EP2836611A4 - Nachweis und quantifizierung von probenverunreinigungen in einer immunrepertoireanalyse - Google Patents

Nachweis und quantifizierung von probenverunreinigungen in einer immunrepertoireanalyse

Info

Publication number
EP2836611A4
EP2836611A4 EP13775514.6A EP13775514A EP2836611A4 EP 2836611 A4 EP2836611 A4 EP 2836611A4 EP 13775514 A EP13775514 A EP 13775514A EP 2836611 A4 EP2836611 A4 EP 2836611A4
Authority
EP
European Patent Office
Prior art keywords
quantitation
detection
immune repertoire
sample contamination
repertoire analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13775514.6A
Other languages
English (en)
French (fr)
Other versions
EP2836611A1 (de
Inventor
Thomas Asbury
Victoria Carlton
Malek Faham
Stephen Macevicz
Martin Head
Thomas Willis
Jianbiao Zheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adaptive Biotechnologies Corp
Original Assignee
Sequenta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/835,093 external-priority patent/US9506119B2/en
Priority claimed from US13/834,794 external-priority patent/US9528160B2/en
Application filed by Sequenta Inc filed Critical Sequenta Inc
Publication of EP2836611A1 publication Critical patent/EP2836611A1/de
Publication of EP2836611A4 publication Critical patent/EP2836611A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP13775514.6A 2012-04-13 2013-04-09 Nachweis und quantifizierung von probenverunreinigungen in einer immunrepertoireanalyse Withdrawn EP2836611A4 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261624002P 2012-04-13 2012-04-13
US201261658317P 2012-06-11 2012-06-11
US201261738277P 2012-12-17 2012-12-17
US201361768269P 2013-02-22 2013-02-22
US13/835,093 US9506119B2 (en) 2008-11-07 2013-03-15 Method of sequence determination using sequence tags
US13/834,794 US9528160B2 (en) 2008-11-07 2013-03-15 Rare clonotypes and uses thereof
PCT/US2013/035857 WO2013155119A1 (en) 2012-04-13 2013-04-09 Detection and quantitation of sample contamination in immune repertoire analysis

Publications (2)

Publication Number Publication Date
EP2836611A1 EP2836611A1 (de) 2015-02-18
EP2836611A4 true EP2836611A4 (de) 2015-12-30

Family

ID=49328112

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13775514.6A Withdrawn EP2836611A4 (de) 2012-04-13 2013-04-09 Nachweis und quantifizierung von probenverunreinigungen in einer immunrepertoireanalyse

Country Status (7)

Country Link
EP (1) EP2836611A4 (de)
JP (1) JP2015512655A (de)
CN (1) CN104395481A (de)
AU (1) AU2013246050B2 (de)
CA (1) CA2869481A1 (de)
SG (1) SG11201406538VA (de)
WO (1) WO2013155119A1 (de)

