EP2812451A4 - Verfahren und zusammensetzungen in zusammenhang mit ros1-fusionen zur diagnostizierung und behandlung von krebs - Google Patents

Verfahren und zusammensetzungen in zusammenhang mit ros1-fusionen zur diagnostizierung und behandlung von krebs

Info

Publication number
EP2812451A4
EP2812451A4 EP13746869.0A EP13746869A EP2812451A4 EP 2812451 A4 EP2812451 A4 EP 2812451A4 EP 13746869 A EP13746869 A EP 13746869A EP 2812451 A4 EP2812451 A4 EP 2812451A4
Authority
EP
European Patent Office
Prior art keywords
diagnosing
methods
treating cancer
compositions relating
ros1 fusions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13746869.0A
Other languages
English (en)
French (fr)
Other versions
EP2812451A2 (de
Inventor
David Hout
John Handshoe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Insight Genetics Inc
Original Assignee
Insight Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insight Genetics Inc filed Critical Insight Genetics Inc
Publication of EP2812451A2 publication Critical patent/EP2812451A2/de
Publication of EP2812451A4 publication Critical patent/EP2812451A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP13746869.0A 2012-02-08 2013-02-08 Verfahren und zusammensetzungen in zusammenhang mit ros1-fusionen zur diagnostizierung und behandlung von krebs Withdrawn EP2812451A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261596720P 2012-02-08 2012-02-08
PCT/US2013/025345 WO2013119950A2 (en) 2012-02-08 2013-02-08 Methods and compositions relating to fusions of ros1 for diagnosing and treating cancer

Publications (2)

Publication Number Publication Date
EP2812451A2 EP2812451A2 (de) 2014-12-17
EP2812451A4 true EP2812451A4 (de) 2016-01-06

Family

ID=48948165

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13746869.0A Withdrawn EP2812451A4 (de) 2012-02-08 2013-02-08 Verfahren und zusammensetzungen in zusammenhang mit ros1-fusionen zur diagnostizierung und behandlung von krebs

Country Status (5)

Country Link
EP (1) EP2812451A4 (de)
JP (1) JP2015508644A (de)
CN (1) CN104364391A (de)
AU (1) AU2013216904A1 (de)
WO (1) WO2013119950A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3044218T3 (da) 2013-09-10 2020-07-27 Univ Texas Terapeutiske midler til targetering af trunkerede adenomatøse polyposis coli (apc)-proteiner
US10231965B2 (en) 2014-02-20 2019-03-19 Ignyta, Inc. Molecules for administration to ROS1 mutant cancer cells
CA2943636C (en) * 2014-03-25 2020-06-09 Quest Diagnostics Investments Incorporated Detection of gene fusions by intragenic differential expression (ide) using average cycle thresholds
US10082496B2 (en) * 2014-09-10 2018-09-25 Board Of Regents Of The University Of Texas System Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis
EP3227276B1 (de) 2014-12-02 2021-09-01 Ignyta, Inc. Kombinationen zur behandlung von neuroblastom
CN104830989A (zh) * 2015-05-25 2015-08-12 上海允英医疗科技有限公司 一种用于ros1与多种基因发生融合突变的检测试剂盒
EP3325667B1 (de) * 2015-07-21 2020-11-11 Guardant Health, Inc. Verriegelte nukleinsäuren zur erfassung von fusionsgenen
BR112018012255A2 (pt) 2015-12-18 2018-12-04 Ignyta Inc método para tratar câncer
AU2018302170B2 (en) 2017-07-19 2024-02-29 Ignyta, Inc. Pharmaceutical compositions comprising entrectinib
CN111225662B (zh) 2017-10-17 2022-11-22 伊尼塔公司 药物组合物和剂型
CN113473990A (zh) * 2018-10-08 2021-10-01 锐新医药公司 用于治疗癌症的shp2抑制剂组合物
WO2024072805A1 (en) * 2022-09-26 2024-04-04 Lau, Johnson Yiu-Nam Compositions, systems, and methods for detection of ovarian cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007084631A2 (en) * 2006-01-20 2007-07-26 Cell Signaling Technology, Inc. Translocation and mutant ros kinase in human non-small cell lung carcinoma
WO2011146945A2 (en) * 2010-05-21 2011-11-24 Cell Signaling Technology, Inc. Alk and ros kinase in cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1454994A1 (de) * 2003-03-07 2004-09-08 Université de la Méditerranée Standardisiertes und optimiertes quantitatives Reverse-Transkriptase-Echtzeit-Polymerasekettenreaktionsverfahren zum Nachweis von minimalen Resterkrankungen bei Leukämie
US20100143918A1 (en) * 2007-01-19 2010-06-10 Cell Signaling Technology, Inc. Translocation and mutant ros kinase in human non-small cell lung carcinoma
AU2010213578B2 (en) * 2009-02-12 2015-01-29 Cell Signaling Technology, Inc. Mutant ROS expression in human cancer
EP3133167B1 (de) * 2009-05-15 2018-09-12 Insight Genetics, Inc. Verfahren in zusammenhang mit alk-fusionen zur diagnostizierung von krebs
WO2011162295A1 (ja) * 2010-06-22 2011-12-29 アステラス製薬株式会社 新規ｒｏｓ１融合体の検出法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007084631A2 (en) * 2006-01-20 2007-07-26 Cell Signaling Technology, Inc. Translocation and mutant ros kinase in human non-small cell lung carcinoma
WO2011146945A2 (en) * 2010-05-21 2011-11-24 Cell Signaling Technology, Inc. Alk and ros kinase in cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHENGUANG LI ET AL: "Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers", PLOS ONE, vol. 6, no. 11, 30 November 2011 (2011-11-30), pages e28204, XP055209333, DOI: 10.1371/journal.pone.0028204 *

Also Published As

Publication number Publication date
JP2015508644A (ja) 2015-03-23
WO2013119950A2 (en) 2013-08-15
WO2013119950A3 (en) 2014-11-13
EP2812451A2 (de) 2014-12-17
CN104364391A (zh) 2015-02-18
AU2013216904A1 (en) 2014-08-28

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