liquid samples and means for connecting the block and multiple pipette head.
  • Such devices may include, for example, holding apertures with holding shafts for receiving holders attached to the multiple pipette head.
  • Standardized standard microplates (cf., for example, standard ANSI_SBS 1-2-3-4-2004) are known and have arrays of wells arranged, for example, at a center distance of 9 mm (96-well microplate) or 4.5 mm (384-well microplate) are.
  • Pipette tips not belonging to these arrays are more or less brutally removed in "rebuilt blocks". Thus, it happens that a first "rebuilt block” is used to pipette the standards, a second "rebuilt block” to pipette the controls, and a third "rebuilt block” to pipet the samples into the designated arrays. If several of the 96 or 384 pipette tips or even a single pipette tip of a block of, for example, 96 or 384 channels is damaged by collision with a labware article (e.g., a microplate), these pipette tips must be laboriously replaced by a service specialist.
  • a labware article e.g., a microplate
  • each insert with all-sided, horizontal play is located in the corresponding receptacle of the block. It is particularly preferred that the pipette tips, and thereby also the cavities, are arranged in an array that corresponds to the arrangement of wells of a standard microplate. In addition, will preferably that each cylindrical insertion opening has a stop which is designed to be applied to a rear end of an inserted pipette tip.
  • FIG. 1 shows a view of a known from the prior art multiple pipette head 6 a liquid handling apparatus 7.
  • a pipetting device 1 comprises a block 2 (see. Fig. 2 ) For holding a plurality of identically shaped pipette tips 3 with a tip axis 4 and for connecting these pipette tips 3 with a plurality of pipette cones 5 of a multi-pipette head 6 of the liquid handling apparatus 7.
  • Such liquid handling apparatuses are known for example under the trade name "Freedom EVO ®" and the current Applicant manufactured and sold.
  • FIG. 2 shows a vertical partial section through a known from the prior art block 2 for holding identically formed pipette tips 3.
  • the known from the prior art block 2 comprises a plurality of block 2 penetrating cavities 8, arranged in this case in parallel in an array which corresponds to the arrangement of wells of a standard microplate.
  • This block 2 also comprises a plurality of arranged on a bottom 9 of the block 2 and a lower opening of the cavities 8 forming, cylindrical insertion openings 10.
  • These insertion openings 10 are designed for frictional recording ever a pipette tip 3 that the tip axes 4 all pipette tips used 3 are arranged substantially parallel to each other in this array.
  • each cylindrical insertion opening 10 has a stop 11, which is designed to act on a rear end of an inserted pipette tip 3.
  • the positive loading of the stop 11 in the cylindrical insertion opening 10 ensures that the transport openings 15 of the pipette tips 3, all of which have exactly the same length within the dimensional accuracy of the production process, lie in one plane.
  • a liquid handling robot not shown
  • an exact elevation position of the transport openings 15 of all pipette tips 3 during pipetting (in particular during aspiration) of liquids can be set.
  • This block 2 further comprises a plurality of conical insertion openings 13 arranged on an upper side 12 of the block 2 and forming an upper opening of the cavities 8.
  • Each of these conical insertion openings 13 is for sealingly inserting a pipette cone 5 of a multiple pipette head 6 (cf. Fig. 1 ) educated.
  • the pipette cone 5 typically comprises a seal 5 ', which usually bears in an elastically deformed sealing manner against a conical insertion opening 13.
  • Such a pipetting device 1 known from the prior art also comprises a number of tubular pipette tips 3 each having a wall 14 extending along the tip axis 4 and having a transport opening 15 arranged at a front end for aspiration and dispensing. of fluid samples.
  • Such a prior art pipetting device 1 also includes means 20 for connecting block 2 and multiple pipette head 6.
  • An exemplary device 20 is shown in FIGS Figures 1 and 2 shown. This device 20 comprises holding openings 20 'with holding axles 21 for receiving holders 22 fastened to the multi-pipette head 6.
  • FIG. 3 shows in a to the Fig. 2