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US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
EP2364368B1 (de) 2008-11-07 2014-01-15 Sequenta, Inc. Verfahren zur überwachung von krankheitszuständen mittels sequenzanalyse
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
ES2726702T3 (es) 2009-01-15 2019-10-08 Adaptive Biotechnologies Corp Perfilado de la inmunidad adaptativa y métodos para la generación de anticuerpos monoclonales
WO2010151416A1 (en) 2009-06-25 2010-12-29 Fred Hutchinson Cancer Research Center Method of measuring adaptive immunity
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
EP2768982A4 (de) 2011-10-21 2015-06-03 Adaptive Biotechnologies Corp Quantifizierung von adaptiven immunzellgenomen in einer komplexen mischung von zellen
US9824179B2 (en) 2011-12-09 2017-11-21 Adaptive Biotechnologies Corp. Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
EP3372694A1 (de) 2012-03-05 2018-09-12 Adaptive Biotechnologies Corporation Festlegung von gepaarten immunrezeptorketten aus frequenzabgestimmten untereinheiten
HUE029357T2 (en) 2012-05-08 2017-02-28 Adaptive Biotechnologies Corp Preparations and devices for measuring and calibrating amplification distortion in multiplex PCR reactions
EP3330384B1 (de) 2012-10-01 2019-09-25 Adaptive Biotechnologies Corporation Immunkompetenzbeurteilung durch adaptive immunrezeptordiversität und klonalitätscharakterisierung
EP4592400A3 (de) 2012-10-17 2025-10-29 10x Genomics Sweden AB Verfahren und produkt zur optimierung einer lokalisierten oder räumlichen detektion einer genexpression in einer gewebeprobe
WO2015160439A2 (en) 2014-04-17 2015-10-22 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
CA2916662C (en) 2013-06-25 2022-03-08 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
US9708657B2 (en) * 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
WO2015134787A2 (en) 2014-03-05 2015-09-11 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
AU2015353581A1 (en) 2014-11-25 2017-06-15 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
CA2976580A1 (en) 2015-02-24 2016-09-01 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing
EP3277294B1 (de) 2015-04-01 2024-05-15 Adaptive Biotechnologies Corp. Verfahren zur identifizierung von menschlichen kompatiblen t-zell-rezeptoren spezifisch für ein antigen-ziel
EP3901282B1 (de) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben
CN105095687B (zh) * 2015-06-26 2018-10-26 南方科技大学 一种免疫组库数据分析方法及终端
EP4282979A3 (de) * 2015-09-01 2024-02-28 The Regents of the University of California Modulare polypeptidbibliotheken sowie verfahren zur herstellung und verwendung davon
JP7064439B2 (ja) * 2015-11-04 2022-05-10 アトレカ インコーポレイテッド 単一細胞に関連する核酸の解析のための、核酸バーコードの組み合わせセット
CN105740650B (zh) * 2016-03-02 2019-04-05 广西作物遗传改良生物技术重点开放实验室 一种快速准确鉴定高通量基因组数据污染源的方法
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
WO2019046817A1 (en) 2017-09-01 2019-03-07 Life Technologies Corporation COMPOSITIONS AND METHODS FOR IMMUNOLOGICAL REPERTOIRE SEQUENCING
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
WO2020018836A1 (en) 2018-07-18 2020-01-23 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
CN112189139B (zh) * 2018-09-26 2024-10-29 北卡罗来纳-查佩尔山大学 用于改进测定的化合物、组合物和方法
CN112867800B (zh) * 2018-12-17 2024-07-12 Illumina公司 用于制备测序文库的方法和手段
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
CN110970091B (zh) * 2019-12-20 2023-05-23 北京优迅医学检验实验室有限公司 标签质控的方法及装置
CN111304309A (zh) * 2020-03-06 2020-06-19 上海韦翰斯生物医药科技有限公司 一种测序平台标签序列污染的检测方法
EP4600376A3 (de) * 2020-06-02 2025-10-22 10X Genomics, Inc. Räumliche transkriptomik für antigenrezeptoren
AU2021283174A1 (en) 2020-06-02 2023-01-05 10X Genomics, Inc. Nucleic acid library methods
EP4421186B1 (de) 2020-06-08 2025-08-13 10X Genomics, Inc. Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon

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Publication number Priority date Publication date Assignee Title
WO1999020798A1 (en) * 1997-10-23 1999-04-29 Exact Laboratories, Inc. Methods for detecting contamination in molecular diagnostics using pcr
WO2005113803A1 (en) * 2004-05-19 2005-12-01 Amplion Limited Detection of amplicon contamination during pcr exhibiting two different annealing temperatures
WO2011139371A1 (en) * 2010-05-06 2011-11-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles

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WO2007087312A2 (en) * 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Molecular counting
ES2546848T3 (es) * 2006-03-10 2015-09-29 Epigenomics Ag Un método para identificar una muestra biológica para el análisis de la metilación
EP2364368B1 (de) * 2008-11-07 2014-01-15 Sequenta, Inc. Verfahren zur überwachung von krankheitszuständen mittels sequenzanalyse
US8748103B2 (en) * 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
WO2012083225A2 (en) * 2010-12-16 2012-06-21 Gigagen, Inc. System and methods for massively parallel analysis of nycleic acids in single cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999020798A1 (en) * 1997-10-23 1999-04-29 Exact Laboratories, Inc. Methods for detecting contamination in molecular diagnostics using pcr
WO2005113803A1 (en) * 2004-05-19 2005-12-01 Amplion Limited Detection of amplicon contamination during pcr exhibiting two different annealing temperatures
WO2011139371A1 (en) * 2010-05-06 2011-11-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MEGAN L MCCLOSKEY ET AL: "Encoding PCR Products with Batch-stamps and Barcodes", BIOCHEMICAL GENETICS, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 45, no. 11-12, 23 October 2007 (2007-10-23), pages 761 - 767, XP019548696, ISSN: 1573-4927, DOI: 10.1007/S10528-007-9114-X *
See also references of WO2013155119A1 *

Also Published As

Publication number Publication date
EP2836611A1 (de) 2015-02-18
WO2013155119A1 (en) 2013-10-17
JP2015512655A (ja) 2015-04-30
AU2013246050A1 (en) 2014-10-23
AU2013246050B2 (en) 2017-03-16
SG11201406538VA (en) 2014-11-27
CA2869481A1 (en) 2013-10-17
CN104395481A (zh) 2015-03-04

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