  • a pipetting device 1 according to the invention comprises at least one such block 2 for holding a multiplicity of identically designed pipette tips 3 with a tip axis 4 and for connecting these pipette tips 3 with a multiplicity
  • each pipette cone 5 comprises a seal 5 ', which is constructed so that it elastically deforms when penetrating the pipette cone 5 into a conical insertion opening 13 and sealingly abuts against this conical insertion openings 13.
  • the block 2 comprises a plurality of cavities 8 penetrating the block 2, which are arranged parallel in an array corresponding to the arrangement of wells of a standard microplate.
  • the inventive block 2 also comprises a plurality of arranged on a bottom 9 of the block 2 and a lower opening of the cavities 8 forming, cylindrical insertion openings 10. These cylindrical insertion openings 10 are designed for frictional recording ever a pipette tip 3 that the tip axes 4 all inserted pipette tips 3 are arranged substantially parallel to each other in this array.
  • the tip axes 4 of the pipette tips 3 are in an orthogonal grid with a lattice constant of 9 mm (for 96-well microplates) or with a Lattice constant of 4.5 mm (for 384-well microplates) arranged. If block 2 is adapted to another standard for microplates, the arrangement of the tip axes 4 of the pipette tips 3 is based on that standard. In any case, each of the cylindrical insertion openings 10 preferably has a stop 11, which is designed to act on a rear end of a pipette tip 3 inserted.
  • the inventive block 2 further comprises a plurality of arranged on an upper surface 12 of the block 2 and an upper opening of the cavities 8 forming conical insertion openings 13, each of which is designed for sealingly inserting a pipette cone 5 of a multi-pipette head 6.
  • a pipetting device 1 according to the invention also comprises a number of tubular pipette tips 3 each having a wall 14 extending along the tip axis 4 and a transport opening 15 arranged at a front end for receiving and dispensing liquid samples.
  • a pipetting device 1 according to the invention also comprises means 20 for connecting block 2 and multiple pipette head 6. These devices 20 may comprise holding openings 20 'with holding axes 21 for receiving holding devices 22 fastened to the multiple pipette head 6 or else configured differently.
  • a pipetting device 1 according to the invention also comprises a plurality of receptacles 16, which are preferably arranged in this array and extend concentrically with the tip axes 4, penetrating the block 2, each of which has a shoulder 17.
  • a pipetting device 1 according to the invention also comprises a plurality of inserts 18 preferably arranged in this array (corresponding to a standard) and concentrically extending to the tip axes 4 for insertion into the receptacles 16 of the block 2.
  • each insert 18 comprises a cavity 8, a cylindrical one Insertion 10 with inserted pipette tip 3 and a conical insertion opening 13 for sealing insertion of a pipette cone 5 of a multiple pipette head 6.
  • Each insert 18 has a support 19, with which he rests in block 2 on the shoulder 17 of the corresponding receptacle 16 rests.
  • FIG. 4 shows an enlarged view of the vertical section of Fig. 3 , whereby the individual elements of the inventive pipetting device 1 can be seen better.
  • Each insert 18 preferably lies in the corresponding receptacle 16 of the block 2 with horizontal play in all directions.
  • the pipette tips 3, and thereby also the cavities 8, are arranged in an array corresponding to the arrangement of wells of a standard microplate.
  • each cylindrical insertion opening 10 has a stop 11 formed to be engaged with a rear end of an inserted pipette tip 3.
  • the pipetting device 1 preferably comprises a retaining device 23 for preventing unwanted extraction of an insert 18 from a receptacle 16 when separating block 2 and multiple pipette head 6.
  • the retaining device 23 is designed as a cover 24 (cf. Fig. 3 ).
  • the lid 24 is fixed on the block 2 with inserted inserts 18 that each of these inserts 18 is held with all workedem, horizontal and vertical play in the corresponding receptacle 16 of the block 2.
  • This cover 24 comprises a plurality of openings 25 which are arranged in the same array as the receptacles 16 of the block 2.
  • each of these openings 25 is designed to be pierceable freely with a pipette cone 5 of a multiple pipette head 6.
  • each of the inserts 18 comprises an at least partially encircling rib 26 and each of the receptacles 16 of the block 2 comprises a corresponding at least partially circumferential groove 27.
  • the rib 26 of an insert 18 inserted into the block 2 snaps and so keeps this bet 18 without game in the corresponding Picture 16 of block 2 (see right side in Fig. 3 ).
  • each of the inserts 18 comprises an at least partially circumferential groove 27 and each of the receptacles 16 of the block 2 comprises a corresponding at least partially encircling rib 26. In this groove 27 of an insert 18 inserted into the block 2, the rib 26 snaps and so keeps this insert 18 without play in the corresponding receptacle 16 of the block. 2
  • the pipette tips 3 are aligned only by the insertion of the pipette cone 5 into the conical insertion opening 13 in the precise array in parallel.
  • the pipette tips 3 are aligned in the second embodiment with rib / groove combination 26,27 by the mutual snap of rib 26 and groove 27 in a precise array parallel.
  • the receptacles 16 of the block 2 for insertion of the pipette tips 3 are stepped several times, wherein the paragraph 17 forms a first stage and a second stage 28 is disposed near the bottom 9 of the block 2.
  • the shoulder 17 is disposed within the block 2 at a level closer to the top 12 than to the bottom 9 of the block 2, because a greater distance between the first and second steps stabilizes the orientation of the insert 18 and thus affects the orientation of the pipette tip 3.
  • each insert 18 has first, second and third maximum diameters 39, 40, 41 (see center of FIG Fig. 3 ; the maximum diameters are marked with thicker double arrows and the corresponding reference numerals are printed in bold).
  • each of the receptacles 16 comprises two cylindrical bores 29, 29 ", a first cylindrical bore 29 extending from the upper side 12 of the block 2 to the shoulder 17 and a further cylindrical bore 29" from the second stage 28 to the bottom 9 of the block 2.
  • each of the receptacles 16 of the block 2 comprises a conical bore 38 which extends from the paragraph 17 to the second stage 28.
  • each insert 18 has first, second and third maximum diameters 39, 40, 41.
  • a pipetting device 1 in which the cover 24 below the openings 25 cylindrical bores 36 which are arranged in the same array as the openings 25 of the lid 24.
  • the cylindrical holes 36 of the lid 24 are preferably the same diameter as the first cylindrical holes 29 of the block 2.
  • These cylindrical holes 36 of the lid 24 provide a vertical clearance 37 in relation to each insert 18 enclosed in a receptacle 16 of the block 2. This free measure can be a few hundredths to a few tenths of a millimeter and ensures that when fixed on the block 2 (eg screwed) cover 24 each of these inserts 18 with all sides, horizontal and especially with vertical play in the corresponding receptacle 16 of the block. 2 is held.
  • the preferred mass for a 96 block is in the following ranges (manufacturing tolerances are not considered): First diameter 30 8.09 mm Second diameter 31 6.61 mm Third diameter 32 5.85 mm First free or gap dimension 33 0.07 mm Second free or gap 34 0.08 mm Third free or gap size 35 0.05 mm Vertical free measure 37 0.10 mm First maximum diameter 39 7.95 mm Second maximum diameter 40 6.45 mm Third maximum diameter 41 5.75 mm.
  • the pipetting device 1 may also have one or more blind inserts 42 (see left side of FIG Fig. 4 ) for insertion into selected receptacles 16 of the block 2.
  • each dummy insert 42 comprises a cavity 8, an open cylindrical insertion opening 10 without inserted pipette tip 3 and a conical insertion opening 13 for sealingly inserting a pipette cone 5 of a multiple pipette head 6.
  • each dummy insert 42 has a support 19 with which it is inserted in block 2 on the shoulder 17 of the corresponding receptacle 16 rests. It is especially preferred that each dummy insert 42 with all-sided, horizontal play in the corresponding receptacle 16 of the block 2 is located.
  • PEEK polyetheretherketone
  • FIG. 5 shows a simplified representation of Fig. 3 after removal of the multiple pipette head 6 and its pipette cones 5.
  • cover 24 of the pipetting device 1 has successfully prevented when separating block 2 and multiple pipette head 6 one or more inserts 18 from their recordings 16 were pulled out.
  • This cover 24 is preferably fixed on the block 2 with inserted inserts 18 that each of these inserts 18 with all discoveredem, horizontal play (which preferably equal to twice the first free or Spaltmasses 33) and vertical clearance (the free mass 37) in the corresponding receptacle 16 of the block 2 is held.
  • the cover 24 comprises a plurality of openings 25 which are arranged in the same array as the receptacles 16 of the block 2.
  • each of these openings 25 is designed to be pierceable freely with a pipette cone 5 of a multiple pipette head 6.
  • FIG. 6 shows a simplified representation of Fig. 3 after removal of the multiple pipette head 6 and its pipette cones 5 when lifting the lid 24.
  • the individual inserts 18 can now be lifted easily and without effort from the receptacles 16 of the block 2.
  • This lifting can be done with an instrument having the shape and mass of a pipette cone 5.
  • Such an instrument (not shown) can be moved by hand or with a robot from a liquid handling apparatus 7 (not shown) and used to remove particular inserts 18 with damaged pipette tips 3 or selected inserts with possibly undamaged pipette tips from the block 2.
  • a method for removing pipette tips 3 from a block 2 of a pipetting device 1 which also comprises a cover 24 as a retaining device 23 for preventing unwanted extraction of an insert 18 from a receptacle 16 when separating block 2 and multiple pipette head 6, according to the invention
  • a cover 24 as a retaining device 23 for preventing unwanted extraction of an insert 18 from a receptacle 16 when separating block 2 and multiple pipette head 6, according to the invention
  • Multiple pipette head 6 and its pipette cones 5 separated from the block 2 the lid 24 lifted from the block 2 and selected inserts 18 are lifted out of the corresponding receptacles 16.
  • FIG. 7 shows an insert 18 with pipette tip 3 after lifting out of the receptacle 16 of the block 2 of Fig. 3 .
  • the first, second and third maximum diameters 39, 40, 41 of the insert 18, which are marked with thicker double arrows and in which the corresponding reference numerals are printed in bold, are particularly clearly visible in this illustration.
  • the cavity 8 is located in the interior of this insert and has in an upper part a concentric to the tip axis 4 arranged, conical insertion opening 13. Also clearly visible here are the preferably circulating support 19 of the insert 18 and the pipette tip 3 of the pipetting device 1 according to the invention, which is inserted with its rear end as far as the stop 11 into the cylindrical insertion opening.
  • FIG. 8 shows an empty receptacle 16 of the block 2 of Fig. 3 , Particularly well visible in this illustration are the first, second and third diameters 30, 31, 32 of the first, second and third cylindrical bores 29, 29 ', 29 "of the receptacle 16.
  • the preferably circumferential shoulder 17 of the receptacle is clearly visible 16 and the second stage 28 near the bottom 9 of the block 2 of the inventive pipetting device 1. Also clearly visible is the difference between the course of the conical bore 38 (left) and the second cylindrical bore 29 '(middle) in the block 2.
  • the empty receptacles 16 can each be equipped with dummy inserts 42, so that with a conventional multiple pipette head 6 of a liquid handling apparatus 7 certain wells can be served and other wells of the same microplate can be bypassed in one pipetting step.
  • a block 2 completely equipped with 96 or 384 inserts 18 and correspondingly many pipette tips 3 and an empty block 2 with an identical array of receptacles 16 are sufficient.
  • block 2 and the inserts 18 have been discussed with respect to a version with 96 pipette tips 3 arranged for use of standard microplates according to the ANSI_SBS 1-2-3-4-2004 standard. By analogy and correspondingly reduced in the relevant dimensions, these statements also apply to blocks 2 and inserts 18, which are designed for the use of standard microplates with 384 wells.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
EP13181354.5A 2013-06-06 2013-08-22 Dispositif de pipetage Active EP2810716B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP16182942.9A EP3112028B1 (fr) 2013-06-06 2013-08-22 Dispositif de pipetage

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH01070/13A CH708139A2 (de) 2013-06-06 2013-06-06 Pipettiervorrichtung.

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP16182942.9A Division-Into EP3112028B1 (fr) 2013-06-06 2013-08-22 Dispositif de pipetage
EP16182942.9A Division EP3112028B1 (fr) 2013-06-06 2013-08-22 Dispositif de pipetage

Publications (2)

Publication Number Publication Date
EP2810716A1 true EP2810716A1 (fr) 2014-12-10
EP2810716B1 EP2810716B1 (fr) 2016-09-14

Family

ID=49118291

Family Applications (2)

Application Number Title Priority Date Filing Date
EP13181354.5A Active EP2810716B1 (fr) 2013-06-06 2013-08-22 Dispositif de pipetage
EP16182942.9A Active EP3112028B1 (fr) 2013-06-06 2013-08-22 Dispositif de pipetage

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP16182942.9A Active EP3112028B1 (fr) 2013-06-06 2013-08-22 Dispositif de pipetage

Country Status (3)

Country Link
US (1) US9333499B2 (fr)
EP (2) EP2810716B1 (fr)
CH (1) CH708139A2 (fr)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN114917975A (zh) * 2022-05-17 2022-08-19 中国科学院沈阳自动化研究所 一种机器人末端移液装置及机器人移液控制方法

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US10758909B2 (en) * 2017-07-25 2020-09-01 Thomas A. HEDGLIN Device to assist in manual transfer of pipette tips
USD901035S1 (en) 2019-07-18 2020-11-03 CLAS Automation Pipette with a flared end
CN115816762A (zh) * 2021-11-30 2023-03-21 苏州新大陆精密科技股份有限公司 一种通用型移液管及其制作模具、制作方法
EP4202444B1 (fr) * 2021-12-23 2025-04-02 TECAN Trading AG Tête de pipetage multicanaux
USD1083135S1 (en) * 2024-01-23 2025-07-08 Eppendorf Se Semi-automated pipetting apparatus
USD1085457S1 (en) * 2024-01-23 2025-07-22 Eppendorf Se Dispensing head for automated pipetting apparatus

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Publication number Priority date Publication date Assignee Title
US5525302A (en) * 1991-02-01 1996-06-11 Astle; Thomas W. Method and device for simultaneously transferring plural samples
EP1136127A2 (fr) * 2000-03-20 2001-09-26 Brand Gmbh + Co Kg Dispositif de pipetage à canaux multiples et tige de pipette associée
WO2002016036A2 (fr) * 2000-08-21 2002-02-28 Mwg-Biotech Ag Tete de pipettage pour robot comportant plusieurs pointes de pipettes
US20040050866A1 (en) * 2000-11-17 2004-03-18 Nikolaus Ingenhoven Device for the take-up and/or release of liquid samples
WO2002059626A1 (fr) * 2001-01-25 2002-08-01 Tecan Trading Ag Dispositif de pipettage
WO2008068605A1 (fr) * 2006-12-07 2008-06-12 Gilson S.A.S. Dispositif de montage d'embout pour dispositif d'échantillonnage

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114917975A (zh) * 2022-05-17 2022-08-19 中国科学院沈阳自动化研究所 一种机器人末端移液装置及机器人移液控制方法

Also Published As

Publication number Publication date
EP2810716B1 (fr) 2016-09-14
EP3112028B1 (fr) 2019-11-27
EP3112028A1 (fr) 2017-01-04
CH708139A2 (de) 2014-12-15
US9333499B2 (en) 2016-05-10
US20140363355A1 (en) 2014-12-11

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